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Biomedical Informatics Research Training At Yale

Perry L Miller, Professor
Anesthesiologyyale University

Grant 5T15LM007056-23 from National Library Of Medicine IRG: ZLM1

Abstract: The Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based in the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s interdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each fellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical informatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational informatics. The overall goal is to provide all trainees with the necessary background and experience that will allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral trainees, 6 postdoctoral trainees, and 2 short-term trainees

Project start date: 1987-07-01

Project end date: 2012-06-30


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Biomedical Informatics Research Training At Yale

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5T15LM007056-22 from National Library Of Medicine IRG: ZLM1

Abstract: The Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based in the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s interdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each fellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical informatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational informatics. The overall goal is to provide all trainees with the necessary background and experience that will allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral trainees, 6 postdoctoral trainees, and 2 short-term trainees

Project start date: 1987-07-01

Project end date: 2012-06-30

5T15LM007056-22 (2008): $938744


5T15LM007056-20 (2006): $1256605

5T15LM007056-19 (2005): $1043144

5T15LM007056-18 (2004): $966927

5T15LM007056-17 (2003): $1188817

MEDICAL INFORMATICS RESEARCH TRAINING AT YALE

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5T15LM007056-15 from National Library Of Medicine IRG: ZLM1

Project start date: 1987-07-01

Project end date: 2002-06-30

5T15LM007056-15 (2001): $398600


5T15LM007056-14 (2000): $545596

5T15LM007056-12 (1998): $327510

5T15LM007056-10 (1996): $259458

5T15LM007056-08 (1994): $249076


Grants awarded to Perry L Miller

Planning A Biomedical Computing Center Of Excellence

Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047

Grant 5P20LM007253-03 from National Library Of Medicine IRG: ZRG1

Abstract: This application proposes a three-year project o plan for, and builds towards, a Biomedical Computing Center of Excellence at Yale. The overall theme of the Center will be "Harnessing Advanced Computing Technologies for Biomedicine." The Center will provide a focus for highly collaborative research and training involving many academic units and research support units within Yale University as a whole. The initial focus will be on four research themes 1) heterogeneous biomedical database design, b) multilevel approaches to facilitate interoperation among biological databases and software tools, c) integrative genomic database analysis, and d) high performance distributed biocomputing. These themes each build upon particular research strengths at Yale. The proposed activities including the following. 1. A central component of the proposal will involve planning for the establishment of the Center of Excellence. 2. A set of ongoing activities will promote interaction and collaboration among the academic units participating in the Center. 3. A Biomedical Computing Education Committee will plan for a full spectrum of educational activities. 4. Three pilot projects will be carried out a) developing a flexible pilot EAV/CR database for describing heterogeneous microarray expression experiments, b) integrative data mining to relate protein characteristics to gene expression patterns, and c) computational and statistical analysis of gene expression as a dynamical system using high performance computing techniques. Although the pilot projects will focus on different computational research themes, they all focus on the challenges posed by the analysis of experimental microarray data. 5. A Biomedical Computing Core will support the activities of the three pilot projects.

Keywords: computer center, computer system design /evaluation, molecular biology information system, education, education evaluation /planning

Project start date: 2001-09-15

Project end date: 2006-08-31

5P20LM007253-03 (2003): $438815


1P20LM007253-01 (2001): $295971

Biomedical Informatics Research Training At Yale

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 2T15LM007056-21 from National Library Of Medicine IRG: ZLM1

Abstract: The Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based in the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s interdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each fellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical informatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational informatics. The overall goal is to provide all trainees with the necessary background and experience that will allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral trainees, 6 postdoctoral trainees, and 2 short-term trainees

