Protein Production
293FT, 293E, CHO

Truly Functional Protein
95% Purity
1-10 mg in 2 weeks

GeneExpressoMax™
293Expresso™

Transfection Reagents
* 90% Efficiency
* 95% Viability
* No sera interference
* Simple protocol
* High-throughput
* Only $98/ml

Baculovirus
Functional Protein
95% Purity
Fast turnaround
1-10 mg from Sf9 cells

Adenovirus, AAV
& Lentivirus

ORF or shRNA
* High Titer
* Cre, FLP, ΦC31
* Protein Kinases
* Transcription Factors
* Luciferases, GFP, RFP
* Protein Production
* Stable Cell Line


Excellgen

INFLUENCES ON THE SUSTAINABILITY OF EVIDENCE-BASED PSYCHOTHERAPIES

Shannon W Stirman
University Of Pennsylvania, 3451 Walnut Street, Philadelphia, Pa 19104

Grant 5K99MH080100-02 from National Institute Of Mental Health

Abstract: is proposing funding through the Pathway to Independence Career Development Award (K99) to conduct a program of training and research that will to develop skills in mixed-methods research strategies and knowledge of theories of dissemination and organizational change. will interface clinical intervention research and organizational research to determine barriers to the sustained use of empirically supported psychotherapies after training occurs within community mental health agencies. The proposed research projects will complement the training program by providing opportunities to implement the mixed- methods strategies to assess barriers to sustained implementation of empirically supported treatments within community based-settings. Mentors at two NIMH-funded research centers at Penn, both of which have developed collaborative relationships with mental health agencies in Philadelphia, will support in the proposed research and training. The first study will employ surveys to examine some hypothesized barriers to the sustainability of new interventions in community mental health settings, as well as micro- ethnographic methods to generate more specific hypotheses regarding barriers specific to these settings. The second study will examine the natural trajectory of the use of cognitive therapy after training in community mental health settings over two years. The relationship between clinician attitudes towards CT, specific organizational factors, and the sustained adoption of CT will be examined using a mixed-methods strategy. A secondary goal of this research will be to conduct the first examination the "real world" modifications that the treatment protocol undergoes as a result of the needs of the client and the realities of clinical practice. These results will inform the development of an RO1 to test a model of the individual and organizational factors that predict the sustainability of adoption within community mental health settings. This research program will yield some of the first data regarding the organizational and individual factors that impact the long-term sustainability of evidence-based psychotherapies. The knowledge gained can lead to the implementation of interventions that appropriately address barriers to the use of evidence-based therapies in community settings, which will in turn promote increased access to interventions that, despite extensive empirical support, currently are not widely available to community mental health consumers

Keywords: Address; Adoption; Attitude; Behavior Therapy, Cognitive; Behavioral Therapy; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Client; Clinical; Cognitive Therapy; Communities; Complement; Complement Proteins; Data; Depression; Development; Funding; Goals; Individual; Intervention; Intervention Strategies; Intervention Studies; K-Awards; K-Series Research Career Programs; Knowledge; Lead; Mental Depression; Mental Health; Mental Hygiene; Mentors; Methodology, Research; Methods; Modeling; Modification; Nature; Organizational Change; Pathway interactions; Pb element; Philadelphia; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Psychological Health; Psychotherapy; Psychotherapy, Cognitive; R01 Mechanism; R01 Program; RGM; RPG; Regimen; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Methodology; Research Methods; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Survey Instrument; Surveys; Testing; Therapy, Cognition; Training; Training Programs; Treatment Protocols; Treatment Regimen; Treatment Schedule; base; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; ethnographic method; heavy metal Pb; heavy metal lead; interventional strategy; pathway; programs; skills; suicidal behavior; suicide behavior; theories

Project start date: 2007-09-26

Project end date: 2010-07-31

Budget start date: 1-AUG-2008

Budget end date: 31-JUL-2010

PFA/PA: PA-07-297

5K99MH080100-02 (2008): $0


Sponsored Links Excellgen http://Excellgen.com

Transient Protein Expression in CHO and HEK293 Cells
Transient Expression, Truly Functional Protein, 95% purity, 1~20 mg, fast turnaround. $5500, $3950
Recombinant Lentivirus & Adenovirus
High Yield and High Titer up to 1010 (lentivirus) and 1013 (adenovirus) for Guaranteed Expression of GOI. $3000, $2500
Baculovirus Protein Expression
Fast turn around, >95% purity functional protein. No outsourcing to China or India. $5500, $3950


