A UNIFIED NEUROANATOMICAL MODEL OF SPEECH PRODUCTION AND PERCEPTION: IMPLICATIONS
Rorden Christopher
University Of South Carolina At Columbiacity: Columbia country: United States (us)
Grant 5R01DC009571-04 from National Institute On Deafness And Other Communication Disorders
Keywords: Acute; Adult; Affect; Anterior; Aphasia; Area; Associative aphasia; Auditory; Auditory area; auditory comprehension; base; Behavior Therapy; Brain Injuries; Broca`s area; Chronic; Chronic Phase; Clinical; Communication; Comprehension; Country; Data; disability; Disease; Disputes; evidence base; frontal lobe; Future; Goals; Health; Hearing; hemisphere damage; Human; Impairment; improved; Individual; Inferior; Injury; insight; Insula of Reil; Interruption; Language; language processing; Left; Lesion; Link; Location; Longitudinal Studies; Maps; Methods; Modeling; Motivation; Motor; Movement; Nature; neuropsychological; Oral; outcome forecast; Output; Parietal Lobe; Participant; Patients; Perception; Play; Production; Recovery; Recruitment Activity; Rehabilitation therapy; relating to nervous system; Research; Resistance; Role; Speech; Speech Discrimination; Speech Disorders; Speech Perception; speech processing; Staging; stroke; Symptoms; Syndrome; Temporal Lobe; Testing; theories; Transcranial magnetic stimulation; Visual; Visual Perception; Wernicke Area; white matter; Work
Relevance: Apraxia of speech (AOS) and conduction aphasia are stroke related speech impairments which are extremely resistant to behavioral therapy, even when intensive treatment is applied. The purpose of this research is to study the underlying brain damage and impairment associated with AOS and conduction aphasia. As a result of this research, we will be able to study how stroke patients with AOS or conduction aphasia can be better rehabilitated to maximize their potential for recovery
Project start date: 2009-02-25
Project end date: 2014-01-31
Budget start date: 1-FEB-2012
Budget end date: 31-JAN-2013
5R01DC009571-04 (2012): $294210
Sponsored Links Excellgen http://Excellgen.com
A UNIFIED NEUROANATOMICAL MODEL OF SPEECH PRODUCTION AND PERCEPTION: IMPLICATIONS
Rorden Christopher, Associate Professor
University Of South Carolina At Columbiacity: Columbia country: United States (us)
Grant 5R01DC009571-03 from National Institute On Deafness And Other Communication Disorders
Abstract: Apraxia of speech (AOS) and conduction aphasia are commonly caused by left hemisphere stroke and often severely affect speech production. Although the clinical profile involved in these disorders is different, the most effective methods for managing them are unclear and many patients with AOS or conduction aphasia show limited recovery despite intensive treatment. We suggest that the underlying impairment in both AOS and conduction aphasia is poorly understood and propose a new framework for characterizing both disorders. Building on our previous research as well as the latest models of speech perception and production, this project will examine the neural bases of AOS and conduction aphasia. The result should be increased understanding of normal and disordered speech/language processing as well as offer new insights into rehabilitation of these two poorly understood disorders. Although the critical lesion locations associated with AOS and conduction aphasia have been controversial, recent studies suggest that damage to Broca´s area and the left posterior inferior parietal lobe cause AOS and conduction aphasia, respectively. Along with others, our research has identified Broca´s area as playing a role in not only the production of speech but also in the visual perception of others´ speech motor movements. Similarly, recent studies (including our own) suggest that the left posterior inferior parietal lobe plays a critical role in speech processing as an interface between auditory speech and motor speech output. These findings suggest that individuals with AOS and conduction aphasia have an impaired speech perception component that may negatively affect recovery efforts aimed at improving speech production. Although this previous research has important theoretical and practical implications for understanding the neural basis of human communication as well as the nature of AOS and conduction aphasia, further study of this issue is imperative. This project will involve testing of a large group of