WEIGHT GAIN PREVENTION PROGRAM
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5R01DK045361-05 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: BEM
Abstract: Obesity is a risk factor for multiple health problems that has proved markedly difficult to treat. The present study examines the feasibility of weight gain prevention as an alternative method for addressing obesity as a public health problem. Pilot studies have established that normal weight volunteers can be successfully recruited for a weight gain prevention intervention and that a program utilizing a combination of educational and incentive strategies may be effective in preventing weight gain over one year. The present study extends this research by increasing the size and diversity of the sample, increasing the duration of treatment, and experimentally evaluating the individual and combined efficacy of the main intervention components (i.e., education and incentives). A total of 1,200 adults (20-45 years old) will be studied. Eight hundred will be volunteers recruited by newspaper ad who are interested in weight control. These will be randomized to one of four groups in a 2 x 2 design (no-treatment, education, incentives, and education plus incentives). Four hundred additional individuals will be recruited from the community who are not specifically interested in weight control. These will be randomized to either education or no-treatment. The study will be conducted through local health departments and will be evaluated over three years. Outcome measures will include body weight, eating and exercise habits, and various psychosocial variables. The study design provides an opportunity to examine predictors of weight change in volunteer and nonvolunteer samples of non-obese individuals as well as to test the hypothesis that low cost intervention strategies will be successful in reducing expected increases of weight with age in these groups.
Keywords: disease /disorder prevention /control, obesity, weight control, eating, exercise, longitudinal human study, questionnaire, young adult human (19-34)
Project start date: 1993-08-01
Project end date: 1999-07-31
5R01DK045361-05 (1997): $66869
Sponsored Links Excellgen http://Excellgen.com
WEIGHT GAIN PREVENTION PROGRAM
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5R01DK045361-03 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: BEM
Abstract: Obesity is a risk factor for multiple health problems that has proved markedly difficult to treat. The present study examines the feasibility of weight gain prevention as an alternative method for addressing obesity as a public health problem. Pilot studies have established that normal weight volunteers can be successfully recruited for a weight gain prevention intervention and that a program utilizing a combination of educational and incentive strategies may be effective in preventing weight gain over one year. The present study extends this research by increasing the size and diversity of the sample, increasing the duration of treatment, and experimentally evaluating the individual and combined efficacy of the main intervention components (i.e., education and incentives). A total of 1,200 adults (20-45 years old) will be studied. Eight hundred will be volunteers recruited by newspaper ad who are interested in weight control. These will be randomized to one of four groups in a 2 x 2 design (no-treatment, education, incentives, and education plus incentives). Four hundred additional individuals will be recruited from the community who are not specifically interested in weight control. These will be randomized to either education or no-treatment. The study will be conducted through local health departments and will be evaluated over three years. Outcome measures will include body weight, eating and exercise habits, and various psychosocial variables. The study design provides an opportunity to examine predictors of weight change in volunteer and nonvolunteer samples of non-obese individuals as well as to test the hypothesis that low cost intervention strategies will be successful in reducing expected increases of weight with age in these groups.
Keywords: disease prevention /control, obesity, weight control, eating, exercise, longitudinal human study, questionnaire, young adult human (21-44)
Project start date: 1993-08-01
Project end date: 1998-07-31
5R01DK045361-03 (1995): $402494
5R01DK045361-02 (1994): $393202
5R01DK045361-04 (1996): $367413
Grants awarded to Robert W Jeffery
DIETARY INTERVENTION METHODS FOR CLINICAL TRIALS
Robert W Jeffery, Professor, Director
Epidemiology And Community Healthuniversity Of Minnesota Twin Cities
450 Mcnamara Alumni Center
minneapolis, Mn 554552070
Grant 2R01HL041332-09A1 from National Heart, Lung, And Blood Institute IRG: ZHL1
Abstract: This proposed study will continue a line of weight loss research that has been ongoing for seven years. The aim of the study is to compare the long-term weight losses achieved in a standard behavioral program with those obtained in an enhanced exercise intervention. The exercise goal in the standard program is 1000 kcal/week, while that in the enhanced exercise program is 2500 kcal/week. The study will be conducted with 180 subjects divided equally among men and women. Half will be recruited in Minneapolis and the other half in Pittsburgh. The primary hypotheses are that the enhanced exercise intervention group will have significantly greater weight losses than will the standard intervention group at the end of the 18 month treatment program and at the 30-month follow-up. In addition, the two conditions will be compared at 0, 6, 12, 18, and 30 months with regard to exercise level, variables that may be related to exercise and weight loss, and measures related to quality of life. Furthermore, the investigators will determine predictors of long-term weight loss and exercise behavior, and will examine the effect of social support on exercise level and weight loss of the enhanced exercise intervention group. Subjects will be randomized to the two conditions at each study center (Minneapolis and Pittsburgh). Both groups will receive the behavioral treatment program that includes group meetings, access to experienced therapists assisted by exercise physiologists, structured meal plans to help subjects reach individualized calorie goals, and training in the use of behavioral strategies to control food intake and increase physical exercise. The standard intervention will strongly encourage subjects to develop an exercise program based primarily on walking and bicycling. The enhanced exercise intervention will involve social support teams, individualized exercise prescriptions, shaping, injury prevention and management, feedback to participants about success in reaching their exercise goals, and financial incentives. Outcome measures will be obesity reflected in changes in weight, body composition, body fat distribution, and dual energy x-ray absorptiometry (DEXA), with the latter assessed only on subjects at the Pittsburgh Center,
