Michael A Friedman
City Of Hope/beckman Research Institute
Project start date: 1997-08-01
Project end date: 2012-11-30
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Michael A Friedman
City Of Hope/beckman Research Institute
Project start date: 1997-08-01
Project end date: 2012-11-30
Michael A Friedman
City Of Hope/beckman Research Institute, 1500 East Duarte Road, Modular, #103, Duarte, Ca 91010-3000
Grant 3P30CA033572-27S1 from National Cancer Institute
Project start date: 1997-08-01
Project end date: 2012-11-30
Budget start date: 1-DEC-2009
Budget end date: 30-NOV-2010
3P30CA033572-27S1 (2010): $94753
3P30CA033572-27S2 (2010): $100000
3P30CA033572-27S3 (2010): $101205
3P30CA033572-27S4 (2010): $151808
Grants awarded to Michael A Friedman
Michael A Friedman
City Of Hope/beckman Research Institute, 1500 East Duarte Road, Modular, #103, Duarte, Ca 91010-3000
Grant 5P30CA033572-27 from National Cancer Institute
Abstract: This renewal application requests funding for the 25th through 29th years of the NCI Cancer Center Support Grant of the City of Hope Comprehensive Cancer Center. The Center now has five research programs one basic research Program (Cancer Biology, CB); three clinical/translational research Programs (Developmental Cancer Therapeutics, DCT; Cancer Immunotherapeutics, Cl; Hematologic Malignancies, HM); and one population research program (Cancer Control and Population Sciences, CCPS). Twelve shared resources support the scientific activities of the members, including two new cores (Small Animal Imaging; Clinical Immunobiology Correlative Studies Laboratory). Three developing cores are proposed (High Throughput Screening; Synthetic & Biopolymer Chemistry; Survey Research). Membership has grown by 45% in the preceding program period with the recruitment of 37 new Full Members, including several key senior leaders (Richard Jove, PhD, Deputy Director; R. Figlin, MD, Associate Director [AD] for Clinical Research). Other key leadership positions have also been filled through internal appointments (Smita Bhatia, MD, MPH, AD for Population Research; Joyce Niland, PhD, AD for Information Sciences; and Yun Yen, MD, PhD, AD for Translational Research). As a result of our program restructuring, recruitment and infrastructure development, we now believe we have a Center where our five Programs represent a continuum in which basic and translational studies in the basic science Program, CB, and one clinical Program, DCT, can be linked to Phase I and II clinical protocols in all three clinical programs (DCT, Cl, HM) and follow-up studies in survivorship and symptom management in the population sciences program (CCPS). All these activities are made possible by a Center and Institutional infrastructure that supports basic and translational research in biological and, now, small molecule approaches to cancer in an extraordinarily collaborative fashion. Such interaction has resulted in the Center´s first SPORE, in lymphoma; a recent W.M. Keck Foundation award; and the renewal of eight large, multi-investigator awards. During the next funding period, we will build on these achievements so that the City of Hope Comprehensive Cancer Center takes the next step in its evolution translating more laboratory discoveries into innovative clinical trials and developing disease-based research programs. The 82 Full Members and 90 Associate Members of the Center Programs have published 1001 articles, book chapters, etc., since the last competitive grant review. Of these, 28% are intraprogrammatic and 22% are interprogrammatic publications
Project start date: 1997-08-01
Project end date: 2012-11-30
Budget start date: 1-DEC-2009
Budget end date: 30-NOV-2010
5P30CA033572-27 (2010): $2318695
Group Treatment For Depression In Heart Failure
Michael A Friedman
Rutgers The St Univ Of Nj New Brunswick Asb Iii New Brunswick, Nj 08901
Grant 5R21MH066106-03 from National Institute Of Mental Health IRG: ZRG1
Abstract: The overall aim of this research is to develop an efficacious group psychotherapy for the treatment of major depression among individuals with congestive heart failure. Both major depression and heart failure are associated with severe loss of functioning and increased mortality, and this co-morbid condition is particularly debilitating. While treating depression among heart failure patients has the potential to improve functioning and prolong life in this population, there are currently no empirically-supported treatments for depression among heart failure patients. Among the several well-validated psychosocial treatments, group cognitive-behavioral therapy (CBT) has been proposed as efficacious, and has established feasibility among heart failure patients. Group CBT may be particularly efficacious among CHF patients with depression due to the potential for increasing patient social support. Initial research suggests that there are several ways in which current group CBT could be improved to treat major depression among CHF patients, including (1) the use of an "open" group format that allows for immediate patient care, (2) integration of individual interventions to individually tailor treatment goals and improve adherence to treatment, and (3) family-based interventions within the group CBT format to mobilize patient social support. The proposed integrated cognitive-behavioral therapy program includes group, individual, and family treatment (GIFT) for depression among individuals with CHF (GIFT-CHF). The current proposal is designed to develop the GIFT-CHF program. The proposal consists of three phases a Development, Pilot, and Revision Phase. During the Development phase of the GIFT-CHF, the goal of the research will be to (a) develop an integrative group therapy program for depressed patients with heart failure (GIFT-CHF); (b) develop a therapist training program; and (c) develop and test the reliability and validity of competence and adherence rating scales. During the Pilot phase of the GIFT-CHF program, the goal will be to conduct a small pilot trial investigating the short-term efficacy of the GIFT-CHF program in comparison to a Standard Medical Care/Wait-List control group, and determine effect size. Finally, during the Revision phase of the GIFT-CHF program, the goal of the research will be based on the results of the Development and Pilot phases, to revise the GIFT-CHF program and treatment manual. This treatment development grant will lay the groundwork for a large-scale treatment outcome study of the GIFT-CHF program for depressed individuals with congestive heart failure.
Keywords: cognitive behavior therapy, congestive heart failure, group therapy, major depression, technology /technique development, comorbidity, group counseling, mental health epidemiology, psychiatry, psychology, psychotherapy, behavioral /social science research tag, clinical research, human subject, patient oriented research
Project start date: 2003-02-14
Project end date: 2008-01-31
5R21MH066106-03 (2005): $194375
5R21MH066106-02 (2004): $155500
1R21MH066106-01A1 (2003): $154113
Michael A Friedman
City Of Hope/beckman Research Institute
Project start date: 1997-08-01
Project end date: 2012-11-30