CSHL COMPUTATIONAL AND COMPARATIVE GENOMICS COURSE

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5T15HG000013-16 from National Human Genome Research Institute

Abstract: The Cold Spring Harbor Laboratory proposes to continue a course entitled "Computational & Comparative Genomics", to be held in the fall of 2008 - 2012. The Computational Genomics course provides experimental biologists with backgrounds in molecular biology, genetics, and biochemistry with the theoretical background and practical experience necessary to use and evaluate computational approaches to genome annotation and analysis, including protein sequence database searching, multiple sequence alignment, identification of promoters and other genetic regulatory elements, and the integration of sequence information into broader models of biological function. The course also provides computer scientists and mathematicians with an introduction to the algorithms, computational methods, and biological problems that are addressed in biological sequence analysis and computational biology. For post-doctoral fellows, and junior and senior investigators who are interested in changing their research direction towards computational biology, the course provides an introduction to computational biology methods and a survey of future directions. Over a seven day period, the students receive a strong grounding in the both the biological and computer science foundations for genome analysis and practical computer laboratory experience on challenging problems. The course is taught by internationally recognized leaders in the field, who provide hands-on demonstrations of the programs and biological databases that they have developed. At the end of the course, students can not only use effectively currently available tools in biological sequence analysis, they can also evaluate critically new computational approaches by considering alternative methods and interpretations, and appreciate the strengths and limitations of computational methods for answering broad biological questions

Keywords: Address; Algorithms; Amino Acid Sequence; Amino Acid Sequence Databases; Area; Arts; Bio-Informatics; Biochemistry; Bioinformatics; Biological; Biological Function; Biological Process; Biological databases; Biology; Chemistry, Biological; Computational Biology; Computers; Computing Methodologies; Curriculum; DNA; DNA Molecular Biology; Data; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Databases, Amino Acid Sequence; Dataphones; Deoxyribonucleic Acid; Educational Curriculum; Educational process of instructing; Ensure; Faculty; Foundations; Future; Genes; Genetic; Genetics, Other; Genome; Genomics; Hand; Home; Home environment; Institution; Investigators; Laboratories; Laboratory Study; Large-Scale Sequencing; Lead; Learning; Method LOINC Axis 6; Methodology; Methods; Methods and Techniques; Methods, Other; Modeling; Modems; Molecular; Molecular Biology; Molecular Biology, Protein Sequencing; Nucleic Acid Regulatory Sequences; Other Genetics; Pb element; Peptide Sequence Determination; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Protein Sequencing; Protein Structure, Primary; Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research; Research Associate; Research Personnel; Researchers; SEQ-AN; Science of Statistics; Scientist; Sequence Alignment; Sequence Analyses; Sequence Analysis; Sequence Databases, Protein; Sequence Determinations, Amino Acid; Sequence Determinations, Protein; Statistics; Students; Survey Instrument; Surveys; Teaching; Techniques; Training; Training Programs; Universities; Update; clinical data repository; clinical data warehouse; comparative; computational methodology; computational methods; computer methods; computer science; data repository; design; designing; experience; falls; genetic regulatory element; genome database; graduate student; heavy metal Pb; heavy metal lead; instructor; interest; lecturer; meetings; post-doc; post-doctoral; programs; protein sequence; relational database; statistics; tool

Project start date: 1991-06-06

Project end date: 2013-07-31

Budget start date: 1-AUG-2009

Budget end date: 31-JUL-2010

5T15HG000013-16 (2009): $48818

Sponsored Links Excellgen http://Excellgen.com

	Recombinant Lentivirus & Adenovirus High Yield and High Titer up to 10¹⁰ (lentivirus) and 10¹³ (adenovirus) for Guaranteed Expression of GOI. ~~$3000~~, $2500
	Transient Protein Expression in CHO and HEK293 Cells Transient Expression, Truly Functional Protein, 95% purity, 1~20 mg, fast turnaround. ~~$5500~~, $3950
	Baculovirus Protein Expression Fast turn around, >95% purity functional protein. No outsourcing to China or India. ~~$5500~~, $3950

CSHL COMPUTATIONAL AND COMPARATIVE GENOMICS COURSE

David J Stewart
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5T15HG000013-17 from National Human Genome Research Institute

Keywords: Address; Algorithms; Amino Acid Sequence Databases; Biochemistry; Biological; Biological Function; Biological Process; Biological databases; Chemistry, Biological; Computational Biology; Computers; Computing Methodologies; DNA Molecular Biology; Databases, Amino Acid Sequence; Educational process of instructing; Foundations; Future; Genetic; Genome; Genomics; Hand; Investigators; Laboratories; Methods; Modeling; Molecular Biology; Nucleic Acid Regulatory Sequences; Other Genetics; Postdoc; Postdoctoral Fellow; Programs (PT); Programs [Publication Type]; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Regulator Regions, Nucleic Acid; Regulatory Regions; Regulatory Regions, Nucleic Acid (Genetics); Regulatory Sequences, Nucleic Acid; Research; Research Associate; Research Personnel; Researchers; SEQ-AN; Scientist; Sequence Alignment; Sequence Analyses; Sequence Analysis; Sequence Databases, Protein; Students; Survey Instrument; Surveys; Teaching; comparative genomics; computational methodology; computational methods; computer methods; computer science; experience; falls; genetic regulatory element; interest; post-doc; post-doctoral; programs; tool

Project start date: 1991-06-06

Project end date: 2013-07-31

Budget start date: 1-AUG-2010

Budget end date: 31-JUL-2011

5T15HG000013-17 (2010): $50282

Grants awarded to David J Stewart

CSHL Conference On Retroviruses

David J Stewart
Cold Spring Harbor Laboratory

Grant 1R13AI081443-01 from National Institute Of Allergy And Infectious Diseases IRG: ZAI1

Abstract: This proposal seeks support for the thirty-fourth in an annual series of meetings on "Retroviruses" to be held at Cold Spring Harbor Laboratory that has emerged as the premiere conference for this field. The proposed meeting will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the field of retroviral biology. The meeting series is focused on the viruses rather than their host or the particular disease they cause. The large majority of the work to be presented will be unpublished and subject to immediate comment and discussion by the audience. The 2009 meeting will be structured in a manner that parallels the biology of the viruses; beginning with the entry phase of the replication cycle, proceeding with post-entry events, assembly and release, integration, reverse transcription, pathogenesis/host factors, RNA-related events (transcription, processing, export, and packaging) and finishing with antivirals. Each session will be chaired by two leading scientists in the field selected from amongst the registered attendees. Oral presentations will be selected by the organizers and session chairs in consultation with the organizers. Selected speakers will include graduate students, postdoctoral fellows and junior faculty. Two special lectures will be presented to provide essential background critical to stimulating discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect 400-450 retrovirologists in attendance

Project start date: 2009-04-01

Project end date: 2010-03-31

2010 COLD SPRING HARBOR LABORATORY CONFERENCE ON SYSTEMS BIOLOGY: GLOBAL REGULATI

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13CA150295-01 from National Cancer Institute

Abstract: This proposal seeks NIH funding to support the seventh in a series of scientific meetings on systems biology approaches to understanding gene regulation in eukaryotes. The proposed 2010 meeting will focus on five key aspects of gene regulation-cis-regulatory logic, transcriptional regulatory networks, nucleosomes and epigenetics, post-transcriptional regulation, and variation and evolution of regulatory networks. In addition, a session will be devoted to emerging technologies for analysis of gene regulation. The 2012 and 2014 meetings will follow a similar format and will include topics highly relevant to the current research at the time of the meeting. How cells control gene expression is a fundamental problem in biology. Ever since the discovery of the genes and the double strand helix structure of the DNA, there have been continuous investigations into this problem. Many great discoveries have been made, including the nuclear machineries that make transcripts as well as the DNA sequences that serve to control gene expression. Despite these efforts, our knowledge of the molecular mechanisms of gene regulation remains sketchy. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined, despite the availability of the complete genome sequences. Now, with the amount of genome sequence information for various organisms rapidly growing, the problem has become ever more pressing. Traditionally, investigators have studied gene regulation by analyzing the DNA-binding preferences of specific transcription factors and/or the cis-regulatory elements that control the expression patterns of single genes. These studies have tentatively identified DNA sequence motifs for around one hundred transcription factors, and have led to the idea that transcriptional regulation at the genome level involves a complex interplay between modular DNA sequence elements such as enhancers, silencers, insulators, and basal promoter elements. The last several years have seen rapid advances in the development of new genomics approaches to analysis of each step of the gene expression. Many of these approaches involve a computational component in their design or interpretation. Other strategies have evolved from the availability of several complete genomic sequences and the prospects of many more to come. These include analyses of sequence conservation among closely related species to detect "phylogenetic footprints" in non-coding regions and the use of genomic microarrays and next-generation sequencing technologies to study DNA-protein and RNA-protein interactions. The results from these new approaches have provided unprecedented details on the gene regulatory processes in prokaryotic as well as eukaryotic cells. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problem of gene regulation. Thus we propose to conduct a meeting to permit a free cross-disciplinary exchange of existing ideas and expertise. It is hoped that this meeting will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. The meeting will be held at Cold Spring Harbor Laboratory on March 23-27, 2010. Twenty-two speakers of international renown have been invited to give oral presentations, and approximately forty-five others will be selected from submitted s from applicants to the meeting. With the exception of the keynote address, oral presentations will be 15´ in length with 5´ for questions and discussions. Poster sessions will be included to encourage meaningful participation by the non-speaking attendees. In addition, we will hold pre-meeting workshops which will familiarize molecular biologists and bioinformaticians with the key concepts, terminology and acronyms needed to understand each others´ disciplines. We expect attendance of approximately 250-300 scientists at the meeting. We particularly encourage female scientists and junior investigators to participate - one of the two keynote speakers, 25% of the remaining invited speakers, and two of the four meeting organizers are women, and the majority of the participants in previous years have been students, postdocs or investigators in their early independent career. Ever since the discovery of genes and the double strand helix structure of the DNA, a central question has concerned how these genes are switched on and off in the cell. Decades of research have contributed to a robust understanding of the basic mechanisms of gene expression, and in recent years efforts have turned towards how sets of genes are turned on or off together. With the outpouring of enormous amounts of biological information about the relation between gene expression and genome architecture (DNA sequence, DNA structure and modification, chromatin structure and modification etc.), a variety of different scientific disciplines have become necessary. Biologists and computer scientists are using these approaches to shed light on the principles underlying the orchestration of sets of genes in normal cellular states and how global regulation can become derailed in disease states such as cancer. This biennial international conference (2010, 2012 and 2014) will provide a forum for these scientists to share their latest discoveries and will bring together the leading experts in the field

Keywords: Address; Architecture; Biological; Biology; Cancers; Cells; Chromatin Structure; Collaborations; Complex; Computers; DNA Binding; DNA Binding Interaction; DNA Sequence; DNA Structure; Development; Discipline; Disease; Disorder; Educational workshop; Elements; Emergent Technologies; Emerging Technologies; Engineering / Architecture; Enhancers; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Eukaryota; Eukaryote; Eukaryotic Cell; Evolution; Female; Functional RNA; Funding; Gene Action Regulation; Gene Expression; Gene Expression Regulation; Gene Regulation; Gene Regulation Process; Genes; Genes, Regulator; Genes, Switch; Genome; Genome, Human; Genomics; Grips; Human Genome; International; Investigation; Investigators; Knowledge; Laboratories; Length; Light; Logic; Malignant Neoplasms; Malignant Tumor; Modification; Molecular; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Coding; Non-Coding RNA; Nuclear; Nucleosomes; Oral; Organism; Participant; Pattern; Photoradiation; Phylogenetic Analysis; Phylogenetics; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Posters; Posters [Publication Type]; Process; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Proteins; RNA-Protein Interaction; Regulation; Regulator Genes; Regulatory Element; Regulatory Protein; RegulatoryElement; Research; Research Personnel; Researchers; SEQ-AN; Scientist; Sequence Analyses; Sequence Analysis; Series; Students; Switch Genes; Systems Biology; Technology; Terminology; Time; Transcript; Transcription Regulation; Transcriptional Control; Transcriptional Regulation; Transcriptional Regulatory Elements; United States National Institutes of Health; Variant; Variation; Woman; Workshop; ing; acronyms; career; conference; design; designing; disease/disorder; eukaryotida; gene discovery; gene product; genetic regulatory protein; genome sequencing; grasp; living system; malignancy; meetings; neoplasm/cancer; new approaches; next generation; novel approaches; novel strategies; novel strategy; posters; preference; regulatory gene; regulatory gene product; symposium; trans acting element; transcription factor