Keywords: exercise, health behavior, human therapy evaluation, obesity, social support network, weight control, weight loss body weight, clinical trial, cue, diet therapy, disease /disorder prevention /control, longitudinal human study, psychological reinforcement behavioral /social science research tag, clinical research, human subject, nutrition related tag
Project start date: 1989-03-01
Project end date: 2002-04-30
2R01HL041332-09A1 (1998): $347829
5R01HL041332-12 (2001): $176055
5R01HL041332-11 (2000): $197815
5R01HL041332-10 (1999): $328138
DIETARY INTERVENTION METHODS FOR CLINICAL TRIAL
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5R01HL041332-07 from National Heart, Lung, And Blood Institute IRG: ZHL1
Abstract: This project is submitted as a competing continuation of a two-center project 5 R01 HL41330 and 5 R01 HL41332. The overall goal continues to be the development of a dietary intervention method that is capable of producing large sustained weight losses and is thus suitable for use in clinical trials related to obesity. A recent study by the investigators showed that a method based on principles of antecedent control, namely the provision of food to participants, was successful in almost doubling weight losses over a 12 month period compared to those attained in a standard behavioral weight control program. These weight losses were associated with substantial improvements in cardiovascular risk factors. The purpose of the present proposal is to better understand the factors responsible for the positive effects of this intervention and to extend the principles of antecedent control to the area of maintenance. Study 1 will determine whether there are long term benefits to the food provision by reexamining the 202 participants in the original study one year after the end of treatment. Study 2 will investigate the factors related to the successful food provision intervention by comparing the additive effects of standard behavioral treatment and the three central components of food provision structured meal plans, prepackaged food and subsidy of the food. It will also explore theoretical mechanisms which may underlie the food provision effect, specifically decision making and stimulus control. Study 3 will evaluate the effectiveness of extending the food provision effect, specifically decision making and stimulus control. Study 3 will evaluate the effectiveness of extending the food provision methodology to families. Overweight spouse pairs will be randomized to treatments in which either one member of the pair participates in treatment and receives food, or both members of the pair participate and are provided with food. Study 4 will determine whether the principles of antecedent control can also be applied to exercise. Participants will be randomized to weight control programs which include either the usual exercise instructions or structured plans for exercise and free passes to exercise facilities near their home. It is hypothesized that providing food for the obese spouse as well as the patient, and providing antecedent control for exercise through structured plans and free passes will both improve the maintenance of weight loss. The proposed studies will provide important data on the effect of these interventions on eating behavior, activity, and body weight, and hopefully result in a more successful long-term weight loss intervention.
Keywords: diet therapy, exercise, health behavior, obesity, social support network, weight control, weight loss, body weight, clinical trial, cue, disease prevention /control, longitudinal human study, psychological reinforcement, human subject, nutrition related tag
Project start date: 1989-03-01
Project end date: 1997-05-31
5R01HL041332-07 (1995): $359601
2R01HL041332-06 (1994): $321586
DIETARY INTERVENTION METHODS FOR CLINICAL TRIALS
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5R01HL041332-05 from National Heart, Lung, And Blood Institute IRG: SRC
Abstract: This project is submitted as a competing continuation of a two-center project 5 R01 HL41330 and 5 R01 HL41332. The overall goal continues to be the development of a dietary intervention method that is capable of producing large sustained weight losses and is thus suitable for use in clinical trials related to obesity. A recent study by the investigators showed that a method based on principles of antecedent control, namely the provision of food to participants, was successful in almost doubling weight losses over a 12 month period compared to those attained in a standard behavioral weight control program. These weight losses were associated with substantial improvements in cardiovascular risk factors. The purpose of the present proposal is to better understand the factors responsible for the positive effects of this intervention and to extend the principles of antecedent control to the area of maintenance. Study 1 will determine whether there are long term benefits to the food provision by reexamining the 202 participants in the original study one year after the end of treatment. Study 2 will investigate the factors related to the successful food provision intervention by comparing the additive effects of standard behavioral treatment and the three central components of food provision structured meal plans, prepackaged food and subsidy of the food. It will also explore theoretical mechanisms which may underlie the food provision effect, specifically decision making and stimulus control. Study 3 will evaluate the effectiveness of extending the food provision effect, specifically decision making and stimulus control. Study 3 will evaluate the effectiveness of extending the food provision methodology to families. Overweight spouse pairs will be randomized to treatments in which either one member of the pair participates in treatment and receives food, or both members of the pair participate and are provided with food. Study 4 will determine whether the principles of antecedent control can also be applied to exercise. Participants will be randomized to weight control programs which include either the usual exercise instructions or structured plans for exercise and free passes to exercise facilities near their home. It is hypothesized that providing food for the obese spouse as well as the patient, and providing antecedent control for exercise through structured plans and free passes will both improve the maintenance of weight loss. The proposed studies will provide important data on the effect of these interventions on eating behavior, activity, and body weight, and hopefully result in a more successful long-term weight loss intervention.