Project start date: 1987-07-01

Project end date: 2012-06-30

2T15LM007056-21 (2007): $907779


2T15LM007056-16 (2002): $758564

CORE--INFORMATICS

Perry L Miller, Professor
Yeshiva University 500 W 185th St New York, Ny 10033

Grant 3P01HG000965-03S29002 from National Human Genome Research Institute

Abstract: The Informatics Core of the proposed project will be based at the Yale Center for Medical Informatics, directed by Dr. Perry Miller. The Informatics Core will build on an existing project which is already developing physical gene mapping database support for all of the participating biological laboratories at Yale. The Informatics Core will include the following activities 1) A shared database will be implemented and maintained for use by all participating laboratories. The database will include laboratory inventories of biologic reagents, experimental results, and maps based on those results. The central server will be a Sybase relational database. Laboratories will access this database using Macintosh computers running the 4th-Dimension (4D) relational database package as a very user-friendly front end, accessing Sybase using "4D SQL Server," a commercial client-server package. 2) Software tools, for example for map assembly, analysis, and display, will run on the server system, on the local Macintoshes, and elsewhere on the network. 3) The database will also serve as a project management tool. 4) Informatics staff will work closely with the staff of the participating laboratories at Yale and at AECOM to develop and refine the database system, and to train them in its use. 5) The informatics activities will be coordinated with the rest of the national and international community in a number of ways. 6) Informatics staff will continue to maintain, modify, and update the database structure as new mapping techniques are developed, and as new types of mapping data are generated that need to be incorporated into the database. 7) Communication between the participating laboratories will be via electronic mail, and will be further enhanced by the coordination of activities that will result from use of the shared database.

Keywords: biomedical facility, computer assisted sequence analysis, genetic mapping, genetic registry /resource /referral center, information system, computer program /software, information dissemination


BIOINFORMATICS AND BIOSTATISTICS CORE

Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5P30DA018343-059001 from National Institute On Drug Abuse IRG: ZDA1

Abstract: The Bioinformatics and Biostatistics Core (BBC) aims at meeting the computational, statistical, and database challenge (including data quality, management, integration, analysis, and archiving) posed by the neuroproteomics research described in this proposal. The BBC, which will be directed by Dr. Perry Miller, consists of three inter-related units i) proteomics data quality and analysis, ii) proteomics database, and iii) functional and interrelative proteomics


BIOMEDICAL INFORMATICS RESEARCH TRAINING AT YALE

Perry L Miller, Professor
Yale University, 47 College Street, Ste 203, New Haven, Ct 06520-8047

Grant 3T15LM007056-23S1 from National Library Of Medicine

Abstract: ROVIDED. he Yale Biomedical Informatics Research Training Program is directed by Prof. Perry L. Miller and is based n the Yale Center for Medical Informatics (YCMI) and many other academic units at Yale, reflecting the diversity of Yale´s collaborative Biomedical Informatics research. Predoctoral training will be carried in Yale´s nterdepartmental PhD program in Computational Biology and Bioinformatics (CBB), which was inaugurated n 2003. The CBB program includes a core curriculum that will be taken by all trainees, for credit or as auditors (in the case of postdoctoral fellows not enrolled for a degree). Postdoctoral training includes each ellow defining one or two projects which can be carried out independently, under faculty supervision. Depending on their specific backgrounds and interests, postdoctoral fellows are encouraged to participate in a variety of other activities, including 1) attending teaching seminars and courses related to Biomedical nformatics including our core curriculum, 2) participating in institutional computing activities in both the clinical and bioscience arenas, and 3) helping in various teaching activities. In addition, a postdoctoral fellow may enroll in a graduate program to study for a Master´s degree or a PhD. The CBB curriculum was recently adapted to allow postdocs to get a CBB degree (MS or PhD) with an elective focus on translational nformatics. The overall goal is to provide all trainees with the necessary background and experience that i/vill allow them to pursue productive careers in Biomedical Informatics broadly defined. The scope of Biomedical Informatics activities is growing rapidly at Yale. We are requesting support for 12 predoctoral rainees, 6 postdoctoral trainees, and 2 short-term trainees