Relevance: SYSTEMS BIOLOGY: GLOBAL REGULATION OF GENE EXPRESSION CONFERENCE Ever since the discovery of genes and the double strand helix structure of the DNA, a central question has concerned how these genes are switched on and off in the cell. Decades of research have contributed to a robust understanding of the basic mechanisms of gene expression, and in recent years efforts have turned towards how sets of genes are turned on or off together. With the outpouring of enormous amounts of biological information about the relation between gene expression and genome architecture (DNA sequence, DNA structure and modification, chromatin structure and modification etc.), a variety of different scientific disciplines have become necessary. Biologists and computer scientists are using these approaches to shed light on the principles underlying the orchestration of sets of genes in normal cellular states and how global regulation can become derailed in disease states such as cancer. This biennial international conference (2010, 2012 and 2014) will provide a forum for these scientists to share their latest discoveries and will bring together the leading experts in the field

Project start date: 2010-03-01

Project end date: 2015-02-28

Budget start date: 1-MAR-2010

Budget end date: 28-FEB-2011

PFA/PA: PA-08-149

1R13CA150295-01 (2010): $5000

2010 COLD SPRING HARBOR LABORATORY CONFERENCE ON MOLECULAR CHAPERONES AND STRESS

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13AG037223-01 from National Institute On Aging

Abstract: This proposal is a request for partial financial support for a meeting on Molecular Chaperones and Stress Responses to be held from May 4 - 8, 2010 at Cold Spring Harbor Laboratory. This meeting is the premier international format for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the involvement of this process in an increasing number of disease states and in normal aging guarantees the excitement of this meeting. Among the highlights of the meeting will be sessions devoted to (1) Protein misfolding and disease, emphasizing the role of alternative folding pathways in protein biogenesis and lifecycle and mounting evidence for chaperone involvement in Alzheimer´s Disease, polyglutamine diseases and the aging process (2) new structural and mechanistic information on some intensively studied chaperones, (3) the role of chaperones in diverse cellular transactions and the signal transduction pathways that integrate them, (4) the crosstalk between protein folding and proteolysis mediated by chaperones, (5) how the various protein folding and quality control systems in a cell function together to provide a robust protein folding environment and how the breakdown of such protein homeostasis (proteostasis) contributes to disease and normal aging, (6) the diverse protein quality control strategies used by a cell to ensure the integrity of the secretory pathway during times of protein folding stress. The field of heat shock proteins and molecular chaperones has grown rapidly and draws interest not only from traditional scientific disciplines in the basic sciences but also from numerous areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will include seven lecture and three poster sessions. The proposed sessions include I- Chaperone Biochemistry & Protein Folding, II- Chaperone Function in Disease and Development, III- Diseases of Protein Misfolding IV- Quality Control & Protein Trafficking V- Evolution and Regulation of Protein Folding Machines, VI- Chaperones and Proteolysis, and VII- Manipulating Chaperone Networks and Protein Folding Pathways. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. A maximum of two additional speakers will be pre-invited per session and the remainder will be selected from submitted s. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators. The subsequent meetings (2012 and 2014) will follow a similar format and will include topics highly relevant to the current research at the time of the meeting. Proteins are composed of polymers of amino acids (or polypeptides) and execute essential tasks in all living organisms. Protein function is critically dependent on the folding of their constituent polypeptides into active three-dimensional objects and experimental evidence accumulated in the recent past has drawn attention to contribution that failure of this process (protein misfolding) makes to some of the most important diseases affecting humanity. The latter include common neurodegenerative disorders, such as Parkinson´s disease and Alzheimer´s disease, common metabolic disorders such as Diabetes Mellitus and a host of other conditions liked to the aging process. The Cold Spring Harbor Meeting on Molecular Chaperones and Stress Responses brings together experts in diverse aspects of protein folding and the cellular response to protein misfolding. As such it serves as the premier clearinghouse for ideas on how to eventually translate the basic discoveries in the area to future treatments of recalcitrant diseases

Keywords: Affect; Aging; Aging Process; Aging-Related Process; Alzheimer; Alzheimer disease; Alzheimer sclerosis; Alzheimer syndrome; Alzheimer`s; Alzheimer`s Disease; Alzheimers Dementia; Alzheimers disease; Amino Acids; Area; Attention; Autoregulation; Basic Research; Basic Science; Biochemistry; Biogenesis; Biomedical Research; Cancers; Cardiac Diseases; Cardiac Disorders; Cell Function; Cell Process; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chaperone; Chemistry, Biological; Communicable Diseases; Degenerative Diseases, Nervous System; Degenerative Neurologic Disorders; Dementia, Alzheimer Type; Dementia, Primary Senile Degenerative; Dementia, Senile; Development; Diabetes Mellitus; Discipline; Disease; Disorder; Ensure; Environment; Equilibrium; Evolution; Explosion; FLR; Failure (biologic function); Financial Support; Future; HSP; Heart Diseases; Heat shock proteins; Homeostasis; Humanities; Idiopathic Parkinson Disease; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; International; Investigators; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Lewy Body Parkinson Disease; Life; Malignant Neoplasms; Malignant Tumor; Mediating; Metabolic Diseases; Metabolic Disorder; Molecular Chaperones; Neurodegenerative Diseases; Neurodegenerative Disorders; Neurologic Degenerative Conditions; Neurologic Diseases, Degenerative; Oral; Organism; Origin of Life; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson`s; Parkinson`s disease; Parkinsons disease; Pathway interactions; Physiological Homeostasis; Poly Q; Polymers; Posters; Posters [Publication Type]; Primary Parkinsonism; Primary Senile Degenerative Dementia; Process; Protein Cleavage; Protein Trafficking; Proteins; Proteolysis; Quality Control; Regulation; Research; Research Personnel; Researchers; Role; Scientist; Senescence; Signal Transduction Pathway; Stress; Stress Proteins; Subcellular Process; System; System, LOINC Axis 4; Thesaurismosis; Time; Traffickings, Protein; Translating; Translatings; aberrant protein folding; abnormal protein folding; ing; aminoacid; balance; balance function; biological adaptation to stress; conference; dementia of the Alzheimer type; diabetes; disease/disorder; failure; gene product; heart disorder; in vivo; interest; language translation; lectures; living system; malignancy; meetings; metabolism disorder; neoplasm/cancer; neurodegenerative illness; normal aging; pathologic protein folding; pathway; poly(glutamine); polyQ; polyglutamine; polypeptide; posters; primary degenerative dementia; protein folding; protein function; protein mis-folding; protein misfolding; protein transport; public health relevance; reaction; crisis; response; senescent; senile dementia of the Alzheimer type; social role; stress response; stress; reaction; symposium

Relevance: Proteins are composed of polymers of amino acids (or polypeptides) and execute essential tasks in all living organisms. Protein function is critically dependent on the folding of their constituent polypeptides into active three-dimensional objects and experimental evidence accumulated in the recent past has drawn attention to contribution that failure of this process (protein misfolding) makes to some of the most important diseases affecting humanity. The latter include common neurodegenerative disorders, such as Parkinson´s Disease and Alzheimer´s Disease, common metabolic disorders such as Diabetes Mellitus and a host of other conditions liked to the aging process. The Cold Spring Harbor Meeting on Molecular Chaperones and Stress Responses brings together experts in diverse aspects of protein folding and the cellular response to protein misfolding. As such it serves as the premier clearinghouse for ideas on how to eventually translate the basic discoveries in the area to future treatments of recalcitrant diseases

Project start date: 2010-05-01

Project end date: 2013-04-30

Budget start date: 1-MAY-2010

Budget end date: 30-APR-2011

PFA/PA: PA-08-149

1R13AG037223-01 (2010): $20000

CSHL Conference On Pharmacogenomics

David J Stewart
Cold Spring Harbor Laboratory
p.o. Box 100
cold Spring Harbor, Ny 11724

Grant 5R13GM072426-04 from National Institute Of General Medical Sciences IRG: ZGM1

Abstract: This proposal is a request for partial financial support for a conference on PHARMACOGENOMICS to be held November 18-21, 2004 at Cold Spring Harbor Laboratory. This represents the second in a series of annual conferences on this topic, following the success of the first Joint Cold Spring Harbor/Wellcome Trust conference held in late September 2003 at the Wellcome Trust Genome Campus in Hinxton, United Kingdom, with plans for the meeting to be held alternately between these two locations on an annual basis. This conference will focus on the opportunities presented by the growing contribution of emerging genomic information and technologies to interdisciplinary approaches in the study of variable responses of humans to drugs and toxic agents, and how research may benefit the individual. The meeting will provide an in-depth focus on diverse areas including the biochemistry and physiology of drug action, uptake and metabolism, and how this is affected by genetics; the opportunities for discovery and design of new therapeutic agents; personalizing medicine; understanding and managing adverse drug reactions; the impact of academic and commercial initiatives; ethical, legal, regulatory and social consequences of genetics applied to medicines. The conference will bring together senior and junior investigators, postdoctoral and postgraduate researchers, medical, regulatory and ethical experts in a range of disciplines to share existing research and experience, and to explore the potential of working together in new international and interdisciplinary research areas for the benefit of individual patients. Co-chairs and a limited number of invited speakers will provide critical focus for the conference, while the remainder of the talks will be selected from the s on the basis of scientific merit and relevance. This balance of talks allows the conference to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators. Cold Spring Harbor Laboratory and the meeting organizers will make particular efforts to encourage attendance and participation by women and minority scientists. The subsequent meetings (2006 and 2008) will follow a similar format and will include topics highly relevant to the current research at the time of the meeting

Keywords: meeting /conference /symposium, pharmacogenetics biochemistry, interdisciplinary collaboration, pharmacokinetics travel

Project start date: 2004-08-01

Project end date: 2009-07-31

5R13GM072426-04 (2007): $1

3R13GM072426-03S1 (2006): $20000

5R13GM072426-03 (2006): $19821

5R13GM072426-02 (2005): $1

1R13GM072426-01 (2004): $18683

5R13GM072426-05 (2008): $21029

COLD SPRING HARBOR LABORATORY CONFERENCE ON PHARMACOGENOMICS & PERSONALIZED THERA

David J Stewart
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13GM096522-01 from National Institute Of General Medical Sciences

Abstract: This proposal is a request for partial financial support for a conference on PHARMACOGENOMICS & PERSONALIZED THERAPY to be held November 17 - 21, 2010 at Cold Spring Harbor Laboratory. This represents the eighth in a series of joint Cold Spring Harbor/Wellcome Trust conferences on Pharmacogenomics held in Hinxton, UK and Cold Spring Harbor in alternate years. This conference will focus on the opportunities presented by the growing contribution of emerging genomic information and technologies to interdisciplinary approaches in the study of variable responses of humans to drugs and toxic agents, and how research may benefit the individual. The meeting will provide an in depth focus on diverse areas including mechanisms in pharmacogenomics; contemporary advances in pharmacogenomics; basic genomics - DNA sequencing and copy number variation; whole-genome associations & translational bioinformatics; cardiovascular pharmacogenomics; cancer pharmacogenomics; clinical application of pharmacogenomics; & public-private partnerships. The conference will bring together senior and junior investigators, postdoctoral and postgraduate researchers, medical, regulatory and ethical experts in a range of disciplines to share existing research and experience, and to explore the potential of working together in new international and interdisciplinary research areas for the benefit of individual patients. Co-chairs and a limited number of invited speakers will provide critical focus for the conference, while the remainder of the talks will be selected from the s on the basis of scientific merit and relevance. This balance of talks allows the conference to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators. Cold Spring Harbor Laboratory and the meeting organizers will make particular efforts to encourage attendance and participation by women and minority scientists. The subsequent meetings (2012 and 2014) will follow a similar format and will include topics highly relevant to the current research at the time of the meeting. This proposed conference on Pharmacogenomics & Personalized Therapy is intended to have a strong multidisciplinary focus and to address diverse issues related to applying genomics to variable drug response in the human population. This conference is intended to provide a format for the exchange of ideas and information and to discuss the latest research findings and technical advances towards the study of pharmacogenetics and pharmacogenomics