Keywords: obesity, weight control, weight loss, adipose tissue, blood glucose, blood pressure, body weight, clinical study /trial, diet therapy, disease prevention /control, eating, exercise, insulin, human subject, longitudinal human study, nutrition related tag
Project start date: 1989-03-01
Project end date: 1994-05-31
5R01HL041332-05 (1993): $294718
THEORY-BASED INTERVENTIONS FOR SMOKING AND OBESITY
Robert W Jeffery, Professor, Director
Epidemiology And Community Healthuniversity Of Minnesota Twin Cities
450 Mcnamara Alumni Center
minneapolis, Mn 554552070
Grant 5R01NS038441-03 from National Institute Of Neurological Disorders And Stroke IRG: ZRG1
Abstract: This application articulates a new theoretical framework for understanding processes that govern short-term versus long-term behavior change, and proposes 2 studies based on this theoretical framework that target long-term smoking cessation and weight loss. This conceptualization of the processes of behavior change argues that short-term behavior change is motivated by the expectation that change in behavior will produce desired outcomes (approach motivation). Maintenance of behavior change, however, is motivated by satisfaction with the benefits afforded by current behavior and by the desire to avoid losing those benefits (avoidance motivation). Thus, interventions that raise people´s expectations about the benefits of behavior change should increase short-term success, whereas those that raise people´s satisfaction with their current behavior should increase behavioral maintenance. Although raising expectations may facilitate short-term success, it may lead to unmet expectations and, thus, undermine motivation for behavioral maintenance. Study 1 tests the effects of intervention strategies that influence outcome expectations. In parallel studies, smokers and overweight individuals will receive treatments that present the benefits of change in "optimistic" or "realistic" terms. It is expected that optimistic outcome expectations will increase short- and long-term rates of smoking cessation, but that realistic expectation conditions will increase long- term weight loss. Study 2 involves parallel studies of smokers and overweight individuals who are randomized to interventions that differ in how people are taught to evaluate their progress. In one condition, their achievements will be evaluated with respect to past outcomes. In the other, achievements will be evaluated in comparison with possible future outcomes. It is expected that both smokers and overweight people will be more satisfied with their success if they compare it to where they were prior to their intervention efforts than if they compare it to their expectations. Greater satisfaction with progress will result in greater success in long-term behavior change. Because unmet expectations are thought to pose a greater problem for weight control, this manipulation is expected to have a greater effect on weight loss than on smoking cessation
Keywords: behavior therapy, expectancy, human therapy evaluation, obesity, smoking cessation, weight loss behavior modification, health behavior, motivation, outcomes research, performance, psychological reinforcement, satisfaction behavioral /social science research tag, clinical research, human subject
Project start date: 1999-01-20
Project end date: 2002-12-31
5R01NS038441-03 (2001): $714673
5R01NS038441-02 (2000): $674595
3R01NS038441-02S1 (2000): $125785
Sponsored Links Excellgen http://Excellgen.com
1R01NS038441-01 (1999): $624568
EXAMINING THE OBESITY EPIDEMIC THROUGH YOUTH, FAMILY, AND YOUNG ADULTS
Robert W Jeffery, Professor
University Of Minnesota Twin Cities, 450 Mcnamara Alumni Center, Minneapolis, Mn 55455-2070
Grant 5U54CA116849-05 from National Cancer Institute
Abstract: The purpose of this Center proposal is to conduct transdisciplinary research, training, and outreach on obesity and cancer in youth, family, and young adults. The proposed Center will address questions about the etiology, prevention, and treatment of obesity in youth and families, and explore biological pathways that may link obesity to cancer. The center proposal includes three specific research projects. Project 1 is a multifactorial, cross-sectional, and prospective observational study examining predictors of obesity development in adolescents, including sociocultural factors, family factors, environmental factors, and individual factors. Project 2 is a study evaluating family-base, weight-gain prevention intervention that particularly emphasizes intervention on environmental contributors to weight gain. Project 3 is a study of the effects of physical activity on estrogen metabolism, oxidative stress, and DNA repair mechanisms in young women. The three R01 grants will be supported by one core, a Data Services and Analysis Core. The proposal also includes a career development component, substantial funding for developmental projects, and a dissemination/translation component. The overall goals are to advance transdisciplinary science in the advancement of understanding of obesity, youth, family, and cancer; to support the career development of new investigators in the field; and to disseminate scientific knowledge about the topic to broader audiences
Keywords: No Project Terms available
Project start date: 2005-09-19
Project end date: 2010-08-31
Budget start date: 1-SEP-2009
Budget end date: 31-AUG-2010
PFA/PA: RFA-CA-05-010
5U54CA116849-05 (2009): $2031160
5U54CA116849-04 (2008): $2105363
Examining The Obesity Epidemic Through Youth, Family, A*
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5U54CA116849-03 from National Cancer Institute IRG: ZCA1
Abstract: The purpose of this Center proposal is to conduct transdisciplinary research, training, and outreach on obesity and cancer in youth, family, and young adults. The proposed Center will address questions about the etiology, prevention, and treatment of obesity in youth and families, and explore biological pathways that may link obesity to cancer. The center proposal includes three specific research projects. Project 1 is a multifactorial, cross-sectional, and prospective observational study examining predictors of obesity development in adolescents, including sociocultural factors, family factors, environmental factors, and individual factors. Project 2 is a study evaluating family-base, weight-gain prevention intervention that particularly emphasizes intervention on environmental contributors to weight gain. Project 3 is a study of the effects of physical activity on estrogen metabolism, oxidative stress, and DNA repair mechanisms in young women. The three R01 grants will be supported by one core, a Data Services and Analysis Core. The proposal also includes a career development component, substantial funding for developmental projects, and a dissemination/translation component. The overall goals are to advance transdisciplinary science in the advancement of understanding of obesity, youth, family, and cancer; to support the career development of new investigators in the field; and to disseminate scientific knowledge about the topic to broader audiences.
Keywords: cancer risk, cooperative study, disease /disorder prevention /control, disease outbreak, obesity, clinical research
Project start date: 2005-09-19
Project end date: 2010-08-31
5U54CA116849-03 (2007): $2064061
5U54CA116849-02 (2006): $2169134
Examining The Obesity Epidemic Through Youth And Family
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 1U54CA116849-01 from National Cancer Institute IRG: ZCA1
Abstract: The purpose of this Center proposal is to conduct transdisciplinary research, training, and outreach on obesity and cancer in youth, family, and young adults. The proposed Center will address questions about the etiology, prevention, and treatment of obesity in youth and families, and explore biological pathways that may link obesity to cancer. The center proposal includes three specific research projects. Project 1 is a multifactorial, cross-sectional, and prospective observational study examining predictors of obesity development in adolescents, including sociocultural factors, family factors, environmental factors, and individual factors. Project 2 is a study evaluating family-base, weight-gain prevention intervention that particularly emphasizes intervention on environmental contributors to weight gain. Project 3 is a study of the effects of physical activity on estrogen metabolism, oxidative stress, and DNA repair mechanisms in young women. The three R01 grants will be supported by one core, a Data Services and Analysis Core. The proposal also includes a career development component, substantial funding for developmental projects, and a dissemination/translation component. The overall goals are to advance transdisciplinary science in the advancement of understanding of obesity, youth, family, and cancer; to support the career development of new investigators in the field; and to disseminate scientific knowledge about the topic to broader audiences.
