Charles A Czeisler, Professor Of Sleep Medicine
Brigham And Women´s Hospital, Research Administration, Boston, Ma 02115
Grant 1P30HL101299-01 from National Heart, Lung, And Blood Institute
Abstract: This NHLBI PSO application requests funding for two years salary plus appropriate start up funds for a newly independent investigator whose research will complement the research underway in the Brigham & Women´s Hospital´s (BWH) Division of Sleep Medicine´s research center. The research center´s mission is to forge a path of discovery in sleep medicine and to train the next generation of leaders in academic sleep medicine. The Division has 31 faculty, 20 postdoctoral fellows and over 50 support staff, with the majority of effort spent on research. These research activities are funded by annual research grants of ~$11.8 million. The Division has a number of interacting research programs and cores, covering most aspects of sleep and circadian physiology, as well as sleep pathophysiology (mechanisms and therapy for the sleep disorders). However, we have identified an important area of research that is not currently well studied in our center, namely the interaction of the circadian system with disease. In particular, there is a critical gap in our understanding of the role of the circadian timing system in causing the very robust morning increase in adverse cardiovascular events (strokes, myocardial infarction, and sudden cardiac death) in vulnerable patient groups. We have identified a spectacular newly independent investigator whose research has moved in this direction and who is poised for promotion to Assistant Professor of Medicine. Should this P03 award be made, the institution is committed to providing appropriate research facilities for this individual, including use of the BWH Intensive Physiological Monitoring Unit in the Center for Clinical Investigation, a component of the Harvard Catalyst-Clinical and Translation Science Center. In addition, the investigator will fully utilize the many career development resources in the BWH Center for Faculty Development and Diversity. Together with close research and career mentorship from senior faculty in the Division´s research center, we anticipate that a PSO award will lead to important discoveries concerning the role of the circadian system in the day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine. A PSO award will lead to important discoveries concerning the role of the circadian system in the very robust day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine
Keywords: Apoplexy; Area; Award; Behavioral; Blood Pressure, High; Blood Vessels; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Circadian Rhythms; Clinical; Clinical Trials; Clinical Trials, Unspecified; Commit; Complement; Complement Proteins; Data; Death, Sudden, Cardiac; Development; Disease; Disorder; Diurnal Rhythm; Dysfunction; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiology; Epidemiology Research; Event; Faculty; Functional disorder; Funding; Future; HOSP; Hemostatic Agents; Hemostatics; Hospitals; Hypertension; Individual; Institution; Investigators; Lead; Measures; Medicine; Mentorship; Mission; Monitoring, Physiologic; Monitoring, Physiological; Myocardial Infarct; Myocardial Infarction; NIH RFA; National Heart, Lung, and Blood Institute; Non obese; Nonobese; Nyctohemeral Rhythm; Obesity; Organ System, Cardiovascular; Outcome; Patients; Pattern; Pb element; Phase; Physiologic Monitoring; Physiology; Physiopathology; Play; Population; Postdoc; Postdoctoral Fellow; Posture; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; R01 Mechanism; R01 Program; RPG; Request for Applications; Research; Research Activity; Research Associate; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Researchers; Resources; Risk; Risk Factors; Risk Marker; Role; Salaries; Science; Science of Medicine; Sleep; Sleep Disorders Therapy; Stroke; System; System, LOINC Axis 4; Time; Training; Translations; Twenty-Four Hour Rhythm; Vascular Accident, Brain; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Vascular, Heart; Vulnerable Populations; Wages; Woman; adiposity; behavior influence; behavioral influence; brain attack; cardiac infarct; cardiovascular risk; cardiovascular risk factor; career; career development; catalyst; cerebral vascular accident; circadian; circadian behavioral rhythms; circadian clock; circadian pacemaker; circadian process; circulatory system; clinical investigation; coronary attack; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; daily biorhythm; disease/disorder; diurnal variation; forging; heart attack; heart infarct; heart infarction; heavy metal Pb; heavy metal lead; hemodynamics; hyperpiesia; hyperpiesis; hypertensive disease; next generation; normotensive; obese; obese people; obese person; obese population; pathophysiology; post-doc; post-doctoral; professor; programs; research facility; social role; stressor; stroke; vascular
Project start date: 2009-09-30
Project end date: 2011-08-31
Budget start date: 30-SEP-2009
Budget end date: 31-AUG-2010
PFA/PA: RFA-OD-09-005
1P30HL101299-01 (2009): $372480
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to Charles A Czeisler
Effects Of Attending Surgeon And Obstetrician Fatigue On Operating Room Safety
Charles A Czeisler, Professor Of Medicine
Brigham And Women´s Hospital
Grant 1R01HL095472-01A1 from National Heart, Lung, And Blood Institute IRG: HSOD
