PRENATAL MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-10 from National Institute Of Child Health And Human Development IRG: SRC
Abstract: The purpose of this program project is to study behavioral and brain function from the intrauterine period through 90 days in rats whose mothers had been malnourished by subjecting them to a diet of moderate protein restriction, both prior to and throughout pregnancy. The program will make use of a model developed in our laboratory in which the offspring of rats fed a 6% casein diet show impaired brain function despite adequate rates of postnatal growth. These rats will be compared with the offspring of rats fed a 25% casein diet on which optimal physical and brain growth occur. An important and unique contribution of the program project will be the interdisciplinary research by the Behavior, Neurophysiology, Neuroanatomy, and Molecular Neurobiology Divisions in the same animal model in order to identify mechanisms underlying observed brain and behavioral deficits. This will be undertaken by emphasis on the hippocampal formation and its inputs which are known to be sensitive to a range of environmental insults. We will also apply postnatal challenge (kindling and drugs) to the central nervous system to compromise any compensatory adaptation in brain structure or function which may have occurred secondary to malnutrition. This area of investigation has considerable relevance for humans because of the documented long-term effects of early malnutrition on mental development and the widespread prevalence of this condition both in developing regions of the world and in the U.S.
Keywords: developmental neurobiology, dietary protein, disease model, malnutrition, mental retardation, mother /embryo /fetus nutrition, nutrition related tag
Project start date: 1987-09-01
Project end date: 1999-06-02
5P01HD022539-10 (1998): $1437803
Sponsored Links Excellgen http://Excellgen.com
PRENATAL MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-09 from National Institute Of Child Health And Human Development IRG: SRC
Abstract: The purpose of this program project is to study behavioral and brain function from the intrauterine period through 90 days in rats whose mothers had been malnourished by subjecting them to a diet of moderate protein restriction, both prior to and throughout pregnancy. The program will make use of a model developed in our laboratory in which the offspring of rats fed a 6% casein diet show impaired brain function despite adequate rates of postnatal growth. These rats will be compared with the offspring of rats fed a 25% casein diet on which optimal physical and brain growth occur. An important and unique contribution of the program project will be the interdisciplinary research by the Behavior, Neurophysiology, Neuroanatomy, and Molecular Neurobiology Divisions in the same animal model in order to identify mechanisms underlying observed brain and behavioral deficits. This will be undertaken by emphasis on the hippocampal formation and its inputs which are known to be sensitive to a range of environmental insults. We will also apply postnatal challenge (kindling and drugs) to the central nervous system to compromise any compensatory adaptation in brain structure or function which may have occurred secondary to malnutrition. This area of investigation has considerable relevance for humans because of the documented long-term effects of early malnutrition on mental development and the widespread prevalence of this condition both in developing regions of the world and in the U.S.
Keywords: developmental neurobiology, dietary protein, disease model, malnutrition, mental retardation, mother /embryo /fetus nutrition, nutrition related tag
Project start date: 1987-09-01
Project end date: 1998-11-30
5P01HD022539-09 (1997): $1382505
5P01HD022539-15 (2003): $1704156
5P01HD022539-14 (2002): $1659084
5P01HD022539-13 (2001): $1629423
5P01HD022539-12 (2000): $1368417
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-130001 from National Institute Of Child Health And Human Development
Keywords: GABA receptor, behavior, developmental neurobiology, mother /embryo /fetus nutrition, protein deficiency, short term memory, benzodiazepine receptor, chlordiazepoxide, dietary protein, discrimination learning, disease /disorder model, hippocampus, immature animal, mature animal, memory, neural inhibition, operant conditioning, psychopharmacology, stress, behavior test, behavioral /social science research tag, laboratory rat, nutrition related tag
