TOOLS TO SUPPORT COMPUTER BASED CLINICAL GUIDELINES
Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 5R01LM006682-03 from National Library Of Medicine IRG: BLR
Abstract: Adapted from ´s ) The proposed research will build, refine, and test in operational use, a set of software tools designed to help support, maintain, and iteratively revalidate computer-based clinical guidelines as they evolve over time. The project will focus on the domain of childhood immunization, and will build upon IMM/Serve, a childhood immunization forecasting program that takes as input a child´s immunization history, and produces recommendations as to which vaccinations are due and which vaccinations should be scheduled next. The effort required to modify and validate such a program as the clinical field evolves over time is a challenging task. It will be extremely important to have a robust set of tools to assist in this process. Partial prototype versions of certain of these tools already exist. 1. The project will refine and extend computer-based tools for immunization knowledge maintenance. These tools will include a) IMM/Def, a program which automatically generates the rule-based logic for the most complex portion ("kernel") of IMM/Serve´s knowledge, and b) IMM/Test, a program which automatically generates a set of test cases to help test the kernel logic. The project will also develop an organized set of strategies for immunization test case generation, and implement those strategies in the refined version of IMM/Test. 2. The project will build a Web site to support immunization knowledge maintenance. 3. The project will keep a detailed record of all modifications and customization of the knowledge, and will represent all the variations of the knowledge using a standardized format such as GLIF, the Guideline Interchange Format being developed as a standard for exchanging guidelines between sites. 4. The project will link IMM/Serve to a database designed to hold IMM/Serve´s analysis of a set of cases, so that the resulting package can be used as a tool to perform compliance assessment. 5. A set of evaluation studies will be carried out to help assess the efficacy of the tools and to help improve their functionality
Keywords: artificial intelligence, computer assisted medical decision making, computer assisted patient care, computer system design /evaluation, immunization, information system, pediatrics Internet, computer human interaction, computer program /software, medical record human data
Project start date: 1998-09-30
Project end date: 2003-08-31
5R01LM006682-03 (2000): $317318
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to Perry L Miller
Planning A Biomedical Computing Center Of Excellence
Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047
Grant 5P20LM007253-03 from National Library Of Medicine IRG: ZRG1
Abstract: This application proposes a three-year project o plan for, and builds towards, a Biomedical Computing Center of Excellence at Yale. The overall theme of the Center will be "Harnessing Advanced Computing Technologies for Biomedicine." The Center will provide a focus for highly collaborative research and training involving many academic units and research support units within Yale University as a whole. The initial focus will be on four research themes 1) heterogeneous biomedical database design, b) multilevel approaches to facilitate interoperation among biological databases and software tools, c) integrative genomic database analysis, and d) high performance distributed biocomputing. These themes each build upon particular research strengths at Yale. The proposed activities including the following. 1. A central component of the proposal will involve planning for the establishment of the Center of Excellence. 2. A set of ongoing activities will promote interaction and collaboration among the academic units participating in the Center. 3. A Biomedical Computing Education Committee will plan for a full spectrum of educational activities. 4. Three pilot projects will be carried out a) developing a flexible pilot EAV/CR database for describing heterogeneous microarray expression experiments, b) integrative data mining to relate protein characteristics to gene expression patterns, and c) computational and statistical analysis of gene expression as a dynamical system using high performance computing techniques. Although the pilot projects will focus on different computational research themes, they all focus on the challenges posed by the analysis of experimental microarray data. 5. A Biomedical Computing Core will support the activities of the three pilot projects.
