STRESS RESPONSES AS PROSPECTIVE PREDICTORS OF GIRLS´ SUICIDALITY AND SELF-INJURY
K Matthew
University Of North Carolina Chapel Hillcity: Chapel Hill country: United States (us)
Grant 5R01MH085505-03 from National Institute Of Mental Health
Keywords: Address; Adolescence; Adolescent; Affective; Arousal; Attention; base; Behavior; behavior test; Behavioral; Biological; biological adaptation to stress; Biological Assay; Biological Factors; Biological Markers; boys; Cardiovascular system; Characteristics; Cognitive; critical developmental period; Data; Depressed mood; depressive symptoms; Development; evidence base; Evidence based treatment; experience; Family; Feeling suicidal; Female Adolescents; follow-up; Gestures; girls; Goals; in vivo; Individual; informant; innovation; Inpatients; Intervention; Interview; Investigation; Knowledge; Lead; Life; Literature; Longitudinal Studies; Measures; Mediation; Mediator of activation protein; Mental Depression; Mental disorders; Methods; Modeling; National Institute of Mental Health (U.S.); Neurosecretory Systems; non-suicidal self injury; Outcome; Outpatients; Parents; Participant; Pattern; Performance; Physiological; predictive modeling; Prevalence; Preventive Intervention; Problem Solving; Process; prospective; psychologic; Psychopathology; public health relevance; Questionnaires; Recording of previous events; Regulation; Reporting; Research; response; Risk; Risk Factors; Sampling; Self Mutilation; Self-Injurious Behavior; social; Social Problems; social stress; Source; Strategic Planning; Stress; stressor; Structure; suicidal; suicidal behavior; Suicide; Suicide attempt; Suicide prevention; Symptoms; System; Testing; Text; Theoretical model; theories; United States National Institutes of Health; Variant; Work
Relevance: Public statement: Although much research has indicated that adolescents with a history of psychopathology are at increased risk for self-injury (e.g., self-mutilation; suicide attempts), little is known about why or how psychological symptoms lead to self-injury. Thus, there are few directions for evidence-based prevention/intervention. This research will examine specific psychological and biological responses to social stress that may increase the risk for girls´ self- injury, and help to elucidate the development of self-injurious behaviors by exploring the course of these behaviors across a sensitive and critical developmental period
Project start date: 2009-12-01
Project end date: 2014-11-30
Budget start date: 1-DEC-2011
Budget end date: 30-NOV-2012
5R01MH085505-03 (2012): $568340
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to K Matthew
TWIN STUDY OF FEMALE ALCOHOLISM AND OTHER DISORDERS
K Matthew
University Of Minnesota Twin Citiescity: Minneapolis country: United States (us)
Grant 5R01AA009367-19 from National Institute On Alcohol Abuse And Alcoholism
Abstract: We propose to complete an age-29 assessment of female twin participants in the Minnesota Twin Family Study (MTFS). The resulting data will allow us to investigate the developmental processes that link adolescent substance abuse with diverse adult outcomes and explore the mechanisms of substance abuse desistence in early adulthood. The female portion of the MTFS is based on 717 pairs of female twins and their parents drawn from two population-based cohorts. The older twin cohort, originally seen at age 17 and followed up at ages 20 and 24, has completed the age-29 assessment. The younger cohort, originally recruited at age 11, before the initiation of significant substance use, has completed follow-ups at ages 14, 17, 20, and 24, and will be followed through age 29. The age-29 assessment is focused on outcomes potentially associated with adolescent substance use and risk and protective factors that might influence substance abuse desistence. Data from both cohorts will be combined to examine the developmental trajectories leading to differences in mental health, social, and neurocognitive outcomes at age 29. In addition, we will identify factors associated with desistance of substance abuse in early adulthood and determine whether desistence ameliorates the negative influence of adolescent-onset abuse on adult outcomes. Importantly, a comparison of findings from this study with those from a funded parallel study in male twins (DA05417) will allow us to explore gender differences in the effects of adolescent substance abuse on adult functioning and in desistence processes in early adulthood. Participants have completed a comprehensive longitudinal assessment, including information from multiple informants (parents, teachers, co-twins), that begins in adolescence or earlier for both cohorts. Our developmentally rich data set measures the initiation and progression of tobacco, alcohol, and illicit drug use; externalizing and internalizing psychopathology; biological indices of risk (e.g., brain event-related potentials, resting EEG, genetic polymorphisms); personality traits; and a wide array of experiential risks (e.g., life-event stress, family and peer relationships, social support, early exposure to substances). We will take advantage of our twin design to examine the contribution of gene-environment interplay in the development of adult adjustment, including making use of monozygotic co-twin controls to determine whether environmental differences in risk exposure (including differences in exposure to abused substances) over the course of development are associated with differences in outcome. The completion of this project will provide for a rigorous and comprehensive evaluation of the long-term effects of adolescent-onset substance abuse on functioning in early adulthood. Adolescent substance abuse is a powerful predictor of adult adjustment and mental health problems. Yet the mechanisms linking early abuse to later maladjustment are not well understood. Using a unique sample of female twins studied prospectively from age 11 to 29, we will examine how adolescent-onset substance abuse affects mental health, social, and neurocognitive functioning in early adulthood
Keywords: Accounting; Address; Adolescence; Adolescent; adolescent substance abuse; adolescent substance use; Adult; Affect; Age; Age of Onset; aged; Alcohol or Other Drugs use; Alcoholism; Alcohols; Attention deficit hyperactivity disorder; base; Biological; Brain; cohort; Controlled Study; Data; Data Analyses; Data Set; design; Development; Developmental Process; Diagnosis; Disease; disinhibitory psychopathology; Drug usage; early adolescence; Electroencephalography; emerging adult; Ensure; Environment; Evaluation; Event; Event-Related Potentials; Exposure to; Failure (biologic function); Family; Family Study; Female; follow-up; Functional disorder; Funding; Genes; Genetic Polymorphism; Heavy Drinking; Illicit Drugs; indexing; Individual; informant; Inherited; Life; Link; Literature; Long-Term Effects; Longitudinal Studies; male; Marriage; Measures; men; Mental Health; Methods; Minnesota; Modeling; Neurocognitive; neuropsychological; neurotoxic; Nicotine; Outcome; Parents; Participant; peer; Personality Traits; population based; Prevention; Process; Psychopathology; Psychophysiology; public health relevance; Recruitment Activity; Research; Rest; Risk; Sampling; Sex Characteristics; social; Social Development; Social support; Stress; Substance abuse problem; substance abuser; Substance Use Disorder; success; teacher; Time; Tobacco; Twin Multiple Birth; Twin Studies; Woman
Relevance: Adolescent substance abuse is a powerful predictor of adult adjustment and mental health problems. Yet the mechanisms linking early abuse to later maladjustment are not well understood. Using a unique sample of female twins studied prospectively from age 11 to 29, we will examine how adolescent-onset substance abuse affects mental health, social, and neurocognitive functioning in early adulthood
Project start date: 1992-09-01
Project end date: 2014-06-30
Budget start date: 1-JUL-2011
Budget end date: 30-JUN-2012
PFA/PA: PA-07-070
5R01AA009367-19 (2011): $668046
A LONGITUDINAL STUDY OF ADOPTED YOUTH AND THEIR FAMILIES
K Matthew
University Of Minnesota Twin Citiescity: Minneapolis country: United States (us)
Grant 5R01MH066140-08 from National Institute Of Mental Health
Abstract: This application seeks renewal funding for a unique and innovative longitudinal study of adopted and non-adopted families. The Sibling Interaction and Behavior Study (SIBS) includes 409 adopted and 208 non-adopted families. At intake, each family consisted of pair of adolescent siblings and their rearing parents, a total of 2394 individuals. SIBS offspring have completed an intake assessment in mid-adolescence, a first follow-up (FU1) assessment in late-adolescence, and are in the midst of a second follow-up (FU2) assessment in early adulthood. Rate of participation at FU1 and to date in FU2 is well above 90 percent. Intake and FU assessments are extensive and include 1) comprehensive assessment of common externalizing (e.g., conduct disorder, substance use disorders, ADHD) and internalizing (depression, anxiety disorders) psychopathology; 2) substance use, abuse, and dependence; 3) individual-level markers of risk (personality, academic ability and progress); 4) family relationships (both parent-offspring and sibling); and 5) other environmental risk factors (e.g., peer group, religiousness, life stress, neighborhood). The current application has 4 specific aims, to 1) complete the FU2 assessment, 2) analyze FU1 and FU2 data to determine the nature of familial risk for common mental disorders; 3) use the principle of Mendelian Randomization to test the effect of adolescent alcohol use and misuse on risk of mental health and substance use disorders in early adulthood; and 4) determine whether individuals adopted in infancy are at heightened risk for mental disorders as young adults. Analysis of SIBS intake data demonstrates that this is a unique study that is making important observations on, for example, the effect of maternal