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION--BEHAVIORAL DIVISION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-100001 from National Institute Of Child Health And Human Development
Keywords: behavior, developmental neurobiology, dietary protein, malnutrition, mother /embryo /fetus nutrition, association learning, attention, disease model, hippocampus, immature animal, kindling, learning, mature animal, memory, neuroanatomy, neurochemistry, neurophysiology, operant conditioning, parent offspring interaction, performance, reinforcer, behavior test, behavioral /social science research tag, laboratory rat, nutrition related tag
PRENATAL MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-08 from National Institute Of Child Health And Human Development IRG: SRC
Project start date: 1987-09-01
Project end date: 1998-11-30
5P01HD022539-08 (1996): $1329332
Sponsored Links Excellgen http://Excellgen.com
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION--BEHAVIORAL DIVISION
Janina R Galler
Institution:
Grant 5P01HD022539-080001 from National Institute Of Child Health And Human Development
Keywords: behavior, developmental neurobiology, dietary protein, malnutrition, mother /embryo /fetus nutrition, association learning, attention, disease model, hippocampus, immature animal, kindling, learning, mature animal, memory, neuroanatomy, neurochemistry, neurophysiology, operant conditioning, parent offspring interaction, performance, reinforcer, behavior test, laboratory rat, nutrition related tag
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Biobehavioral Sciencesboston University Medical Campus
85 East Newton Street, M-921
boston, Ma 021182394
Grant 5P01HD022539-06 from National Institute Of Child Health And Human Development IRG: SRC
Keywords: developmental neurobiology, dietary protein, malnutrition, mental retardation, mother /embryo /fetus nutrition nutrition related tag
Project start date: 1987-09-01
Project end date: 1994-11-30
5P01HD022539-06 (1993): $1176209
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION--BEHAVIORAL DIVISION
Janina R Galler
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-060001 from National Institute Of Child Health And Human Development
Keywords: behavior, developmental neurobiology, dietary protein, malnutrition, mother /embryo /fetus nutrition, association learning, attention, hippocampus, immature animal, learning, mature animal, memory, neuroanatomy, neurochemistry, neurophysiology, operant conditioning, parent offspring interaction, performance, reinforcer, behavior test, laboratory rat, nutrition related tag
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-05 from National Institute Of Child Health And Human Development IRG: SRC
Keywords: developmental neurobiology, dietary protein, malnutrition, mental retardation, mother /embryo /fetus nutrition, nutrition related tag
Project start date: 1987-09-01
Project end date: 1993-11-30
5P01HD022539-05 (1992): $1056685
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION--BEHAVIORAL DIVISION
Janina R Galler
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-050001 from National Institute Of Child Health And Human Development
Keywords: behavior, developmental neurobiology, dietary protein, malnutrition, mother /embryo /fetus nutrition, association learning, attention, hippocampus, immature animal, learning, mature animal, memory, neuroanatomy, neurochemistry, neurophysiology, operant conditioning, parent offspring interaction, performance, reinforcer, behavior test, laboratory rat, nutrition related tag
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Boston University Medical Campus 715 Albany St, 560 Boston, Ma 021182394
Grant 5P01HD022539-03 from National Institute Of Child Health And Human Development IRG: HDMR
Keywords: NUTRITION RELATED CONTROL TAG, NUTRITION, MATERNAL-FETAL NUTRITION, NUTRITIONAL ABNORMALITIES, MALNUTRITION, PROTEINS, FETAL PROTEINS, mental retardation
Project start date: 1987-09-01
Project end date: 1990-11-30
Grants awarded to Janina R Galler
MALNUTRITION AND MENTAL HEALTH: A RAT MODEL
Janina R Galler, Senior Scientist
Judge Baker Children´s Center, 53 Parker Hill Avenue, Boston, Ma 02120-3225
Grant 5R01MH074811-04 from National Institute Of Mental Health