Keywords: computer center, computer system design /evaluation, molecular biology information system, education, education evaluation /planning
Project start date: 2001-09-15
Project end date: 2006-08-31
5P20LM007253-03 (2003): $438815
1P20LM007253-01 (2001): $295971
BIOMEDICAL INFORMATICS RESEARCH TRAINING AT YALE
Perry L Miller, Professor
Yale University, 47 College Street, Ste 203, New Haven, Ct 06520-8047
Grant 5T15LM007056-24 from National Library Of Medicine
Abstract: The Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based in the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s interdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each fellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical informatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational informatics. The overall goal is to provide all trainees with the necessary background and experience that will allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral trainees, 6 postdoctoral trainees, and 2 short-term trainees
Keywords: Bio-Informatics; Bioinformatics; Clinical; Computational Biology; Curriculum; Doctor of Philosophy; Educational Curriculum; Educational process of instructing; Enrollment; Faculty; Goals; Informatics; Master`s Degree; Medical Informatics; Ph.D.; PhD; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Research; Research Associate; Research Training; Supervision; Teaching; Training; Training Programs; base; biomed informatics; biomedical informatics; career; enroll; experience; interest; post-doc; post-doctoral; post-doctoral training; postdoctoral training; pre-doc; pre-doctoral; predoc; predoctoral; programs
Project start date: 1987-07-01
Project end date: 2012-06-30
Budget start date: 1-JUL-2010
Budget end date: 30-JUN-2011
PFA/PA: RFA-LM-06-001
5T15LM007056-24 (2010): $865488
5T15LM007056-23 (2009): $1090657
5T15LM007056-22 (2008): $938744
2T15LM007056-21 (2007): $907779
2T15LM007056-16 (2002): $758564
5T15LM007056-20 (2006): $1256605
5T15LM007056-19 (2005): $1043144
5T15LM007056-18 (2004): $966927
Sponsored Links Excellgen http://Excellgen.com
5T15LM007056-17 (2003): $1188817
Perry L Miller, Professor
Yeshiva University 500 W 185th St New York, Ny 10033
Grant 3P01HG000965-03S29002 from National Human Genome Research Institute
Abstract: The Informatics Core of the proposed project will be based at the Yale Center for Medical Informatics, directed by Dr. Perry Miller. The Informatics Core will build on an existing project which is already developing physical gene mapping database support for all of the participating biological laboratories at Yale. The Informatics Core will include the following activities 1) A shared database will be implemented and maintained for use by all participating laboratories. The database will include laboratory inventories of biologic reagents, experimental results, and maps based on those results. The central server will be a Sybase relational database. Laboratories will access this database using Macintosh computers running the 4th-Dimension (4D) relational database package as a very user-friendly front end, accessing Sybase using "4D SQL Server," a commercial client-server package. 2) Software tools, for example for map assembly, analysis, and display, will run on the server system, on the local Macintoshes, and elsewhere on the network. 3) The database will also serve as a project management tool. 4) Informatics staff will work closely with the staff of the participating laboratories at Yale and at AECOM to develop and refine the database system, and to train them in its use. 5) The informatics activities will be coordinated with the rest of the national and international community in a number of ways. 6) Informatics staff will continue to maintain, modify, and update the database structure as new mapping techniques are developed, and as new types of mapping data are generated that need to be incorporated into the database. 7) Communication between the participating laboratories will be via electronic mail, and will be further enhanced by the coordination of activities that will result from use of the shared database.
Keywords: biomedical facility, computer assisted sequence analysis, genetic mapping, genetic registry /resource /referral center, information system, computer program /software, information dissemination
SHARED RESOURCES-BIOMEDICAL INFORMATICS
Perry L Miller
Yale University, 47 College Street, Ste 203, New Haven, Ct 06520-8047
Abstract: The Biomedical Informatics Shared Resource builds upon a longstanding collaboration among the Yale Center for Medical Informatics (YCMI), the YCC Clinical Research Service (CRS), and the Yale Department of Pathology Informatics Group. The Shared Resource was inaugurated in 1996 with the initial goal of developing a multi-disciplinary database to collect, store, curate, and help analyze data .for clinical trials and clinical research studies, a system now called Trial/DB. Over the past decade, the activities of the Shared Resource have significantly broadened. Trial/DB is now robustly operational and is being used for all YCC investigator initiated trials, and is continuing to be augmented and refined to meet the needs of YCC researchers. The TrialTracker system was built to track administrative informatics about trials, and is now used for all YCC trials. One major current project is developing a Cancer Data Repository (CaDR) building on the Yale Tumor Registry system. The development of the CaDR is a step toward developing a much broader institutional clinical data repository at Yale, using cancer as a pilot domain. Another initiative, in support of YCC bioscience, involves maintaining and refining two databases and related software tools, Cruella (for tissue array research) and GeneCube (for DMA microarray research). The Shared Resource is also involved in a number of activities related to the national caBIG initiative. Additional activities include 1) incrementally integrating Trial/DB, and ultimately the CaDR, with other information systems used by the YCC, and 2) coordinating YCC´s activities with data-intensive genomic/proteomic informatics and clinical imaging infrastructure being developed at Yale. Overall usage of this facility by Cancer Center members is 94.6% (88.8% Peer-reviewed). The Shared Resource is utilized by 17 YCC users, based in 7 of the 8 YCC programs
