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Excellgen

Gail L Daumit
Johns Hopkins University

Project start date: 2012-01-18

Project end date: 2016-12-31


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Grants awarded to Gail L Daumit

ACTIVATING CONSUMERS TO EXERCISE IN COMMUNITY PSYCHIATRY THROUGH PEER SUPPORT.

Gail L Daumit, Associate Professor
Johns Hopkins University, W400 Wyman Park Building, Baltimore, Md 21218

Grant 5R34MH078613-03 from National Institute Of Mental Health

Abstract: Persons with severe mental illness (SMI) carry a tremendous burden of medical comorbid illness and die at least 10 years earlier than the U.S. population due in large part to early cardiovascular death. Regular physical activity decreases cardiovascular disease risk and improves longevity independent of weight or weight loss, yet effective interventions tailored to increase physical activity in persons with SMI are lacking. Social support positively influences physical activity in the general population, and peer support interventions are successful in health behavior change to prevent HIV. Hence, peer-supported physical activity may be an effective strategy to decrease cardiovascular risk in persons with SMI. The objective of this R34 application is to design and test a culturally appropriate physical activity intervention based in a peer-support model for persons with SMI in an urban community psychiatry program. We will adapt the peer support model from the HIV prevention peer outreach Self Help in Eliminating Lethal Disease Study. We propose the following Specific Aims 1) Design a physical activity intervention emphasizing peer-support for persons with SMI in community psychiatry; 2) Conduct a randomized controlled study that tests the preliminary efficacy of the peer-supported physical activity intervention; 3) Evaluate the peer educators´ experiences and compare peer educators´ outcomes to participant outcomes; and 4) Use data from this pilot study to develop an R-01 proposal for a full-scale randomized controlled trial. We will recruit and train 20 peer educators to deliver the peer-supported physical activity (PS+PA) intervention. 40 participants will receive the physical activity intervention with peer-support (PS+PA) and will be compared to 40 receiving the same physical activity (PA) intervention without peer-support. All participants receive the PA intervention, providing group exercise classes and supervised open-gym hours for individual exercise. In the (PS+PA) arm, peer-educators will provide emotional, informational, instrumental and appraisal support to motivate subjects to participate in exercise. The primary outcome at 4 months will be cardiorespiratory fitness measured by heart rate response to submaximal treadmill test. Secondary outcomes will be a) moderate physical activity measured by accelerometry; b) waist circumference; c) weight; d) health status; and e) depression symptom level. Process outcomes will be a) self-efficacy and b) participation. This innovative proposal will use behavioral change methods successful in HIV prevention to design and test a peer-supported physical activity intervention in community psychiatry. We believe peer support will provide a novel and effective model for increasing physical activity in SMI. This study will provide important data for future work to reduce cardiovascular risk and improve health in persons with SMI