Abstract: Using a rodent model, our previous studies have established that impulsivity is a major behavioral consequence of prenatal protein malnutrition. In humans, evidence is mounting that impulsivity plays a central role in many psychopathological conditions, including attention deficit hyperactivity disorder (ADHD), antisocial and other personality disorders, and also in drug addiction. Importantly, impulsivity may be a common factor in those mental health disorders associated with early childhood malnutrition. In our 35 year follow-up study in Barbados of individuals with a history of malnutrition, we have documented a four-fold increase in the prevalence of ADHD. We are currently assessing in the adults, now 33-38 years of age, mental health outcomes, including attention deficits and impulsivity, associated with childhood malnutrition. The proposed animal research will validate our rat model of prenatal malnutrition and will make use of an innovative multidisciplinary approach to study the neural substrates of impulsivity and inattention. The following aims are based on the overall hypothesis that significant alterations in dopaminergic (DA), noradrenergic (NE) and serotonergic (5-HT) modulation of neurons from the prefrontal cortex (RFC) underlie increased impulsivity and decreased attention. Two highly integrated Specific Aims will test this hypothesis. In Aim 1, adult rats with and without prenatal protein malnutrition will be assessed with regard to performance on a) the 5-choice serial reaction time test of impulsivity, response accuracy and perseveration; b) the delayed reward operant test of impulsivity, and; c) the attentional set-shifting test of attention. In Aim 2 the neural substrates of relevant behaviors measured in Aim 1 will be further examined using in vivo studies in the same animals. All studies of Aim 2 will be performed on behaviorally tested prenatally protein malnourished and well-nourished subjects, and include a) 2-deoxyglucose examination of metabolic activity in the PFC and other regions of brain and b) in vivo microdialysis assessment of DA, NE and 5-HT release in the PFC. Since prenatal malnutrition is a major public health problem in developing countries and also in Western populations, the validation of our model is likely to lead to research with widespread clinical relevance. As indicated, the proposed project parallels our ongoing human study in Barbados, affording a tremendous and unique advantage to maximize the impact of our translational research
Keywords: 1, 2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-; 2-Deoxy-D-glucose; 2-Deoxyglucose; 2-Desoxy-D-glucose; 21+ years old; 3, 4-Dihydroxyphenethylamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 4-(2-Aminoethyl)-1, 2-benzenediol; 5-HT; 5-Hydroxytryptamine; 5HT; AD/HD; ADHD; Addiction, Drug; Adult; Age-Years; Amygdala; Amygdaloid Body; Amygdaloid Nucleus; Amygdaloid structure; Animal Experimental Use; Animal Experimentation; Animal Model; Animal Models and Related Studies; Animal Research; Animals; Attention; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Attentional deficit; Autoradiography; Barbados; Behavior; Behavioral; Brain; Brain region; Chemical Dependence; Childhood; Choice Behavior; Cognitive; Cognitive Discrimination; Common Rat Strains; D-arabino-Hexose, 2-deoxy-; Decision Making; Deoxyglucose; Dependence, Drug; Developing Countries; Developing Nations; Discrimination; Discrimination (Psychology); Disease; Disorder; Dissociation; Dopamine; Dorsal; Drug Addiction; Drug Dependency; Dysfunction; Encephalon; Encephalons; Enteramine; Follow-Up Studies; Followup Studies; Fore-Brain; Forebrain; Functional disorder; Future; Glean; High Prevalence; Hippophaine; History; Human; Human, Adult; Human, General; Hydroxytyramine; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Impulsive Behavior; Impulsivity; Individual; Investigation; Investigators; Lead; Learning; Left; Less-Developed Countries; Less-Developed Nations; Levarterenol; Levonorepinephrine; Life; Literature; Malnutrition; Mammals, Rats; Man (Taxonomy); Man, Modern; Measures; Medial; Mediating; Mental Health; Mental Hygiene; Mental disorders; Mental health disorders; Metabolic; Microdialysis; Modeling; Nerve Cells; Nerve Transmitter Substances; Nerve Unit; Nervous; Nervous System, Brain; Neural Cell; Neurobiology; Neurochemistry; Neurocyte; Neurons; Neurotransmitters; Noradrenaline; Norepinephrine; Nucleus Accumbens; Nutritional Deficiency; Outcome; Pb element; Performance; Personality Disorders; Physiopathology; Play; Population; Prefrontal Cortex; Prevalence; Principal Investigator; Programs (PT); Programs [Publication Type]; Prosencephalon; Proteins; Psychiatric Disease; Psychiatric Disorder; Psychological Health; Public Health; Publishing; Radioautography; Rat; Rattus; Reaction Time; Recording of previous events; Research; Research Personnel; Researchers; Response