Keywords: Analysis, Data; Bite; Cancer Center; Cancer Genetics Network; Cancers; Clinical Informatics; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials Database; Clinical Trials, Unspecified; Collaborations; Computer Software Tools; Confidentiality; DNA Chips; DNA Microarray; DNA Microarray Chip; DNA Microchips; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Development; Funding; Genomics; Goals; IT Systems; Image; Informatics; Information Systems; Information Technology Systems; Infrastructure; Internet; Investigators; Malignant Neoplasms; Malignant Tumor; Medical Informatics; Medical center; NCI; NCI Organization; NCRR; National Cancer Institute; National Center for Research Resources; Pathology; Peer Review; Programs (PT); Programs [Publication Type]; Proteomics; Research; Research Infrastructure; Research Personnel; Researchers; Resource Sharing; Secure; Security; Services; Software Tools; System; System, LOINC Axis 4; Systems, Data; Time; Tissue Arrays; Tissue Chip; Tissue Microarray; Tools, Software; Vendor; WWW; Work; base; biomed informatics; biomedical informatics; caBIG; cancer Biomedical Informatics Grid; clinical data repository; clinical data warehouse; clinical investigation; data repository; experiment; experimental research; experimental study; imaging; informatics shared resource; malignancy; meetings; member; neoplasm/cancer; privacy of information; programs; relational database; research study; tool; tumor registry; web; world wide web
Budget start date: 1-AUG-2010
Budget end date: 31-JUL-2011
5P30CA016359-32_9008 (2010): $188076
5P30CA016359-31_9008 (2009): $178813
BIOINFORMATICS AND BIOSTATISTICS CORE
Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 5P30DA018343-059001 from National Institute On Drug Abuse IRG: ZDA1
Abstract: The Bioinformatics and Biostatistics Core (BBC) aims at meeting the computational, statistical, and database challenge (including data quality, management, integration, analysis, and archiving) posed by the neuroproteomics research described in this proposal. The BBC, which will be directed by Dr. Perry Miller, consists of three inter-related units i) proteomics data quality and analysis, ii) proteomics database, and iii) functional and interrelative proteomics
BIOMEDICAL INFORMATICS RESEARCH TRAINING AT YALE
Perry L Miller, Professor
Yale University, 47 College Street, Ste 203, New Haven, Ct 06520-8047
Grant 3T15LM007056-23S1 from National Library Of Medicine
Abstract: ROVIDED. he Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based n the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s nterdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each ellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical nformatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational nformatics. The overall goal is to provide all trainees with the necessary background and experience that i/vill allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral rainees, 6 postdoctoral trainees, and 2 short-term trainees
Keywords: Area; Base Sequence; Bio-Informatics; Bioinformatics; Biologic Sciences; Biological; Biological Sciences; Biological databases; Biomedical Research; Categories; Clinical; Clinical Data; Clinical Decision Support Systems; Clinical Evaluation; Clinical Informatics; Clinical Research; Clinical Study; Clinical Testing; Collaborations; Comparative Genome Hybridization; Computational Biology; Computer Analysis; Computer Software Tools; Computers; Confidentiality; Consultations; Curriculum; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Decision Making; Decision Support Systems, Clinical; Discipline; Disease; Disorder; Doctor of Philosophy; Education, Medical; Educational Curriculum; Educational process of instructing; Electrical Engineering; Enrollment; Face; Faculty; Foundations; Generalized Growth; Genes; Genes, Structural; Genetic; Genome; Genomics; Goals; Grant; Growth; Guidelines; Health; History; Housing; IT Systems; Individual; Informatics; Informatics, Clinical; Information Systems; Information Technology Systems; Institutes; Laboratories; Learning; Life Sciences; Macromolecular Structure; Master`s Degree; Medical Education; Medical Informatics; Methods; Methylation; Modeling; Molecular; Molecular Structure; Neurobiology; Nucleotide Sequence; Ontology; Organism; Pattern; Ph.D.; PhD; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Privacy; Programs (PT); Programs [Publication Type]; Protein Methylation; R01 Mechanism; R01 Program; RPG; Recording of previous events; Recruitment Activity; Research; Research Associate; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Residencies; Schools; Science; Scientist; Sequence Alignment; Software Tools; Soil; Solid; Structural Genes; Structure; Students; Supervision; Systems, Data; Teaching; Time; Tissue