Keywords: AIDS Virus; AIDS prevention; AIDS/HIV prevention; Acquired Immune Deficiency Syndrome Virus; Acquired Immunodeficiency Syndrome Virus; Arm; Behavior; Behavioral; Body Weight decreased; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cessation of life; Chronotropism, Cardiac; Chronotropisms, Cardiac; Class; Community Psychiatry; Data; Death; Disease; Disease model; Disorder; Elements; Emotional; Emotional Depression; Exercise; Exercise, Physical; Future; General Population; General Public; Goals; HIV; HIV Prevention; HIV/AIDS prevention; HTLV-III; Health; Health Status; Health behavior change; Heart; Heart Rate; Hour; Human Immunodeficiency Viruses; Human T-Cell Leukemia Virus Type III; Human T-Cell Lymphotropic Virus Type III; Human T-Lymphotropic Virus Type III; Individual; Intervention; Intervention Strategies; Investigators; LAV-HTLV-III; Lead; Length of Life; Level of Health; Life Style; Lifestyle; Longevity; Lymphadenopathy-Associated Virus; Measures; Medical; Mental disorders; Mental health disorders; Methods; Methods and Techniques; Methods, Other; Modeling; Modification; Mortality; Mortality Vital Statistics; NIDA; NIMH; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Mental Health (U.S.); Obesity; Organ System, Cardiovascular; Outcome; Over weight; Overweight; Participant; Pb element; Persons; Physical activity; Pilot Projects; Population; Prevention intervention; Process; Programs (PT); Programs [Publication Type]; Psychiatric Disease; Psychiatric Disorder; Randomized Controlled Trials; Range; Recruitment Activity; Research Personnel; Researchers; Self Efficacy; Social support; Symptoms of depression; Techniques; Testing; Training; Treadmill Tests; United States National Institute of Mental Health; Unspecified Mental Disorder; Upper arm; Vascular, Heart; Virus-HIV; Weight; Weight Loss; Weight Reduction; Work; adiposity; base; body weight loss; cardiovascular disease risk; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; circulatory system; comparison group; corpulence; corpulency; corpulentia; depressive; depressive symptoms; design; designing; disease/disorder; disorder model; experience; fitness; heavy metal Pb; heavy metal lead; improved; innovate; innovation; innovative; interventional strategy; life span; lifespan; mental illness; multidisciplinary; novel; obese; obese people; obese person; obese population; outreach; peer; pilot study; prevent; preventing; programs; psychiatric rehabilitation; psychological disorder; randomized controlled study; recruit; response; self help; serious mental illness; severe mental illness; social support network; trial comparing; waist circumference; weight loss intervention; wt-loss

Project start date: 2006-09-01

Project end date: 2010-07-31

Budget start date: 1-AUG-2008

Budget end date: 31-JUL-2010

PFA/PA: RFA-MH-06-002

5R34MH078613-03 (2008): $0


5R34MH078613-02 (2007): $214979

1R34MH078613-01 (2006): $220838

RANDOMIZED TRIAL OF ACHIEVING HEALTHY LIFESTYLES IN PSYCH REHABILITATION

Gail L Daumit, Associate Professor
Johns Hopkins University, 3400 N Charles St, Baltimore, Md 21218

Grant 5R01MH080964-03 from National Institute Of Mental Health

Abstract: Overweight and obesity are highly prevalent among persons with severe mental illness (SMI); these conditions likely contribute substantially to premature cardiovascular disease and the 20 percent shortened life expectancy in SMI. Persons with SMI need effective, appropriately tailored behavioral interventions to achieve and maintain weight loss. Psychiatric rehabilitation programs provide logical intervention settings because consumers often attend regularly and exercise can take place on-site. Through the NIMH R34,"Achieving Healthy Lifestyles in Psych Rehabilitation", we tailored a comprehensive behavioral weight loss intervention efficacious in the general population to persons with SMI in psychiatric rehabilitation centers. We performed a pre/post pilot study (n=52) and demonstrated preliminary efficacy with high levels of recruitment, retention and demonstrated weight loss. The objective of this R-01 application is to perform a randomized clinical trial (ACHIEVE Trial) to definitively test the efficacy of this innovative, practical intervention to accomplish and sustain weight loss in overweight and obese persons with SMI. In the proposed multi-site trial, we will enroll 320 consumers with SMI who attend ten psychiatric rehabilitation centers in urban and suburban areas across Maryland and randomize participants to the ACHIEVE intervention or usual care. Intervention participants will receive group and individual weight management education and counseling sessions and group physical activity classes at each site. In the initial 6 month intensive intervention period, study interventionists will lead the sessions and also train rehabilitation program staff. A 12 month maintenance intervention will follow where interventionists continue leading some sessions and rehabilitation staff gradually assume responsibility for delivering much of the intervention. Co-primary outcomes will be change in weight from baseline to 6 and 18 months. Secondary outcomes will be change at 6 and 18 months for a) moderate physical activity by accelerometry and physical fitness by 6 minute walk; b) waist circumference; c) lipids; d) blood pressure; e) Framingham cardiovascular risk score; f) health status with SF-36; and g) depression symptoms with CES-D. We also will evaluate formally intervention cost. This proposed multi-site randomized clinical trial will provide a rigorous evaluation of a practical behavioral intervention designed to accomplish and sustain weight loss in persons with SMI. If successful, the intervention will be a model program that could be disseminated widely and should provide important health benefits by ameliorating cardiovascular disease risk in this vulnerable population. Obesity is very common in persons with severe mental illness, and effective weight-loss interventions for this high-risk group are needed urgently. We will perform a randomized trial in 10 psychiatric rehabilitation centers to test a practical weight-loss intervention with nutrition counseling and exercise classes that is proven in the general population and tailored to persons with severe mental illness. If successful, the intervention will be a model program that could be disseminated widely and should provide important health benefits by decreasing heart disease risk in this vulnerable population