Abstract: Up to 98,000 patients die each year in the United States due to medical error. While nurse and physician-in-training sleep deprivation has been found to significantly increase the risk of medical errors and occupational injuries, very little information has emerged on the relationship between senior (attending) physician work hours and patient safety. In surgery and obstetrics, the hours of attending physicians can match or exceed those of physicians-in-training. Whether such long work hours might degrade the performance of experienced attending physicians as severely as that of resident-physicians, however, is unknown. Experienced attending physicians may be less prone to attentional failures and performance decrements than younger physicians-in-training who have a stronger physiologic drive to sleep when awake for long hours. Conversely, sleep quality tends to deteriorate with age, which could lead to a buildup of sleep debt and an increased risk of fatigue-related error. In a prior intensive observational study, we found that physicians-in-training working recurrent 24-hour shifts made 36% more serious medical errors and five times as many serious diagnostic errors as those whose scheduled work is limited to 16 consecutive hours. We propose to conduct an intensive study of attending surgeons and obstetricians that will measure intra-operative processes of care and errors. In doing so, we will draw upon both our own experience conducting intensive studies of sleep and medical error, as well as emerging tools to quantify surgical safety and outcomes. Our specific aims will be 1. To test the hypothesis that the incidence of technical performance problems - as prospectively assessed by direct intra-operative observation, as well as healthcare provider reports - will be significantly higher during surgical cases performed the day following an overnight case (i.e., a case occurring between 12am and 7am) compared with matched cases on days without any preceding night work. 2. To test the hypothesis that the incidence of attentional failures, miscommunications, and teamwork problems - as prospectively assessed by direct intra-operative observation, as well as provider reports - will be significantly higher during surgical cases performed the day following an overnight case compared with matched cases on days without any preceding night work. 3. To test the hypothesis that the incidence of intra-operative serious medical errors (adverse events and near misses) - as assessed by a combination of direct observation, provider reports, and systematic chart surveillance - will be significantly higher during surgical cases performed the day following an overnight case compared with matched cases on days without any preceding night work. The proposed study will build upon our prior studies of sleep deprivation and safety to help develop an understanding of the effects of extended work hours across medical specialties and levels of training. Between 44,000 and 98,000 patients die each year in the United States due to medical error. We have previously found that the traditional long work hours of physicians-in-training greatly increase their risk of making medical errors, but there remains considerable debate in the medical community about whether experienced physicians´ performance deteriorates with sleep deprivation. We plan to conduct an intensive study in the operating room using established direct observational techniques and measurement tools to determine if sleep deprivation increases senior surgeons´ and obstetricians´ risk of error
Project start date: 2009-04-01
Project end date: 2013-03-31
After-Effects Of Entrainment On Human Circadian Period
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5R01NS040982-04 from National Institute Of Neurological Disorders And Stroke IRG: ZRG1
Abstract: Until recently, it was widely believed that the intrinsic period of the human circadian pacemaker was 25 h. However, using a forced desynchrony laboratory-based protocol in which the confounding effects of light and activity on circadian period assessment are controlled, we have found that the intrinsic period of the circadian system is close to 24 h (average 24.18 h). Similarly, we have found that blind individuals without light perception (NPL) living in society have circadian rhythms of melatonin which free-run with a period averaging approximately 24.5 h. While these data also suggest that the intrinsic circadian period is closer to 24 h than previously thought, the discrepancy between blind and sighted subjects suggests that the circadian pacemaker may be affected by unidentified factors. One likely factor is the absence of after- effects of entrainment to the 24 h light-dark cycle in non- entrained blind individuals, who may thus have a longer circadian period than sighted subjects observed upon release from entrainment. Similarly, blind subjects entrained by non-photic time cues in society may differ from sighted and non-entrained blind subjects upon release from entrainment due to differences in after-effects of photic- and non-photic synchronizers. We propose to investigate the role of after-effects of entrainment by assessing the circadian period of blind individuals under field and forced desynchrony conditions and comparing them to healthy sighted subjects who have been and will be studied. Specifically we will test the hypotheses that 1) the endogenous circadian period of the melatonin and temperature rhythms is significantly longer in NPL subjects than sighted subjects; 2) the circadian period of NPL subjects observed in field conditions in which non-photic time cues are non-uniformly distributed is significantly longer than when assessed under controlled forced desynchrony conditions; 3) those NPL subjects who are entrained in society but who are insensitive to light will have, on average, a significantly shorter circadian period than those NPL subjects who are not entrained in society. This work has significant implications for understanding how intrinsic period relates to prior entrainment and the role of after-effects of entrainment. It will help define the limits of entrainment for non-photic synchronizers and will evaluate the efficacy of such time cues to treat circadian rhythm sleep-wake disorders in both the blind and sighted populations.