Keywords: Address; Area; Articulation; Bio-Informatics; Bioinformatics; Biological Models; Biotechnology; CNP; Cancers; Cardiovascular; Cardiovascular Body System; Cardiovascular system; Cardiovascular system (all sites); Copy Number Polymorphism; DNA Sequence; Data; Development; Discipline; Drugs; Ensure; Environment; Equilibrium; Ethics; European; Faculty; Financial Support; Fostering; Genome; Genomics; Human; Human, General; Individual; Industry; Information Technology; Interdisciplinary Research; Interdisciplinary Study; International; Investigators; Joints; Laboratories; Malignant Neoplasms; Malignant Tumor; Man (Taxonomy); Man, Modern; Medical; Medication; Minority; Model System; Models, Biologic; Multidisciplinary Collaboration; Multidisciplinary Research; Oral; Organ System, Cardiovascular; Participant; Patients; Pharmaceutic Preparations; Pharmaceutical Agent; Pharmaceutical Preparations; Pharmaceuticals; Pharmacogenetics; Pharmacogenomics; Pharmacologic Substance; Pharmacological Substance; Population; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Research; Research Associate; Research Institute; Research Personnel; Researchers; Science; Scientist; Series; Study, Interdisciplinary; Time; Trust; Vascular, Heart; Woman; Work; ing; balance; balance function; base; circulatory system; clinical applicability; clinical application; conference; copy number variation; drug/agent; experience; graduate student; interdisciplinary approach; interest; malignancy; meetings; multidisciplinary; neoplasm/cancer; post-doc; post-doctoral; postdoctoral investigator; posters; public-private partnership; response; success; symposium

Relevance: This proposed conference on Pharmacogenomics & Personalized Therapy is intended to have a strong multidisciplinary focus and to address diverse issues related to applying genomics to variable drug response in the human population. This conference is intended to provide a format for the exchange of ideas and information and to discuss the latest research findings and technical advances towards the study of pharmacogenetics and pharmacogenomics

Project start date: 2010-09-30

Project end date: 2015-08-31

Budget start date: 30-SEP-2010

Budget end date: 31-AUG-2011

PFA/PA: PA-10-071

1R13GM096522-01 (2010): $15000

Sponsored Links Excellgen http://Excellgen.com

	Baculovirus Protein Expression Fast turn around, >95% purity functional protein. No outsourcing to China or India. ~~$5500~~, $3950
	Recombinant Lentivirus & Adenovirus High Yield and High Titer up to 10¹⁰ (lentivirus) and 10¹³ (adenovirus) for Guaranteed Expression of GOI. ~~$3000~~, $2500
	Transient Protein Expression in CHO and HEK293 Cells Transient Expression, Truly Functional Protein, 95% purity, 1~20 mg, fast turnaround. ~~$5500~~, $3950

CSHL Course: Making And Using DNA Microarrays

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 5T15CA086855-08 from National Cancer Institute IRG: NCI

Abstract: The sequencing of an ever increasing number of eukaryotic genomes of model and non-model organisms, including the recent completion of the first human genome, is providing a rapidly expanding pipeline of probable genes, many of which have as yet only a putative biological function ascribed to them on the basis of sequence similarity with known genes. Even where the biological function is known, it is becoming clear that the genome holds an extraordinary amount of as yet ill-understood regulatory information as to the temporal and spatial expression of these genes to provide for the exquisite cellular and tissue architectures common while unique to all organisms. This is surely an exhilarating reminder that much of the natural world remains to be explored at the molecular level. DNA microarrays provide a natural vehicle for this exploration. Comprehensive genome-wide surveys of gene expression patterns or function are now possible in a large number of organisms including humans, often at the level of individual cell type or tissue. The results can be viewed as maps that reflect the order and logic of the genetic program, rather than the physical order of genes on chromosomes. Increasingly, a temporal component is being added to many microarray studies to provide a dynamic view of the world within the cell. Furthermore, the molecular pathology of diseases such as cancer and bacterial or viral infection is now open to analysis by DNA microarray analysis and complementary technologies. Research using DNA microarrays and other genome-scale technologies should also help to rapidly accelerate our knowledge of gene function and molecular biology between the model organisms and other species. In this eight-day laboratory and lecture course, students will learn how to troubleshoot the array-making equipment, prepare DNA microarrays from a variety of sources, perform hybridization experiments using the prepared arrays, and learn in detail how to analyze and present data arising from these experiments. It should be emphasized that more and more emphasis will be placed on the data handling and analysis aspects of this field as the technology matures. The goal of the course is to train students so that they can return to their own laboratories and immediately apply this powerful technology in their own research.

Project start date: 1999-09-30

Project end date: 2007-04-30

5T15CA086855-08 (2006): $57421

5T15CA086855-07 (2005): $57072

2T15CA086855-06 (2004): $55635

CSHL Conference On Physiological Geonomics & Rat Models

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 1R13RR018831-01 from National Center For Research Resources IRG: RIRG

Abstract: The rat has long been a major model system for biomedical research. Since the rat genome project was initiated in 1996, there has been an explosion in the number of genomics reagents (10,000 genetic markers, multiple genetic maps, radiation hybrids and their associated maps, >250,000 ESTs), genomic databases, physiological databases, an animal repository, and most recently, the availability of the draft genomic sequence. These reagents, tools and databases have been developed by international teams, but have been largely funded by the combined efforts of the majority of the NIH Institutes, with NHLBI being the leading institute in terms of funding and direction. After extensive discussion with members of the community and with staff at Cold Spring Harbor, the first "rat meeting" was held there in December 1999. The 1999 meeting on "Physiological Genomics and Rat Models" was successful in part because this represented the first rat meeting not dominated by a specific disease group, and helped to initiate the beginnings of the "rat community" of laboratories and investigators interested in applying this model system to their work. The meeting was held again in December 2001, and is planned to be held every two years at Cold Spring Harbor for at least the next five years, with a revised working title of "Rat Genomics and Models". This grant is therefore seeking support to help offset the costs of this important meeting for the next three meetings (2003, 2005, 2007). This support will help maintain the continued quality of the meeting by enabling more speakers to be invited, as well as junior and minority scientists to be supported; thereby allowing the organizers more flexibility in bringing new investigators into this growing field.

Keywords: biological model, functional /structural genomics, laboratory rat, meeting /conference /symposium, model design /development, science education, travel

Project start date: 2003-09-30

Project end date: 2006-09-29

1R13RR018831-01 (2003): $19990

CSHL CONFERENCE ON GLIA IN HEALTH

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13NS071615-01 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development

Abstract: The proposed meeting, "Glia in Health & Disease", will be held at Cold Spring Harbor Laboratory on July 22 - 26th, 2010 and subsequently in 2012 and 2014. It is becoming increasingly clear that glial cells are critical participants in every major aspect of brain development, function, and disease. Far more active than once thought, glia play key roles in the development and function of axons and synapses, nervous system plasticity, and blood flow. Glia secrete many substances whose roles are not yet understood, and they are central players in CNS injury and disease. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. It will span a broad range of areas of investigation including genetics, molecular biology, biochemistry, physiology, and high resolution imaging. Studies from both invertebrate and vertebrate model systems will be presented. The meeting plans to 1) assemble an international meeting of scientists interested in various aspects of glial biology and neuron-glia interactions in health and disease; 2) discuss new and exciting developments in the field by selecting talks from openly submitted s on the basis of scientific merit; 3) provide an opportunity to junior as well as senior participants to present their data; and 4) promote collaborative interactions that extend beyond the meeting. Mammalian brains are made up of several kinds of cell. Much emphasis in modern neuroscience has been placed on the function of neurons that provide the "wiring" in the brain, but glial cells, almost equal in abundance to neurons, are increasingly understood to do more than play a supporting role. In the last ten years, it has become apparent that glial cells are critical participants in every major aspect of brain development, function, and disease. Evidence is also growing that glia play an important role in modulating blood flow in the brain, acting to direct oxygenated blood to more active regions. Finally, many lines of research are converging to elucidate how glia modulate neurotransmission, and thus how they may provide an additional layer of regulation and control to information processing in the brain. This biennial international conference (2010, 2012 and 2014) will provide a forum for these scientists to share their latest discoveries and will bring together the leading experts in the field

Keywords: Area; Axon; Biochemistry; Biological Models; Biology; Blood; Blood flow; Brain; CNS Injury; Cells; Central Nervous System Injury; Chemistry, Biological; DNA Molecular Biology; Data; Development; Disease; Disorder; Encephalon; Encephalons; Genetic; Glia; Glial Cells; Goals; Health; Image; Injury of central nervous system; International; Invertebrata; Invertebrates; Invertebrates, General; Investigation; Kolliker`s reticulum; Laboratories; Model System; Models, Biologic; Molecular Biology; NRVS-SYS; Nerve Cells; Nerve Impulse Transmission; Nerve Transmission; Nerve Unit; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neuroglia; Neuroglial Cells; Neurologic Body System; Neurologic Organ System; Neuronal Transmission; Neurons; Neurosciences; Non-neuronal cell; Participant; Physiology; Play; Regulation; Research; Resolution; Reticuloendothelial System, Blood; Role; Scientist; Synapses; Synaptic; ing; base; central nervous system injury; conference; disease/disorder; imaging; information processing; interest; meetings; nerve cement; neuronal; neurotransmission; public health relevance; social role; symposium

Relevance: CONFERENCE ON GLIA IN HEALTH & DISEASE Mammalian brains are made up of several kinds of cell. Much emphasis in modern neuroscience has been placed on the function of neurons that provide the "wiring" in the brain, but glial cells, almost equal in abundance to neurons, are increasingly understood to do more than play a supporting role. In the last ten years, it has become apparent that glial cells are critical participants in every major aspect of brain development, function, and disease. Evidence is also growing that glia play an important role in modulating blood flow in the brain, acting to direct oxygenated blood to more active regions. Finally, many lines of research are converging to elucidate how glia modulate neurotransmission, and thus how they may provide an additional layer of regulation and control to information processing in the brain.This biennial international conference (2010, 2012 and 2014) will provide a forum for these scientists to share their latest discoveries and will bring together the leading experts in the field

Project start date: 2010-07-01

Project end date: 2011-06-30

Budget start date: 1-JUL-2010

Budget end date: 30-JUN-2011

PFA/PA: PA-08-149

1R13NS071615-01 (2010): $14989

2010 CSHL AXON GUIDANCE, SYNAPTIC PLASTICITY AND REGENERATION CONFERENCE

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13NS071658-01 from National Institute Of Neurological Disorders And Stroke

