MARIETTA COMMUNITY ACTIVELY RESEARCHING EXPOSURE STUDY
Erin N Haynes, Adjunct Assistant Professor
University Of Cincinnati, Sponsored Research Services, Cincinnati, Oh 45221
Grant 3R01ES016531-02S3 from National Institute Of Environmental Health Sciences
Abstract: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators.Project Summary Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1 Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2 Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3 Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children
Keywords: 0-11 years old; 0-6 weeks old; 21+ years old; 3, 4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1, 2-benzenediol; Address; Adult; Affect; Age; Air; Animals; Apoptosis; Apoptosis Pathway; Awareness; Awarenesses; Biochemical; Biological; Blood; Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Canada; Cell Death, Programmed; Central Nervous System; Child; Child Development; Child Youth; Children (0-21); Chinese; Chinese People; Chronic; Code; Coding System; Cognitive; Collection; Common Rat Strains; Communities; Complex; Data; Development; Differentiation and Growth; Distress; Dopamine; Dose; Dust; Dysfunction; Effects, Longterm; Elements; Embryonic Tissue, Placenta; Encephalon; Encephalons; Environmental Exposure; Environmental Factor; Environmental Health; Environmental Health Science; Environmental Risk Factor; Environmental Toxin; Exhibits; Exposure to; Fetus; Financing, Personal; Functional disorder; Gasoline; Gustation; Hair; Health; Health Policy; Hemato-Encephalic Barrier; Home; Home environment; Human; Human, Adult; Human, Child; Human, General; Hydrogen Oxide; Hydroxytyramine; Infant; Infant and Child Development; Infant, Newborn; Knowledge; Language Tests; Lead; Location; Long-Term Effects; Mammals, Rats; Man (Taxonomy); Man, Modern; Manganese; Manuals; Mathematics; Measures; Memory; Mental disorders; Mental health disorders; Metal exposure; Metals; Mn element; Moods; Motor; Nail plate; Nails; Neighborhoods; Neonatal; Nervous System, Brain; Nervous System, CNS; Neural Development; Neuraxis; Neurodevelopmental Deficit; Neurologic; Neurological; Newborn Infant; Newborns; Odors; Ohio; Oral; Outcome; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Pathway interactions; Pb element; Performance; Personal Financing; Physiopathology; Pilot Projects; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Policies; Pollution; Population; Predisposition; Process; Psychiatric Disease; Psychiatric Disorder; Public Health; Quality Control; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reaction Time; Recruitment Activity; Relative; Relative (related person); Research; Research Design; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Specimen; Resources; Response RT; Response Time; Reticuloendothelial System, Blood; Risk; Rural; Sampling; Sensory; Specimen; Study Section; Study Type; Susceptibility; Symptoms; Taste; Taste Perception; Testing; Time; Tooth; Tooth structure; Toxic Environmental Agents; Toxic Environmental Substances; Toxicant exposure; Training; Universities; Unspecified Mental Disorder; Visual; Water; adult human (21+); advocacy organizations; air cleaner; air monitoring; base; biomarker; children; conference; dissemination research; drinking water; early childhood; environmental risk; environmental toxicant; exposure to metal; health care policy; heavy metal Pb; heavy metal lead; interest; meetings; member; mental illness; neurobehavior; neurobehavioral; neurodevelopment; neuron toxicity; neuronal toxicity; neuropsychiatric; neuropsychiatry; neurotoxic; neurotoxicity; newborn human (0-6 weeks); pathophysiology; pathway; personal finances; pilot study; psychological disorder; psychomotor reaction time; public health medicine (field); recruit; response; sample collection; specimen collection; study design; symposium; teeth; toxic exposure; youngster
Project start date: 2008-04-01
Project end date: 2010-08-31
Budget start date: 1-JUN-2009
Budget end date: 31-AUG-2010
PFA/PA: PAR-07-283
3R01ES016531-02S3 (2009): $97244
Sponsored Links Excellgen http://Excellgen.com
MARIETTA COMMUNITY ACTIVELY RESEARCHING EXPOSURE STUDY
Erin N Haynes, Adjunct Assistant Professor
University Of Cincinnati, Sponsored Research Services, Cincinnati, Oh 45221
Grant 3R01ES016531-02S4 from National Institute Of Environmental Health Sciences
Abstract: Project Summary Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1 Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2 Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3 Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children