Keywords: blindness, circadian rhythm, environmental adaptation, photobiology, photostimulus, body temperature, controlled environment, cue, field study, melatonin, rest, sleep, adult human (21+), clinical research, electroencephalography, electromyography, electrooculography, human subject, polysomnography, questionnaire
Project start date: 2001-07-15
Project end date: 2005-06-30
5R01NS040982-04 (2004): $317500
5R01NS040982-03 (2003): $317500
1R01NS040982-01A1 (2001): $317500
DISRUPTED SLEEP IN THE ELDERLY--CIRCADIAN ETIOLOGY
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-190607 from National Center For Research Resources IRG: RIRG
Abstract: To determine the effect of varying the intensity of a single, 6.5 hour pulse of continuous bright light in older subjects. A secondary purpose is to examine the effects of varying intensities of light on plasma melatonin concentration in older subjects. Data will be compared to similar data previously collected in young subjects.
Keywords: circadian rhythm, human old age (65+), human therapy evaluation, phototherapy, sleep disorder, disease /disorder etiology, light intensity, melatonin, blood chemistry, clinical research, human subject
ASSESSMENT OF DAYTIME SLEEPINESS BEFORE AND AFTER LIGHT EXPOSURE
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-050221 from National Center For Research Resources
Abstract: This study was designed to investigate whether an increase in circadian rhythm amplitude accomplished through exposure to bright indoor light during the morning hours causes a concurrent decrease in daytime sleepiness. The multiple sleep latency test(MSLT) and subjective measures of alertness will be used.
Keywords: BIOPERIODICITY, CIRCADIAN RHYTHMS, BRAIN, REGULATORY CENTERS, SLEEP, ENVIRONMENTAL HEALTH, LIGHTING, NEUROLOGIC MANIFESTATIONS, SLEEP DISORDERS, OPTICS, LIGHT INTENSITY, THERAPY EVALUATION, HUMAN, phototherapy, ENVIRONMENT CONTROLLED, photobiology, HUMAN, CLINICAL
CLINICAL METHOD OF DETERMINING THE PHASE OF THE CIRCADIAN TIMING SYSTEM IN MAN
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-100363 from National Center For Research Resources
Abstract: This series of studies attempts to develop and validate an alternative to the methods of spectral analysis/waveform eduction for determining circadian phase. Our proposed alternative requires only two days of laboratory study, compared with the weeks of laboratory study required for those methods. Used CDMAS this year.
Keywords: diurnal rhythm, method development, human data
DEVELOPMENT OF A CLINICAL METHOD FOR DETERMINING THE CIRCADIAN PHASE
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-080264 from National Center For Research Resources
Abstract: This series of studies attempts to develop and validate an alternative to the methods of spectral analysis/waveform eduction for determining circadian phase. Our proposed alternative requires only two days of laboratory study, compared with the weeks of laboratory study required for those methods. Used CDMAS this year.