depression, the impact of parent antisocial behavior, the consequences of adolescent alcohol abuse, and the mental health of US adopted youth. Continued support for this program of research will allow us to chart the trajectory of the development of common mental disorders from mid-adolescence through early adulthood, using an adoption design that allows us to identify familial environmental as well as genetic contributions to risk. The Sibling Interaction and Behavior Study (SIBS) is a longitudinal study of 409 adoptive and 208 non-adoptive families as the offspring in those families have aged from middle-adolescence through late-adolescence to early adulthood. This unique project is determining the environmental consequences of parent psychopathology (e.g., maternal depression), the effect of adolescent alcohol misuse on early-adult mental health problems, and whether individuals adopted as infants have heightened risk for mental health problems as young adults
Keywords: 12-20 years old; 21+ years old; abnormal psychology; abuse of substances; Active Follow-up; AD/HD; Address; ADHD; Adolescence; adolescence (12-20); Adolescent; adolescent alcohol; adolescent alcohol abuse; adolescent alcohol use; adolescent drinking; Adolescent Youth; Adopted; Adoption; Adult; adult human (21+); adult youth; Affect; Age; Alcohol abuse; alcohol misuse; Alcohol or Other Drugs use; alcohol problem; anti social; antisocial; Antisocial Personality; Antisocial Personality Disorder; Anxiety; Anxiety Disorders; AOD use; attention deficit hyperactive disorder; Attention deficit hyperactivity disorder; Attention-Deficit Disorder, Predominantly Hyperactive-Impulsive Type; base; Behavior; Behavioral; behavioral problem; Causality; Childhood; cohort; Comorbidity; Conduct Disorder; Data; Dependence; depressed mother; Depression; design; designing; Development; Diagnostic and Statistical Manual; Dimensions; Disease; disease causation; disease etiology; disease/disorder; disease/disorder etiology; Disorder; disorder etiology; DSM; Economics; emerging adult; Environment; Environmental Factor; environmental risk; Environmental Risk Factor; ethanol abuse; ethanol misuse; Etiology; Family; Family Relations; Family Relationship; Family Study; follow-up; Funding; Genetic; hazardous alcohol use; Health; heavy metal lead; heavy metal Pb; Hereditary; Home; Home environment; Human, Adult; Hyperactivity Disorder NOS; Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type; Hyperkinetic Syndrome; Individual; infancy; Infant; infantile; Inherited; innovate; innovation; innovative; Intake; Intervention; Intervention Strategies; interventional strategy; Investigation; juvenile; juvenile human; Lead; Left; Life; Life Stress; Literature; long-term study; longitudinal design; Longitudinal Studies; maternal depression; Mediating; Mental Depression; Mental disorders; Mental Health; Mental health disorders; Mental Hygiene; mental illness; Methods; mid life; mid-life; middle age; middle aged; midlife; Nature; Neighborhoods; neurotoxic; novel; offspring; Outcome; Parents; Pattern; Pb element; pediatric; Peer Group; Personality; Play; Position; Positioning Attribute; Preventive; Problem behavior; problem drinking; programs; Programs (PT); Programs [Publication Type]; Progress Reports; Psychiatric Disease; Psychiatric Disorder; psychological disorder; Psychological Health; Psychopathology; Public Health; public health medicine (field); randomisation; randomization; Randomized; randomly assigned; Research; Risk; Risk Assessment; Risk Marker; Role; Sampling; Sampling Studies; Siblings; social; social role; Sociopathic Personality; Source; Stress; substance abuse; Substance abuse problem; substance use; Substance Use Disorder; teen drinking; teenage; teenage drinking; Telephone Interviews; Testing; Time; Transmission; transmission process; underage drinking; Unspecified Mental Disorder; young adult; Youth; Youth 10-21; Youth Drinking
Relevance: The Sibling Interaction and Behavior Study (SIBS) is a longitudinal study of 409 adoptive and 208 non-adoptive families as the offspring in those families have aged from middle-adolescence through late-adolescence to early adulthood. This unique project is determining the environmental consequences of parent psychopathology (e.g., maternal depression), the effect of adolescent alcohol misuse on early-adult mental health problems, and whether individuals adopted as infants have heightened risk for mental health problems as young adults
Project start date: 2002-07-01
Project end date: 2013-12-31
Budget start date: 1-JAN-2011
Budget end date: 31-DEC-2011
PFA/PA: PA-07-070
5R01MH066140-08 (2011): $478507
MOLECULAR BIOLOGY AND VIRULENCE OF CTX PHAGE
K Matthew
Brigham And Women´s Hospitalcity: Boston country: United States (us)
Grant 5R37AI042347-16 from National Institute Of Allergy And Infectious Diseases
Project start date: 1998-01-01
Project end date: 2012-12-31
Budget start date: 1-JAN-2011
Budget end date: 31-DEC-2011
PFA/PA: PA-07-070
5R37AI042347-16 (2011): $311850