PBDE BODY BURDENS, HOUSE DUST CONCENTRATIONS AND ASSOCIATIONS WITH THYROID HORMON
Boyd Dana
Emory Universitycity: Atlanta country: United States (us)
Grant 5R21ES019697-02 from National Institute Of Environmental Health Sciences
Keywords: 5 year old; Adult; Age; age group; Albumins; Anesthesia procedures; Animals; Antibodies; Anxiety; Binding (Molecular Function); Blood; Blood specimen; Body Burden; Child; Childhood; cohort; Collaborations; consumer product; Detection; Development; Dust; Ear structure; early childhood; early life exposure; Endocrine; Endocrine disruption; Endocrine system; Endocrinologist; Environment; Epidemiologic Studies; Epidemiologist; Epidemiology; Exposure to; Flame Retardants; General Anesthesia; Globulins; Health; Home environment; Homeostasis; House Dust; Housing; Human; Human body; Individual; Investigation; Iodide Peroxidase; Laboratories; Measures; Operative Surgical Procedures; Participant; Pathway interactions; Persons; phenyl ether; Pilot Projects; public health relevance; Public Health Schools; Reporting; Research Project Grants; Resources; Reverse Triiodothyronine; Route; Sampling; Scientist; Serum; Source; Thyroglobulin antibody; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroid stimulating immunoglobulins; Thyrotropin; Thyroxine; Tube; Tympanostomy; uptake
Relevance: Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products. Despite indications that children have substantially higher exposures to these compounds than adults, little is known about body burdens, exposure pathways and health effects of PBDEs in young children. These questions are investigated in a pilot cohort of 80 children ages 2 to 5 years
Project start date: 2010-12-15
Project end date: 2012-11-30
Budget start date: 1-DEC-2011
Budget end date: 30-NOV-2012
5R21ES019697-02 (2012): $104625
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Grants awarded to Boyd Dana
PBDE BODY BURDENS, HOUSE DUST CONCENTRATIONS AND ASSOCIATIONS WITH THYROID HORMON
Boyd Dana, Assistant Professor
Emory Universitycity: Atlanta country: United States (us)
Grant 1R21ES019697-01 from National Institute Of Environmental Health Sciences
Abstract: This developmental research project explores relationships among polybrominated diphenyl ether (PBDE) flame retardant concentrations in house dust, PBDE body burdens, and circulating thyroid hormone levels in early childhood. The study is motivated by recent epidemiologic evidence of an association between PBDE serum levels and thyroid disruption in adults, and limited but compelling reports of substantially higher PBDE body burdens in children compared to adults. In a pilot study of 80 children, we seek to establish the feasibility of investigating relationships between PBDE exposure routes, serum concentrations and thyroid function in a larger epidemiologic study, while building the in-house laboratory capacity to measure the range of PBDE congeners in serum and house dust. Serum samples will be obtained from a cohort of 80 children between 2 and 5 years of age who are under general anesthesia for ear tube surgery (myringotomy). Serum will be analyzed for an expanded panel of thyroid markers as well as congener-specific concentrations of PBDEs. In a subset of 20 study participants, house dust will be collected from the main activity room of the home and analyzed for PBDE concentrations. The study aims are to (a) build laboratory capacity to measure congener- specific PBDE concentrations in human serum and house dust (b) characterize the distribution of serum concentrations of PBDEs in a cohort of 80 children between 2 and 5 years, (c) explore associations between serum levels of PBDEs and thyroid hormones in young children, and (d) explore correlations between PBDEs concentrations in house dust and PBDE serum levels in young children to assess dust as a major route of exposure. Collaboration between analytical chemists, epidemiologists, exposure scientists, and pediatric endocrinologists will facilitate investigation of PBDEs from sources in the environment to human body burdens to effects on the endocrine system in a vulnerable and understudied age group. Study findings will contribute to our understanding of the body burden, endocrine effects and exposure routes of brominated flame retardants in early childhood, and will help guide the direction of future research efforts targeting early-life exposures to PBDEs and endocrine disruption. Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products. Despite indications that children have substantially higher exposures to these compounds than adults, little is known about body burdens, exposure pathways and health effects of PBDEs in young children. These questions are investigated in a pilot cohort of 80 children ages 2 to 5 years