Abstract: The proposed meeting to be held at Cold Spring Harbor Laboratory on "Axon Guidance, Synaptic Plasticity, and Regeneration" on September 21 - 25, 2010, 2012 and 2014 will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the field. This proposal seeks support for the seventh of a biennial series of meetings held at Cold Spring Harbor Laboratory that has emerged as the premiere meeting for this field. Topics to be discussed for the 2010 meeting will include i. the identification and characterization of guidance signals and their receptors; ii. the dissection of the signal transduction machinery that translates activation of receptors into changes in motility; iii. the identification and characterization of signals that regulate synapse formation and synaptic specificity; iv. the identification of the signaling mechanisms by which neuronal activity sculpts patterns of synaptic connectivity; v. mechanisms of neuronal polarity and dendritic patterning; vi. the relationship between mechanisms that mediate development of neural circuits and behavior; vii. stem cells, regeneration and disease. Diverse experimental approaches (including cell biology, biochemistry, genetics, and electrophysiology) and systems (including various vertebrate and invertebrate model systems for investigating neural connectivity and function) will be highlighted. Given the diverse approaches currently employed in this field, communication among workers is essential to advance research and understanding of fundamental mechanisms that regulate wiring of the nervous system. Oral presentations will be selected by the session chairs in consultation with the organizers. Each session will be chaired by two leading scientists in the field. Selected speakers will include graduate students, postdoctoral fellows and junior faculty. Three special lectures will be presented to provide essential background critical to stimulating discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect 400-450 neuroscientists in attendance. Axon guidance is the subfield of brain development focused on how nerve cells send out axons to reach the correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately, remains a major puzzle. Upon reaching their targets, axons form synapses (a process called synaptogenesis) with other nerve cells. It is now clear that there is a high degree of dynamic behavior or plasticity at the level of individual synapses, a process that may play an important role in how we learn and remember. This conference of international scientists will meet to discuss the latest research in this important field

Keywords: Area; Axon; Behavior; Biochemistry; Biological Models; Brain; Cell Communication and Signaling; Cell Locomotion; Cell Migration; Cell Movement; Cell Signaling; Cellular Migration; Cellular biology; Chemistry, Biological; Communication; Consultations; DISSEC; Development; Disease; Disorder; Dissection; Electrophysiology; Electrophysiology (science); Encephalon; Encephalons; Faculty; Genetic; Individual; International; Intracellular Communication and Signaling; Invertebrata; Invertebrates; Invertebrates, General; Laboratories; Learning; Lectures; Lectures (PT); Lectures [Publication Type]; Mediating; Model System; Models, Biologic; Mother Cells; Motility; Motility, Cellular; NRVS-SYS; Natural regeneration; Nerve Cells; Nerve Unit; Nervous; Nervous System; Nervous System, Brain; Nervous system structure; Neural Cell; Neurocyte; Neurologic Body System; Neurologic Organ System; Neurons; Neurophysiology / Electrophysiology; Oral; Participant; Pattern; Play; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Process; Progenitor Cells; Receptor Activation; Receptor Protein; Regeneration; Research; Research Associate; Role; Scientist; Series; Signal Transduction; Signal Transduction Systems; Signaling; Specificity; Stem cells; Synapses; Synaptic; Synaptic plasticity; System; System, LOINC Axis 4; Translating; Translatings; Work; axon growth cone guidance; axon guidance; biological signal transduction; cell biology; cell motility; conference; disease/disorder; graduate student; language translation; lectures; meetings; neural; neural circuit; neural circuitry; neuronal; post-doc; post-doctoral; posters; public health relevance; receptor; regenerate; relating to nervous system; social role; symposium; synapse formation; synaptogenesis

Relevance: Axon guidance is the subfield of brain development focused on how nerve cells send out axons to reach the correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately, remains a major puzzle. Upon reaching their targets, axons form synapses (a process called synaptogenesis) with other nerve cells. It is now clear that there is a high degree of dynamic behavior or plasticity at the level of individual synapses, a process that may play an important role in how we learn and remember. This conference of international scientists will meet to discuss the latest research in this important field

Project start date: 2010-08-01

Project end date: 2011-07-31

Budget start date: 1-AUG-2010

Budget end date: 31-JUL-2011

PFA/PA: PA-08-149

1R13NS071658-01 (2010): $10000

CSHL Course On Proteomics

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 5T15CA098595-03 from National Cancer Institute IRG: NCI

Abstract: The proposed Cold Spring Harbor Laboratory Course on Proteomics is to be held November 5-18, 2002, 2003 and 2004. This intensive laboratory and lecture course will focus on two major themes in proteomics. In the profiling section of the course, students will learn methodologies of protein preparation from diverse samples, sample analysis by 2-D gel electrophoresis and mass spectrometry, and the application of bioinformatics tools to identify proteins and assess their relative abundance. In the functional proteomics section of the course, students will learn the use of recombinational cloning to move many genes simultaneously to different expression vectors, how to apply robotics to high-throughput methods, and how to perform high-throughput expression, purification and characterization of proteins. The overall aim of the course is to provide each student with the fund of knowledge and hands-on experience necessary to be able to perform and analyze proteomics experiments, and to learn to identify new opportunities in applying proteomics approaches to his/her own research.

Project start date: 2003-07-01

Project end date: 2006-06-30

5T15CA098595-03 (2005): $68483

5T15CA098595-02 (2004): $66792

1T15CA098595-01 (2003): $65150

5T15CA098595-08 (2010): $80080

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5T15CA098595-07 (2009): $78059

5T15CA098595-06 (2008): $76096

5T15CA098595-05 (2007): $74192

2T15CA098595-04 (2006): $72343

CSHL Conference On Phosphorylation, Signaling And Disease

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 1R13CA126443-01 from National Cancer Institute IRG: ZCA1

Abstract: The proposed 2007 meeting on the Phosphorylation, Signaling and Disease will bring together about 250-300 scientists from the international community working on different aspects of protein phosphorylation and signal transduction. The meeting will provide an intense, in-depth forum for presenting new findings and formulating new ideas in different areas of molecular research in which rapid progress is being made. 2007 Sessions will include (1) Receptor-Proximal Signaling; (2) Physiology and Disease; (3) Cancer; (4) Metabolic and Stress Signaling; (5) Model Systems; (6) Signaling Pathways in Survival and Proliferation; and (7) Downstream Signaling. It is noteworthy that many kinases and phosphatases have been implicated in the etiology of cancer and other diseases, and therefore represent potential targets in the development of novel therapeutics. The meeting will feature anchoring talks by leading scientists working in these areas who will chair the individual sessions. One of the key strengths of the proposed meeting is that because the large majority of talks are selected from the openly submitted s three months prior to the meeting, ample opportunity is provided for junior scientists to present their results, and also for the presentation of important, late-breaking findings. The 2007 meeting is intended to provide a format for the exchange of ideas and information, to discuss the latest research findings and technical advances, and to facilitate interaction amongst groups active in diverse systems.

Keywords: meeting /conference /symposium, neoplasm /cancer, phosphorylation, ing, community, lead, model, physiology, protein, receptor, stress

Project start date: 2007-05-04

Project end date: 2008-04-30

1R13CA126443-01 (2007): $4000

Neurobiology Of Drosophila Conference

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 1R13NS060548-01 from National Institute Of Neurological Disorders And Stroke IRG: ZNS1

Abstract: The planned conference on the "Neurobiology of Drosophila" will convene a group of junior and senior scientists to discuss the latest advances in neurobiology research that are being made in the highly successful model system of the fruit fly Drosophila melanogaster. This proposal seeks support for the 2007 conference, which is the 12th biennial international meeting in this series. This meeting focuses on advances made using the combined power of genetics, molecular biology, biochemistry, cell biology, electrophysiology, imaging, and behavioral analysis to address fundamental issues in neurobiology. The topics covered will range from molecular biology to complex behavior and include neuronal and glial fate, neural circuits and function, cell biology and pathology, sensory systems, behavior, synaptic transmission, process formation, and technology development. By vote of the previous participants, the meeting will remain of moderate size (430 participants) and will have no parallel sessions so as to facilitate discussion, exchange of ideas and techniques, and to promote new collaborations in this rapidly evolving field. All applicants will be encouraged to submit an and the majority of participants will present a talk or poster. Speakers will be chosen by session leaders and the meeting organizers from the most timely and interesting s submitted a few months in advance of the conference, ensuring that late-breaking science is covered in all of the talks. In the event that the conference is oversubscribed, participants will be chosen to include at least one representative from each participating laboratory. This conference has an excellent track record for highlighting the work of younger investigators and women. To encourage participation by junior investigators, a special lecture is presented by a graduate student who has written the best Ph.D. thesis since the previous meeting (Elkins lecture). The subsequent meetings (2009 and 2011) will follow a similar format and will include topics that are highly relevant at the time of the meeting. This Neurobiology of Drosophila conference focuses on advances made using the combined power of genetics, molecular biology, biochemistry, cell biology, electrophysiology, imaging, and behavioral analysis to address fundamental issues in neurobiology using the Model Organism Drosophila Melanogaster. The topics covered will range from molecular biology to complex behavior and include neuronal and glial fate, neural circuits and function, cell biology and pathology, sensory systems, behavior, synaptic transmission, process formation, and technology development. By vote of the previous participants, the meeting will remain of moderate size (430 participants) and will have no parallel sessions so as to facilitate discussion, exchange of ideas and techniques, and to promote new collaborations in this rapidly evolving field. All applicants will be encouraged to submit an and the majority of participants will present a talk or poster. Speakers will be chosen by session leaders and the meeting organizers from the most timely and interesting s submitted a few months in advance of the conference, ensuring that late-breaking science is covered in all of the talks.

Keywords: Drosophilidae, meeting /conference /symposium, neurobiology, ing, behavior, biochemistry, cell biology, electrophysiology, model, molecular biology, molecular genetics, motivation, neural transmission, organism, pathology, technology /technique development

Project start date: 2007-07-01

Project end date: 2008-06-30

1R13NS060548-01 (2007): $10000

CSHL CONFERENCE ON MOUSE DEVELOPMENT, GENETICS AND GENOMICS

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13HD066880-01 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development

Abstract: The mouse is undoubtedly the premiere genetic system for a variety of mammalian studies. Significant advances have been made in a number of diverse fields using the mouse as a model system, in particular, in developmental biology, immunology, hematology, neurobiology, and oncology. Over the last two decades, there has been a dramatic increase in experimental studies in the mouse, largely as a result of striking technical and conceptual developments, culminating in the 2007 Nobel prize in physiology or medicine being awarded to three mouse geneticists "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells". This conference grant application seeks support for the twenty-third of an annual series of meetings that has emerged as the premiere meeting for this field. The meeting series alternates between Cold Spring Harbor and a European venue, with the 2010 meeting to be held at the Cold Spring Harbor Laboratory. The proposed meeting on "Mouse Development Genetics & Genomics" will assemble leaders in the field, junior faculty, postdoctoral fellows, and graduate students to discuss the latest research, and to share information about new, cutting-edge developments in the field. Topics to be discussed for the 2010 meeting will include Germ Cells and Stem Cells; Patterning; Neurobiology; Epigenetics; Organogenesis; Genetics and Genomics; Human Disease Models; as well as New Technologies. Given the diverse approaches currently employed in this field, communication among workers is essential to advance research and understanding of fundamental processes in mammalian development, and how these processes are disrupted in a variety of diseases. Oral presentations will be selected by the session chairs in consultation with the organizers. Each session will be chaired by two leading scientists in the field. Selected speakers will include graduate students, postdoctoral fellows, and junior faculty. The meeting will commence with a special lecture in honor of the late Dr. Rosa Beddington. In 2010, the organizing committee has established a Keynote Lecture that will cover a topic of central interest to the meeting to complement the Beddington lecture. There will also be two or three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and 300-350 mouse geneticists and genomicists are expected in attendance. Over the last two decades, there has been a dramatic increase in elegant genetic studies in the mouse, largely as a result of striking technical and conceptual developments, culminating in the 2007 Nobel prize in physiology or medicine being awarded to three mouse geneticists "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells". The mouse has undoubtedly become the premiere genetic system for a variety of mammalian studies - significant advances have been made in a number of diverse fields including developmental biology, immunology, hematology, neurobiology and oncology. These efforts have been accelerated by the availability of large amounts of genome-wide data that underscore the similarities between mice and humans at the gene and biochemical level. This conference series continues to build on the success of the mouse as a model for human development and disease. The series is notable because the majority of talks are selected from openly submitted s giving ample opportunity for broad and diverse representation of junior scientists including graduate students to present their latest research. National Institutes of Health funding will be used to support invited speakers, and junior scientists and members of under-represented constituencies within the field who would otherwise not be able to attend