Keywords: Age; Area; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Pressure; Body Weight Changes; Body Weight decreased; Cardiovascular Diseases; Clinic; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive function abnormal; Conditioning Therapy; Control Groups; Cost Effective Analyses; Cost Effectiveness Analysis; Counseling; Depression; Disturbance in cognition; Drugs; Education; Educational aspects; Emotional Depression; Enrollment; Epidemic; Evaluation; Exercise; Exercise, Physical; Food; Gender; General Population; General Public; Grant; Health; Health Benefit; Health Status; Impaired cognition; Individual; Intervention; Intervention Strategies; Lead; Length of Life; Level of Health; Life Expectancy; Life Style; Life Style Modification; Lifestyle; Lipids; Longevity; Maintenance; Maintenances; Maryland; Measures; Medical; Medication; Mental Depression; Mental Health; Mental Hygiene; Modeling; NIMH; National Institute of Mental Health; National Institute of Mental Health (U.S.); Nutrition; Nutritional Science; Obesity; Out-patients; Outcome; Outpatients; Over weight; Overweight; Participant; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical Fitness; Physical Health Services / Rehabilitation; Physical activity; Pilot Projects; Policy Maker; Population; Programs (PT); Programs [Publication Type]; Psyche structure; Psychiatric Diagnosis; Psychological Health; Randomized; Randomized Clinical Trials; Rehabilitation; Rehabilitation Centers; Rehabilitation therapy; Rehabilitation, Medical; SF-36; SUBGP; Science of nutrition; Site; Subgroup; Symptoms; Symptoms of depression; Testing; Training; Trials, Randomized Clinical; United States National Institute of Mental Health; Vulnerable Populations; Walking; Weight; Weight Change; Weight Loss; Weight Reduction; adiposity; behavior change; behavior intervention; behavioral intervention; body weight loss; cardiac disease risk; cardiac disorder risk; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; corpulence; corpulency; corpulentia; cost; cost efficient analysis; depressive; depressive symptoms; drug/agent; efficacy testing; enroll; group intervention; heart disease risk; heart disorder risk; heavy metal Pb; heavy metal lead; high risk; innovate; innovation; innovative; intervention design; interventional strategy; life span; lifespan; mental; multi-site trial; nutrition; obese; obese people; obese person; obese population; pilot study; preclinical study; premature; primary outcome; programs; psychiatric rehabilitation; randomisation; randomization; randomized trial; randomly assigned; rehabilitative; secondary outcome; serious mental illness; severe mental illness; skills training; suburb; successful intervention; therapy design; treatment as usual; treatment design; waist circumference; weight loss intervention; wt-loss

Project start date: 2008-03-01

Project end date: 2012-11-30

Budget start date: 1-DEC-2009

Budget end date: 30-NOV-2010

PFA/PA: PA-07-211

5R01MH080964-03 (2010): $1166601


Achieving Healthy Lifestyles In Psych Rehabilitation

Gail L Daumit, Associate Professor
Medicinejohns Hopkins University
w400 Wyman Park Building
baltimore, Md 212182680

