Monique K Lebourgeois
University Of Colorado At Boulder
Project start date: 2010-04-26
Project end date: 2015-01-31
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Grants awarded to Monique K Lebourgeois
SLEEP AND EMOTION REGULATION ACROSS EARLY CHILDHOOD
Monique K Lebourgeois, Assistant Professor (research)
Brown University, 164 Angell Street, Providence, Ri 02912
Grant 1R01MH086566-01A1 from National Institute Of Mental Health
Abstract: This research focuses on the co-development and co-regulation of the sleep and emotion processes during early childhood (ages 2-5 years). The specific aims of this research are (1) to examine the early developmental progression of sleep homeostasis (i.e., accumulation and dissipation); (2) to examine early developmental changes in the circadian process (i.e., phase, amplitude, phase angle of entrainment); and (3) to determine the impact of acute sleep restriction on physiological and behavioral measures of emotion regulation. Given the prevalence of early emotional/behavioral problems (7%-24%) and their stability, identifying factors that may alter pathways to mental illness is critical. Sleep-wake regulation is one such factor. Healthy, normally developing young children (n=40; ages 2-5 years) will participate in four annual 30-day in-home assessments of sleep homeostasis, circadian rhythms, and emotion regulation. Aim 1 addresses developmental changes in the accumulation (build up) and dissipation (decay) of sleep homeostasis. Children are studied while following a strict sleep wake schedule. On five non-consecutive days, the timing of polysomnographic sleep recordings varies as a function of prior wakefulness. EEG spectral power in the slow- wave activity range (.75Hz-4.5Hz) is computed in NREM sleep after 4hrs, 7hrs, 10hrs, 13hrs, and 16hrs of extended wakefulness. Accumulation parameters (time constant, upper asymptote) are estimated by SWA in the first NREM sleep episode of each recording. Dissipation is measured as the time course of SWA during NREM sleep episodes in all-night recordings (13hrs and 16hrs extended wakefulness). Aim 2 addresses developmental changes in circadian measures, including circadian phase [salivary dim-light melatonin onset (DLMO)], urinary melatonin amplitude, and phase angle of entrainment (DLMO-to-bedtime and DLMO-to-wake time intervals). The third aim addresses the effects of sleep restriction on emotion regulation in structured and unstructured home-based contexts. It is hypothesized that sleep restriction will (a) increases negative responsivity; (b) decrease positive responsivity; (c) decrease attention, inhibitory control, and use of adaptive regulation strategies; and (d) heighten physiological responses (respiratory sinus arrhythmia, cortisol reactivity) to emotionally eliciting stimuli/situations Emotional/behavioral problems are prevalent in young children (7%-24%) and commonly persist into adolescence and adulthood. Identifying mechanisms that contribute to the development of mental illness and understanding intra- and inter-individual differences in brain-behavior interactions is critical. This longitudinal research focuses on sleep bioregulation as a factor that may alter pathways to mental illness by studying the co-development and co-regulation of the sleep and emotion systems in early childhood. An integrative understanding of these systems may uncover points of entry for prevention and treatment of mental illness
Keywords: 0-11 years old; 12-20 years old; 2 year old; 21+ years old; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Acute; Address; Adolescence; Adolescent; Adolescent Youth; Adult; Aeroseb-HC; Age; Arrhythmia, Sinus; Attention; Attenuated; Autoregulation; Behavior; Behavioral; Biological; Biology; Brain region; Cetacort; Characteristics; Child; Child Youth; Children (0-21); Chronotropism, Cardiac; Chronotropisms, Cardiac; Circadian Rhythms; Cognitive; Conflict; Conflict (Psychology); Controlled Study; Cort-Dome; Cortef; Cortenema; Cortisol; Cortispray; Cortril; Data; Dermacort; Development; Diurnal Rhythm; Drowsiness; Drowsinesses; EEG; Eldecort; Electroencephalography; Emotional; Emotions; Heart Rate; History; Home; Home environment; Homeostasis; Human, Adult; Human, Child; Hydrocortisone; Hydrocortone; Hytone; Individual; Individual Differences; Intercept; Link; Literature; Measures; Medical; Melatonin; Mental disorders; Mental health disorders; Monitoring, Sleep; Moods; Nutracort; Nyctohemeral Rhythm; Pathway interactions; Performance; Phase; Physiologic; Physiological; Physiological Homeostasis; Polysomnography; Pregn-4-ene-3, 20-dione, 11, 17, 21-trihydroxy-, (11beta)-; Prevalence; Prevention; Problem behavior; Process; Proctocort; Psychiatric Disease; Psychiatric Disorder; Psychopathology; Recording of previous events; Regulation; Research; Risk; Role; SCHED; Salivary; Schedule; Sinus Arrhythmia; Sleep; Sleep Deprivation; Societies; Somnography; Somnolence; Stimulus; Structure; System; System, LOINC Axis 4; Temperament; Therapeutic Hydrocortisone; Time; Twenty-Four Hour Rhythm; Unspecified Mental Disorder; Wakefulness; Wakefulnesses; abnormal psychology; adolescence (12-20); adult human (21+); base; behavior influence; behavior measurement; behavioral influence; behavioral measure; behavioral measurement; behavioral problem; biological systems; brain behavior; children; circadian; circadian process; daily biorhythm; diurnal variation; early childhood; emotion regulation; emotional expression; expression of emotion; juvenile; juvenile human; mental illness; pathway; polysomnographic; positive emotion; positive emotional state; psychological disorder; public health relevance; respiratory; response; showing emotion; sleep control; sleep measurement; sleep polysomnography; sleep regulation; social role; stressor; teenage; time interval; two year old; urinary; youngster