Keywords: cancer risk, cooperative study, disease /disorder prevention /control, disease outbreak, obesity, clinical research
Project start date: 2005-09-19
Project end date: 2010-08-31
1U54CA116849-01 (2005): $2220159
EVALUATING INNOVATIVE WEIGHT REDUCTION STRATEGIES FOR COLLEGE STUDENTS
Robert W Jeffery, Professor
University Of Minnesota Twin Cities, 450 Mcnamara Alumni Center, Minneapolis, Mn 55455-2070
Grant 5U01HL096767-02 from National Heart, Lung, And Blood Institute
Abstract: The goal of this research is to develop and test innovative strategies to help prevent unhealthy weight gain in college students attending 2-year community or technical colleges. The intervention we propose for Phase 2, and will refine through our formative experiences in Phase 1, will be based on social ecological and social networks model with students randomized to conditions. Students (n=600) with BMIs between 18.5 and 29.9 will be recruited to participate in a randomized intervention trial. After the initial screening and consent procedures, students will complete baseline measures that include assessment of body composition; a blood draw and blood pressure; medical and weight history; a 24-hour dietary telephone recall; and for a subsample, 7 days of accelerometer data; a behavioral and psychosocial survey; and a home food inventory. After the completion of baseline assessments, students will be randomized into intervention conditions or a control condition. The intensive intervention phase ofthe research, lasting a semester, will include three intervention approaches to be evaluated including 1) a web-based curriculum (WBC) designed to be offered as a 1 credit college course; 2) a personalized intervention (PI) using electronic, group and individual information and feedback using ecological momentary assessment; and 3) an enhanced web based course (WBC+E). The content focus for all ofthe intervention approaches targets four behaviors related to healthy weight maintenance including eating a healthy diet, being active and reducing sedentary time, getting adequate sleep, and managing stress. The supported intervention phase will follow with the creation of a virtual social network support (SNS) intervention using Facebook or a similar on-line social networking web site to reinforce, inform and encourage exchange and support between all participants from the three intervention arms. The SNS will be led by trained peer leaders that will be identified during phase 1 ofthe trial. Control students will receive their health assessments, existing public health information on maintaining a healthy weight and information regarding health services offered on their school´s campus. The effectiveness and sustainability of the intervention approaches will be evaluated. . RELEVANCE (See instructions) Young adults have been identified as one ofthe population groups at greatest risk for unhealthy weight gain. Young adults attending 2-year colleges may be particularly vulnerable as they often come from lower income homes and are juggling working full time, going to school and often are parents. They have dietary, activity, sleep ahd stress management patterns that put them at greater risk for overweight. (End of )
Keywords: AOD use; Active Follow-up; Affect; After Care; After-Treatment; Aftercare; Alcohol or Other Drugs use; Arm; BMI percentile; BMI z-score; Behavior; Behavioral; Blood; Blood Pressure; Body Composition; Body Weight decreased; Body mass index; Caloric Intake; Categories; Communities; Consent; Cues; Curriculum; Data; Depression; Diet good; Dose; Eating; Educational Curriculum; Effectiveness; Electronics; Emotional Depression; Energy Intake; Equipment and supply inventories; Feedback; Food; Food Intake; Future; Gender; Goals; Grant; Health; Health Services; Healthy diet; History; Home; Home environment; Hour; Incidence; Individual; Instruction; Internet; Intervention; Intervention Strategies; Intervention Trial; Inventory; Low income; Measurement; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Medical; Mental Depression; Mental Health; Mental Hygiene; Methods; Mind; On-Line Systems; Online Systems; Outcome; Over weight; Overweight; Parents; Participant; Pattern; Phase; Phone; Physical activity; Population Group; Prevalence; Preventive Intervention; Procedures; Property; Property, LOINC Axis 2; Psychological Health; Psychometric; Psychometrics; Public Health; Quetelet index; Randomized; Recording of previous events; Recruitment Activity; Relaxation; Research; Reticuloendothelial System, Blood; Risk; Schools; Screening procedure; Sleep; Social Network; Social support; Socio-economic status; Socioeconomic Status; Status, Socioeconomic; Stress; Students; Survey Instrument; Surveys; Symptoms of depression; TXT; Telephone; Testing; Text; Time; Training; Upper arm; WWW; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Work; ing; adult youth; base; body weight gain; body weight increase; body weight loss; caloric dietary content; college; college student; computerized data processing; data processing; depressive; depressive symptoms; design; designing; effectiveness trial; experience; follow-up; health care service; innovate; innovation; innovative; instrument; interventional strategy; network models; online computer; peer; prevent; preventing; preventional intervention strategy; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; recruit; screen time; screening; screenings; sedentary; signal processing; social; social networking website; social support network; stress buffering; stress management; substance use; television watching; tool; tv watching; university student; virtual; web; web based; weight gain prevention; weight maintenance; world wide web; wt gain; wt-loss; young adult
Project start date: 2009-08-15
Project end date: 2014-05-31
Budget start date: 1-JUN-2010
Budget end date: 31-MAY-2011
PFA/PA: RFA-HL-08-007
5U01HL096767-02 (2010): $796259
DATA AND STATISTICAL SERVICES CORE
Robert W Jeffery, Professor
University Of Minnesota Twin Cities, 450 Mcnamara Alumni Center, Minneapolis, Mn 55455-2070
Grant 5U54CA116849-05_9001 from National Cancer Institute
Abstract: The Data and Statistical Services Core provides comprehensive data collection, processing, and analysis services for TREC investigators. These include instrument design, sample selection, mail and phone surveying, data entering, computerized data editing, analysis file creation, statistical analyses consultation, and computer programming. These services will be provided to investigators of the three large projects in the TREC, as well as to developmental project grantees and career development trainees. The Core director, Dr. Eileen Harwood, who will manage and direct the Core, has extensive experience in the area and also manages the Data Services Core of the University of Minnesota Comprehensive Cancer Center. Statistical expertise in the Core is particularly noteworthy in regard to the projects proposed for this TREC. Cutting edge statistical approaches to multilevel modeling and analyses of studies with group-randomized designs are an especially noteworthy skill of the Core staff that will be especially helpful to two of our three research projects. It is believed that this group will be an important asset to TREC investigators