Keywords: diagnosis design /evaluation, diurnal rhythm, brain electrical activity, electroencephalography, human clinical subject
Sponsored Links Excellgen http://Excellgen.com
DEVELOPMENT OF CLINICAL METHOD FOR DETERMINING PHASE, ETC
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-150594 from National Center For Research Resources
Abstract: This series of studies attempts to develop and validate an alternative to the methods of spectral analysis/waveform education for determining circadian phase. Our proposed alternative requires only two days of laboratory study, compared with the weeks of laboratory study required for those methods. Used CDMAS this year.
Keywords: analytical method, circadian rhythm, method development, diagnosis design /evaluation, computer processing of clinical data, computer program /software, human subject
Project start date: 1998-12-01
Project end date: 1999-11-30
Charles A Czeisler
Brigham And Women´s Hospital, Research Administration, Boston, Ma 02115
Grant 5P30HL101299-02 from National Heart, Lung, And Blood Institute
Abstract: This NHLBI PSO application requests funding for two years salary plus appropriate start up funds for a newly independent investigator whose research will complement the research underway in the Brigham & Women´s Hospital´s (BWH) Division of Sleep Medicine´s research center. The research center´s mission is to forge a path of discovery in sleep medicine and to train the next generation of leaders in academic sleep medicine. The Division has 31 faculty, 20 postdoctoral fellows and over 50 support staff, with the majority of effort spent on research. These research activities are funded by annual research grants of ~$11.8 million. The Division has a number of interacting research programs and cores, covering most aspects of sleep and circadian physiology, as well as sleep pathophysiology (mechanisms and therapy for the sleep disorders). However, we have identified an important area of research that is not currently well studied in our center, namely the interaction of the circadian system with disease. In particular, there is a critical gap in our understanding of the role of the circadian timing system in causing the very robust morning increase in adverse cardiovascular events (strokes, myocardial infarction, and sudden cardiac death) in vulnerable patient groups. We have identified a spectacular newly independent investigator whose research has moved in this direction and who is poised for promotion to Assistant Professor of Medicine. Should this P03 award be made, the institution is committed to providing appropriate research facilities for this individual, including use of the BWH Intensive Physiological Monitoring Unit in the Center for Clinical Investigation, a component of the Harvard Catalyst-Clinical and Translation Science Center. In addition, the investigator will fully utilize the many career development resources in the BWH Center for Faculty Development and Diversity. Together with close research and career mentorship from senior faculty in the Division´s research center, we anticipate that a PSO award will lead to important discoveries concerning the role of the circadian system in the day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine. A PSO award will lead to important discoveries concerning the role of the circadian system in the very robust day/night pattern of adverse cardiovascular events, and greatly facilitate the career development of one of the most promising future leaders in academic sleep medicine
Project start date: 2009-09-30
Project end date: 2011-08-31
Budget start date: 1-SEP-2010
Budget end date: 31-AUG-2011
PFA/PA: RFA-OD-09-005
5P30HL101299-02 (2010): $360608
COMPARISON OF PRAVASTATIN AND LOVASTATIN
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-080293 from National Center For Research Resources
Abstract: This is a double-blind comparison of the effects these drugs have on nocturnal sleep and daytime performance/alertness measures in healthy adult males.
Keywords: antihypercholesterolemic agent, drug adverse effect, lovastatin, sleep disorder, attention, performance, sleep, human clinical subject, human volunteer subject, male
DIURNAL NATURE AND PULSATILITY OF PARATHYROID HORMONE
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-090375 from National Center For Research Resources
Abstract: This is a Clinical Associate Physician project designed to characterize the diurnal and pulsatile nature of parathyroid hormone in normal healthy volunteers. Insight into mechanisms controlling calcium homeostasis may lead to further insights into pathological conditions such as osteoporosis.