Growth; Tools, Software; Training; Training Programs; Underrepresented Minority; Vocabulary; Vocabulary Words; Work; base; biological systems; biomed informatics; biomedical informatics; career; clinical data repository; clinical data warehouse; clinical phenotype; clinical test; college student; comparative; comparative genomic hybridization; computational analysis; computational tools; computer science; computerized tools; data modeling; data repository; database design; density; design; designing; disease/disorder; enroll; experience; facial; falls; genome-wide; graduate student; interest; living system; member; neurobiological; nucleic acid sequence; ontogeny; post-doc; post-doctoral; post-doctoral training; postdoctoral training; pre-doc; pre-doctoral; predoc; predoctoral; privacy of information; programs; protein structure; recruit; relational database; research clinical testing; simulation; square foot; under-represented minority; underserved minority; university student
Project start date: 2009-08-01
Project end date: 2010-07-31
Budget start date: 1-AUG-2009
Budget end date: 31-JUL-2010
PFA/PA: RFA-LM-06-001
3T15LM007056-23S1 (2009): $98792
Sponsored Links Excellgen http://Excellgen.com
TOOLS TO SUPPORT COMPUTER BASED CLINICAL GUIDELINES
Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 1R01LM006682-01 from National Library Of Medicine IRG: BLR
Abstract: Adapted from ´s ) The proposed research will build, refine, and test in operational use, a set of software tools designed to help support, maintain, and iteratively revalidate computer-based clinical guidelines as they evolve over time. The project will focus on the domain of childhood immunization, and will build upon IMM/Serve, a childhood immunization forecasting program that takes as input a child´s immunization history, and produces recommendations as to which vaccinations are due and which vaccinations should be scheduled next. The effort required to modify and validate such a program as the clinical field evolves over time is a challenging task. It will be extremely important to have a robust set of tools to assist in this process. Partial prototype versions of certain of these tools already exist. 1. The project will refine and extend computer-based tools for immunization knowledge maintenance. These tools will include a) IMM/Def, a program which automatically generates the rule-based logic for the most complex portion ("kernel") of IMM/Serve´s knowledge, and b) IMM/Test, a program which automatically generates a set of test cases to help test the kernel logic. The project will also develop an organized set of strategies for immunization test case generation, and implement those strategies in the refined version of IMM/Test. 2. The project will build a Web site to support immunization knowledge maintenance. 3. The project will keep a detailed record of all modifications and customization of the knowledge, and will represent all the variations of the knowledge using a standardized format such as GLIF, the Guideline Interchange Format being developed as a standard for exchanging guidelines between sites. 4. The project will link IMM/Serve to a database designed to hold IMM/Serve´s analysis of a set of cases, so that the resulting package can be used as a tool to perform compliance assessment. 5. A set of evaluation studies will be carried out to help assess the efficacy of the tools and to help improve their functionality
Keywords: artificial intelligence, computer assisted medical decision making, computer assisted patient care, computer system design /evaluation, immunization, information system, pediatrics Internet, computer human interaction, computer program /software, medical record human data
Project start date: 1998-09-30
Project end date: 2001-08-31
1R01LM006682-01 (1998): $272102
Informatics Research In Support Of SenseLab
Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 5P01DC004732-090002 from National Institute On Deafness And Other Communication Disorders IRG: ZRG1
Keywords: computational neuroscience, data management, olfaction data collection methodology /evaluation, informatics Internet
Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047
Grant 5P01DC004732-049001 from National Institute On Deafness And Other Communication Disorders IRG: ZMH1
MEDICAL INFORMATICS RESEARCH TRAINING AT YALE
Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 3T15LM007056-15S1 from National Library Of Medicine IRG: ZLM1
Project start date: 1987-07-01
Project end date: 2002-06-30
3T15LM007056-15S1 (2001): $200000
5T15LM007056-15 (2001): $398600
Sponsored Links Excellgen http://Excellgen.com
5T15LM007056-14 (2000): $545596
BIOMEDICAL APPLICATIONS OF THE NEXT GENERATION INTERNET
Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 5N01LM093540-001 from National Library Of Medicine
Project start date: 1999-09-30
Project end date: 2002-09-29
5N01LM093540-001 (2000): $445071
MEDICAL INFORMATICS RESEARCH TRAINING AT YALE
Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047
Grant 3T15LM007056-14S1 from National Library Of Medicine IRG: ZLM1
Project start date: 1987-07-01
Project end date: 2002-06-30
3T15LM007056-14S1 (2000): $50000
5T15LM007056-12 (1998): $327510
2T15LM007056-11 (1997): $331436
5T15LM007056-10 (1996): $259458
5T15LM007056-08 (1994): $249076
MEDICAL INFORMATICS RESEARCH TRAINING
Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047
Grant 2T15LM007056-06 from National Library Of Medicine IRG: BLR
Project start date: 1987-07-01
Project end date: 1997-06-30
2T15LM007056-06 (1992): $240008