Keywords: Analysis, Data; Area; Collaborations; Complex; Comprehensive Cancer Center; Computer Programs and Programming; Consultations; Data; Data Analyses; Data Collection; Data Set; Dataset; Development; Epidemic; Family; Feasibility Studies; Investigators; Mails; Manuscripts; Methods; Minnesota; Obesity; Phone; Procedures; Process; R01 Mechanism; R01 Program; RPG; Randomized; Research; Research Design; Research Grants; Research Personnel; Research Project Grants; Research Projects; Research Projects, R-Series; Researchers; Sampling; Secure; Services; Staging; Study Type; Survey Instrument; Surveys; T-Cell Receptor-Rearrangement Excision DNA Circles; TREC; Telephone; Universities; Writing; Youth; Youth 10-21; adiposity; adult youth; career development; computer program; computer programming; computerized; corpulence; corpulency; corpulentia; data management; design; designing; experience; innovate; innovation; innovative; instrument; methods to study multiple-level influences; multilevel analysis; multilevel model; multilevel modeling; obese; obese people; obese person; obese population; protocol development; randomisation; randomization; randomly assigned; sharing data; skills; statistical service; study design; young adult
Budget start date: 1-SEP-2009
Budget end date: 31-AUG-2010
PFA/PA: RFA-CA-05-010
5U54CA116849-05_9001 (2009): $314941
Sponsored Links Excellgen http://Excellgen.com
CORE--OBESITY EPIDEMIOLOGY AND INTERVENTION
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5P30DK050456-109003 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: Taken directly ) The overall goals of the Epidemiology and Intervention Core is (sic) to make high quality services for epidemiologic and behavioral intervention studies available to MORC investigators. These include population selection, recruitment, and survey; data base management; nutrition assessment; body composition, energy expenditure, and fitness assessment; intervention development for outpatient and community studies; and eating disorders assessment. The services provided through this Core are organized in five sections 1. A data services section provides expertise in population selection, survey, study participant recruitment and follow-up; data entry, and data base management. 2. The nutrition assessment section provides expertise in dietary assessment methods, including instrument design, data collection, and nutrient analyses. 3. The physical activity section provides expertise in measurement of body composition, energy expenditure, fitness testing, and exercise prescription. 4. The intervention section provides guidance in the development of diet and exercise interventions for outpatient populations in clinic and community settings. 5. The eating disorders section provides training and guidance in the assessment and treatment of eating disorders. Each of these service sections provides a range of services, including consultation on methods selection and development, assistance with data collection, and training of study staff and students in these methods.
Keywords: biomedical facility, epidemiology, obesity, weight control, behavior modification, bioenergetics, body composition, counseling, data collection methodology /evaluation, diet, disease /disorder prevention /control, eating disorder, exercise, information system, nutrition, population survey, training, calorimetry, human data, nutrition related tag
Clinical Center For Look AHEAD: Health In Diabetes
Robert W Jeffery, Professor, Director
Epidemiology And Community Healthuniversity Of Minnesota Twin Cities
450 Mcnamara Alumni Center
minneapolis, Mn 554552070
Grant 3U01DK057182-03S1 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZDK1
Abstract: Revised ) Overweight and obesity are major health problems in the United States, affecting more than 50% of adults. The long-term consequences of being overweight or obese include increased mortality and increased morbidity from a variety of associated disease states. Short-term weight loss has been demonstrated to ameliorate obesity-related metabolic abnormalities and cardiovascular disease risk factors. However, observational studies have raised concerns about negative effects of weight loss and weight cycling over the long term, including increased mortality. Look AHEAD (Action For Health in Diabetes) is a 2-armed randomized controlled clinical trial studying overweight and obese volunteers with type 2 diabetes at 16 clinical centers. Approximately 5,000 volunteers with type 2 diabetes aged 45-75 years with body mass index > 25 kg/m will be recruited, including approximately equal numbers of men and women and at least 33% participants from ethnic minority groups. The primary objective of Look AHEAD is to examine the long-term health effects of an intensive Lifestyle Intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. The Lifestyle intervention is implemented with individual supervision and group sessions and aims to achieve at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity on average and to sustain these goals. This program will be compared to a control condition involving a program of Diabetes Support and Education. The primary hypothesis is that the incidence rate of the first post-randomization occurrence of a composite outcome, which includes cardiovascular death (including fatal myocardial infarction and stroke), non-fatal myocardial infarction, and non-fatal stroke, over a planned follow-up period of up to 11.5 years will be reduced among participants assigned to the Lifestyle Intervention compared to those assigned to Diabetes Support and Education. The study is projected to have 90% probability of detecting an 18% difference in this primary outcome between the 2 groups. A composite secondary outcome of all deaths, CVD events, and CVD procedures has been defined. Additional outcomes include diabetes control and complications, fitness, general health, health-related quality of life, and psychological outcomes. The cost and cost effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed
Keywords: human therapy evaluation, noninsulin dependent diabetes mellitus, obesity, weight loss atherosclerosis, behavior therapy, body composition, cardiovascular disorder, carotid artery, chemotherapy, clinical trial, cooperative study, diet, disease /disorder proneness /risk, exercise, outcomes research, quality of life clinical research, human subject, nutrition related tag
Project start date: 1999-09-30
Project end date: 2006-08-31
3U01DK057182-03S1 (2001): $7425
5U01DK057182-03 (2001): $1137126
5U01DK057182-02 (2000): $794713
1U01DK057182-01 (1999): $408460
STUDY OF HEALTH OUTCOMES OF WEIGHT LOSS
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities 450 Mcnamara Alumni Center Minneapolis, Mn 554552070