Keywords: Applications Grants; Award; Biochemical; Biological Models; Cancer, Oncology; Communication; Complement; Complement Proteins; Consultations; Data; Development; Developmental Biology; Disease; Disease model; Disorder; ES cell; Employee Strikes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; European; Faculty; Funding; Gametes; Genes; Genetic; Genomics; Germ Cells; Germ-Line Cells; Grant Proposals; Grants, Applications; Hematology; Human; Human Development; Human, General; Immunology; Immunology (Including BRMP); Immunology (NCI Program); Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Mammals, Mice; Man (Taxonomy); Man, Modern; Medicine; Mice; Model System; Modeling; Models, Biologic; Modification; Mother Cells; Murine; Mus; NIH; National Institutes of Health; National Institutes of Health (U.S.); Neurobiology; Nobel Prize; Oral; Organogenesis; Participant; Pattern; Physiology; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Process; Progenitor Cells; Reproductive Cells; Research; Research Associate; Rosa; Rose; Science of Medicine; Scientist; Series; Sex Cell; Stem cells; Strikes; Strikes, Employee; System; System, LOINC Axis 4; United States National Institutes of Health; Work; ing; conference; disease/disorder; disorder model; embryonic stem cell; experiment; experimental research; experimental study; genome-wide; graduate student; human disease; initial cell; interest; lectures; meetings; member; mouse development; neurobiological; new technology; oncology; post-doc; post-doctoral; posters; research study; sexual cell; stem cell of embryonic origin; success; symposium

Relevance: Mouse Development, Genetics & Genomics Over the last two decades, there has been a dramatic increase in elegant genetic studies in the mouse, largely as a result of striking technical and conceptual developments, culminating in the 2007 Nobel prize in physiology or medicine being awarded to three mouse geneticists "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells". The mouse has undoubtedly become the premiere genetic system for a variety of mammalian studies - significant advances have been made in a number of diverse fields including developmental biology, immunology, hematology, neurobiology and oncology. These efforts have been accelerated by the availability of large amounts of genome-wide data that underscore the similarities between mice and humans at the gene and biochemical level. This conference series continues to build on the success of the mouse as a model for human development and disease. The series is notable because the majority of talks are selected from openly submitted s giving ample opportunity for broad and diverse representation of junior scientists including graduate students to present their latest research. National Institutes of Health funding will be used to support invited speakers, and junior scientists and members of under-represented constituencies within the field who would otherwise not be able to attend

Project start date: 2010-08-01

Project end date: 2011-07-31

Budget start date: 1-AUG-2010

Budget end date: 31-JUL-2011

PFA/PA: PA-08-149

1R13HD066880-01 (2010): $8500

CSHL Conference On Mouse Molecular Genetics: Development & Disease

David J Stewart
Cold Spring Harbor Laboratory
p.o. Box 100
cold Spring Harbor, Ny 11724

Grant 1R13HD059260-01 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development IRG: CHHD

Project start date: 2008-09-01

Project end date: 2009-08-31

1R13HD059260-01 (2008): $6000

CSHL COURSE: PROGRAMMING FOR BIOLOGY

David J Stewart
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5T15HG000048-11 from National Human Genome Research Institute

Abstract: The goal of the Cold Spring Harbor Laboratory Course in Programming for Biology is to provide biologists with the knowledge and tools they need to deal with the genomic information explosion. Complementary to training in end-user tools such as BLAST, this course teaches researchers how to take charge of their data, analyze it, manage it and display it by creating programs, databases, and other software systems. Beginning with an intensive review of basic procedural Perl programming, this 14 day course will teach object-oriented Perl and its use in the implementation of complex analysis pipelines using practical software engineering and scientific computing methods. The course combines formal lectures with hands-on laboratories in which students solve a series of computational problem sets drawn from common scenarios in biology research and data management. Students also pose problems using their own data and work together in groups and with faculty to solve them. Computer programming is now an indispensable part of biology research. The Programming for Biology course was designed to give biologists the expanded bioinformatics skills necessary to analyze their increased volume of data in order to pursue their research

Keywords: Analysis, Data; Bio-Informatics; Bioinformatics; Biology; Blast Cell; Blasts; Charge; Complex; Computer Programs and Programming; Computer Software Development; Computer Software Engineering; Data; Data Analyses; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Educational process of instructing; Engineering, Software; Explosion; Faculty; Ferrata cell; Genomics; Goals; Hand; Hematohistioblast; Hemocytoblast; Hemohistioblast; Instruction; Investigators; Knowledge; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Methods; Programs (PT); Programs [Publication Type]; Research; Research Personnel; Researchers; Series; Software Engineering; Students; Teaching; Training; Work; clinical data repository; clinical data warehouse; computer program; computer programming; data management; data repository; design; designing; lectures; programs; relational database; scientific computing; skills; software systems; tool

Project start date: 2000-07-07

Project end date: 2014-08-31

Budget start date: 1-SEP-2010

Budget end date: 31-AUG-2011

5T15HG000048-11 (2010): $61800

2T15HG000048-10 (2009): $60000

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2008 CSHL GERM CELLS CONFERENCE

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5R13HD058377-03 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development

Abstract: The germ line is the tissue specialized for generation of gametes; it includes oocytes and sperm in addition to immature germ cells such as germline stem cells. The somatic tissues of the gonad are intimately linked with the correct development and health of the germ line. The germline tissue is of tremendous practical and scholarly significance. It may well be the ultimate source of stem cells for tissue replacement in diseased or injured individuals, and it impacts issues of both contraception and fertility. Therefore, germline biology is crucial for both medicine and agriculture. Major intellectual and technical advances have spurred new and exciting findings in germ cell research. This impressive progress derives from a range of studies in both vertebrates and invertebrates. It is therefore critical that researchers from diverse technical and academic arenas be brought together to share their insights and discoveries. This proposal seeks support for the sixth, seventh, and eighth of a biennial series of meetings held at Cold Spring Harbor Laboratory that has emerged as the premiere meeting for this field. The 2008 Germ Cells meeting will be held October 1-5, 2008 at the Cold Spring Harbor Laboratory, and subsequent meetings will be held in the fall of 2010 and 2012. This meeting series is intended to provide a public forum for discussion of all aspects of germ cell research, from specification of primordial germ cells in the early embryo to the function of gametes in adults. The meeting will embrace investigations of germ cells in diverse organisms, including model organisms and humans. We expect to attract 250-300 participants from around the world. There are no competing meetings of similar scope in this important research area. Eight broad topics have been chosen for platform presentations Themes in Germ Cell Biology, Germ Line and Reprogramming, Germ Cell Patterning and Specification, Germ Cell Formation In Vitro, Germ Line Stem Cells, Epigenetic Regulation, Post-Transcriptional Regulation of Germ Cell Development, and Germline Programs. Each session will be organized and co-chaired by two experts in the field. Speakers generally will include the chairs plus one or two additional invited speakers for each session; the remainder will be selected from submitted s. We will encourage platform presentations from young scientists. We will also ensure time for interactions between scientists, particularly during meals and in poster sessions. Animals and plants are composed of two types of cells the ´mortal´ somatic cells, which form the body of the organism, and the ´immortal´ germ cells, which produce the next generation. During development, precursor or primordial germ cells are created in the embryo, eventually to become mature germ cells - sperm or eggs. This international conference will cover the latest research in germ cell biology. A better understanding of these processes will help to tackle infertility in human beings and certain kinds of developmental defects in children, as well as improved plant and animal breeding for agriculture and livestock management

Keywords: 0-11 years old; 21+ years old; Adult; Agriculture; Animal Model; Animal Models and Related Studies; Animals; Area; Biology; Body Tissues; Cannot achieve a pregnancy; Cellular biology; Child; Child Youth; Children (0-21); Contraception; Contraceptive methods; Defect; Development; Difficulty conceiving; Embryo; Embryonic; Ensure; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Farm Animal; Fecundability; Fecundity; Fertility; Fertility Control; Gametes; Generations; Germ Cells; Germ Lines; Germ-Line Cells; Gonadal structure; Gonads; Health; Human; Human, Adult; Human, Child; Human, General; In Vitro; Individual; Infertility; Inhibition of Fertilization; International; Invertebrata; Invertebrates; Invertebrates, General; Investigation; Investigators; Laboratories; Link; Livestock; Livestocks; Man (Taxonomy); Man, Modern; Medicine; Mother Cells; Oocytes; Organism; Ovocytes; Participant; Pattern; Plants; Plants, General; Post-Transcriptional Control; Post-Transcriptional Regulation; Post-Transcriptional Regulation Process; Posters; Posters [Publication Type]; Primordial Germ Cell; Process; Progenitor Cells; Programs (PT); Programs [Publication Type]; Regulation; Reproductive Cells; Research; Research Personnel; Researchers; Science of Medicine; Scientist; Series; Sex Cell; Somatic Cell; Source; Sperm; Spermatozoa; Stem cells; Structure of primordial sex cell; Time; Tissues; Vertebrate Animals; Vertebrates; ing; adult human (21+); agricultural; animal breeding; cell biology; cell type; children; conference; egg; falls; improved; infertile; initial cell; injured; insight; living system; meetings; model organism; next generation; posters; programs; sexual cell; sperm cell; symposium; unable to bear children; vertebrata; youngster; zoosperm

Project start date: 2008-07-01

Project end date: 2013-06-30

Budget start date: 1-JUL-2010

Budget end date: 30-JUN-2011

PFA/PA: PA-06-041

5R13HD058377-03 (2010): $6000

5R13HD058377-02 (2009): $1

1R13HD058377-01 (2008): $6000

Cold Spring Harbor 72nd Symposiumon Quantitative Biology: Clocks And Rhythms

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 1R13NS058217-01 from National Institute Of Neurological Disorders And Stroke IRG: ZNS1

Abstract: The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from the U.S., as well as from broad, so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal requests support for the 72nd Cold Spring Harbor Symposium which will focus on "Clocks and Rhythms". The meeting will address the phenomenon of biological clocks and their function and dysfunction in a variety of cells, tissues and organisms. All living organisms have internal body clocks that keep track of time, notably the dark-light cycle of the normal day. The molecular basis of these clocks has been the focus of intensive research over the past half-century. Biological rhythms depend upon the body clock, and in turn influence and are regulated by sleep and wakefulness, diet, metabolic rate, and body temperature. Disruption of these rhythms not only affects sleep patterns but also has been found to cause depression and related illness. The 2007 Cold Spring Harbor Symposium will bring together the leading experts in the field to discuss their latest findings.