Keywords: 0-11 years old; 0-6 weeks old; 21+ years old; 3, 4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1, 2-benzenediol; Address; Adult; Affect; Age; Air; Animals; Apoptosis; Apoptosis Pathway; Awareness; Awarenesses; Biochemical; Biological; Blood; Blood - brain barrier anatomy; Blood-Brain Barrier; Brain; Canada; Cell Death, Programmed; Central Nervous System; Child; Child Development; Child Youth; Children (0-21); Chinese; Chinese People; Chronic; Code; Coding System; Cognitive; Collection; Common Rat Strains; Communities; Complex; Data; Development; Differentiation and Growth; Distress; Dopamine; Dose; Dust; Dysfunction; Effects, Longterm; Elements; Embryonic Tissue, Placenta; Encephalon; Encephalons; Environmental Exposure; Environmental Factor; Environmental Health; Environmental Health Science; Environmental Risk Factor; Environmental Toxin; Exhibits; Exposure to; Fetus; Financing, Personal; Functional disorder; Gasoline; Gustation; Hair; Health; Health Policy; Hemato-Encephalic Barrier; Home; Home environment; Human; Human, Adult; Human, Child; Human, General; Hydrogen Oxide; Hydroxytyramine; Infant; Infant and Child Development; Infant, Newborn; Knowledge; Language Tests; Lead; Location; Long-Term Effects; Mammals, Rats; Man (Taxonomy); Man, Modern; Manganese; Manuals; Mathematics; Measures; Memory; Mental disorders; Mental health disorders; Metal exposure; Metals; Mn element; Moods; Motor; Nail plate; Nails; Neighborhoods; Neonatal; Nervous System, Brain; Nervous System, CNS; Neural Development; Neuraxis; Neurodevelopmental Deficit; Neurologic; Neurological; Newborn Infant; Newborns; Odors; Ohio; Oral; Outcome; Parkinsonian; Parkinsonian Condition; Parkinsonian Diseases; Parkinsonian Disorders; Parkinsonian Syndrome; Parkinsonism; Pathway interactions; Pb element; Performance; Personal Financing; Physiopathology; Pilot Projects; Placenta; Placenta-Tissue, Cells; Placentoma, Normal; Placentome; Policies; Pollution; Population; Predisposition; Process; Psychiatric Disease; Psychiatric Disorder; Public Health; Quality Control; R01 Mechanism; R01 Program; RPG; Rat; Rattus; Reaction Time; Recruitment Activity; Relative; Relative (related person); Research; Research Design; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Research Specimen; Resources; Response RT; Response Time; Reticuloendothelial System, Blood; Risk; Rural; Sampling; Sensory; Specimen; Study Section; Study Type; Susceptibility; Symptoms; Taste; Taste Perception; Testing; Time; Tooth; Tooth structure; Toxic Environmental Agents; Toxic Environmental Substances; Toxicant exposure; Training; Universities; Unspecified Mental Disorder; Visual; Water; adult human (21+); advocacy organizations; air cleaner; air monitoring; base; biomarker; children; conference; dissemination research; drinking water; early childhood; environmental risk; environmental toxicant; exposure to metal; health care policy; heavy metal Pb; heavy metal lead; interest; meetings; member; mental illness; neurobehavior; neurobehavioral; neurodevelopment; neuron toxicity; neuronal toxicity; neuropsychiatric; neuropsychiatry; neurotoxic; neurotoxicity; newborn human (0-6 weeks); pathophysiology; pathway; personal finances; pilot study; psychological disorder; psychomotor reaction time; public health medicine (field); recruit; response; sample collection; specimen collection; study design; symposium; teeth; toxic exposure; youngster
Project start date: 2009-09-04
Project end date: 2011-08-31
Budget start date: 4-SEP-2009
Budget end date: 31-AUG-2011
PFA/PA: PAR-07-283
3R01ES016531-02S4 (2009): $349484
Grants awarded to Erin N Haynes
UNIVERSITY OF CINCINNATI-MARIETTA-PARKERSBURG METROPOLITAN AREA RECIPROCAL RESEAR
Erin N Haynes, Adjunct Assistant Professor
University Of Cincinnati, Sponsored Research Services, Cincinnati, Oh 45221
Grant 5R03ES017362-02 from National Institute Of Environmental Health Sciences
Abstract: Marietta-Parkersburg Metropolitan Area is a rural Appalachian community. The area has been home to the only manganese (Mn) refinery in the US and Canada for over 50 years. The residents are very concerned about the quality of their air and related health effects. Caroline Beidler, a local resident, has created and directs, Neighbors for Clean Air (NCA). Beidler has sought the assistance of Dr. Erin Haynes at the University of Cincinnati to help her and her community understand the health effects of chronic exposure to air Mn. Together we have conducted a community-wide survey to evaluate the community´s level of concern about environmental air pollution in their region caused by industrial emissions and to learn about their perceptions of air quality and its impact on their health. Their sources of information related to local industrial emissions, their level of trust for these information sources, and how they rate the level of knowledge from each information source was also evaluated. We found that the community relies upon local media for air quality information, yet