Keywords: diurnal rhythm, parathyroid hormone, calcium, clinical study /trial, homeostasis, human subject, human volunteer subject
SLEEP, AGING AND CIRCADIAN RHYTHM DISORDERS
Charles A Czeisler, Professor Of Sleep Medicine
Brigham And Women´s Hospital, Research Administration, Boston, Ma 02115
Grant 3P01AG009975-14S3 from Office Of The Director, National Institutes Of Health
Abstract: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. Sleep in older people is marked by difficulty with initiation, frequent arousals, and early awakening. While the consequences of acute sleep deprivation have been investigated in older people, very little is known about the consequences of the chronic insufficient sleep experienced by many older people. Moreover, the interaction between the misalignment of circadian phase, so common in older people, and chronic insufficient sleep has not been studied. Our proposal seeks to address that gap in our knowledge by using a well-established laboratory model to study what differences may exist between the sleep efficiency of older and younger subjects under conditions of chronic sleep restriction (ratio 19 hours scheduled wake 5 hours scheduled sleep), carried out on a forced-desynchrony protocol, and by assessing the recuperative capabilities under conditions of sleep extension following this restriction. The design of our human subjects protocol provides a tremendous opportunity to investigate an array of cognitive performance measures under these conditions of chronic sleep restriction and subsequent sleep extension. The Polysomnography Core of the proposed Program Project will provide accurate and reliable scoring of polysomnographic recordings from subjects participating in the experimental protocol as well as from prospective subjects during the screening process. A ´metabolic aging´ experiment has been included in our proposal with the goal of understanding the endocrine and cardiovascular consequences of sleep restriction in both young and older subjects. In the previous cycle of this Program Project, it was hypothesized that sleep difficulties in older people might be due to loss of neurons in the ventrolateral preoptic nucleus (VLPO). A critical component of this proposal is the continued pursuit of this mammalian model for sleep regulation during aging. With aging, there is a loss of neurons in the ventrolateral preoptic nucleus (VLPO), which is necessary for normal sleep, with aging, and we hypothesize that rats with partial lesions of the VLPO are a high fidelity model for sleep in older people. We will test this model for its validity for older people by performing a series of studies that parallel the human components of this Program Project grant, both in older rats and in rats with partial VLPO lesions. We hypothesize that the VLPO lesioned rat is a good model for sleep in older people who have VLPO cell loss, and to use this model to test the efficacy of treatment designed to restore VLPO function, which we hope will restore sleep as well as improve cognitive and motor skills that deteriorate with aging and poor sleep. The core components - Administrative, Analytic and Polysomnography - are effective in providing support across projects and most importantly, providing for cohesion of efforts across the entire Program Project. The results of this research will have important implications for understanding the role of sleep in the health, safety, and neurocognitive functions of older people
Project start date: 2009-08-01
Project end date: 2010-10-31
Budget start date: 1-AUG-2009
Budget end date: 31-OCT-2010
3P01AG009975-14S3 (2009): $97773
Sponsored Links Excellgen http://Excellgen.com
REPRODUCTIVE FUNCTION IN WOMEN--CIRCADIAN INTERACTION
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-100380 from National Center For Research Resources
Abstract: The purpose of this study is to examine the interaction between the reproductive cycle and the circadian rhythms of temperature, hormones, and behavioral measures in women age 18-35. Completed inpatient study (scatter beds). Uses CDMAS only.
Keywords: diurnal rhythm, female reproductive system, reproduction, sex cycle, behavior, body temperature, hormone, adolescence (12-20), female, human data, young adult human (21-44)
CIRCADIAN RHYTHM OF RESPIRATORY CONTROL DURING 24-64 HOURS EXTENDED WAKEFULNESS
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-150536 from National Center For Research Resources
Abstract: The purpose of this study is to examine the daily rhythm of breathing and respitory control during a 24-64 hour period of continuous wakefulness to better understand how the respitory control system is related to the circadian timing system in humans.
Keywords: circadian rhythm, pulmonary respiration, wakefulness, clinical trial, respiration regulatory center, clinical research, human subject
CIRCADIAN PHASE ESTIMATION AFTER SCHEDULED VS UNSCHEDULED ROUTINE
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-100436 from National Center For Research Resources
Abstract: The purpose of this study is to examine how the daily temperature cycle correlates with natural variation in hormone levels, kidney activity, and psycho-motor performance when patients are on their normal routine and to compare that with results from similar testing obtained when they are free from external time cycles.