RT; Response Time; Reversal Learning; Rewards; Rodent Model; Role; Science of neurochemistry; Series; Serotonin; Specificity; System; System, LOINC Axis 4; Testing; Third-World Countries; Third-World Nations; Translational Research; Translational Research Enterprise; Translational Science; Under-Developed Countries; Under-Developed Nations; Undernutrition; Unspecified Mental Disorder; Validation; Visual; adult human (21+); amygdaloid nuclear complex; anti social; antisocial; attention deficit hyperactive disorder; base; behavior measurement; behavior test; behavioral measure; behavioral measurement; behavioral test; clinical relevance; clinically relevant; cohort; dietary deficiency; disease/disorder; early childhood; extracellular; frontal cortex; frontal lobe; gene product; heavy metal Pb; heavy metal lead; human study; in vivo; inattention; inattentiveness; innovate; innovation; innovative; interdisciplinary approach; mental illness; model organism; multidisciplinary; neural; neurobiological; neurochemistry; neuronal; noradrenergic; pathophysiology; pediatric; prenatal; programs; psychological disorder; psychomotor reaction time; public health medicine (field); relating to nervous system; response; social role; trait; translation research enterprise; unborn
Project start date: 2007-09-19
Project end date: 2012-06-30
Budget start date: 1-JUL-2010
Budget end date: 30-JUN-2011
5R01MH074811-04 (2010): $381473
5R01MH074811-03 (2009): $378869
5R01MH074811-02 (2008): $369420
1R01MH074811-01A2 (2007): $405504
INTERACTIVE EFFECTS OF PRENATAL COCAINE & MALNUTRITION
Janina R Galler, Professor Of Psychiatry And Public Healt
Ctr/economics And Mental Hlthboston University Medical Campus
85 East Newton Street, M-921
boston, Ma 021182394
Grant 5R01DA007934-02 from National Institute On Drug Abuse IRG: DACB
Abstract: The purpose of this series of studies is to determine if the combination of prenatal cocaine exposure and prenatal protein malnutrition in the rat results in significant physical and behavioral abnormalities in the offspring. Because malnutrition does pose added risk, current models of prenatal cocaine exposure using only well-nourished rats may be underestimating the impact of cocaine on the mother and her offspring. It is our hypothesis that prenatal cocaine-exposure in concert with malnutrition has more severe consequences for brain development and function than either insult alone. Moreover, cocaine exposure may compromise the nutritional status of the fetus. Thus, a secondary hypothesis is that many of the independent effects of prenatal cocaine will resemble those of prenatal malnutrition. An animal model of prenatal cocaine exposure will be developed using a 2 x 2 design in which well-nourished and malnourished rats are administered the drug using a treatment paradigm which better parallels the timing and pattern of human cocaine abuse than existing models. Reproductive success of the experimental dams, the incidence of malformations in the offspring and their subsequent physical growth will be documented. During postnatal development and in adulthood, the behavior of the progeny will be examined using a battery of tests which have previously been established as sensitive indicators of behavioral change consequent to prenatal protein malnutrition. Finally, basic pharmacokinetic parameters of cocaine distribution in the brain and blood of malnourished and well-nourished fetuses will be investigated. Potential differences are of critical importance in understanding the severity of impact on CNS development and the behavior of the offspring. The research proposed in this application has considerable implications for humans because of the increasing use of cocaine by low-income, inner city women of child-bearing age, whose nutritional status is likely to be compromised
Keywords: cocaine, disease model, drug abuse, embryo /fetus toxicology, malnutrition, model design /development, mother /embryo /fetus nutrition behavior disorder, congenital disorder, growth /development, pharmacokinetics behavior test, laboratory rat
Project start date: 1993-04-01
Project end date: 1996-03-31
5R01DA007934-02 (1994): $289090
1R01DA007934-01A1 (1993): $268465
PRENATAL MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Behav Dev & Mental Retardationboston University Medical Campus
85 East Newton Street, M-921
boston, Ma 021182394
Grant 3P01HD022539-12S1 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development IRG: ZHD1