Grant 5U01DK057182-07 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZDK1
Abstract: Revised ) Overweight and obesity are major health problems in the United States, affecting more than 50% of adults. The long-term consequences of being overweight or obese include increased mortality and increased morbidity from a variety of associated disease states. Short-term weight loss has been demonstrated to ameliorate obesity-related metabolic abnormalities and cardiovascular disease risk factors. However, observational studies have raised concerns about negative effects of weight loss and weight cycling over the long term, including increased mortality. Look AHEAD (Action For Health in Diabetes) is a 2-armed randomized controlled clinical trial studying overweight and obese volunteers with type 2 diabetes at 16 clinical centers. Approximately 5,000 volunteers with type 2 diabetes aged 45-75 years with body mass index > 25 kg/m will be recruited, including approximately equal numbers of men and women and at least 33% participants from ethnic minority groups. The primary objective of Look AHEAD is to examine the long-term health effects of an intensive Lifestyle Intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. The Lifestyle intervention is implemented with individual supervision and group sessions and aims to achieve at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity on average and to sustain these goals. This program will be compared to a control condition involving a program of Diabetes Support and Education. The primary hypothesis is that the incidence rate of the first post-randomization occurrence of a composite outcome, which includes cardiovascular death (including fatal myocardial infarction and stroke), non-fatal myocardial infarction, and non-fatal stroke, over a planned follow-up period of up to 11.5 years will be reduced among participants assigned to the Lifestyle Intervention compared to those assigned to Diabetes Support and Education. The study is projected to have 90% probability of detecting an 18% difference in this primary outcome between the 2 groups. A composite secondary outcome of all deaths, CVD events, and CVD procedures has been defined. Additional outcomes include diabetes control and complications, fitness, general health, health-related quality of life, and psychological outcomes. The cost and cost effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed.
Keywords: human therapy evaluation, noninsulin dependent diabetes mellitus, obesity, weight loss, atherosclerosis, behavior therapy, body composition, cardiovascular disorder, carotid artery, chemotherapy, clinical trial, cooperative study, diet, disease /disorder proneness /risk, exercise, outcomes research, quality of life, clinical research, human subject, nutrition related tag
Project start date: 1999-09-30
Project end date: 2006-07-31
5U01DK057182-07 (2005): $1199890
5U01DK057182-06 (2004): $917749
Sponsored Links Excellgen http://Excellgen.com
3U01DK057182-05S1 (2003): $7425
5U01DK057182-05 (2003): $1742980
MAINTENANCE TAILORED OBESITY TREATMENT
Robert W Jeffery, Professor
University Of Minnesota Twin Cities, 450 Mcnamara Alumni Center, Minneapolis, Mn 55455-2070
Grant 5R01DK064596-05 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: Recent dramatic increases in prevalence have made obesity the number one nutritional problem in the US. Of particular concern is the fact that, although available treatments are effective in producing clinically significant weight loss, their ability to sustain weight loss long term is poor. The present research proposal is based on a conceptual analysis of this problem that argues for greater attention to two issues related to the temporal dynamics of the challenge of long-term weight control. These are 1) the environment is continually changing and is not supportive of weight control and 2) the intervention methods that are effective in inducing short-term changes in behaviors and weight often lose their potency over time because of habituation. A 30-month randomized trial is proposed to evaluate a maintenance-tailored treatment for obesity that is designed to address these factors. Obese men and women will be randomized to either standard behavior therapy (SBT) or to a maintenance-tailored treatment (MTT) for 18 months, followed by 12 months of no-treatment follow-up. The MTT treatment will differ from SBT because 1) it will deliberately change treatment approaches over time instead of keeping them fixed and 2) it will focus on adaptation to change as the core treatment objective. It is hypothesized that weight losses in the MTT group will be better than those in the SBT group at 30 months. It is also hypothesized that MTT participants will show better compliance to behavioral assignments, express more enjoyment and awareness of the treatment process, and have higher efficacy expectations in regard to handling future challenges to weight control
Keywords: Active Follow-up; Address; Adherence; Adherence (attribute); Area; Attention; Awareness; Awarenesses; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Body Weight decreased; Condition; Conditioning Therapy; Controlled Clinical Trials, Randomized; Cues; Development; Dimensions; Educational process of instructing; Environment; Expectancy; Future; Health; Individual; Intervention; Intervention Strategies; Jobs; Life Style Modification; Maintenance; Maintenances; Measures; Methods; Methods and Techniques; Methods, Other; Numbers; Nutritional; Obesity; Occupations; Outcome; Participant; Physiologic; Physiological; Prevalence; Principal Investigator; Process; Process Measure; Professional Postions; Programs (PT); Programs [Publication Type]; Psychological reinforcement; R01 Mechanism; R01 Program; RPG; Randomized; Randomized Controlled Clinical Trials; Recommendation; Reinforcement; Reinforcement (Psychology); Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Proposals; Risk; Self Efficacy; Standards; Standards of Weights and Measures; Teaching; Techniques; Testing; Time; Today; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; Woman; adiposity; base; behavior intervention; behavioral intervention; body weight loss; clinical significance; clinically significant; corpulence; corpulency; corpulentia; design; designing; diet and exercise; expectation; follow-up; interventional strategy; men; men`s; obese; obese people; obese person; obese population; obesity treatment; programs; psychosocial; randomisation; randomization; randomized trial; randomly assigned; reinforcer; skills; success; weight control; wt-loss
Project start date: 2004-08-15
Project end date: 2010-06-30
Budget start date: 1-JUL-2008
Budget end date: 30-JUN-2010
5R01DK064596-05 (2008): $0
5R01DK064596-04 (2007): $429409
5R01DK064596-03 (2006): $532083
5R01DK064596-02 (2005): $553786
1R01DK064596-01A1 (2004): $448335
WEIGHT GAIN PREVENTION PROGRAM
Robert W Jeffery, Professor, Director
University Of Minnesota Twin Cities
450 Mcnamara Alumni Center
minneapolis, Mn 554552070
Grant 1R01DK045361-01A1 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: BEM
