Marco Santello, Associate Professor
Arizona State University-tempe Campus Orspa Tempe, Az 852873503
Grant 5R01AR047301-04 from National Institute Of Arthritis And Musculoskeletal And Skin Diseases IRG: ZRG1
Abstract: Neurological and musculo-skeletal diseases severely impair the complex coordination of finger motion and forces that characterizes our ability to grasp and manipulate objects. Knowledge of the physiological control mechanisms of prehension is essential for an understanding of the pathologies that affect hand function. The long-term objective of the present proposal is to characterize the normal patterns of muscle activation responsible for the control of grasping movements, in particular the strategies used by the nervous system to coordinate the large number of muscles of the hand. This objective will be pursued by studying the simultaneous activation of multiple hand muscles and the coordination of grip forces. The present proposal has three specific aims to characterize the organization of hand muscle activity as a function of hand and wrist posture (Aim number 1); to determine whether motor unit synchronization is dependent on task constraints (object s size and center of mass location; Aim number 2) and grip type (power vs. precision grip, and object shape; Aim number 3). The proposed studies are based on the hypothesis, supported by previous work, that the coordination of multiple grip forces is based on synergies reducing the number of degrees of freedom that has to be controlled independently. We will determine how the activity of multiple hand muscles is coordinated as a function of finger/wrist posture and task constraints. Hand muscle activity will be measured by intramuscular electromyographic recording as (a) interference multi-unit EMG and (b) single motor unit activity. Contact forces exerted by each finger will be measured in three dimensions by force sensors. The issues examined by this basic research are relevant to efforts in rehabilitation and restoration of hand function.
Keywords: biomechanics, hand, limb movement, muscle function, neuromuscular function, neuroregulation, central nervous system, finger, form /pattern perception, wrist, clinical research, electromyography, human subject, microelectrode, statistics /biometry
Project start date: 2002-04-01
Project end date: 2007-09-05
5R01AR047301-04 (2005): $125954
Sponsored Links Excellgen http://Excellgen.com
Marco Santello, Associate Professor
Arizona State University-tempe Campus Orspa Tempe, Az 852873503
Grant 5R01AR047301-03 from National Institute Of Arthritis And Musculoskeletal And Skin Diseases IRG: ZRG1
Abstract: Neurological and musculo-skeletal diseases severely impair the complex coordination of finger motion and forces that characterizes our ability to grasp and manipulate objects. Knowledge of the physiological control mechanisms of prehension is essential for an understanding of the pathologies that affect hand function. The long-term objective of the present proposal is to characterize the normal patterns of muscle activation responsible for the control of grasping movements, in particular the strategies used by the nervous system to coordinate the large number of muscles of the hand. This objective will be pursued by studying the simultaneous activation of multiple hand muscles and the coordination of grip forces. The present proposal has three specific aims to characterize the organization of hand muscle activity as a function of hand and wrist posture (Aim number 1); to determine whether motor unit synchronization is dependent on task constraints (object s size and center of mass location; Aim number 2) and grip type (power vs. precision grip, and object shape; Aim number 3). The proposed studies are based on the hypothesis, supported by previous work, that the coordination of multiple grip forces is based on synergies reducing the number of degrees of freedom that has to be controlled independently. We will determine how the activity of multiple hand muscles is coordinated as a function of finger/wrist posture and task constraints. Hand muscle activity will be measured by intramuscular electromyographic recording as (a) interference multi-unit EMG and (b) single motor unit activity. Contact forces exerted by each finger will be measured in three dimensions by force sensors. The issues examined by this basic research are relevant to efforts in rehabilitation and restoration of hand function.
Keywords: biomechanics, hand, limb movement, muscle function, neuromuscular function, neuroregulation, central nervous system, finger, form /pattern perception, wrist, clinical research, electromyography, human subject, microelectrode, statistics /biometry
Project start date: 2002-04-01
Project end date: 2006-03-31
5R01AR047301-03 (2004): $145015
5R01AR047301-02 (2003): $145136
5R01AR047301-08 (2010): $278461
5R01AR047301-07 (2009): $249372
5R01AR047301-06 (2008): $249596
Grants awarded to Marco Santello
Marco Santello, Associate Professor
Exercise Sciencearizona State University-tempe Campus
orspa
tempe, Az 852873503
Grant 1R01AR047301-01A2 from National Institute Of Arthritis And Musculoskeletal And Skin Diseases IRG: ZRG1
Abstract: Neurological and musculo-skeletal diseases severely impair the complex coordination of finger motion and forces that characterizes our ability to grasp and manipulate objects. Knowledge of the physiological control mechanisms of prehension is essential for an understanding of the pathologies that affect hand function. The long-term objective of the present proposal is to characterize the normal patterns of muscle activation responsible for the control of grasping movements, in particular the strategies used by the nervous system to coordinate the large number of muscles of the hand. This objective will be pursued by studying the simultaneous activation of multiple hand muscles and the coordination of grip forces. The present proposal has three specific aims to characterize the organization of hand muscle activity as a function of hand and wrist posture (Aim number 1); to determine whether motor unit synchronization is dependent on task constraints (object´s size and center of mass location; Aim number 2) and grip type (power vs. precision grip, and object shape; Aim number 3). The proposed studies are based on the hypothesis, supported by previous work, that the coordination of multiple grip forces is based on synergies reducing the number of degrees of freedom that has to be controlled independently. We will determine how the activity of multiple hand muscles is coordinated as a function of finger/wrist posture and task constraints. Hand muscle activity will be measured by intramuscular electromyographic recording as (a) interference multi-unit EMG and (b) single motor unit activity. Contact forces exerted by each finger will be measured in three dimensions by force sensors. The issues examined by this basic research are relevant to efforts in rehabilitation and restoration of hand function