Abstract: The purpose of this program project is to study behavioral and brain function from the intrauterine period through 120 days in rats whose mothers had been malnourished by subjecting them to a diet of moderate protein restriction, both prior to and throughout pregnancy. The program will make use of a model developed in our laboratory in which the offspring of rats fed a 6% casein diet show impaired brain function despite adequate rates of postnatal growth. These rats will be compared with the offspring of rats fed a 25% casein diet on which optimal physical and brain growth occur. An important and unique contribution of the program project will be the interdisciplinary research by the Behavior, Neurophysiology, Neuroanatomy, and Molecular Neurobiology Divisions in the same animal model in order to identify mechanisms underlying observed brain and behavioral deficits. This will be undertaken by emphasis on the hippocampal formation and its inputs which are known to be sensitive to a range of environmental insults. All divisions will explore the hypothesis that prenatal malnutrition enhances the inhibitory process in the hippocampal formation due to alterations in the GABA system. Accordingly, we plan to challenge the central nervous system and during later development, using drugs activating at the BZ/GABAa complex and exposure to stress, to compromise any compensatory adaptation in brain structure or function which may have occurred secondary to malnutrition. This area of investigation has considerable relevance for humans because of the documented long-term effects of early childhood malnutrition during periods of rapid brain growth on later mental development and the widespread prevalence of this condition both in developing regions of the world and in the U.S
Keywords: GABA receptor, developmental neurobiology, hippocampus, mental retardation, mother /embryo /fetus nutrition, protein deficiency nutrition related tag
Project start date: 1987-09-01
Project end date: 2004-04-30
3P01HD022539-12S1 (2000): $289532
2P01HD022539-11 (1999): $1294844
MENTAL HEALTH OUTCOMES FOLLOWING CHILDHOOD MALNUTRITION
Janina R Galler
Judge Baker Children´s Center, 53 Parker Hill Avenue, Boston, Ma 02120-3225
Grant 5R01MH065877-06 from National Institute Of Mental Health
Abstract: Malnutrition affects 25% of the children world-wide. In a series of over 40 published papers, we have documented the long-term effects of early protein-calorie malnutrition (PEM) and kwashiorkor in 333 Barbadian children and matched comparison cases from the same socioeconomic backgrounds. Now 30 to 35 years of age, the index children were diagnosed with moderate to severe protein-energy or protein malnutrition during their first year of life after which no further episodes occurred. All previously malnourished children were nutritionally rehabilitated shortly after their illness and were followed by the National Nutrition Centre on a regular basis, until they reached 11 years of age. Birth and postnatal data were available for all children in the study, and they were studied comprehensively throughout their school years (ages five to 18). When compared with controls at 5 to 11 years of age, previously malnourished children demonstrated a striking fourfold increase (15% versus 60%) in the incidence of behaviors associated with attention deficit disorder. Attentional problems at earlier ages predicted poor performance on the Eleven-Plus Examination, the national common entrance exam for high school placement taken by all Barbadian school children at 11 years of age. Attention problems persisted in 50% of the index children up to 18 years of age. Other deficits in the previously malnourished children included reduced IQ scores, soft neurological signs, learning disabilities and impaired social skills. In contrast, physical growth was delayed but showed complete "catch-up" by 16 years of age. To determine whether environmental factors contributed to these findings, socioeconomic conditions and factors in the child´s home environment were evaluated at all stages of development, including at the time that malnutrition occurred. Data analyses controlling for these ecological factors confirmed significant independent effects of childhood malnutrition in all cases. In the current study, we propose to extend our studies of this population to their adult years. We plan to evaluate behavioral, cognitive and mental health outcomes, because of deficits documented in earlier years and other long-term studies of prenatal malnutrition, notable the Dutch Famine study, which pointed to the importance of aberrant mental health outcomes in adulthood. Given the availability in Barbados of 98% of our original population and the existence of the comprehensive set of longitudinal data that document their physical and mental development from birth through 18 years of age, we believe a follow-up study of this population in their adult years will make a significant contribution to our understanding of the long-term consequences of postnatal malnutrition on behavioral and mental health outcomes. To our knowledge, there are no other published studies on the adult consequences of postnatal malnutrition in human populations