these reporters are not trained in science or environmental journalism. The community also uses websites to search for information on industrial emissions and health effects; however, reliable sites are difficult to find, navigate, and interpret. Thus, Beidler and Haynes have created a "University of Cincinnati-Marietta- Parkersburg Metropolitan Area Reciprocal Research Relationship" Project. The goal of this project is to create reciprocal research partnerships to determine the health effects associated with the Marietta-Parkersburg Metropolitan Area community´s exposure to Mn while engaging the community in the research process to ultimately inform regional and national policy for Mn emissions. Our main objective is to implement and evaluate a multifaceted Community Based Participatory Research (CBPR) program that bridges the gap between an affected community and the research scientists. The following specific aims for the project are Specific Aim 1 Create reciprocal training and research opportunities for the Marietta-Parkersburg Metropolitan Area community and University of Cincinnati scientific researchers; Specific Aim 2 Create a reciprocal educational relationship among Marietta-Parkersburg Metropolitan Area journalists (radio, newspaper and TV reporters), University of Cincinnati research scientists and environmental journalists to establish a well-defined network between journalists and research scientists; and Specific Aim 3 Evaluate the success of the overall community-research partnership through qualitative research methods. Given the community´s intense interest in understanding their air quality and resulting health effects, the developing partnership between UC and the Marietta-Parkersburg Metropolitan area, and the opportunity for community involvement in innovative research studies, we anticipate that the results of this proposal will provide a model community-research partnership with reproducible deliverables for national and international community-based participatory research studies
Keywords: 0-11 years old; Address; Advocate; Affect; Air; Air Pollution; Area; Broadcast Media; Canada; Child; Child Youth; Children (0-21); Chronic; Collaborations; Communities; Community Education; Community Health Education; Community Health Taining; Community HealthTutoring; Coupled; Decision Making; Education for Intervention; Education, Medical, Continuing; Educational Intervention; Educational workshop; Environment; Environmental Exposure; Environmental Pollution; Exposure to; Face; Faculty; Focus Groups; Fostering; Goals; Health; Health Education, Community; Health Instruction; Health Training; Health Tutoring; Health education; Home; Home environment; Human, Child; Instruction Intervention; International; Internships; Investigators; Journalism; Knowledge; Learning; Manganese; Media, Broadcast; Methodology, Research; Mn element; Modeling; Multimedia; Multimedium; Newspapers; Perception; Physicians; Policies; Position; Positioning Attribute; Printing; Process; Programs (PT); Programs [Publication Type]; Public Health; Publishing; Qualitative Research; Radio; Reporter; Reporting; Research; Research Methodology; Research Methods; Research Personnel; Research Training; Researchers; Risk; Rural; Rural Community; Science; Scientist; Site; Socio-economic status; Socioeconomic Status; Source; Status, Socioeconomic; Survey Instrument; Surveys; TV; Television; Testing; Training; Training Intervention; Trust; Universities; Washington; Workshop; air cleaner; children; college; college student; community based participatory research; continuing medical education; environmental contaminant; environmental contamination; experience; experiment; experimental research; experimental study; facial; graduate student; improved; innovate; innovation; innovative; instructional intervention; interest; low socioeconomic status; meetings; member; metropolitan; prevent; preventing; programs; public health medicine (field); research study; success; university student; web site; youngster
Project start date: 2008-09-25
Project end date: 2010-08-31
Budget start date: 1-SEP-2009
Budget end date: 31-AUG-2010
PFA/PA: RFA-OD-07-001
5R03ES017362-02 (2009): $62400
1R03ES017362-01 (2008): $62400
Neurobehavioral Effect Of Low Level Mangenese Exposure
Erin N Haynes
University Of Cincinnati Sponsored Research Services Cincinnati, Oh 45221
Grant 5R21ES013524-02 from National Institute Of Environmental Health Sciences IRG: ECDA
