MECHANISMS OF DISEASE PATHOGENESIS IN REGULATORY T CELL DEFICIENCY
B Calvin
University Of California Los Angelescity: Los Angeles country: United States (us)
Grant 5R01AI085090-03 from National Institute Of Allergy And Infectious Diseases
Keywords: Allergens; Allergic; Autoantigens; Autoimmune Diseases; Autoimmune Process; Autoimmunity; Bacteria; base; Biological Response Modifiers; Cell physiology; Cells; cytokine; Dendritic Cells; design; Development; Disease; Disease Outcome; Disease Progression; disorder prevention; Effector Cell; Environment; environmental agent; Exocytosis; Failure (biologic function); forkhead protein; General Population; Generations; Goals; Granzyme; Human; Hypersensitivity; IL2RA gene; Immune; Immune response; Immune system; Immune System Diseases; Immune Tolerance; Immunotherapy; improved; Individual; Induced Mutation; Inflammation; Inflammatory; insight; Interleukin-10; Interleukin-2; Intervention; Life; loss of function mutation; Lung; Lymphoproliferative Disorders; Maintenance; Measures; microbial; Molecular; Mus; Mutation; Natural Immunity; Nature; novel; novel therapeutic intervention; Onset of illness; Organ; Pathogenesis; Pathologic; Pathology; Pathway interactions; Peripheral; peripheral tolerance; Play; Population; precursor cell; Process; public health relevance; Regulatory T-Lymphocyte; research study; Role; Skin; Specificity; Surface; Syndrome; Systemic disease; T-Lymphocyte; Testing; Thymus Gland; Tissues; transcription factor; Transforming Growth Factor beta; Vaccines
Relevance: Regulatory T cell (TR) deficiency disorders encompass a number of heritable immunological diseases characterized by disproportionate immune responses to disease and environmental agents (e.g. bacteria, allergens, vaccines) and to self tissues, leading to allergic, autoimmune and inflammatory sequelae that are life threatening or fatal. Many individuals suffering from TR cell deficiency have mutations in the transcription factor FOXP3, which controls the differentiation and the function of TR cells. We are proposing to elucidate the mechanisms by which FOXP3 mutations induce disease, and explore the capacity of therapy with TR cells to rescue the disease manifestations. Our studies would uncover novel mechanisms by which the immune system regulates diseases of allergy, inflammation and autoimmunity, and will help identify novel therapeutic approaches relevant to both these disorder and the more common allergic inflammatory and autoimmune diseases in the general population
Project start date: 2009-12-10
Project end date: 2014-11-30
Budget start date: 1-DEC-2011
Budget end date: 30-NOV-2012
5R01AI085090-03 (2012): $340808
Sponsored Links Excellgen http://Excellgen.com