Grants awarded to Shannon W Stirman

INFLUENCES ON THE SUSTAINABILITY OF EVIDENCE-BASED PSYCHOTHERAPIES

Shannon W Stirman
Boston University Medical Campus, 85 East Newton Street, M-921, Boston, Ma 02118-2340

Grant 4R00MH080100-03 from National Institute Of Mental Health

Abstract: is proposing funding through the Pathway to Independence Career Development Award (K99) to conduct a program of training and research that will to develop skills in mixed-methods research strategies and knowledge of theories of dissemination and organizational change. will interface clinical intervention research and organizational research to determine barriers to the sustained use of empirically supported psychotherapies after training occurs within community mental health agencies. The proposed research projects will complement the training program by providing opportunities to implement the mixed- methods strategies to assess barriers to sustained implementation of empirically supported treatments within community based-settings. Mentors at two NIMH-funded research centers at Penn, both of which have developed collaborative relationships with mental health agencies in Philadelphia, will support in the proposed research and training. The first study will employ surveys to examine some hypothesized barriers to the sustainability of new interventions in community mental health settings, as well as micro- ethnographic methods to generate more specific hypotheses regarding barriers specific to these settings. The second study will examine the natural trajectory of the use of cognitive therapy after training in community mental health settings over two years. The relationship between clinician attitudes towards CT, specific organizational factors, and the sustained adoption of CT will be examined using a mixed-methods strategy. A secondary goal of this research will be to conduct the first examination the "real world" modifications that the treatment protocol undergoes as a result of the needs of the client and the realities of clinical practice. These results will inform the development of an RO1 to test a model of the individual and organizational factors that predict the sustainability of adoption within community mental health settings. This research program will yield some of the first data regarding the organizational and individual factors that impact the long-term sustainability of evidence-based psychotherapies. The knowledge gained can lead to the implementation of interventions that appropriately address barriers to the use of evidence-based therapies in community settings, which will in turn promote increased access to interventions that, despite extensive empirical support, currently are not widely available to community mental health consumers

Keywords: Address; Adoption; Attitude; Behavior Therapy, Cognitive; Behavioral Therapy; Career Development Awards; Career Development Awards and Programs; Career Development Programs K-Series; Client; Clinical; Cognitive Therapy; Communities; Complement; Complement Proteins; Data; Development; Funding; Goals; Individual; Intervention; Intervention Strategies; Intervention Studies; K-Awards; K-Series Research Career Programs; Knowledge; Lead; Mental Health; Mental Hygiene; Mentors; Methodology, Research; Methods; Modeling; Modification; Nature; Organizational Change; Pathway interactions; Pb element; Philadelphia; Programs (PT); Programs [Publication Type]; Protocols, Treatment; Psychological Health; Psychotherapy; Psychotherapy, Cognitive; R01 Mechanism; R01 Program; RGM; RPG; Regimen; Research; Research Career Program; Research Career Programs, K-Series; Research Grants; Research Methodology; Research Methods; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Survey Instrument; Surveys; Testing; Therapy, Cognition; Training; Training Programs; Treatment Protocols; Treatment Regimen; Treatment Schedule; base; clinical practice; cognitive behavior intervention; cognitive behavior modification; cognitive behavioral intervention; cognitive behavioral modification; cognitive behavioral therapy; community setting; depression; evidence base; heavy metal Pb; heavy metal lead; interventional strategy; pathway; programs; skills; suicidal behavior; suicide behavior; theories

Project start date: 2010-03-05

Project end date: 2012-12-31

Budget start date: 5-MAR-2010

Budget end date: 31-DEC-2010

PFA/PA: PA-07-297

4R00MH080100-03 (2010): $248581


1K99MH080100-01A1 (2007): $89117

Shannon W Stirman
Boston University Medical Campus

Project start date: 2010-03-05

Project end date: 2012-12-31