Grant 5R34MH070368-03 from National Institute Of Mental Health IRG: ZMH1

Abstract: Overweight and obesity are highly prevalent among people with severe mental illness (SMI); these conditions in the SMI likely contribute substantially to hypertension, diabetes mellitus, coronary disease, and early mortality. Through increased appetite and other possible mechanisms, most a typical antipsychotics cause weight gain. Yet, given their effectiveness and fewer neurologic side effects, these medications will likely remain a mainstay of pharmacotherapy in the foreseeable future. At the same time, weight gain may play a role in non-adherence to antipsychotics. Effective behavioral weight loss interventions exist for the general population; however, they are probably not appropriate for people with SMI, who have special needs. Healthy lifestyle interventions for people with SMI are urgently needed. Psychiatric rehabilitation programs provide a unique context for testing nutrition and exercise interventions through their emphasis on skills building in a supportive environment. In this R34 application we propose a pilot study with three aims 1) Design a healthy lifestyle intervention for psychiatric rehabilitation clients that is based on state-of-the art interventions for the general population, incorporates client input, and is appropriately adapted to client needs; 2) Test the intervention´s feasibility and preliminary efficacy; and 3) Use pilot data from this study to develop an R01 application for a full-scale randomized controlled trial of the intervention. The multifaceted intervention will combine skills training and environment/social support through a) healthy modification of on-site meals; b) nutrition and exercise behavioral counseling; and c) on-site exercise. We will enroll 50 clients and measure whether the 6 month intervention leads to a) 10 pound weight loss; b) regular moderate physical activity; and c) improvement in quality of life, health status and mental health. This R34 will provide valuable pilot data for future work to improve healthy lifestyles and reduce chronic medical illness in people with SMI

Keywords: disease /disorder prevention /control, mental disorder, obesity, therapy design /development, weight control behavioral /social science research tag, clinical research, human subject, patient oriented research

Project start date: 2005-01-10

Project end date: 2008-12-31

5R34MH070368-03 (2007): $177314


5R34MH070368-02 (2006): $188808

1R34MH070368-01A1 (2005): $200282

PREVENTABLE MORTALITY IN MARYLAND MEDICAID SMI

Gail L Daumit, Associate Professor
Johns Hopkins University, 3400 N Charles St, Baltimore, Md 21218

Grant 5R01MH074070-04 from National Institute Of Mental Health

Abstract: Excess mortality among persons with severe mental illness (SMI) is documented consistently, yet higher suicide rates only partially explain this mortality difference. Previous research has focused little attention on the contribution of somatic disease or poor quality care to mortality in persons with SMI, who likely are at higher risk than others for poorer quality care, including adverse events. This study will utilize and extend an existing NIMH-funded community-based cohort of 6,235 adults with SMI, ages 21-62 in 1993, enrolled in Maryland Medicaid, and followed from fiscal years 1994-2000. Matching to the National Death Index revealed over 18% (N=1142) have died at a mean age of only 51 years. This magnitude of early mortality, almost 3 times the expected rate for Maryland residents, is alarming. A retrospective study is proposed to examine potentially preventable causes of mortality in persons with SMI. In Maryland Medicaid cohorts of 6,235 adults with SMI and 30,000 disabled adults without SMI our Specific Aims are 1) Estimate the relative risk of mortality from specific health problems (alcohol and substance abuse, injury and chronic medical conditions); 2) Examine the relative risk of mortality associated with poor quality of care for coronary artery disease, diabetes, schizophrenia, bipolar disorder and major depression. In the SMI cohort we will then 3) Examine the risk of in-hospital mortality or mortality within 30 days of hospital discharge associated with the occurrence of adverse events in medical and surgical hospitalizations; and 4) Compare the occurrence and types of adverse events to a completed state-of-the art patient safety study of admissions to general hospitals. Specific Aims 1 and 2 will implement a longitudinal analysis of Medicaid administrative data through 2004 and apply quality of care indicators for chronic conditions. Specific Aim 3 will use a case-crossover design where adverse events from hospital records around the time of death will be compared to those in a randomly selected earlier hospitalization for the same subject. Specific Aim 4 will compare adverse event data in Specific Aim 3 to a patient safety study in the general population using the same chart ion instrument. This innovative study will illuminate factors contributing to premature death in the SMI that may be amenable to improved quality of care, and/or improved patient safety, and will provide a basis for prioritizing interventions to improve longevity in the SMI