Keywords: body temperature, diurnal rhythm, hormone regulation /control mechanism, kidney function, neuroendocrine system, psychomotor function, human subject
CLINICAL TRIAL OF THE EFFECT OF BRIGHT LIGHT IN MEN VS WOMEN
Charles A Czeisler, Professor Of Medicine
Institution:
Grant 5M01RR002635-120518 from National Center For Research Resources
Abstract: The purpose of this study is to examine how the daily light-dark cycle in the environment affects the timing of hormone release, the timing of the daily cycle of body temperature, the sleep-wake cycle, and the inner body functions which ordinarily vary with the time of day. These studies may help to understand the basis of certain diseases and how light may be used in this treatment.
Keywords: diurnal rhythm, phototherapy, sex difference, body temperature regulation, clinical trial, female, hormone regulation /control mechanism, male, clinical research, human subject
CIRCADIAN RHYTHMS IN PATIENTS WITH CHRONIC SPINAL CORD LESIONS
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-150581 from National Center For Research Resources
Abstract: The purpose of this study is to examine how the daily light-dark cycle in the enviroment affects the timing of hormone release, the timing of the daily cycle of body temperature, the sleep-wake cycle, and the inner body functions which ordinarily vary with the time of day.
Keywords: circadian rhythm, neuroendocrine system, spinal cord injury, body temperature, hormone metabolism, sleep, wakefulness, clinical research, human subject
Project start date: 1998-12-01
Project end date: 1999-11-30
Sponsored Links Excellgen http://Excellgen.com
PHOTOTHERAPY TREATMENT OF SHIFT ROTATION INSOMNIA
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-190468 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate the impact of phototherapy on the daytime sleep and nocturnal performance of individuals during a combined laboratory and field based simulation of a complete shift rotation.
Keywords: human therapy evaluation, occupational health /safety, phototherapy, sleep disorder, clinical research, human subject
CLINICAL TRIAL OF MELATONIN AS HYPNOTIC
Charles A Czeisler, Professor Of Medicine
Institution:
Grant 5M01RR002635-120502 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate the impact of exercise on sleep and daytime performance.
Keywords: hormone regulation /control mechanism, melatonin, sedative /hypnotic, clinical trial, exercise, performance, sleep, clinical research, human subject
LIGHT PULSES ON CIRCADIAN ENTRAINMENT
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-190586 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate the ability of multiple, short duration high-level light intensities to keep the biological clock synchronized to a long term 24-hour duty and sleep/wake schedule.
Keywords: circadian rhythm, photostimulus, biological clock, light intensity, neuroendocrine system, sleep, wakefulness, clinical research, human subject
Sponsored Links Excellgen http://Excellgen.com
CIRCADIAN RHYTHMS OF BLIND PERSONS
Charles A Czeisler, Professor Of Medicine
Institution:
Grant 5M01RR002635-120295 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate circadian rhythms in both young and older blind individuals to determine if their circadian rhythms are in synchrony with the external environment. Subjects undergo a circadian phase evaluation 3-5 times during a 3-month period.
Keywords: blindness, diurnal rhythm, age difference, aging, clinical research, human subject
CIRCADIAN RHYTHMS IN BLIND PERSONS
Charles A Czeisler, Professor Of Medicine
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-150295 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate circadian rhythms in both young and older blind individuals to determine if their circadian rhythms are in synchrony with the external environment. Subjects undergo a circadian phase evaluation 3-5 times during a 3-month period.
Keywords: blindness, circadian rhythm, age difference, aging, environmental adaptation, clinical research, human subject
EARLY AWAKENING IN ELDERLY--CIRCADIAN EVALUATION/TREATMENT/PHOTOTHERAPY
Charles A Czeisler
Brigham And Women s Hospital Research Administration Boston, Ma 02115
Grant 5M01RR002635-100290 from National Center For Research Resources
Abstract: The purpose of this study is to evaluate circadian rhythms in both healthy and depressed elderly individuals who wake earlier than desired in the morning. After initial evaluation, subjects may be treated with bright light (phototherapy) in an attempt to change the time of their daily sleep episode.
Keywords: diurnal rhythm, human therapy evaluation, phototherapy, sleep disorder, wakefulness, depression, human old age (65+), photobiology, visible light, human subject
Sponsored Links Excellgen http://Excellgen.com