Keywords: biomechanics, hand, limb movement, muscle function, neuromuscular function, neuroregulation central nervous system, finger, form /pattern perception, wrist clinical research, electromyography, human subject, microelectrode, statistics /biometry
Project start date: 2002-04-01
Project end date: 2006-03-31
1R01AR047301-01A2 (2002): $166937
2R01AR047301-05A2 (2007): $289203
SENSORIMOTOR INTEGRATION UNDERLYING HAND CONTROL IN CARPAL TUNNEL SYNDROME
Marco Santello
Arizona State University-tempe Campus, Orspa, Tempe, Az 85287-3503
Grant 5R01HD057152-03 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development
Abstract: Effective control of object grasping and manipulation relies on the ability to adjust forces of individual digits to the properties of the object being grasped such as its weight, center of mass or texture. These adjustments rely on (a) detecting object properties through sensory feedback derived primarily from receptors in the fingertips and hand muscles and (b) integrating this feedback with activation of hand muscles appropriate for grasping and manipulation. However, the fine tuning of hand muscle activity to object properties can be disrupted by a number of neurological and musculo-skeletal diseases such as Carpal Tunnel Syndrome (CTS). This compresion neuropathy of the median nerve is one of the most common and debilitating diseases affecting hand function. CTS results in self-reported loss of manual dexterity (e.g., difficulties with fine manipulation, dropping objects, etc.) which is due to somatosensory deficits in the thumb, index, middle and lateral half of the ring finger, and, in severe cases, motor deficits in the thumb. As whole- hand grasping require sensing object properties from all digits to accurately adjust their forces, the study of CTS offers a unique opportunity to improve our understanding the mechanisms underlying sensorimotor integration during whole-hand grasping and manipulation. This primary objective will be pursued by using CTS as a research model to address these important questions of sensorimotor control of grasping. An additional secondary objective is to use the results of the proposed research to improve our understanding of the extent to which increasing impairment in nerve function affects sensorimotor transformations necessary for learning and executing specific aspects of skilled object manipulation. We will pursue two Specific Aims (1) to quantify the extent to which patients with CTS are able to coordinate all digit forces and contact points when altering object properties (center of mass, weight and texture) and their predictability during five-digit grasping; and (2) to determine the extent to which patients with CTS are able to coordinate digit forces as a function of the number of digits (two, three, four, and five) involved in the grasp. In both Aims, multi-dimensional measures of grasp control from patients with mild and moderately severe CTS will be compared with those obtained from age- and gender-matched healthy controls. PUBLIC HEALTH RELEVANCE. The objectives of the proposed research are relevant to public health as they address a debilitating neuromuscular disease of the hand, Carpal Tunnel Syndrome (CTS), that affects the quality of life in 6 to 14 million adults in the United States. We propose to use CTS as a model to improve our understanding of the mechanisms underlying sensorimotor integration responsible for skilled object manipulation. The knowledge gained through our proposed research will provide significant insight into how electrodiagnostic measures of nerve function relate to specific aspects of grasp control, thus improving the interpretability and applications of these clinical measures
Keywords: 21+ years old; Address; Adult; Affect; Age; Behavior; Carpal Tunnel Syndrome; Clinical; Complex; Compression Neuropathy, Carpal Tunnel; Data; Digit; Digit structure; Disease; Disorder; Drops; Ensure; Entrapment Neuropathy, Carpal Tunnel; Feedback; Fingers; Freedom; Friction; Gender; Grips; Hand; Hand functions; Human, Adult; Impairment; Individual; Knowledge; Lateral; Lead; Learning; Left; Liberty; Lifetime Risk; Location; Manuals; Maps; Measures; Medial; Median Nerve; Median Neuropathy, Carpal Tunnel; Memory; Modeling; Motor; Muscle; Muscle Tissue; Musculoskeletal Diseases; Nerve; Nerve compression syndrome; Nervous; Neurologic; Neurological; Neuromuscular Diseases; Neuropathy; Neurosciences; Outcome; Patient Self-Report; Patients; Pb element; Performance; Population; Pressure; Pressure- physical agent; Process; Property; Property, LOINC Axis 2; Public Health; QOL; Quality of life; Randomized; Receptor Protein; Relative; Relative (related person); Research; Research Proposals; Ring Finger; Ring Finger Domain; Ring Finger Motif; Ring-Type Zinc Finger Domain; Role; Self-Report; Sensory; Severities; Spatial Distribution; Structure of median nerve; Surface; Syndrome; Tactile; Testing; Texture; Thumb; Thumb structure; United States; Using hands; Visual; Weight; adult human (21+); clinical applicability; clinical application; design; designing; disease/disorder; grasp; heavy metal Pb; heavy metal lead; improved; indexing; insight; median nerve; motor control; motor deficit; musculoskeletal disorder; myoneural disorder; neuromuscular disorder; neuropathic; pressure; public health medicine (field); public health relevance; randomisation; randomization; randomly assigned; receptor; response; sensory feedback; skeletal disorder; social role; somatosensory
Project start date: 2008-09-30
Project end date: 2013-07-31
Budget start date: 1-AUG-2010
Budget end date: 31-JUL-2011
PFA/PA: PA-07-070
5R01HD057152-03 (2010): $187599
5R01HD057152-02 (2009): $190155
1R01HD057152-01A1 (2008): $272461