Keywords: 21 year old; 21+ years old; Active Follow-up; Acute; Administrative Supplement; Admission; Admission activity; Adult; Adverse Experience; Adverse event; Affective Psychosis, Bipolar; After Care; After-Treatment; Aftercare; Age; Alcohol abuse; Alcohols; American; Area; Arts; Attention; Bipolar Disorder; Blood Pressure, High; Cancers; Cardiac Diseases; Cardiac Disorders; Caring; Cause of Death; Cessation of life; Chemical Class, Alcohol; Chronic; Chronic Disease; Chronic Illness; Chronic lung disease; Colorado; Communities; Coronary Arteriosclerosis; Coronary Artery Disease; Coronary Artery Disorder; Coronary Atherosclerosis; Crossover Design; Data; Death; Designs, Cross-Over; Diabetes Mellitus; Diagnosis; Disabled Persons; Disabled Population; Disease; Disorder; Drugs; Enrollment; Event; Excess Mortality; FLR; Failure (biologic function); Frequencies (time pattern); Frequency; Funding; General Hospitals; General Population; General Public; Goals; HOSP; Handicapped; Health; Heart Diseases; Hospital Mortality; Hospital Records; Hospitalization; Hospitals; Hospitals, General; Human, Adult; Hypertension; Injury; Inpatients; Intervention; Intervention Strategies; Interview; Investigators; Length of Life; Length of Stay; Life Expectancy; Longevity; Major Depressive Disorder; Malignant Neoplasms; Malignant Tumor; Maryland; Medicaid; Medical; Medical Errors; Medical Mistakes; Medication; Method LOINC Axis 6; Methodology; Morbidity; Morbidity - disease rate; Mortalities, In-house; Mortality; Mortality Vital Statistics; Mortality, Inhospital; Number of Days in Hospital; Operation; Operative Procedures; Operative Surgical Procedures; Out-patients; Outpatients; Participant; Patients; People with Disabilities; Persons; Persons with Disabilities; Pharmaceutic Preparations; Pharmaceutical Preparations; Pharmacies; Pharmacy facility; Population; Psyche structure; Psychosis, Manic-Depressive; QOC; Quality of Care; Relative Risks; Research; Research Personnel; Researchers; Retrospective Studies; Risk; Risks, Relative; Sampling; Schizophrenia; Schizophrenic Disorders; Secondary Prevention; Substance abuse problem; Surgical; Surgical Interventions; Surgical Procedure; Time; Utah; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; abuse of substances; adult human (21+); alcohol problem; base; bipolar affective disorder; chronic disease/disorder; chronic disorder; cohort; comparison group; dementia praecox; design; designing; diabetes; directed attention; directs attention; disabled; disabled people; disease/disorder; drug/agent; enroll; ethanol abuse; failure; follow-up; hazardous alcohol use; heart disorder; high risk; hospital days; hospital length of stay; hospital stay; hyperpiesia; hyperpiesis; hypertensive disease; improved; indexing; innovate; innovation; innovative; instrument; interventional strategy; life span; lifespan; longitudinal analysis; major depression; malignancy; manic depressive disorder; manic depressive illness; mental; neoplasm/cancer; patient population; patient safety; premature; prevent; preventing; problem drinking; safety study; schizophrenic; serious mental illness; severe mental illness; substance abuse; suicide rate; surgery; twenty-one year old