Keywords: circadian rhythm, meeting /conference /symposium, travel

Project start date: 2007-04-01

Project end date: 2008-03-31

1R13NS058217-01 (2007): $10000

CSHL COURSE ON YEAST GENETICS AND GENOMICS

David J Stewart
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 2T15HG004331-04 from National Human Genome Research Institute

Abstract: The Cold Spring Harbor Laboratory Yeast Genetics and Genomics Course proposes to continue with a long tradition of serving a critical role in the training of investigators new to the use of Saccharomyces cerevisiae for biological research. The course title reflects a greater emphasis on familiarizing participants with the use of the latest techniques in genomics and proteomics. This highly intensive three-week course is designed to make each student proficient in the fundamentals of yeast genetics, which then establishes the conceptual backbone for the more sophisticated methods that are covered as the course progresses. The laboratory experiments are broken into twelve multi-part sections that cover a variety of topics including 1. Fundamentals of working with yeast; classical genetics and related topics in cell biology; 2. Introduction to yeast molecular biology; 3. Live cell microscopy techniques and image-based assays and analysis methods; 4. Genetic and physical interaction analysis; and 5. Genomics. The experimental portion of the course is complemented by daily theoretical lectures by the instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. As a result every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The course has a well-established reputation for, and seeks to continue, serving a diverse community of biologists as well as the physical sciences; biophysics, mathematics, chemistry, engineering, computer science. Researchers are attracted to the course as a consequence of the clear benefit from the utilization of yeast, given the large number of resources available in this model organism. In addition, educators that seek to incorporate yeast approaches in undergraduate courses are occasional students in the course. Although the general organization of the course is intended to remain the same from year to year, there is a natural evolution in content as the broad field of yeast biology and genomics changes; as instructors are replaced (~1 per year) new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Since at least two instructors remain from year to year, this evolution does not come at the sacrifice of continuity. The primary objective of the Yeast Genetics and Genomics summer course is to provide participants with intense instruction in classical, molecular and genomics approaches to the genetics of yeast. This course provides an intensive laboratory and lecture experience over a three week period that will prepare the participant to enter directly into research in yeast genetics and genomics

Keywords: Animal Model; Animal Models and Related Studies; Arts; Assay; Bioassay; Biologic Assays; Biological Assay; Biology; Biophysics; Cells; Cellular biology; Chemistry; Communities; Complement; Complement Proteins; Curriculum; DNA Molecular Biology; Educational Curriculum; Educational process of instructing; Engineering; Engineerings; Evolution; Genetic; Genomics; Imaging Procedures; Imaging Techniques; Instruction; Investigators; Laboratories; Lectures; Lectures (PT); Lectures [Publication Type]; Life; Mathematics; Methods; Methods and Techniques; Methods, Other; Microscopy; Molecular; Molecular Biology; Participant; Proteomics; Research; Research Personnel; Research Resources; Researchers; Resources; Role; S cerevisiae; Saccharomyces cerevisiae; Science of Chemistry; Series; Spinal Column; Spine; Students; System; System, LOINC Axis 4; Teaching; Technics, Imaging; Techniques; Technology; Vertebral column; Work; Yeast, Baker`s; Yeast, Brewer`s; Yeasts; backbone; base; biological research; cell biology; computer science; design; designing; experience; experiment; experimental research; experimental study; instructor; investigator training; lectures; model organism; physical science; public health relevance; research study; social role; yeast genetics

Relevance: RELEVANCE (See instructions): The primary objective of the Yeast Genetics and Genomics summer course is to provide participants with intense instruction in classical, molecular and genomics approaches to the genetics of yeast. This course provides an intensive laboratory and lecture experience over a three week period that will prepare the participant to enter directly into research in yeast genetics and genomics

Project start date: 2007-07-01

Project end date: 2013-06-30

Budget start date: 18-SEP-2010

Budget end date: 30-JUN-2011

2T15HG004331-04 (2010): $51905

5T15HG004331-03 (2009): $50393

1T15HG004331-01 (2007): $47500

CSHL Computational And Comparative Genomics Course

David J Stewart
Cold Spring Harbor Laboratory
p.o. Box 100
cold Spring Harbor, Ny 11724

Grant 2T15HG000013-15 from National Human Genome Research Institute IRG: GNOM

Project start date: 1991-06-06

Project end date: 2013-07-31

2T15HG000013-15 (2008): $47397

CSHL Genome Informatics Conference

David J Stewart
Cold Spring Harbor Laboratory
p.o. Box 100
cold Spring Harbor, Ny 11724

Grant 1R13HG004482-01 from National Human Genome Research Institute IRG: GNOM

Abstract: The Cold Spring Harbor Laboratory conference on Genome Informatics will focus on the provision and utilization of large scale genomic data and annotations. Genomic resources provide the fundamental descriptions of an increasing array of organisms at the molecular level. This meeting forms part of a series that alternates annually between Cold Spring Harbor, USA and Hinxton, UK, The goal of the series is to explore both the latest provision of these resources, and perhaps most importantly, their use as engines of biological discovery. This ranges from the storage of data and their associated data models, to the design of effective algorithms to uncover non-obvious aspects of these datasets, to ontologies to concisely describe biological information, and software systems to support curation, visualization, and exploration. The conference also covers the use of genomics in combination with various imaging applications and the latest attempts to understand microbial pathogenesis based on genomics. The conference has expanded its remit over the last few years, to ensure it remains current with the latest applications of informatics, all the while ensuring a strong focus on biological informatics. The conference brings together some of the leading scientists in this growing field, and we strongly encourage researchers from other large scale information handling disciplines to attend

Project start date: 2007-08-02

Project end date: 2008-07-31

1R13HG004482-01 (2007): $22000

2010 COLD SPRING HARBOR LABORATORY SYMPOSIUM ON QUANTITATIVE BIOLOGY: NUCLEAR ORG

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13GM093545-01 from National Institute Of General Medical Sciences

Abstract: Stewart, David Cold Spring Harbor Laboratory Conference 75th Annual Symposium on Quantitative Biology Nuclear Organization and Function June 2 - 7, 2010 The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from abroad, as well as the U.S., so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal request support for the period 2010 to cover the 75th Cold Spring Harbor Symposium which will focus on "Nuclear Organization and Function" and reflects the growing convergence between descriptive cell biological approaches to the nucleus and mechanism-driven approaches to nuclear processes that is now shedding light on the connections and dynamics between processes, to better establish how the structural and functional organization of the primary control center of the cell operates. In particular, this application seeks federal support for junior participants including selected Symposium Fellows to actively present their latest work at this historic occasion, as well as some of the invited speakers who form the core of the meeting. The nucleus is the operational headquarters of the cell, where the DNA and chromosome that make up our genetic material are housed. The nucleus has a well defined periphery or membrane through which materials including proteins, nucleic acids and small molecules have to traffic into and out the nucleus through gate-like pores. It is becoming increasingly clear that inside the nucleus, a complicated and dynamic architecture helps to determines when and how genes are turned on and off. Human diseases including accelerated aging are now understood to involve aberrations in some of these structures or mechanisms. This Symposium will address the dynamic organization and function of the nucleus, and how advances in our understanding of these systems may help in preventing or treating these diseases

Keywords: Address; Aging; Architecture; Archives; Area; Biochemistry; Biological; Biology; Cell Nucleus; Cells; Cellular biology; Chemistry, Biological; Chromosomes; DNA; DNA Molecular Biology; Data; Deoxyribonucleic Acid; Disease; Disorder; Engineering / Architecture; Ensure; Genes; Genetic; Genetic Materials; Housing; Interview; Laboratories; Light; Membrane; Minority; Molecular Biology; New York; Nuclear; Nucleic Acids; Nucleus; Participant; Photoradiation; Postdoc; Postdoctoral Fellow; Process; Programs (PT); Programs [Publication Type]; Proteins; Publishing; RFP; Request for Proposals; Research; Research Associate; Science; Scientist; Senescence; Senior Scientist; Staging; Structure; System; System, LOINC Axis 4; Video Recording; Videorecording; Woman; Work; biological research; cell biology; conference; disease/disorder; gene product; graduate student; human disease; meetings; membrane structure; post-doc; post-doctoral; prevent; preventing; programs; public health relevance; senescent; small molecule; symposium; trafficking; video recording system

Relevance: The nucleus is the operational headquarters of the cell, where the DNA and chromosome that make up our genetic material are housed. The nucleus has a well defined periphery or membrane through which materials including proteins, nucleic acids and small molecules have to traffic into and out the nucleus through gate-like pores. It is becoming increasingly clear that inside the nucleus, a complicated and dynamic architecture helps to determines when and how genes are turned on and off. Human diseases including accelerated aging are now understood to involve aberrations in some of these structures or mechanisms. This Symposium will address the dynamic organization and function of the nucleus, and how advances in our understanding of these systems may help in preventing or treating these diseases

Project start date: 2010-04-01

Project end date: 2011-03-31

Budget start date: 1-APR-2010

Budget end date: 31-MAR-2011

PFA/PA: PA-08-149

1R13GM093545-01 (2010): $10000

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2009 CSHL 74th Symposium On Evolution: The Molecular Landscape

David J Stewart
Cold Spring Harbor Laboratory

Grant 1R13GM086910-01 from National Institute Of General Medical Sciences IRG: ZGM1

Abstract: Stewart, David Cold Spring Harbor Laboratory Conference 74th Annual Symposium on Quantitative Biology EVOLUTION THE MOLECULAR LANDSCAPE May 27 - June 2, 2009 The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from abroad, as well as the U.S., so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal request support for the period 2009 to cover the 74th Cold Spring Harbor Symposium which will focus on "Evolution the Molecular Landscape" and is dedicated to Charles Darwin on the occasion of the bicentennial of his birth and the 150th anniversary of the publication of On the Origin of Species. The meeting will address our current understanding of evolutionary principles and mechanisms in a broad diversity of organisms. In particular, this application seeks federal support for junior participants including selected Symposium Fellows to actively present their latest work at this historic occasion. Given the anniversary of both Darwin´s birthday and the publication of his most important work, we are aware of many celebrations, exhibitions and events being held around the world. The 74th Cold Spring Harbor Symposium will distinguish itself from many of these gatherings by addressing a broad variety of evolutionary themes at a scientific level. In contrast with large society meetings, the Symposium´s intended scope is more focused, with greater emphasis placed on distilling our current understanding of evolutionary mechanisms and principles at the molecular level

Project start date: 2009-01-01

Project end date: 2009-12-31

CSHL CONFERENCE ON PTEN PATHWAYS

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5R13CA121807-03 from National Cancer Institute

Abstract: PTEN protein negatively regulates cellular signals used in a wide variety of physiological processes. At the molecular level, PTEN is a phosphatase that destroys the second messenger phosphatidylinositol-3,4,5-triphosphate (Pl- 3,4,5-P) by removing a phosphate from the inositol ring. When PTEN is mutated, PI-3,4,5-P levels rise in the cell. PI-3 kinase proteins generate PI-3,4,5-P. PTEN and PI-3 kinase are key mediators of many cell surface receptors. Insulin is perhaps the best understood signal that utilizes PTEN and PI-3 kinase. T his highly conserved pathway employs the insulin receptor to stimulate PI-3 kinase. Elevated PI-3,4,5-P levels activate AKT kinase, which can phosphorylate the FOXO family members to attenuate their transcriptional activity. PTEN also regulates many other proteins in the cell and has been implicated in the control of the cell cycle, metabolism, cell growth, apoptosis, oxidation, and migration. Aberrant PTEN pathway signaling is associated with cancer, diabetes, and Parkinson´s disease. Genetic alteration of the PTEN/PI-3 kinase pathway in cancer is extremely common and is an outstanding target for therapy. This meeting will comprehensively address topics of basic research, disease models, and therapeutic intervention for the ultimate purpose of improving patient care. This proposal seeks support for three successive biennial meetings to be held in 2006, 2008 and 2010

