Gregory Wu
Washington University
Project start date: 2008-09-01
Project end date: 2013-06-30
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T CELL REGULATION BY DENDRITIC CELLS IN EAE
Gregory Wu, Assistant Professor
Washington University, Campus Box 1054, Saint Louis, Mo 63130-4899
Grant 5K08NS062138-03 from National Institute Of Neurological Disorders And Stroke
Abstract: This proposal describes a 5-year training program for the development of an academic career in neuroimmunology. The PI has previous training in neuroscience, completed formal residency training in neurology, and is currently expanding his clinical skills in multiple sclerosis and scientific skills in neuroimmunology research. Drs. Terri Laufer and Gary Koretzky, internationally recognized authorities in immunology, will mentor the Pi´s scientific development. Dr. Laufer is a rheumatology clinician-scientist well regarded for her diverse work in autoimmunity. Dr. Koretzky, the Vice Chair for Research in the Department of Medicine and endowed Professor in Pathology, has mentored numerous students, post-doctoral fellows and junior faculty members. To further promote the investigator´s scientific development, an Advisory Committee comprising highly regarded medical scientists with expertise in neuroimmunology, including Drs. Francisco A. Gonzalez-Scarano, Steven Reiner, Youhai Chen and Michael K. Racke, has been established. The proposed research focuses on the role of dendritic cells in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system. The process involved in generating the auto-reactive CD4 T cells required for EAE is unclear. Dendritic cells are a special class of antigen presenting cell capable of activating CD4 T cells and initiating a wide array of effector functions. Dendritic cells are thought to be important during multiple phases of disease in EAE. Therefore, understanding the contributions of dendritic cells to EAE is of particular relevance to the pathogenesis of multiple sclerosis. Given the mentor´s expertise in T cell-dendritic cell interactions in autoimmunity, Dr. Laufer´s laboratory is the ideal setting to study the precise roles played dendritic cells during inflammatory responses targeting the central nervous system. Specific aims include 1) defining the mechanisms for dendritic cell-dependent CD4 T cell activation in EAE, and 2) studying the contributions of different subsets of dendritic cells during various phases of EAE. The quality of the research facilities and the diversity of the resources available at the sponsoring institution, in combination with the intellectual and academic strength of the sponsors, provide an ideal environment in which to conduct this proposed training program
Keywords: APC; ATGN; Address; Advisory Committees; Anatomic; Anatomical Sciences; Anatomy; Animal Model; Animal Models and Related Studies; Antigen Presentation; Antigen-Presenting Cells; Antigens; Autoimmune; Autoimmune Process; Autoimmune Responses; Autoimmune Status; Autoimmunity; Blood monocyte; Body Tissues; CD4 Positive T Lymphocytes; CD4 T cells; CD4 lymphocyte; CD4+ T cell; CD4+ T-Lymphocyte; CD4-Positive Lymphocytes; Cell Communication; Cell Interaction; Cell Locomotion; Cell Migration; Cell Movement; Cell Surface Antigens; Cell-to-Cell Interaction; Cells, CD4; Cellular Migration; Central Nervous System; Chronic; Clinical Skills; Complex; Demyelinating Disease of Central Nervous System; Demyelinating Disorder of Central Nervous System; Demyelinations; Dendritic Cells; Development; Disease; Disorder; EAE; Encephalomyelitis; Encephalomyelitis, Allergic; Environment; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; Faculty; Goals; Histocompatibility; INFLM; Immune; Immune Targeting; Immunization; Immunologic Accessory Cells; Immunologic Stimulation; Immunological Stimulation; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Immunostimulation; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Institution; Investigators; Kinetic; Kinetics; Laboratories; MHC Receptor; MS (Multiple Sclerosis); Major Histocompatibility Complex Receptor; Mammals, Mice; Marrow monocyte; Mediating; Medical; Medicine; Mentors; Methods; Mice; Modeling; Monocytes / Macrophages / APC; Motility; Motility, Cellular; Multiple Sclerosis; Murine; Mus; Myelin; Myeloencephalitis; Nervous System, CNS; Neuraxis; Neurology; Neurosciences; Pathogenesis; Pathology; Pattern; Peptides; Phase; Phenotype; Play; Population; Postdoc; Postdoctoral Fellow; Predisposition; Process; Program