Project start date: 2006-01-01

Project end date: 2010-06-30

Budget start date: 1-JAN-2009

Budget end date: 30-JUN-2010

PFA/PA: PA-05-018

5R01MH074070-04 (2009): $118513


5R01MH074070-02 (2007): $442598

1R01MH074070-01A1 (2006): $519505

Sponsored Links Excellgen http://Excellgen.com

Transient Protein Expression in CHO and HEK293 Cells
Transient Expression, Truly Functional Protein, 95% purity, 1~20 mg, fast turnaround. $5500, $3950
Baculovirus Protein Expression
Fast turn around, >95% purity functional protein. No outsourcing to China or India. $5500, $3950
Recombinant Lentivirus & Adenovirus
High Yield and High Titer up to 1010 (lentivirus) and 1013 (adenovirus) for Guaranteed Expression of GOI. $3000, $2500

MENTAL & SOMATIC ILLNESS: NEEDS, SERVICES, AND OUTCOMES

Gail L Daumit, Assistant Professor
Johns Hopkins University W400 Wyman Park Building Baltimore, Md 212182680

Grant 5K08MH001787-05 from National Institute Of Mental Health IRG: ZMH1

Abstract: Dr. Daumit trained in Internal Medicine at the Massachusetts General Hospital (1993-1996). At Johns Hopkins, she was a Robert Wood Johnson Clinical Scholar (1996-1998), and is presently a Fellow in the Division of General Internal Medicine and the Welch Center for Prevention, Epidemiology, and Clinical Research. She is committed to improving care delivery for persons with mental illness, and is working with senior faculty members with strong experi3ence in mental illness research. She seeks this Mentored Clinical Scientist Development Award to study access to care and coordination of health care delivery among persons with a mental illness and a co-morbid medical and/or substance abuse condition. Persons with a mental illness are at substantial risk of having unmet needs for health care. For those with both a mental illness and substance abuse disorder or chronic medical condition, the challengers of meeting needs for care are likely greater. However, much is not known about the effect of specific co-morbidities on the need for health care and the extent of barriers faced in meeting these needs. In particular, information is lacking on what disease-related, sociodemographic, and health system factors put these individuals at risk for poor outcomes. Dr. Daumit will conduct cross-sectional and longitudinal analyses of a community based population using data from the NIMH funded Baltimore Epidemiologic Catchment Area Follow-up Study to examine needs and unmet needs for mental health, substance abuse, and medical treatment. She will assess the contribution of patient sociodemographic factors to needs for care and also study the provision of care by different provider types. She will then examine similar questions in the NIMH funded Maryland Medicaid Patterns and Outcomes Study. In this severely mentally ill population, se will next study the impact of Medicaid managed care on meeting needs for care, and outcomes and quality of care. These studies will allow her to identify characteristics of high risk patients who may benefit from better integrated care systems. In the latter part of the award, she will conduct focus groups with patients, providers, and administrators to explore options for effective mental, medical and addiction care models, ultimately leading to the planning of an intervention to improve care. The combination of research utilizing existing data sources, ongoing studies, and primary data collection in the supportive environment of Johns Hopkins will give Dr. Daumit the experience and tools she needs to develop into an independent clinician research in the epidemiology and health services research of mental disorders.