Abstract: Obesity is a risk factor for multiple health problems that has proved markedly difficult to treat. The present study examines the feasibility of weight gain prevention as an alternative method for addressing obesity as a public health problem. Pilot studies have established that normal weight volunteers can be successfully recruited for a weight gain prevention intervention and that a program utilizing a combination of educational and incentive strategies may be effective in preventing weight gain over one year. The present study extends this research by increasing the size and diversity of the sample, increasing the duration of treatment, and experimentally evaluating the individual and combined efficacy of the main intervention components (i.e., education and incentives). A total of 1,200 adults (20-45 years old) will be studied. Eight hundred will be volunteers recruited by newspaper ad who are interested in weight control. These will be randomized to one of four groups in a 2 x 2 design (no-treatment, education, incentives, and education plus incentives). Four hundred additional individuals will be recruited from the community who are not specifically interested in weight control. These will be randomized to either education or no-treatment. The study will be conducted through local health departments and will be evaluated over three years. Outcome measures will include body weight, eating and exercise habits, and various psychosocial variables. The study design provides an opportunity to examine predictors of weight change in volunteer and nonvolunteer samples of non-obese individuals as well as to test the hypothesis that low cost intervention strategies will be successful in reducing expected increases of weight with age in these groups
Keywords: disease prevention /control, obesity, weight control eating, exercise, longitudinal human study human volunteer subject, questionnaire, young adult human (21-44)
Project start date: 1993-08-01
Project end date: 1998-07-31
1R01DK045361-01A1 (1993): $261887
ENVIRONMENTAL INTERVENTION FOR WEIGHT GAIN PREVENTION
Robert W Jeffery
Department/ Educational Institution Type:
Grant 5R01DK067362-05 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: Obesity is a rapidly growing health problem in the US for which neither effective treatment nor preventive measures are currently available. It is now widely accepted that environmental factors that encourage eating and discourage physical activity are important contributors to the problem, and it has been suggested that environmental interventions may be needed to achieve reductions in population obesity. The proposed study will assess the efficacy of a multi-component environmental intervention in preventing weight gain among working adults. Eight worksites will be randomized to either an intervention or a no-treatment control group. Intervention will be comprised of 1) changing the availability, portion sizes, and prices of foods and beverages sold to employees in their worksites in ways that encourage healthier food choices; 2) increasing the availability of physical activity opportunities at the worksite by implementing walking programs and increasing stairwell access and attractiveness; 3) placing scales in the work environment to encourage body weight monitoring and to enable workers to set goals for their weight; and 4) to provide educational materials to all employees to make them aware of the environmental interventions and of behavioral practices likely to be effective in preventing weight gain. Body weight, eating behavior, and physical activity will be measured at baseline and two years in a cohort of employees from each worksite. Aggregate measures of behavior will also be obtained through direct observation and management records. It is hypothesized that employees in intervention worksites will decrease energy intake, increase energy expenditure, and reduce weight gain compared to those in comparison sites over two years. It is also anticipated that the effects of the intervention on behavior and weight will be related to degree of exposure to intervention activities
Keywords: 21+ years old; Active Follow-up; adiposity; Adult; adult human (21+); Affect; Behavior; Behavioral; Beverages; Biological; Body Weight; body weight gain; body weight increase; caloric dietary content; Caloric Intake; cohort; Consensus; Control Groups; corpulence; corpulency; corpulentia; Cues; design; designing; Eating; Eating Behavior; Educational Materials; effective therapy; Elements; Elevator; Employee; energy balance; Energy Expenditure; Energy Intake; Energy Metabolism; Environment; environmental change; Environmental Factor; environmental intervention; environmental risk; Environmental Risk Factor; Exposure to; follow-up; Food; Food Intake; Food Services; Frequencies (time pattern); Frequency; Goals; Health; Home; Home environment; Human, Adult; incentive; Incentives; inducement; Intervention; intervention effect; Intervention Strategies; interventional strategy; Investigators; Job Environment; Job Location; Job Place; Job Setting; Job Site; Location; Measures; Mediator; Mediator of Activation; Mediator of activation protein; Monitor; obese; obese people; obese person; obese population; Obesity; Over weight; Overweight; Physical activity; Population; Prevalence; prevent; preventing; Preventive; Price; pricing; programs; Programs (PT); Programs [Publication Type]; Public Health; public health medicine (field); public health priorities; randomisation; randomization; Randomized; randomly assigned; Records; Research; Research Personnel; Researchers; Schools; Site; System; System, LOINC Axis 4; Time; Treatment Effectiveness; Walking; Weight; Weight Gain; weight gain prevention; Weight Increase; Work; work environment; Work Location; Work Place; work setting; Work-Site; Workplace; Worksite; wt gain
Project start date: 2005-04-01
Project end date: 2011-03-31
Budget start date: 1-APR-2009
Budget end date: 31-MAR-2011
5R01DK067362-05 (2009): $567100
5R01DK067362-02 (2006): $599338
Sponsored Links Excellgen http://Excellgen.com
1R01DK067362-01A1 (2005): $607562
OBESITY TREATMENT IN A MANAGED CARE SETTING
Robert W Jeffery, Professor, Director
Epidemiology And Community Healthuniversity Of Minnesota Twin Cities
450 Mcnamara Alumni Center
minneapolis, Mn 554552070
Grant 1R01DK053826-01A1 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: EDC