Abstract: Manganese (Mn) is an essential element, but it is neurotoxic in excess. The lowest level of Mn associated with adverse effects and the ideal biomarker for measuring low-level Mn exposure is poorly defined. Moreover, there is some evidence that Mn and lead (Pb) are biologically synergistic in their toxicity. A noninvasive method of detecting Mn exposure in the brain, its target organ of toxicity, would be invaluable for the study of Mn neurotoxicity. Mn readily crosses the blood-brain-barrier, selectively accumulating in the caudate and the globus pallidus. Magnetic resonance imaging (MRI) can reflect Mn deposition in the brain. Given the increased use of Mn in gasoline and the emerging data on adverse health effects of low-level Pb exposure, it is critical to conduct studies to identifying a suitable biomarker of Mn exposure and to identify the health effects of low-level Mn exposure. We seek to explore the following specific aims Specific Aim 1 Validate a noninvasive biomarker of chronic, low-level Mn exposure. Specific Aim 2 Characterize the neurobehavioral effects of chronic, low-level Mn exposure using currently accepted biomarkers of exposure and a MRI biomarker. Specific Aim 3 Characterize the neurobehavioral effects of combined exposure to Pb and Mn using currently accepted biomarkers of exposure and a MRI biomarker. The Cincinnati Lead Study cohort, the longest running cohort study of Pb exposed children, provides a unique opportunity to examine Mn deposition in the brain of young adults with low-level Mn exposure and extensive measures of lifetime Pb exposure and neurological development. If we demonstrate that MRI is a valid measure of low-level Mn exposure and Mn exposure predicts impaired neurobehavioral functions, then this study will substantially advance environmental health research and have broad implications for policy to control environmental exposure to Mn.
Keywords: biomarker, environmental exposure, manganese, metal poisoning, neuropsychology, neurotoxicology, noninvasive diagnosis, caudate nucleus, environmental contamination, lead, lenticular nucleus, toxicant interaction, behavioral /social science research tag, clinical research, human subject, magnetic resonance imaging
Project start date: 2005-01-01
Project end date: 2007-11-30
5R21ES013524-02 (2006): $139826
Neurobehavioral Effect Of Low Level Manganese Exposure
Erin N Haynes
University Of Cincinnati Sponsored Research Services Cincinnati, Oh 45221
Grant 1R21ES013524-01 from National Institute Of Environmental Health Sciences IRG: ECDA
Abstract: Manganese (Mn) is an essential element, but it is neurotoxic in excess. The lowest level of Mn associated with adverse effects and the ideal biomarker for measuring low-level Mn exposure is poorly defined. Moreover, there is some evidence that Mn and lead (Pb) are biologically synergistic in their toxicity. A noninvasive method of detecting Mn exposure in the brain, its target organ of toxicity, would be invaluable for the study of Mn neurotoxicity. Mn readily crosses the blood-brain-barrier, selectively accumulating in the caudate and the globus pallidus. Magnetic resonance imaging (MRI) can reflect Mn deposition in the brain. Given the increased use of Mn in gasoline and the emerging data on adverse health effects of low-level Pb exposure, it is critical to conduct studies to identifying a suitable biomarker of Mn exposure and to identify the health effects of low-level Mn exposure. We seek to explore the following specific aims Specific Aim 1 Validate a noninvasive biomarker of chronic, low-level Mn exposure. Specific Aim 2 Characterize the neurobehavioral effects of chronic, low-level Mn exposure using currently accepted biomarkers of exposure and a MRI biomarker. Specific Aim 3 Characterize the neurobehavioral effects of combined exposure to Pb and Mn using currently accepted biomarkers of exposure and a MRI biomarker. The Cincinnati Lead Study cohort, the longest running cohort study of Pb exposed children, provides a unique opportunity to examine Mn deposition in the brain of young adults with low-level Mn exposure and extensive measures of lifetime Pb exposure and neurological development. If we demonstrate that MRI is a valid measure of low-level Mn exposure and Mn exposure predicts impaired neurobehavioral functions, then this study will substantially advance environmental health research and have broad implications for policy to control environmental exposure to Mn.
Keywords: biomarker, environmental exposure, manganese, metal poisoning, neuropsychology, neurotoxicology, noninvasive diagnosis, caudate nucleus, environmental contamination, lead, lenticular nucleus, toxicant interaction, behavioral /social science research tag, clinical research, human subject, magnetic resonance imaging
Project start date: 2005-01-01
Project end date: 2006-11-30
1R21ES013524-01 (2005): $196545
Marietta Community Actively Researching Exposure Study
Erin N Haynes
Environmental Healthuniversity Of Cincinnati
Grant 5R01ES016531-02 from National Institute Of Environmental Health Sciences IRG: ZRG1
Project start date: 2008-04-01
Project end date: 2013-02-28