Relevance: Emotional/behavioral problems are prevalent in young children (7%-24%) and commonly persist into adolescence and adulthood. Identifying mechanisms that contribute to the development of mental illness and understanding intra- and inter-individual differences in brain-behavior interactions is critical. This longitudinal research focuses on sleep bioregulation as a factor that may alter pathways to mental illness by studying the co-development and co-regulation of the sleep and emotion systems in early childhood. An integrative understanding of these systems may uncover points of entry for prevention and treatment of mental illness
Project start date: 2010-04-26
Project end date: 2015-01-31
Budget start date: 26-APR-2010
Budget end date: 31-JAN-2011
PFA/PA: PA-09-137
1R01MH086566-01A1 (2010): $586909
7R01MH086566-02 (2010): $596475
SLEEP-WAKE REGULATION AND EMOTION IN EARLY CHILDHOOD
Monique K Lebourgeois, Assistant Professor (research)
Brown University, 164 Angell Street, Providence, Ri 02912
Grant 5K01MH074643-05 from National Institute Of Mental Health
Abstract: This Mentored Research Scientist Award (K01) will enable the candidate to become an independent scientist focusing on maturational changes in bioregulatory sleep-wake processes and their relationship to the development of emotion regulation in early childhood (2-5 years). Career goals are to understand the role of sleep in emotion regulation and to apply basic bioregulatory processes research toward the development of interventions for the prevention of early sleep and emotional problems. Short-term research goals are to examine age-related differences in homeostatic and circadian processes and the effects of sleep (nap) restriction on emotion regulation in young children. The proposed 16-day cross-sectional home-based study with 2- and 5-year-olds (N=36) assesses (a) age-related differences in the accumulation of homeostatic sleep pressure (relationship between extended wakefulness and EEC slow-wave activity in naps taken after 4, 7, 10, 13, and 17 hours on five separate days), circadian phase (salivary melatonin onset), and phase angle (interval between circadian phase and wake time), and (b) the effects of nap restriction on emotion regulation (physiological and behavioral measures). The candidate will complete rigorous training with Mary Carskadon, Ph.D., an expert in sleep-wake regulation in young humans, and co-mentors with expertise in spectral analysis/mathematical modeling (Peter Achermann, Ph.D.) and emotion regulation (Ronald Seifer, Ph.D). Training goals are to develop a broader understanding of bioregulatory and developmental domains underlying sleep, circadian rhythms, and emotion; gain expertise in sleep-wake scoring, EEG spectral analysis, arid analysis of circadian rhythms data; acquire training in administering, coding, and analyzing data from emotion regulation measures; and increase understanding of longitudinal data analytic techniques. With this training, the candidate will be prepared for future longitudinal work on maturation changes in bioregulatory sleep-wake process in association with the development of emotion regulation
Keywords: 0-11 years old; 2 year old; 21+ years old; 5 year old; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-; Acute; Address; Adolescent; Adolescent Youth; Adult; Age; Analysis, Data; Attention; Autoregulation; Behavior; Biological; Biology; Characteristics; Child; Child Youth; Childhood; Children (0-21); Circadian Rhythms; Code; Coding System; Conflict; Conflict (Psychology); Controlled Study; Data; Data Analyses; Development; Disease; Disorder; Diurnal Rhythm; Doctor of Philosophy; EEG; Electroencephalography; Emotional; Emotions; Environment; Frequencies (time pattern); Frequency; Future; Goals; History; Home; Home environment; Homeostasis; Hour; Human; Human, Adult; Human, Child; Human, General; Individual; Individual Differences; Investigators; K05 Mechanism; K05 Program; Letters; Link; Literature; Man (Taxonomy); Man, Modern; Math Models; Measures; Medical; Melatonin; Mentors; Method LOINC Axis 6; Methodology; Methods and Techniques; Methods, Other; Moods; Napping; Nursery Schools; Nyctohemeral Rhythm; Performance; Ph.D.; PhD; Phase; Physiologic; Physiological; Physiological Homeostasis; Position; Positioning Attribute; Pressure; Pressure- physical agent; Preventive Intervention; Principal Investigator; Problem behavior; Process; Programs (PT); Programs [Publication Type]; Recording of previous events; Regulation; Research; Research Personnel; Research Scientist Award; Researchers; Resistance; Risk; Role; SCHED; Salivary; Schedule; Schools, Nursery; Scientist; Self-control as a personality trait; Sleep; Sleep Wake Cycle; Societies; Stress; Techniques; Temperament; Time; Training; Twenty-Four Hour Rhythm; Universities; Wakefulness; Wakefulnesses; Work; adult human (21+); age dependent; age related; awake; base; behavior influence; behavior measurement; behavioral influence; behavioral measure; behavioral measurement; behavioral problem; biological systems; career; children; circadian; circadian process; daily biorhythm; disease/disorder; diurnal variation; early childhood; emotion regulation; executive control; executive function; experience; externalizing behavior; five year old; interest; intervention development; juvenile; juvenile human; mathematical model; mathematical modeling; onset of sleep; pediatric; pressure; preventional intervention strategy; programs; psychologic; psychological; resistant; response; self control; skills; sleep control; sleep onset; sleep regulation; social; social role; therapy development; treatment development; two year old; youngster
Project start date: 2005-09-23
Project end date: 2010-07-31
Budget start date: 1-AUG-2009
Budget end date: 31-JUL-2010
PFA/PA: PA-00-019
5K01MH074643-05 (2009): $150922
5K01MH074643-04 (2008): $148126
5K01MH074643-03 (2007): $145420
5K01MH074643-02 (2006): $142740
1K01MH074643-01 (2005): $137606