Vector/Host-Parasite Interface Of Leishmaniasis In Colombia
Diane Mcmahonpratt, Professor
Epidemiology And Public Healthyale University
Grant 2D43TW006589-06 from Fogarty International Center, IRG: ZRG1
Abstract: The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training program will implement research capacity in the molecular analysis of the interaction between Leishmania and both the sandfly vector and the mammalian host. The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University. Colombian scientists will receive training at Yale through the conduct of mentored research, auditing of postgraduate courses and short courses on research skills, such as biosafety, responsible conduct of research, and scientific writing. Workshops will be offered each year at CIDEIM with the participation of Yale Faculty (on site and teleconferencing) to build and multiply research skills and introduce national investigators to concepts and principles of molecular analysis (bioinformatics and data mining, functional genomics, expression analysis). Predoctoral trainees will be selected among postgraduate students from Colombian universities who conduct thesis research in CIDEIM. Students will be recent graduates of human or veterinary medicine and basic science who have qualified for scholarship support within the framework of COLCIENCIAS´ Young Investigator program. Post-doctoral training and scientific exchange for periods of up to 4 months will be available to research staff of CIDEIM whose research is relevant to the vector or host- Leishmania interaction. During year 5 of the program, formal postgraduate courses on the molecular genetic analyses of host (mammalian/vector)-pamsite interactions will be offered to national and regional students by CIDEIM. Overall, the training conducted will prepare investigators in new areas of research, implement training by teleconferencing, and assure the capacity to offer formal courses for Colombian and regional post-graduate students. All of these will contribute to the sustainability of research capacity
Project start date: 2003-09-01
Project end date: 2013-03-31
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Grants awarded to Diane Mcmahonpratt
Multidisciplinary Parasitology Training Program
Diane Mcmahonpratt, Professor
Epidemiology And Public Healthyale University
Grant 5T32AI007404-17 from National Institute Of Allergy And Infectious Diseases, IRG: MID
Abstract: This application is a request for continued support for a predoctoral and postdoctoral Multidisciplinary Parasitology and Vector Biology Training Program at Yale University. Yale University historically has had a major commitment to the study of parasitology, with an integrated multidisciplinary program in parasitology and vector biology involving research laboratories within the Graduate, Medical and Public Health Schools at Yale University [Epidemiology & Public Health, Ecology and Evolutionary Biology, Medicine, Microbial Pathogenesis, Pharmacology]. The program has continued to grow over the past five years, with new faculty (Drs. Bucala, Anderson, Holford, Galvani and Warren) now participating in the program. Research within the program uniquely spans the breadth of modern parasitology and vector biology [epidemiology, immunology, cell biology, molecular biology, entomology, biology]. Further, the program is uniquely focused on international/ tropical public health, offering training opportunities for fellows and graduate students through funded research programs and ongoing collaborative projects in Africa, Asia and South America. The training faculty members have a strong history of working together collaboratively in research and teaching and serve together on student thesis and advisory committees. The program currently includes predoctoral and post-doctoral (Ph.D.) training. Trainees [predoctoral and postdoctoral], in addition to having access to the various facilities at Yale University, participate in several seminar and journal clubs focused on topics relevant to parasitology and vector biology. Further, trainees participate and present their research as part of a formal research-in-progress seminar series. Former trainees in the program have gone on to postdoctoral work (in the case of predoctoral trainees) and to positions as faculty in medical schools, universities, colleges or research staff in scientific research institutes and medically related industry
Project start date: 1991-08-01
Project end date: 2012-08-31
Vector/Host-Parasite Interface Of Leishmaniasis In Colombia
Diane Mcmahonpratt, Professor
Epidemiology And Public Healthyale University
Grant 2D43TW006589-06 from Fogarty International Center, IRG: ZRG1
Abstract: The goal of the training grant is to build research capacity to identify strategies and devise means to interrupt the cycle of transmission and pathogenesis of leishmaniasis through intervention of the invertebrate and vertebrate host pathogen interactions. To achieve this goal, the training program will implement research capacity in the molecular analysis of the interaction between Leishmania and both the sandfly vector and the mammalian host. The proposed program builds upon the existing research capacity and ongoing projects of the developing country institution in clinical, epidemiological and biological aspects of cutaneous and visceral leishmaniasis and other transmissible diseases, prior collaboration with Yale faculty, and the critical mass of faculty and infrastructure for the conduct of molecular analyses of kinetoplastid parasites and host responses available at Yale University. Colombian scientists will receive training at Yale through the conduct of mentored research, auditing of postgraduate courses and short courses on research skills, such as biosafety, responsible conduct of research, and scientific writing. Workshops will be offered each year at CIDEIM with the participation of Yale Faculty (on site and teleconferencing) to build and multiply research skills and introduce national investigators to concepts and principles of molecular analysis (bioinformatics and data mining, functional genomics, expression analysis). Predoctoral trainees will be selected among postgraduate students from Colombian universities who conduct thesis research in CIDEIM. Students will be recent graduates of human or veterinary medicine and basic science who have qualified for scholarship support within the framework of COLCIENCIAS´ Young Investigator program. Post-doctoral training and scientific exchange for periods of up to 4 months will be available to research staff of CIDEIM whose research is relevant to the vector or host- Leishmania interaction. During year 5 of the program, formal postgraduate courses on the molecular genetic analyses of host (mammalian/vector)-pamsite interactions will be offered to national and regional students by CIDEIM. Overall, the training conducted will prepare investigators in new areas of research, implement training by teleconferencing, and assure the capacity to offer formal courses for Colombian and regional post-graduate students. All of these will contribute to the sustainability of research capacity
Project start date: 2003-09-01
Project end date: 2013-03-31