Development; Property; Property, LOINC Axis 2; Proteins; Receptors, Antigen, T-Cell; Research; Research Associate; Research Personnel; Research Resources; Researchers; Residencies; Resources; Rest; Rheumatology; Role; Science of Anatomy; Science of Medicine; Scientist; Sclerosis, Disseminated; Sensitization, Immunologic; Sensitization, Immunological; Staging; Students; Surface Antigens; Surface Markers, Immunologic; Surface Markers, Immunological; Susceptibility; T cell regulation; T cell response; T-Cell Activation; T-Cell Receptor; T-Cells; T-Lymphocyte; T4 Cells; T4 Lymphocytes; Task Forces; Testing; Thymus-Dependent Lymphocytes; Time; Tissue Compatibility; Tissues; Training; Training Programs; Veiled Cells; Work; accessory cell; anatomy; authority; autoimmune encephalomyelitis; base; career; cell motility; central nervous system demyelinating disorder; cytokine; disease/disorder; experiment; experimental research; experimental study; gene product; helper T cell; immunogen; immuurology; insular sclerosis; irradiation; macrophage; member; model organism; monocyte; neuroimmunology; post-doc; post-doctoral; professor; research facility; research study; self recognition (immune); skills; social role; thymus derived lymphocyte; trafficking
Project start date: 2008-09-01
Project end date: 2013-06-30
Budget start date: 1-JUL-2010
Budget end date: 30-JUN-2011
PFA/PA: PA-06-512
5K08NS062138-03 (2010): $163274
Grants awarded to Gregory Wu
T CELL REGULATION BY DENDRITIC CELLS IN EAE
Gregory Wu, Assistant Professor
Washington University, Campus Box 1054, Saint Louis, Mo 63130-4899
Grant 7K08NS062138-02 from National Institute Of Neurological Disorders And Stroke
Abstract: This proposal describes a 5-year training program for the development of an academic career in neuroimmunology. The PI has previous training in neuroscience, completed formal residency training in neurology, and is currently expanding his clinical skills in multiple sclerosis and scientific skills in neuroimmunology research. Drs. Terri Laufer and Gary Koretzky, internationally recognized authorities in immunology, will mentor the Pi´s scientific development. Dr. Laufer is a rheumatology clinician-scientist well regarded for her diverse work in autoimmunity. Dr. Koretzky, the Vice Chair for Research in the Department of Medicine and endowed Professor in Pathology, has mentored numerous students, post-doctoral fellows and junior faculty members. To further promote the investigator´s scientific development, an Advisory Committee comprising highly regarded medical scientists with expertise in neuroimmunology, including Drs. Francisco A. Gonzalez-Scarano, Steven Reiner, Youhai Chen and Michael K. Racke, has been established. The proposed research focuses on the role of dendritic cells in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system. The process involved in generating the auto-reactive CD4 T cells required for EAE is unclear. Dendritic cells are a special class of antigen presenting cell capable of activating CD4 T cells and initiating a wide array of effector functions. Dendritic cells are thought to be important during multiple phases of disease in EAE. Therefore, understanding the contributions of dendritic cells to EAE is of particular relevance to the pathogenesis of multiple sclerosis. Given the mentor´s expertise in T cell-dendritic cell interactions in autoimmunity, Dr. Laufer´s laboratory is the ideal setting to study the precise roles played dendritic cells during inflammatory responses targeting the central nervous system. Specific aims include 1) defining the mechanisms for dendritic cell-dependent CD4 T cell activation in EAE, and 2) studying the contributions of different subsets of dendritic cells during various phases of EAE. The quality of the research facilities and the diversity of the resources available at the sponsoring institution, in combination with the intellectual and academic strength of the sponsors, provide an ideal environment in which to conduct this proposed training program
Keywords: Dendritic Cells; EAE; Encephalomyelitis, Allergic; Experimental Allergic Encephalitis; Experimental Allergic Encephalomyelitis; Experimental Autoimmune Encephalitis; Experimental Autoimmune Encephalomyelitis; T cell regulation; Veiled Cells; autoimmune encephalomyelitis
Project start date: 2008-09-01
Project end date: 2013-06-30
Budget start date: 1-SEP-2009
Budget end date: 30-JUN-2010
PFA/PA: PA-06-512
7K08NS062138-02 (2009): $163274
1K08NS062138-01A1 (2008): $172606