stroke patients with left hemisphere damage as well as transcranial magnetic stimulation (TMS) to examine the effect of permanent (brain damage in stroke patients) and transient (TMS in normal participants) cortical interruption on speech processing. The long-term goals of this research are to better understand the neural bases of AOS and conduction aphasia. Treatments aimed at improving speech production in patients with AOS or conduction aphasia have traditionally proceeded with the assumption that speech perception is intact in both disorders. Therefore, it is crucial to understand the relationship between impaired speech production and perception in AOS and conduction aphasia. As a result, future treatments of thes frustrating and recovery resistant disorders can be greatly improved. Apraxia of speech (AOS) and conduction aphasia are stroke related speech impairments which are extremely resistant to behavioral therapy, even when intensive treatment is applied. The purpose of this research is to study the underlying brain damage and impairment associated with AOS and conduction aphasia. As a result of this research, we will be able to study how stroke patients with AOS or conduction aphasia can be better rehabilitated to maximize their potential for recovery
Keywords: 21+ years old; Acquired brain injury; Acute; Adult; adult human (21+); Affect; Alogia; Alogias; Anepia; Anepias; Anterior; Aphasia; Aphasia, Conduction; Apoplexy; Area; Area, Broca; Associative aphasia; Auditory; Auditory area; auditory comprehension; Auditory Cortex; base; Behavior Conditioning Therapy; behavior intervention; Behavior Modification; Behavior or Life Style Modifications; Behavior Therapy; Behavior Treatment; Behavioral Conditioning Therapy; behavioral intervention; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; body movement; brain attack; brain damage; Brain Injuries; brain lesion (from injury); Broca`s area; Central Lobe; Cerebral Stroke; cerebral vascular accident; Cerebrovascular accident; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Chronic; Chronic Phase; Clinical; Communication; Comprehension; Conditioning Therapy; Country; Data; disability; Disease; disease/disorder; Disorder; Disputes; Dysphasia, Associative; Dysphasia, Conduction; Dysphasias, Associative; Dysphasias, Conduction; evidence base; Forecast of outcome; frontal cortex; frontal lobe; Future; Goals; Health; Hearing; hearing perception; hemisphere damage; Human; Human, Adult; Human, General; Impairment; improved; Individual; Inferior; Injury; insight; Insula; Insula of Reil; Interruption; Island of Reil; Language; language processing; Left; Lesion; Life Style Modification; Link; Location; Logagnosia; Logamnesia; Logamnesias; Logasthenia; Logasthenias; long-term study; Longitudinal Studies; Man (Taxonomy); Man, Modern; Maps; Methods; Modeling; Motivation; Motor; Movement; Nature; Nervous; neural; neuropsychological; Oral; outcome forecast; Output; parietal cortex; Parietal Lobe; Parietal Lobe of the Brain; Participant; Patients; Perception; Physical Health Services / Rehabilitation; Play; Production; Prognosis; Recovery; recruit; Recruitment Activity; Rehabilitation; Rehabilitation therapy; Rehabilitation, Medical; rehabilitative; relating to nervous system; Research; Resistance; resistant; Role; social role; sound perception; Speech; Speech Discrimination; Speech Disorders; Speech Manifestations; Speech Perception; speech processing; Staging; Stroke; stroke; Structure of Broca`s area; substantia alba; Symptoms; Syndrome; temporal cortex; Temporal Lobe; temporal lobe/cortex; Testing; theories; Transcranial magnetic stimulation; Vascular Accident, Brain; Visual; Visual Perception; Wernicke Area; white matter; Work
Relevance: Apraxia of speech (AOS) and conduction aphasia are stroke related speech impairments which are extremely resistant to behavioral therapy, even when intensive treatment is applied. The purpose of this research is to study the underlying brain damage and impairment associated with AOS and conduction aphasia. As a result of this research, we will be able to study how stroke patients with AOS or conduction aphasia can be better rehabilitated to maximize their potential for recovery
Project start date: 2009-02-25
Project end date: 2014-01-31
Budget start date: 1-FEB-2011
Budget end date: 31-JAN-2012
PFA/PA: PA-07-070
5R01DC009571-03 (2011): $273543