Christian J Hopfer
University Of Colorado Denver
Project start date: 2008-07-01
Project end date: 2012-12-31
Sponsored Links Excellgen http://Excellgen.com
GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCE
Christian J Hopfer, Associate Professor
University Of Colorado Denver, Grants And Contracts, Mail Stop F428, Aurora, Co 80045-2505
Grant 5R01DA021913-03 from National Institute On Drug Abuse
Keywords: 12-20 years old; Active Follow-up; Addiction, Drug; Address; Adolescence; Adolescent; Adolescent Youth; Affect; Age; Agreement; Behavior; Behavioral; Candidate Disease Gene; Candidate Gene; Cell Communication and Signaling; Cell Signaling; Chemical Dependence; Clinical; Collaborations; Communities; Comorbidity; Conduct Disorder; DNA; Data; Data Banks; Data Bases; Data Set; Databank, Electronic; Databanks; Database, Electronic; Databases; Dataset; Deoxyribonucleic Acid; Dependence, Drug; Dependence, Substance; Development; Drug Addiction; Drug Dependency; Drug abuse; Elements; Family; Genetic; Genotype; Guidelines; Health; Individual; Intracellular Communication and Signaling; Investigators; Maps; Molecular; NIDA; National Institute of Drug Abuse; Neurobiology; Pattern; Phenotype; Plant Roots; Predisposition gene; Psychiatrist; Psychologist; Psychopathology; Qualifying; Research Personnel; Research Resources; Researchers; Resources; Role; Sample Size; Sampling; Siblings; Signal Transduction; Signal Transduction Systems; Signaling; Site; Substance Addiction; Susceptibility Gene; Technology; Testing; abnormal psychology; abuse of drugs; abuses drugs; adolescence (12-20); aged; anti social; antisocial; association test; biological signal transduction; clinical data repository; clinical data warehouse; cost; data repository; early onset; follow up assessment; follow-up; genetic association; genetic epidemiology; juvenile; juvenile human; lymphoblastoid cell line; multidisciplinary; neurobiological; predisposing gene; proband; relational database; root; sharing data; social role; teenage
Project start date: 2008-07-01
Project end date: 2012-12-31
Budget start date: 1-JAN-2010
Budget end date: 31-DEC-2010
PFA/PA: PA-05-067
5R01DA021913-03 (2010): $619631
Grants awarded to Christian J Hopfer
A Family Study Of Substance Use & Coonduct Disorder
Christian J Hopfer, Associate Professor Of Psychiatry
University Of Colorado Denver/hsc Aurora Grants And Contracts, Mail Stop F428 Aurora, Co 800450508
Grant 5R01DA015522-05 from National Institute On Drug Abuse IRG: SNEM
Abstract: This is a proposal to expand a family study of adjudicated adolescent boys and girls with Substance Use Disorders (SUD) and Conduct Disorder (CD). In this revised application, we propose to evaluate the families of 400 adolescent probands, identified through court records, as well as 200 controls and their family members. Expanding the study to include more families will allow for an adequate sample size to discriminate between different comorbidity models of SUD and CD and the assessment of parental and sibling influences on SUD and CD. DNA will be collected in order to assess for degree of genetic relatedness and non-paternity. The specific aims of the proposal are to 1) test competing models of the comorbidity between SUD and CD in sibling pairs, where one of the siblings is an adjudicated adolescent, 2) examine the influence of parents and siblings on the development of SUD and CD in families with at least one adjudicated adolescent, and 3) compare the observed familial aggregation of SUD and CD between the proposed sample and a sample of families of youth in treatment for SUD and CD. SUD and CD are severe, life-threatening conditions of adolescence. Mortality rates among such adolescents reportedly are fivefold greater than among their age-mates. This research may lead to the identification of familial influences influencing the expression of these pathological behaviors. This may lead to improved phenotypes, improving the search for specific genetic or environmental causes of these destructive behaviors. The ultimate goal of this research is to reverse that process through therapeutic correction of those pathological genetic or environmental factors.
Keywords: adolescence (12-20), comorbidity, conduct disorder, family genetics, family structure /dynamics, substance abuse related disorder, antisocial personality, genetic screening, legal /correctional, parent offspring interaction, sibling relations, substance abuse related behavior, behavior test, behavioral /social science research tag, clinical research, human subject, interview, questionnaire, statistics /biometry
Project start date: 2003-09-10
Project end date: 2008-06-30
5R01DA015522-05 (2007): $505001
5R01DA015522-04 (2006): $575391
5R01DA015522-03 (2005): $564852
5R01DA015522-02 (2004): $538128
A Family Study Of Substance Use And Conduct Disorder
Christian J Hopfer, Associate Professor Of Psychiatry
University Of Colorado Denver/hsc Aurora Grants And Contracts, Mail Stop F428 Aurora, Co 800450508
Grant 1R01DA015522-01A1 from National Institute On Drug Abuse IRG: SNEM
Abstract: This is a proposal to expand a family study of adjudicated adolescent boys and girls with Substance Use Disorders (SUD) and Conduct Disorder (CD). In this revised application, we propose to evaluate the families of 400 adolescent probands, identified through court records, as well as 200 controls and their family members. Expanding the study to include more families will allow for an adequate sample size to discriminate between different comorbidity models of SUD and CD and the assessment of parental and sibling influences on SUD and CD. DNA will be collected in order to assess for degree of genetic relatedness and non-paternity. The specific aims of the proposal are to 1) test competing models of the comorbidity between SUD and CD in sibling pairs, where one of the siblings is an adjudicated adolescent, 2) examine the influence of parents and siblings on the development of SUD and CD in families with at least one adjudicated adolescent, and 3) compare the observed familial aggregation of SUD and CD between the proposed sample and a sample of families of youth in treatment for SUD and CD. SUD and CD are severe, life-threatening conditions of adolescence. Mortality rates among such adolescents reportedly are fivefold greater than among their age-mates. This research may lead to the identification of familial influences influencing the expression of these pathological behaviors. This may lead to improved phenotypes, improving the search for specific genetic or environmental causes of these destructive behaviors. The ultimate goal of this research is to reverse that process through therapeutic correction of those pathological genetic or environmental factors.
Keywords: adolescence (12-20), comorbidity, conduct disorder, family genetics, family structure /dynamics, substance abuse, antisocial personality, genetic screening, legal /correctional, parent offspring interaction, sibling relations, substance abuse related behavior, behavior test, behavioral /social science research tag, clinical research, human subject, interview, questionnaire, statistics /biometry
Project start date: 2003-09-10
Project end date: 2008-06-30
1R01DA015522-01A1 (2003): $418224
Christian J Hopfer
University Of Colorado Denver
Project start date: 2012-04-01
Project end date: 2017-03-31