Keywords: 0-11 years old; 1-Phosphatidylinositol 3-Kinase; AKT; ATP[{..}]1-phosphatidyl-1D-myo-inositol 3-phosphotransferase; Address; Adhesion Plaques; Affect; Akt protein; Alleles; Allelomorphs; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Attenuated; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; BZS; Basic Research; Basic Science; Binding Proteins; Biochemical; Bladder; Brain; Breast; Breast Carcinoma; Cancer cell line; Cancer of Breast; Cancer of Prostate; Cancers; Candidate Disease Gene; Candidate Gene; Carcinoma of the Thyroid Gland; Cell Communication and Signaling; Cell Cycle Control; Cell Cycle Regulation; Cell Cycle Regulation, Including Apoptosis; Cell Death, Programmed; Cell Signaling; Cell Surface Receptors; Cell-Matrix Adherens Junctions; Cells; Cellular Expansion; Cellular Growth; Child; Child Youth; Childhood; Children (0-21); Chiro-Inositol; Chromosomes; Colon; Colon or Rectum; Colorectal; Cowden Syndrome; Cowden`s Disease; DNA Methylation; Development; Diabetes Mellitus; Disease; Disease model; Disorder; EC 2.7; Elephant Man Disease; Emerogenes; Encephalon; Encephalons; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Family; Family member; Female; Focal Adhesions; Focal Contacts; Generalized Growth; Genes; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Genes, Suppressor; Genetic; Genetic Alteration; Genetic Change; Genetic defect; Genital System, Male, Prostate; Germ-Line Mutation; Germinoblastoma; Germline Mutation; Growth; Hamartoma; Hamartoma Syndrome, Multiple; Head and Neck Cancer, Thyroid; Hereditary Mutation; Human; Human Prostate; Human Prostate Gland; Human, Child; Human, General; Humulin R; INSR; Idiopathic Parkinson Disease; Inositide Phospholipids; Inositol; Inositol Phosphates; Inositol Phosphoglycerides; Inositol Phospholipids; Insulin; Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-; Insulin Receptor; Insulin Receptor Protein-Tyrosine Kinase; Insulin, Regular; Insulin-Dependent Tyrosine Protein Kinase; Intermediary Metabolism; Intracellular Communication and Signaling; Intracellular Second Messengers; Investigators; Kanner`s Syndrome; Kinases; Lewy Body Parkinson Disease; Ligand Binding Protein; Link; Location; Lung; Lymphoma; Lymphoma (Hodgkin`s and Non-Hodgkin`s); Lymphoma, Malignant; METBL; MHAM; MMAC1; MMAC1 protein; MMAC1 protein, human; Macrocephaly; Malignant Melanoma; Malignant Neoplasms; Malignant Tumor; Malignant Tumor of the Breast; Malignant Tumor of the Prostate; Malignant neoplasm of breast; Malignant neoplasm of prostate; Malignant prostatic tumor; Mammalian Cell; Mammary Carcinoma; Man (Taxonomy); Man, Modern; Mediator; Mediator of Activation; Mediator of activation protein; Megacephaly; Megalocephaly; Mesoinositol; Metabolic Processes; Metabolism; Molecular; Molecular Genetic; Molecular Genetics; Multiple Hamartoma Syndrome; Mutate; Mutated in Multiple Advanced Cancers 1; Mutation; Names; Nervous System Diseases; Nervous System, Brain; Neurologic Disorders; Neurological Disorders; Novolin R; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Organ; Organism-Level Process; Organismal Process; PDK1; PDPK1; PDPK1 gene; PI-3 Kinase; PI-3K; PI3-Kinase; PKB protein; PRO0461; PTEN; PTEN Tyrosine Phosphatase; PTEN gene; PTEN protein; PTEN protein, human; PTEN-MMAC1 protein, human; PTEN1; Paralysis Agitans; Parkinson; Parkinson Disease; Parkinson`s; Parkinson`s disease; Parkinsons disease; Pathogenesis; Pathway interactions; Patient Care; Patient Care Delivery; Patients; Phosphatase and Tensin Homolog; Phosphatases; Phosphatidyl Inositol; Phosphatidylinositol 3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphatidylinositols; Phosphohydrolases; Phosphoinositide 3-Hydroxykinase; Phosphoinositides; Phosphomonoesterases; Phosphoric Monoester Hydrolases; Phosphotransferases; Physiologic Processes; Physiological Processes; Primary Parkinsonism; Promoter; Promoters (Genetics); Promotor; Promotor (Genetics); Prostate; Prostate CA; Prostate Cancer; Prostate Gland; Prostatic Cancer; Prostatic Gland; Protein Kinase B; Proteins; Proteus Syndrome; Proteus syndrome (PS); Proto-Oncogene Proteins c-akt; PtdIns; PtdIns 3-Kinase; RAC-PK protein; Receptors, Cell Surface; Research; Research Personnel; Researchers; Respiratory System, Lung; Reticulolymphosarcoma; Risk; Sarcoma, Germinoblastic; Scientist; Second Messenger Systems; Second Messengers; Second-Site Suppressor Genes; Signal Pathway; Signal Transduction; Signal Transduction Systems; Signaling; Skin; Skin Neoplasms; Suppressor Genes; Syndrome; Therapeutic Intervention; Thyroid Cancer; Thyroid carcinoma; Tissue Growth; Transphosphorylases; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tumor of the Skin; Type I Phosphatidylinositol Kinase; Type III Phosphoinositide 3-Kinase; Urinary System, Bladder; Wiedemann syndrome 2; Woman; base; biological signal transduction; c-akt protein; cell growth; children; conference; diabetes; disease/disorder; disorder model; gene product; genome mutation; human PTEN protein; improved; intervention therapy; malignancy; malignant breast neoplasm; meetings; melanoma; migration; mutated in multiple advanced cancers 1 protein; mutated in multiple advanced cancers 1 protein, human; neoplasm/cancer; nervous system disorder; neurological disease; oncosuppressor gene; ontogeny; oxidation; pathway; pediatric; phosphatase and tensin homolog (mutated in multiple advanced cancers 1), human; phosphatase and tensin homolog deleted from chromosome 10, human; phosphatase and tensin homologue on chromosome ten; proteiform syndrome; protein expression; protein-serine-threonine kinase (rac); proto-oncogene protein RAC; proto-oncogene protein akt; pulmonary; rac protein kinase; related to A and C-protein; second messenger; symposium; tensin; tensin1; triphosphate; tripolyphosphate; tumor; tumor suppressor; urinary bladder; youngster

Project start date: 2006-03-01

Project end date: 2011-02-28

Budget start date: 1-MAR-2010

Budget end date: 28-FEB-2011

PFA/PA: PAR-03-176

5R13CA121807-03 (2010): $7000

5R13CA121807-02 (2008): $7000

1R13CA121807-01 (2006): $15000

CSHL Conference On Molecular And Cellular Biology Of Plasminogen Activation

David J Stewart
Cold Spring Harbor Laboratory

Grant 1R13HL095204-01 from National Heart, Lung, And Blood Institute IRG: ZHL1

Abstract: Proteolytic regulation, in general, and plasminogen activation in particular, are rapidly advancing fields at the interface of scientific research, clinical medicine, and biotechnology. The XIIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation will meet in Cold Spring Harbor, New York from March 31 - April 4, 2009. This biennial meeting has become a major forum for the free exchange of information beyond that achieved by publication and presentation at more formal meetings. The Workshop is unique in that the scientific program is entirely -driven. Thus, all of the presentations are selected from submitted s. In addition, emphasis is placed upon involving young investigators and trainees to participate in each session. s will be scored according to scientific merit, and then organized into a final program of short talks and posters. The program will accommodate approximately 50 short (10-15 min) oral presentations. Junior investigators are expected to constitute 30-40% of attendees. Both chairpersons and nearly half of the projected discussion leaders are women. Topics to be discussed will include the structure and function of plasminogen activators and related proteins, and the newly discovered roles of the plasminogen activation system in cardiovascular biology, neurobiology, tumor biology, tissue remodeling and repair, infection, and host defense. In addition, we will add new sessions designed to consider the plasmin/plasminogen activator-matrix metalloproteinase interface. Also new will be sessions devoted to the growing list of recently discovered serine proteases and membraneassociated proteases. Finally, the program will encompass one session each on high throughput genomic and proteomic tools for protease biology and on protease targeting for therapeutic purposes. The Cold Spring Harbor Laboratory Conference Facility provides proximity to the New York airports, state-of-the-art audio-visual facilities, comfortable housing, and outstanding meal services. Because of the -driven nature of this meeting, the material presented is largely unpublished, and therefore overlaps minimally with other related meetings

Project start date: 2009-04-01

Project end date: 2010-03-31

CSHL 2010 CONFERENCE ON MOLECULAR GENETICS AND BACTERIA & PHAGES

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13AI091053-01 from National Institute Of Allergy And Infectious Diseases

Abstract: PI STEWART, DAVID J. Project 1R13AI091053-01 Title CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages Accession Number 3254930 ================== NOTICE THIS WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== COLD SPRING HARBOR LABORATORY CONFERENCE ON THE MOLECULAR GENETICS OF BACTERIA AND PHAGES AUGUST 24 - 28, 2010 PROJECT SUMMARY The Molecular Genetics of Bacteria and Phages Conference, traditionally held at Cold Spring Harbor and now being held in alternate years at the University of Wisconsin in Madison and at the Cold Spring Harbor Laboratory, is a central forum for the presentation of new results in prokaryotic molecular genetics. On the order of 200-400 participants attend, representing laboratories throughout the world, and most present either short talks or posters. Its breadth makes it an important focus for the exchange of information in this era of scientific specialization. Topics covered include fundamental work on bacterial replication, recombination, repair, transposition, transcription, control of gene expression, translation, signaling, heat shock, protein folding and secretion, stress response, cell development and division, and pathogenesis. In recent years, efforts have been made to include emerging areas such as genomics and metagenomics, sociomicrobiology, molecular ecology, structural biology and systems analysis. For many graduate students and postdoctoral fellows, this is the first large meeting at which they have an opportunity to speak. Due to its highly interactive nature, the meeting provides an important opportunity for these young scientists to meet and talk to the senior scientists they know from the literature. In response to the large numbers of students who attend the meeting and the diversity of topics covered, established and distinguished scientists are invited to chair each session. This strengthens the meeting because each chairperson gives a short introduction in which he or she summarizes some of the key facets of the field to be covered and provides a conceptual framework for the major questions that the talks will address. As an additional benefit, publicizing the judiciously chosen chairpeople and session topics in announcements of the meeting encourages the submission of s in exciting new areas and stimulates attendance by a larger constituency. COLD SPRING HARBOR LABORATORY CONFERENCE ON THE MOLECULAR GENETICS OF BACTERIA AND PHAGES AUGUST 24 - 28, 2010 LAY STATEMENT The unicellular microorganisms known as bacteria can be found in almost all ecosystems on the planet, from extreme environments to the human gut. Humans have evolved robust immunity to live alongside many bacteria, and indeed to use bacteria in processes from cheese-making to biotechnology, but under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis. Much as plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their metabolism and biochemistry. Phages have been used by scientists for many decades as exquisite genetic tools to probe many fundamental aspects of the molecular machinery at work in bacteria. This work has helped us to understand how bacteria control their life cycle, how cells reproduce and divide, and how they survive in and sense their environment. Research is now shifting from how individual bacterial cells function to how colonies of microorganisms collaborate and survive, and how these colonies adapt to changes in their environment, in niches as varied as in the soil, under the sea, or in an animal or human host. This international conference will provide a forum for scientists working on related topics to share their latest discoveries and will bring together the leading experts in the field

Keywords: Address; Animals; Area; Bacteria; Bacteriophages; Biochemistry; Biotechnology; Cell Communication and Signaling; Cell Function; Cell Process; Cell Signaling; Cell physiology; Cells; Cellular Function; Cellular Physiology; Cellular Process; Chair; Chairman; Chairperson; Chairwoman; Cheese; Chemistry, Biological; Cholera; Communicable Diseases; Development; Ecologic Systems; Ecology; Ecosystem; Environment; Environmental Science; Functional Metagenomics; Gene Expression; Gene Transcription; Genetic; Genetic Transcription; Genomics; HSP; Heat shock proteins; Homologous Recombinational Repair; Human; Human, General; Immunity; Individual; Infectious Disease Pathway; Infectious Diseases; Infectious Diseases and Manifestations; Infectious Disorder; Intermediary Metabolism; International; Intracellular Communication and Signaling; Laboratories; Life; Life Cycle; Life Cycle Stages; Literature; METBL; Man (Taxonomy); Man, Modern; Metabolic Processes; Metabolism; Metagenomics; Microorganisms, General; Molecular; Molecular Genetic; Molecular Genetics; Nature; Participant; Pathogenesis; Phages; Planets; Plants; Plants, General; Postdoc; Postdoctoral Fellow; Posters; Posters [Publication Type]; Process; RNA Expression; Recombination Repair; Research; Research Associate; Scanning; Scientist; Sea; Senior Scientist; Signal Transduction; Signal Transduction Systems; Signaling; Soil; Stress Proteins; Students; Subcellular Process; Syphilis; Systems Analyses; Systems Analysis; Systems, Ecological; TXT; Text; Transcription; Transcription, Genetic; Translations; Tuberculosis; Universities; Virus; Viruses, General; Wisconsin; Work; ing; bacterial virus; biological adaptation to stress; biological signal transduction; conference; disseminated TB; disseminated tuberculosis; graduate student; great pox; life course; meetings; microorganism; post-doc; post-doctoral; posters; protein folding; reaction; crisis; recombinational repair; response; stress response; stress; reaction; structural biology; symposium; tool; tuberculous spondyloarthropathy

