Hector F Rios
University Of Michigan At Ann Arbor
Project start date: 2010-07-02
Project end date: 2013-06-30
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to Hector F Rios
THE IMPORTANCE OF PERIOSTIN IN PERIODONTAL HEALTH AND DISEASE
Hector F Rios, Assistant Professor
University Of Michigan At Ann Arbor, 1040 Wolverine Tower, Ann Arbor, Mi 48109-1274
Grant 1K23DE019872-01A1 from National Institute Of Dental & Craniofacial Research
Abstract: The candidate´s background in Oral and Molecular Biology as well as his training in Periodontics equips him with the tools to explore innovative approaches to understand and address clinically relevant health problems. The training and the research proposed in this application are designed to increase his investigating skills to translate important laboratory findings into the clinical arena, with the ultimate goal of developing into an independent clinical and translational scientist. In the Years 1-2, the proposed curriculum will be completed. In Years 1-3, the research described will be conducted and the data will be utilized to prepare an R01 grant application. In humans, loss of periodontal integrity leading to periodontal destruction is known as periodontitis. It is known that periodontitis is triggered by specific periodontal pathogens in a susceptible host. However, the mechanism by which these microorganisms compromise the modulation of cell-matrix interactions is not clearly understood. The proteins modulating these interactions are known collectively as matricellular molecules. The goal of the research proposal is to study the importance of Periostin, a novel matricellular molecule and periodontal ligament marker, in periodontal health and disease. We have shown that Periostin null mice suffer severe alveolar bone loss over time resulting in tooth loss. We hypothesize that Periostin levels are decreased during periodontal disease, leading to increased host susceptibility to periodontal breakdown. The clinical validation of this finding is fundamental as it may trigger the development of innovative solutions that will ultimately help the patients. The proposed career development plan is designed to secure sufficient time to achieve two main objectives 1) to gain additional training in the translational application of laboratory based research findings to clinical research, including further statistical training, and grantsmanship; and 2) to use the data collected and newly developed clinical research expertise to position him as a qualified candidate for a future independent investigator award in patient-oriented research. This project will allow Dr. Rios to further explore the possible relationship between Periostin and periodontal disease necessary for the development of human clinical trials. The data generated will have important implications for our understanding of periodontal biology in the context of cell-matrix dynamics and their role in periodontal homeostasis. These studies may highlight novel pathways that determine periodontal disease susceptibility that could be targeted in the treatment of inflammatory periodontal diseases
Keywords: 21+ years old; Address; Adult; Algorithms; Alveolar; Alveolar Bone Loss; Alveolar Resorption; Alveolodental Ligament; Alveolodental Membrane; Analysis, Data; Animal growth regulators, transforming growth factors; Applications Grants; Autoregulation; Award; Basic Research; Basic Science; Biology; Biostatistical Methods; Blood Serum; Body Tissues; Cardiac infarction; Cell Communication and Signaling; Cell Signaling; Cells; Cellular Matrix; Chronic Periodontitis; Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Commit; Consent; Curriculum; Cytoskeletal System; Cytoskeleton; DNA Molecular Biology; Data; Data Analyses; Dental; Development; Development Plans; Diagnosis; Diathesis; Disease; Disease Progression; Disease susceptibility; Disorder; Educational Curriculum; Environment; Esteroproteases; Event; Extracellular Matrix, Integrins; Fibroblasts; Foundations; Future; GFAC; Gingival Crevicular Fluid; Gingival Exudate; Goals; Grant Proposals; Grants, Applications; Growth Agents; Growth Factor; Growth Factors, Proteins; Growth Substances; Head and Neck, Saliva; Healed; Health; Heart; Homeostasis; Human; Human Development; Human, Adult; Human, General; Inflammatory; Integrins; Interleukins; Intracellular Communication and Signaling; Investigators; Knockout Mice; Lab Findings; Laboratories; Laboratory Finding; Learning; Liquid substance; Longitudinal Studies; MMPs; Man (Taxonomy); Man, Modern; Matrix Metalloproteinases; Measures; Mechanics; Mice, Knock-out; Mice, Knockout; Microorganisms, General; Modeling; Molecular; Molecular Biology; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Myocardial Infarct; Myocardial Infarction; Natural regeneration; Null Mouse; Oral; Oral health; Paradentium; Paradentiums; Parodontosis; Pathway interactions; Patients; Pattern; Peptidases; Peptide Hydrolases; Periodontal Bone Loss; Periodontal Diseases; Periodontal Ligament; Periodontal Membrane; Periodontal Resorption; Periodontic; Periodontic specialty; Periodontics; Periodontitis; Periodontium; Phenotype; Physiological Homeostasis; Population; Position; Positioning Attribute; Predisposition; Prevalence; Prevention; Probability Theory; Process; Property; Property, LOINC Axis 2; Proteases; Proteinases; Proteins; Proteolytic Enzymes; Public Health; QOL; Qualifying; Quality of life; Receptor Protein; Recovery; Recruitment Activity; Regeneration; Regulation; Reporting; Research; Research Personnel; Research Proposals; Research Training; Researchers; Risk Factors; Role; Saliva; Scientist; Screening procedure; Secure; Serum; Signal Transduction; Signal Transduction Systems; Signaling; Solutions; Staging; Structure; Susceptibility; Systemic disease; Time; Tissues; Tooth; Tooth Loss; Tooth Supporting Structures; Tooth structure; Training; Transforming Growth Factors; Translating; Translatings; Tumor Growth Factors; Validation; Wound Healing; Wound Repair; adult human (21+); application in practice; base; biological signal transduction; biomarker; cardiac infarct; career; career development; clinical investigation; clinical relevance; clinically relevant; computer based prediction; coronary attack; coronary infarct; coronary infarction; cytokine; dental health; design; designing; disease/disorder; disease/disorder proneness/risk; fluid; gene product; healing; heart attack; heart infarct; heart infarction; high standard; injury response; innovate; innovation; innovative; insight; intracellular skeleton; language translation; liability to disease; liquid; long-term study; longitudinal analysis; microbial; microorganism; modifiable risk; novel; pathogen; pathway; patient oriented research; patient oriented study; periodontal disorder; periodontium disease; periodontium disorder; periostin; practical application; predictive modeling; public health medicine (field); public health relevance; receptor; recruit; regenerate; repair; repaired; response; response to injury; sample collection; screening; screenings; skills; social role; specimen collection; teeth; tissue repair; tool; unspecified interleukin
Relevance: The data generated will have important implications for our understanding of periodontal biology in the context of cell-matrix dynamics and their role in periodontal homeostasis. These studies may highlight novel pathways that determine periodontal disease susceptibility that could be targeted in the treatment of inflammatory periodontal diseases
Project start date: 2010-07-02
Project end date: 2013-06-30
Budget start date: 2-JUL-2010
Budget end date: 30-JUN-2011
PFA/PA: PA-09-043
1K23DE019872-01A1 (2010): $131003