Brandon E Gibb
State University New York Binghamton
Project start date: 2009-09-30
Project end date: 2012-08-31
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to Brandon E Gibb
Development Of Negative Attributional Styles
Brandon E Gibb, Assistant Professor
Psychologytemple University
1601 N. Broad Street
philadelphia, Pa 19122
Grant 1F31MH064302-01A1 from National Institute Of Mental Health IRG: ZRG1
Abstract: The primary goal of the current study is to better understand the development of depression by examining factors that may contribute to the development of a cognitive vulnerability to depression. Understanding the development of depression is important given that depression is the second most common psychological disorder, with lifetime prevalence estimates as high as 17.1 percent , and estimates that the economic burden of depression in the United States is $43.7 billion annually. Thus, understanding how vulnerability to depression develops is an important step in targeting interventions to buffer against the development of that vulnerability, thereby reducing the risk of depression onset. In the current study, therefore , the independent, unique, and combined influences of a number of factors hypothesized to contribute to the development of negative attributional styles in children will be examined over a 6-month longitudinal follow-up. These factors will include variables previously identified in longitudinal studies as contributing to the development of children?s and adolescents? attributional styles as well as factors demonstrating cross-sectional relationships with attributional styles but not yet examined longitudinally. In this way, the current study will seek to both integrate and extend previous findings
Keywords: attribution, child mental disorder, depression, disease /disorder etiology child abuse, child psychology, longitudinal human study, predoctoral investigator adolescence (12-18), child (0-11), clinical research, human subject
Project start date: 2001-09-28
Project end date: 2002-06-30
1F31MH064302-01A1 (2001): $20736
PATHWAYS TO DEPRESSION IN CHILDREN OF DEPRESSED MOTHERS
Brandon E Gibb
State University New York Binghamton, Vestal Pky E, Po Box 6000, Binghamton, Ny 13902-6000
Grant 5R01HD057066-02 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development
Abstract: Although the link between maternal and child depression is well established, little is known about the mechanisms by which this risk is conferred. The proposed study is designed to address this gap. In so doing, we seek to integrate and extend findings from two separate lines of research cognitive-interpersonal models of depression and psychiatric genetics. The proposed study involves a longitudinal investigation of mothers and their children (ages 8-14 years) drawn from the community and assessed every six months for two years. Two groups of mothers will be recruited for the study (a) those with a history of major depressive disorder (MDD) during their child´s life and (b) those with no lifetime history of any depressive disorder and no current Axis I disorder. Our primary goal is to examine the development of children´s cognitive vulnerability to depression (negative attributional style and attention and interpretation biases for facial displays of emotion). We hypothesize that maternal history of MDD will be associated with the presence of more negative cognitive styles in their children and that these cognitive styles will become more negative over the course of the follow-up as a function of mother´s ongoing depressive symptom levels. We also hypothesize that negative events in the children´s lives (maternal criticism as well as general negative events) will predict negative changes in children´s cognitive styles. Integrating recent findings from psychiatric genetics, we predict that these effects on children´s cognitive styles will be moderated by two specific genetic risk factors - a functional polymorphism in the serotonin transporter gene (5-HTTLPR) and a candidate polymorphism in the brain-derived neurotrophic factor (BDNF) gene. Our secondary goal is to test a transactional cognitive-interpersonal mediation model linking maternal and child depression. In testing this model, we hypothesize that mothers with a history of MDD, compared to control mothers, will exhibit elevated levels of depressive symptoms across the follow-up. These depressive symptom elevations are hypothesized to contribute to the occurrence of negative events in children´s lives, which will then contribute to the development of children´s negative cognitive styles. These negative cognitive styles, then, are hypothesized to contribute to children´s symptoms and diagnoses of depression. Building from the stress-generation literature, we will also test the hypothesis that children´s levels of depression will reciprocally predict prospective changes in negative events and children´s cognitive styles. We also predict that children´s 5-HTTLPR and BDNF genotypes will moderate the impact of mother depression, negative events, and children´s cognitions upon child depression, allowing increased precision in predicting which children are at greatest risk for the intergenerational transmission of depression. A tertiary goal is to examine the specificity of the links in the mediational model to children´s depression versus other disorders (e.g., anxiety and disruptive behavior disorders)