Keywords: health care service availability, health care service utilization, health science research analysis /evaluation, mental disorder, mental health epidemiology, mental health service, outcomes research, Medicare /Medicaid, comorbidity, disease /disorder proneness /risk, health care cost /financing, health care model, longitudinal human study, managed care, patient care management, psychosomatic disorder, substance abuse, behavioral /social science research tag, clinical research, health services research tag, human data, human subject

Project start date: 2000-03-01

Project end date: 2005-11-30

5K08MH001787-05 (2004): $142363


5K08MH001787-04 (2003): $140394

5K08MH001787-02 (2001): $132696

1K08MH001787-01 (2000): $113756

Gail L Daumit
Johns Hopkins University

Project start date: 2008-03-01

Project end date: 2012-11-30


RANDOMIZED TRIAL OF ACHIEVING HEALTHY LIFESTYLES IN PSYCH REHABILITATION

Gail L Daumit
Department/ Educational Institution Type:

Grant 5R01MH080964-04 from National Institute Of Mental Health

Keywords: adiposity; Age; Area; behavior change; Behavior Conditioning Therapy; behavior intervention; Behavior Modification; Behavior or Life Style Modifications; Behavior Therapy; Behavior Treatment; Behavioral; Behavioral Conditioning Therapy; behavioral intervention; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Pressure; Body Weight Changes; Body Weight decreased; body weight loss; cardiac disease risk; cardiac disorder risk; cardiovascular disease risk; Cardiovascular Diseases; cardiovascular disorder; cardiovascular disorder risk; cardiovascular risk; cardiovascular risk factor; Clinic; Cognitive decline; Cognitive Disturbance; cognitive dysfunction; cognitive function; Cognitive function abnormal; Cognitive Impairment; cognitive loss; cognitively impaired; Conditioning Therapy; Control Groups; corpulence; corpulency; corpulentia; cost; Cost Effective Analyses; Cost Effectiveness Analysis; cost efficient analysis; Counseling; Depression; depressive; depressive symptoms; Disturbance in cognition; drug/agent; Drugs; Education; Educational aspects; efficacy testing; Emotional Depression; enroll; Enrollment; Epidemic; Evaluation; Exercise; Exercise, Physical; Food; Gender; General Population; General Public; Grant; group intervention; Health; Health Benefit; Health Status; heart disease risk; heart disorder risk; heavy metal lead; heavy metal Pb; high risk; Impaired cognition; Individual; innovate; innovation; innovative; Intervention; intervention design; Intervention Strategies; interventional strategy; Lead; Length of Life; Level of Health; Life Expectancy; life span; Life Style; Life Style Modification; lifespan; Lifestyle; Lipids; Longevity; Maintenance; Maintenances; Maryland; Measures; Medical; Medication; mental; Mental Depression; Mental Health; Mental Hygiene; Modeling; multi-site trial; National Institute of Mental Health; National Institute of Mental Health (U.S.); NIMH; nutrition; Nutrition; Nutritional Science; obese; obese people; obese person; obese population; Obesity; Out-patients; Outcome; Outpatients; Over weight; Overweight; Participant; Pb element; Persons; Pharmaceutic Preparations; Pharmaceutical Preparations; Physical activity; Physical Fitness; Physical Health Services / Rehabilitation; Pilot Projects; pilot study; Policy Maker; Population; preclinical study; premature; primary outcome; programs; Programs (PT); Programs [Publication Type]; Psyche structure; Psychiatric Diagnosis; psychiatric rehabilitation; Psychological Health; randomisation; randomization; Randomized; Randomized Clinical Trials; randomized trial; randomly assigned; Rehabilitation; Rehabilitation Centers; Rehabilitation therapy; Rehabilitation, Medical; rehabilitative; Science of nutrition; secondary outcome; serious mental illness; severe mental illness; SF-36; Site; skills training; SUBGP; Subgroup; suburb; successful intervention; Symptoms; Symptoms of depression; Testing; therapy design; Training; treatment as usual; treatment design; United States National Institute of Mental Health; Vulnerable Populations; waist circumference; Walking; Weight; Weight Change; Weight Loss; weight loss intervention; Weight Reduction; wt-loss

Project start date: 2008-03-01

Project end date: 2012-11-30

Budget start date: 1-DEC-2010

Budget end date: 30-NOV-2011

PFA/PA: PA-07-211

5R01MH080964-04 (2011): $967149