Keywords: 0-11 years old; 11 year old; 12-20 years old; 16 year old; 18 year old; 21+ years old; AD/HD; ADHD; Address; Adolescence; Adult; Affect; Age; Age-Years; Analysis, Data; Attention; Attention Deficit Disorder; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; Barbados; Behavior; Behavioral; Birth; Blood Pressure, High; Censuses; Child; Child Youth; Childhood; Children (0-21); Cognitive; Data; Data Analyses; Depression; Developing Countries; Developing Nations; Development; Diagnosis; Dietary Deficiency of Infants; Disease; Disorder; Effects, Longterm; Employee Strikes; Environmental Factor; Environmental Risk Factor; Evaluation; Famines; Follow-Up Studies; Followup Studies; Generalized Growth; Growth; Health Status; Home; Home environment; Human; Human, Adult; Human, Child; Human, General; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Hypertension; Incidence; Individual; Infant Malnutrition; Infant Nutritional Deficiency; Infant Undernutrition; Infantile Malnutrition; Infection; Investigators; Knowledge; Kwashiorkor; Learning Disabilities; Learning disability; Less-Developed Countries; Less-Developed Nations; Level of Health; Life; Long-Term Effects; Longitudinal Studies; Malnutrition; Malnutrition, Infant; Malnutrition, Protein-Energy; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Mental Depression; Mental Health; Mental Hygiene; Monitor; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Neurologic; Neurological; Nutrition; Nutritional Deficiency; Nutritional Science; Obesity; Outcome; Paper; Participant; Parturition; Performance; Population; Population Study; Poverty; Predisposition; Prevalence; Programs (PT); Programs [Publication Type]; Protein-Calorie Malnutrition; Protein-Energy Malnutrition; Proteins; Psychological Health; Psychoses; Psychotic Disorders; Public Policy; Publishing; Reporting; Research Personnel; Researchers; Risk Factors; Role; Schools; Science of nutrition; Series; Solutions; Staging; Strikes; Strikes, Employee; Susceptibility; Symptoms; Testing; Third-World Countries; Third-World Nations; Time; Tissue Growth; UNICEF; Under-Developed Countries; Under-Developed Nations; Undernutrition; Underweight; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; adiposity; adolescence (12-20); adult human (21+); anti social; antisocial; attention deficit hyperactive disorder; base; children; cognitive function; corpulence; corpulency; corpulentia; dietary deficiency; disease/disorder; early childhood; eighteen year old; eleven year old; environmental risk; executive control; executive function; gene product; high school; hyperpiesia; hyperpiesis; hypertensive disease; improved; indexing; infancy; infantile; interest; intergenerational; interpersonal competence; interpersonal competency; long-term study; mental development; neurobehavioral; next generation; nutrition; obese; obese people; obese person; obese population; ontogeny; pediatric; postnatal; prenatal; programs; sixteen year old; social; social competence; social competency; social role; social skills; socioeconomic; socioeconomically; socioeconomics; teenage; unborn; youngster
Project start date: 2004-05-01
Project end date: 2011-05-31
Budget start date: 1-JUN-2010
Budget end date: 31-MAY-2011
5R01MH065877-06 (2010): $1
5R01MH065877-04 (2007): $388500
Sponsored Links Excellgen http://Excellgen.com
7R01MH065877-05 (2007): $0
5R01MH065877-03 (2006): $374866
5R01MH065877-02 (2005): $372710
1R01MH065877-01A1 (2004): $405759
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION
Janina R Galler, Professor Of Psychiatry And Public Healt
Biobehavioral Sciencesboston University Medical Campus
85 East Newton Street, M-921
boston, Ma 021182394
Grant 3P01HD022539-06S1 from National Institute Of Child Health And Human Development IRG: SRC
Keywords: developmental neurobiology, dietary protein, malnutrition, mental retardation, mother /embryo /fetus nutrition nutrition related tag
Project start date: 1987-09-01
Project end date: 1994-11-30
3P01HD022539-06S1 (1994): $275857