Relevance: COLD SPRING HARBOR LABORATORY CONFERENCE ON THE MOLECULAR GENETICS OF BACTERIA AND PHAGES AUGUST 24 - 28, 2010 LAY STATEMENT The unicellular microorganisms known as bacteria can be found in almost all ecosystems on the planet, from extreme environments to the human gut. Humans have evolved robust immunity to live alongside many bacteria, and indeed to use bacteria in processes from cheese-making to biotechnology, but under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis. Much as plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their metabolism and biochemistry. Phages have been used by scientists for many decades as exquisite genetic tools to probe many fundamental aspects of the molecular machinery at work in bacteria. This work has helped us to understand how bacteria control their life cycle, how cells reproduce and divide, and how they survive in and sense their environment. Research is now shifting from how individual bacterial cells function to how colonies of microorganisms collaborate and survive, and how these colonies adapt to changes in their environment, in niches as varied as in the soil, under the sea, or in an animal or human host. This international conference will provide a forum for scientists working on related topics to share their latest discoveries and will bring together the leading experts in the field

Project start date: 2010-07-01

Project end date: 2011-06-30

Budget start date: 1-JUL-2010

Budget end date: 30-JUN-2011

PFA/PA: PA-08-149

1R13AI091053-01 (2010): $18500

COLD SPRING HARBOR LABORATORY 2010 CONFERENCE OF VERTEBRATE ORGANOGENESIS

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 1R13HD065371-01 from Eunice Kennedy Shriver National Institute Of Child Health & Human Development

Abstract: One of the goals of modern biomedical research is to promote the repair and regeneration of damaged tissues and organs. This includes the engineering or grafting of replacement tissues from stem cells and the enhancement of endogenous repair processes. In order to achieve this goal we need a detailed understanding of how normal organs are assembled during embryonic development. In addition, we need to know more about changes in damaged tissues and the consequences of abnormal development. Recent advances in stem cell biology are impressive, and have strengthened our collective optimism that gene and stem cell-based therapies may eventually become realistic approaches in the treatment of many diseases, particularly those that have a significant pathological effect on specific organs. Central to that goal is a clear understanding of the genes and mechanisms controlling vertebrate organogenesis in health and disease, and a meeting focusing on those topics is long due. A number of meetings and symposia dealing with developmental biology are held around the world every year. However, of those focus exclusively on vertebrate organogenesis, nor do they combine speakers covering both normal development and pathological changes associated with organ damage and disease. Meetings sponsored by the Cold Spring Harbor Laboratory have a history of being the forum where new discoveries, concepts, and scientific connections are presented. The proposed inaugural conference will set the standards to continue with this meeting in a two years basis. The organizers expect this conference to become the reference meeting "to attend" by those working in related topics. This conference aims to provide a forum in which basic and disease-oriented researchers working in various animal models in diverse aspects of organ development can present their latest findings as well as an overview of the field in normal and pathological conditions. In this setting, the conference will provide the opportunity for an important exchange of information and ideas among basic scientists, clinical fellows, and scientists working in biotech companies, and ideally, help to establish fruitful collaborations. Six major topics have been chosen for detailed discussion, each including basic and disease-oriented presentations, as a reflection of the most advanced and interesting areas of study in development & disease. These topics are all ultimately united by the use of approaches that pursue answers to key biological questions. A clear demonstration of the interest on this type of conference is the fact that the organizers have already managed to confirm the participation of an outstanding list of speakers that includes most of the leaders on each of the organs/tissues to be discussed at this conference. NARRATIVE The specific goals of this conference are to bring together a diverse group of scientists, clinicians, and biotech companies interested in studying various molecular, cellular, and genetic aspects of vertebrate organogenesis in basic, clinical, and translational settings. This meeting is intended to provide a unique format for the exchange of ideas and information, to discuss the latest research findings and technical advances, and to facilitate the intellectual unification of research on vertebrate organogenesis and related disease states in diverse systems

Keywords: Animal Model; Animal Models and Related Studies; Area; Biological; Biomedical Research; Body Tissues; Cell Therapy; Clinical; Collaborations; Development; Developmental Biology; Disease; Disorder; Embryo Development; Embryogenesis; Embryonic Development; Engineering; Engineerings; Genes; Genetic; Goals; Health; History; Investigators; Laboratories; Molecular; Mother Cells; Natural regeneration; Organ; Organogenesis; Process; Progenitor Cells; Recording of previous events; Regeneration; Research; Research Personnel; Researchers; Scientist; Stem cells; System; System, LOINC Axis 4; Therapy, Cell; Tissues; Work; base; cell-based therapy; conference; disease/disorder; interest; meetings; model organism; optimism; postiive attitude; regenerate; repair; repaired; stem cell biology; symposium

Relevance: Inagural Cold Spring Harbor meeting on Vertebrate Organogenesis Narrative The specific goals of this conference are to bring together a diverse group of scientists, clinicians, and biotech companies interested in studying various molecular, cellular and genetic aspects of vertebrate organogenesis in basic, clinical and translational settings. This meeting is intended to provide a unique format for the exchange of ideas and information, to discuss the latest research findings and technical advances, and to facilitate the intellectual unification of research on vertebrate organogenesis and related disease states in diverse systems

Project start date: 2010-04-01

Project end date: 2015-03-31

Budget start date: 1-APR-2010

Budget end date: 31-MAR-2011

PFA/PA: PA-08-149

1R13HD065371-01 (2010): $12000

CSHL 2008 CONFERENCE ON MECHANISMS AND MODELS OF CANCER

David J Stewart, Executive Director, Meetings And Courses
Cold Spring Harbor Laboratory, P.o. Box 100, Cold Spring Harbor, Ny 11724

Grant 5R13CA133972-02 from National Cancer Institute

Abstract: Molecular alterations in tumor suppressor genes and oncogenes and their associated pathways and networks contribute in a very significant way to the development of human cancers. The last several years have seen an enormous increase in research dealing with cancer genes and their roles in growth control and various stages of tumor development. The proposed conference, in the tradition of Cold Spring Harbor meetings, will emphasize new discoveries and provide an open forum for the presentation of the latest research and results on different aspects of research on molecular mechanisms and cell and animal models of cancer. This proposal seeks support for three successive biennial meetings to be held in 2008, 2010 and 2012. The 2008 meeting will include the following topics Cancer Genetics & Epigenetics; Mouse Models of Cancer; Stem Cells and Organismal Development; Signaling Mechanisms; Microenvironment & Inflammation; Experimental Therapeutics; DNA Damage and Cell Cycle Checkpoints; and Senescence & Apoptosis. The precise scope of the individual sessions will be decided on the basis of the openly submitted s. Each session will be chaired by two established scientists in the field including the organizers, who will establish the format of each session based on the submitted s. The chairs will introduce and give an overview of the topics in their sessions. Particular attention will be given to encouraging the active participation of graduate students, postdoctoral fellows and new investigators, as well as the attendance of leading scientists in the field. Two leading experts in diverse areas of cancer genetics will deliver keynote addresses during the conference. It is anticipated that the meeting will provide unique opportunities for the exchange of data and ideas by both junior and senior investigators in different areas of research as they apply to cancer genetics and tumor suppressor genes. Given the success of past meetings held at CSHL on this topic between 1996 and 2006, we anticipate the attendance of about 400 scientists from laboratories around the world

Keywords: Address; Animal Cancer Model; AnimalModel; Anti-Oncogenes; Antioncogenes; Apoptosis; Apoptosis Pathway; Area; Attention; Cancer Genes; Cancer Model; Cancer Staging; Cancer-Promoting Gene; CancerModel; Cancers; Cell Communication and Signaling; Cell Cycle Checkpoint; Cell Death, Programmed; Cell Signaling; Cells; DNA Damage; DNA Injury; Development; Diagnostic Neoplasm Staging; Emerogenes; Epigenetic; Epigenetic Change; Epigenetic Mechanism; Epigenetic Process; Generalized Growth; Genes, Cancer Suppressor; Genes, Onco-Suppressor; Growth; Human Development; INFLM; Individual; Inflammation; Intracellular Communication and Signaling; Investigators; Laboratory Scientists; Malignant Neoplasms; Malignant Tumor; Molecular; Mother Cells; Neoplasm Staging; Oncogenes; Oncogenes, Recessive; Oncogenes-Tumor Suppressors; Pathway interactions; Postdoc; Postdoctoral Fellow; Progenitor Cells; Research; Research Associate; Research Personnel; Researchers; Role; Scientist; Signal Transduction; Signal Transduction Systems; Signaling; Stem cells; T-Stage; Therapeutic; Tissue Growth; Transforming Genes; Tumor Staging; Tumor Suppressing Genes; Tumor Suppressor Genes; Tumor stage; ing; base; biological signal transduction; cancer genetics; conference; data exchange; graduate student; malignancy; meetings; mouse model; neoplasm/cancer; oncosuppressor gene; ontogeny; pathway; post-doc; post-doctoral; senescence; social role; success; symposium

Project start date: 2008-08-01

Project end date: 2013-07-31

Budget start date: 1-AUG-2010

Budget end date: 31-JUL-2011

PFA/PA: PA-06-041

5R13CA133972-02 (2010): $6000

1R13CA133972-01 (2008): $0

CSHL Conference On Mechanisms And Models Of Cancer

David J Stewart
Cold Spring Harbor Laboratory P.o. Box 100 Cold Spring Harbor, Ny 11724

Grant 1R13CA121749-01 from National Cancer Institute IRG: ZCA1

Abstract: Molecular alterations in tumor suppressor genes and oncogenes and their associated pathways and networks contribute in a very significant way to the development of human cancers. The last several years have seen an enormous increase in research dealing with cancer genes and their roles in growth control and various stages of tumor development. The proposed conference, in the tradition of Cold Spring Harbor meetings, will emphasize new discoveries and provide an open forum for the presentation of the latest research and results on different aspects of research on molecular mechanisms and cell and animal models of cancer. This proposal seeks support for three successive biennial meetings to be held in 2006, 2008 and 2010. The 2006 meeting will include the following topics Cancer Signaling Pathways; Cell Cycle and Senescence; DNA Damage and Apoptosis Response; Tumor Microenvironment; Genomic Analysis and Screens; Oncogene/Tumor Suppressor Gene Networks in Tumor Development and Therapy; Rationalized Therapeutics; Animal Models of Cancer; Stem Cells and Cancer. The precise scope of the individual sessions will be decided on the basis of the openly submitted s. Each session will be chaired by two established scientists in the field including the organizers, who will establish the format of each session based on the submitted s. The chairs will introduce and give an overview of the topics in their sessions. Particular attention will be given to encouraging the active participation of graduate students, postdoctoral fellows and new investigators, as well as the attendance of leading scientists in the field. It is anticipated that the meeting will provide unique opportunities for the exchange of data and ideas by both junior and senior investigators in different areas of research as they apply to cancer genetics and tumor suppressor genes. Given the success of past meetings held at CSHL on this topic between 1996 and 2005, we anticipate the attendance of about 400 scientists from laboratories around the world.

Keywords: disease /disorder model, meeting /conference /symposium, neoplasm /cancer, travel

Project start date: 2006-07-01

Project end date: 2007-06-30

1R13CA121749-01 (2006): $4662

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