Keywords: 0-11 years old; 21+ years old; 3, 3`, 5`-Triiodothyronine; 3, 5, 3`, 5`-Tetraiodothyronine; 5 year old; 5`-Deiodinase; Adult; adult human (21+); Age; age group; Age Group Unspecified; Albumins; Anesthesia; Anesthesia procedures; Animals; anti-thyroglobulin; anti-thyroglobulin antibody; Antibodies; antithyroglobulin; Anxiety; Aspiration of middle ear; Autoregulation; Binding; Binding (Molecular Function); Blood; Blood Sample; Blood Serum; Blood specimen; Body Burden; Child; Child Youth; Childhood; children; Children (0-21); cohort; Collaborations; consumer product; Deiodinase; Detection; Development; diphenyl ether; Dust; Ear; Ear structure; early childhood; early life exposure; EC 1.11.1.8; Endocrine; endocrine disrupting; Endocrine disruption; endocrine gland/system; Endocrine system; Endocrine system (all sites); Endocrine/Metabolic Organ System; Endocrinologist; Environment; Epidemiologic Research; Epidemiologic Studies; Epidemiological Studies; Epidemiologist; Epidemiology; Epidemiology Research; Exposure to; Fire Retardants; five year old; Flame Retardants; General Anesthesia; Globulins; Head and Neck, Thyroid; Health; Home; Home environment; Homeostasis; Hormonal System; House Dust; Housedust; Housing; Human; Human body; Human Figure; Human, Adult; Human, Child; Human, General; Individual; Investigation; Iodide Peroxidase; Iodide[{..}]hydrogen-peroxide oxidoreductase; Iodinase; Iodoperoxidase (Heme Type); Iodotyrosine Deiodase; Iodotyrosine Deiodinase; L-3, 5, 3`, 5`-Tetraiodothyronine; L-Thyroxine; L-Tyrosine, O-(4-hydroxy-3, 5-diiodophenyl)-3-iodo-; Laboratories; Levothyroxine; Man (Taxonomy); Man, Modern; Measures; Metabolic/Endocrine Body System; Middle ear paracentesis; Molecular Interaction; Monodeiodinase; Monoiodotyrosine Deiodinase; Myringostomy; Myringotomy; O-(4-Hydroxy-3, 5-diiodophenyl) 3, 5-diiodo-L-tyrosine; O-(4-Hydroxy-3, 5-diiodophenyl)-3, 5-diiodotyrosine; Operation; Operative Procedures; Operative Surgical Procedures; Paracentesis of tympanum; Participant; pathway; Pathway interactions; pediatric; Persons; phenyl ether; Physiological Homeostasis; Pilot Projects; pilot study; public health relevance; Public Health Schools; R01 Mechanism; R01 Program; Recombinant Thyroid-Stimulating Hormone; Recombinant TSH; Reporting; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Resources; Resources; Reticuloendothelial System, Blood; Reverse T3 Thyroid hormone; Reverse Triiodothyronine; Route; RPG; Sampling; Scientist; Serum; Serum Globulin; Source; surgery; Surgical; Surgical Interventions; Surgical Procedure; T4 Thyroid Hormone; Therapeutic Levothyroxine; Thyreotropin; Thyroglobulin antibody; Thyroid; thyroid function; Thyroid Function Tests; Thyroid Gland; Thyroid Gland Function Tests; Thyroid Gland Hormone; Thyroid Hormones; Thyroid Peroxidase; Thyroid Stimulating Hormone; Thyroid stimulating immunoglobulins; Thyroid-Stimulating Antibodies; Thyroid-Stimulating Hormone; Thyroperoxidase; Thyrotropin; thyroxin; Thyroxine; Tube; Tympanocentesis; Tympanostomy; Tympanotomy; Tyrosine Iodinase; Tyrosine, O-(4-hydroxy-3, 5-diiodophenyl)-3, 5-diiodo-; uptake; youngster
Relevance: Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products. Despite indications that children have substantially higher exposures to these compounds than adults, little is known about body burdens, exposure pathways and health effects of PBDEs in young children. These questions are investigated in a pilot cohort of 80 children ages 2 to 5 years
Project start date: 2010-12-15
Project end date: 2012-11-30
Budget start date: 15-DEC-2010
Budget end date: 30-NOV-2011
PFA/PA: PA-10-069
1R21ES019697-01 (2011): $319719