Keywords: 0-11 years old; 5HT transporter; 5HTT protein; Active Follow-up; Address; Age; Age of Onset; Alloys; Anxiety; Attention; BDNF; Behavior Disorder, Disruptive; Brain-Derived Neurotrophic Factor; Characteristics; Child; Child Development; Child Youth; Children (0-21); Cognition; Cognitive; Communities; Depression; Depressive disorder; Development; Diagnosis; Disease; Disorder; Disruptive Behavior Disorder; Early Diagnosis; Emotional Depression; Emotions; Event; Exhibits; Expressed Emotion; Face; Family member; Generations; Genes; Genetic Polymorphism; Genotype; Goals; History; Human, Child; Infant and Child Development; Intervention; Intervention Strategies; Investigation; Life; Link; Literature; MGC34632; Major Depressive Disorder; Mediation; Mental Depression; Modeling; Mothers; Negotiating; Negotiation; Neurosis, Depressive; Pathway interactions; Polymorphism (Genetics); Polymorphism, Genetic; Prospective Studies; Psychopathology; Recording of previous events; Recruitment Activity; Recurrence; Recurrent; Research; Risk; Severities; Social support; Specificity; Stress; Symptoms; Symptoms of depression; Testing; Time; Transmission; abnormal psychology; child depression; children; depressed mother; depressive; depressive symptoms; design; designing; disease/disorder; disruptive behavioral disorder; early detection; facial; follow-up; genetic risk factor; inherited factor; intergenerational; interventional strategy; major depression; maternal depression; pathway; polymorphism; prospective; psychiatric genetics; psychogenetics; recruit; serotonin transporter; sex; social support network; sodium-dependent serotonin transporter; transmission process; youngster
Relevance: The proposed study represents an important step in understanding why children of depressed mothers are at increased risk for depression themselves. If the proposed developmental model is supported, the results could help to further advance efforts for the early detection of children at greatest risk of developing depression. In addition, the results could pave the way for more focused interventions for at-risk children
Project start date: 2009-09-30
Project end date: 2011-08-31
Budget start date: 1-SEP-2010
Budget end date: 31-AUG-2011
PFA/PA: PA-07-070
5R01HD057066-02 (2010): $487166
1R01HD057066-01A2 (2009): $387693
Mechanisms Of Risk In Children Of Depressed Mothers
Brandon E Gibb, Assistant Professor
State University New York Binghamton Vestal Pky E, Po Box 6000 Binghamton, Ny 139026000
Grant 5R03HD048664-02 from National Institute Of Child Health And Human Development IRG: CHHD
Abstract: Although the link between maternal and child depression is well established, little is known about the mechanism by which this risk is conferred. The proposed study is designed to address this gap by evaluating an etiological model linking maternal and child depression. In so doing, we will seek to integrate and extend findings from two separate lines of research - the expressed emotion and cognitive vulnerability to depression literatures. The proposed study involves the cross-sectional assessment of mothers and their children (ages 8-12 years). Two groups of mothers will be recruited for the study (a) those with a history of major depressive disorder (MDD) during their child s life and (b) those with no lifetime history of any DSM-IV Axis I disorder. In testing our model, we hypothesize that mothers levels of expressed emotion-criticism toward their children, as well as children s negative cognitive styles, will mediate the link between maternal diagnostic status (depressed versus nonclinical control) and children s symptoms and diagnoses of depression. A secondary goal of the proposed study is to examine the specificity of the links in the mediational model to children s depression versus other disorders (e.g., anxiety and disruptive behavior disorders).
Keywords: child behavior, disease /disorder etiology, disease /disorder proneness /risk, major depression, maternal behavior, mother child interaction, cognition, emotion, longitudinal human study, mental health epidemiology, middle childhood (6-11), psychopathology, behavior test, behavioral /social science research tag, clinical research, human subject, interview
Project start date: 2005-02-01
Project end date: 2007-07-31
5R03HD048664-02 (2006): $73482
1R03HD048664-01 (2005): $75250