Abstract: Obesity is a major and growing health problem in the US. It affects more than 50 million Americans, causes significant morbidity (e.g. diabetes, hypertension), and contributes to increased mortality. New methods are thus much needed for delivering effective weight management serves to large numbers of people at a reasonable cost. The present research is designed to evaluate such weight management systems within the context of a managed care organization (MCO). A cohort of 1500 overweight members of an MCO will be identified and followed for 2 years. Five hundred (500) will be randomized to each of three experimental groups 1) "usual care" control, 2) mail-based intervention comprised of an interactive program of weight counseling through the mail, and 3) phone-based intervention comprised of an interactive program of weight counseling by phone. Participation in available programs will be optional. The weight management systems will be evaluated in terms of the proportion of members who choose to enroll and mean weight change. Program costs and medical care utilization will also be examined. It is hypothesized that MCO members assigned to both the phone-based and mail- based groups will enroll in those weight control programs at higher rates than members assigned to the control group do to programs available as "usual care." It is also hypothesized that mean weight losses over 2 years among members who are offered mail-based and phone-based programs will be greater than in the control group. The proposed research is important because it focuses on long-term management of an important health problem in an applied setting (MCO) where such systems of long-term care might be realistically used. It also addresses important issues of cost and population outreach, and would provide a basis for determining whether such weight management systems are economically viable for primary health care providers
Keywords: counseling, human therapy evaluation, managed care, obesity body weight, health care cost /financing, health care service utilization clinical research, health services research tag, human subject
Project start date: 1999-03-01
Project end date: 2004-02-29
1R01DK053826-01A1 (1999): $613090
5R01DK053826-05 (2003): $349201
5R01DK053826-04 (2002): $551340
5R01DK053826-03 (2001): $662436
5R01DK053826-02 (2000): $663613
HEALTH OUTCOMES OF WEIGHT LOSS: LOOK AHEAD -ACTION FOR HEALTH IN DIABETES
Robert W Jeffery, Professor
University Of Minnesota Twin Cities, 450 Mcnamara Alumni Center, Minneapolis, Mn 55455-2070
Grant 3U01DK057182-11S2 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: Look AHEAD is randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145 overweight volunteers with type 2 diabetes. Participants are randomized to an intensive lifestyle intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity, or to a control program of diabetes support and education. The primary outcome of Look AHEAD is the aggregate occurrence of severe cardiovascular events (fatal and non-fatal Ml and stroke and cardiovascular deaths) over a planed follow-up of 11.5 years. The original grant application provided funding for the first 7 years of the study (1 year for study design and 6 for execution of the trial). The present grant application is for an additional 7 years of funding to complete the Look AHEAD trial. All aspects of the study have proceeded extremely well - the sample of 5,145 was recruited on time; retention has been excellent and the intervention has been effective in producing initial weight loss and maintaining it over time. All 16 clinical sites have been successful in recruitment, retention, and delivery of the intervention and the DSMB has been very positive about the execution of the trial. The present application reviews the overall design of Look AHEAD, progress to date, and plans for the future. Specific Aims are to retain the cohort over time, continue to complete annual in-person visits and semi-annual telephone interviews for outcome assessments and continue to administer the lifestyle intervention. These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention
Keywords: 21+ years old; Active Follow-up; Adherence; Adherence (attribute); Adult; Affect; Angioplasty; Aortocoronary Bypass; Apoplexy; Applications Grants; Arm; BMI percentile; BMI z-score; Body Weight decreased; Body mass index; Bypass; Caloric Intake; Cardiac Failure Congestive; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Carotid Endarterectomy; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Community Health Centers; Congestive Heart Failure; Control Groups; Coronary Artery Bypass; Coronary Artery Bypass Grafting; Coronary Artery Bypass Surgery; Country; Data; Death; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Education; Educational aspects; Effectiveness of Interventions; Effects, Longterm; Energy Intake; Epidemic; Event; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Funding; Future; Goals; Grant; Grant Proposals; Grants, Applications; HOSP; Health; Heart Decompensation; Heart Failure, Congestive; Hospitalization; Human, Adult; Incidence; Indirect Costs; Intervention; Intervention Strategies; Investigators; Long-Term Effects; Longitudinal Studies; MODY; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Metabolic; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Myocardial Infarct; Myocardial Infarction; NIDDM; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ System, Cardiovascular; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Over weight; Overweight; Participant; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Persons; Physical activity; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Quetelet index; Randomized; Randomized Clinical Trials; Recruitment Activity; Research Design; Research Personnel; Researchers; Risk Factors; Sampling; Satellite Centers; Stroke; Study Type; T2D; T2DM; Telephone Interviews; Testing; Time; Type 2 diabetes; Type II diabetes; United States; United States National Institutes of Health; Upper arm; Vascular Accident, Brain; Vascular, Heart; Visit; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; adiposity; adult human (21+); adult onset diabetes; base; body weight gain; body weight increase; body weight loss; brain attack; caloric dietary content; cardiac infarct; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cerebral vascular accident; circulatory system; clinical research site; clinical site; cohort; coronary angioplasty; coronary attack; coronary bypass; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cost effectiveness; design; designing; diabetes; disease/disorder; effect of intervention; follow-up; hazard; heart attack; heart infarct; heart infarction; intervention design; intervention effect; intervention program; interventional strategy; intraluminal angioplasty; ketosis resistant diabetes; life style intervention; lifestyle intervention; long-term study; maturity onset diabetes; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; obese; obese people; obese person; obese population; obesity risk; peripheral blood vessel disorder; primary outcome; programs; public health medicine (field); randomisation; randomization; randomly assigned; recruit; secondary outcome; stroke; study design; therapy design; treatment design; volunteer; weight loss intervention; wt gain; wt-loss
Project start date: 1999-09-30
Project end date: 2013-07-31
Budget start date: 1-FEB-2010
Budget end date: 30-JUL-2010
PFA/PA: RFA-DK-05-504
3U01DK057182-11S2 (2010): $44270
5U01DK057182-12 (2010): $938757
5U01DK057182-11 (2009): $928618
5U01DK057182-10 (2008): $944395
Sponsored Links Excellgen http://Excellgen.com