Keywords: Area; Base Sequence; Bio-Informatics; Bioinformatics; Biologic Sciences; Biological; Biological Sciences; Biological databases; Biomedical Research; Categories; Clinical; Clinical Data; Clinical Decision Support Systems; Clinical Evaluation; Clinical Informatics; Clinical Research; Clinical Study; Clinical Testing; Collaborations; Comparative Genome Hybridization; Computational Biology; Computer Analysis; Computer Software Tools; Computers; Confidentiality; Consultations; Curriculum; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Decision Making; Decision Support Systems, Clinical; Discipline; Disease; Disorder; Doctor of Philosophy; Education, Medical; Educational Curriculum; Educational process of instructing; Electrical Engineering; Enrollment; Face; Faculty; Foundations; Generalized Growth; Genes; Genes, Structural; Genetic; Genome; Genomics; Goals; Grant; Growth; Guidelines; Health; History; Housing; IT Systems; Individual; Informatics; Informatics, Clinical; Information Systems; Information Technology Systems; Institutes; Laboratories; Learning; Life Sciences; Macromolecular Structure; Master`s Degree; Medical Education; Medical Informatics; Methods; Methylation; Modeling; Molecular; Molecular Structure; Neurobiology; Nucleotide Sequence; Ontology; Organism; Pattern; Ph.D.; PhD; Position; Positioning Attribute; Postdoc; Postdoctoral Fellow; Privacy; Programs (PT); Programs [Publication Type]; Protein Methylation; R01 Mechanism; R01 Program; RPG; Recording of previous events; Recruitment Activity; Research; Research Associate; Research Grants; Research Project Grants; Research Projects; Research Projects, R-Series; Research Training; Residencies; Schools; Science; Scientist; Sequence Alignment; Software Tools; Soil; Solid; Structural Genes; Structure; Students; Supervision; Systems, Data; Teaching; Time; Tissue Growth; Tools, Software; Training; Training Programs; Underrepresented Minority; Vocabulary; Vocabulary Words; Work; base; biological systems; biomed informatics; biomedical informatics; career; clinical data repository; clinical data warehouse; clinical phenotype; clinical test; college student; comparative; comparative genomic hybridization; computational analysis; computational tools; computer science; computerized tools; data modeling; data repository; database design; density; design; designing; disease/disorder; enroll; experience; facial; falls; genome-wide; graduate student; interest; living system; member; neurobiological; nucleic acid sequence; ontogeny; post-doc; post-doctoral; post-doctoral training; postdoctoral training; pre-doc; pre-doctoral; predoc; predoctoral; privacy of information; programs; protein structure; recruit; relational database; research clinical testing; simulation; square foot; under-represented minority; underserved minority; university student

Project start date: 2009-08-01

Project end date: 2010-07-31

Budget start date: 1-AUG-2009

Budget end date: 31-JUL-2010

PFA/PA: RFA-LM-06-001

3T15LM007056-23S1 (2009): $98792


TOOLS TO SUPPORT COMPUTER BASED CLINICAL GUIDELINES

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5R01LM006682-03 from National Library Of Medicine IRG: BLR

Abstract: Adapted from ´s ) The proposed research will build, refine, and test in operational use, a set of software tools designed to help support, maintain, and iteratively revalidate computer-based clinical guidelines as they evolve over time. The project will focus on the domain of childhood immunization, and will build upon IMM/Serve, a childhood immunization forecasting program that takes as input a child´s immunization history, and produces recommendations as to which vaccinations are due and which vaccinations should be scheduled next. The effort required to modify and validate such a program as the clinical field evolves over time is a challenging task. It will be extremely important to have a robust set of tools to assist in this process. Partial prototype versions of certain of these tools already exist. 1. The project will refine and extend computer-based tools for immunization knowledge maintenance. These tools will include a) IMM/Def, a program which automatically generates the rule-based logic for the most complex portion ("kernel") of IMM/Serve´s knowledge, and b) IMM/Test, a program which automatically generates a set of test cases to help test the kernel logic. The project will also develop an organized set of strategies for immunization test case generation, and implement those strategies in the refined version of IMM/Test. 2. The project will build a Web site to support immunization knowledge maintenance. 3. The project will keep a detailed record of all modifications and customization of the knowledge, and will represent all the variations of the knowledge using a standardized format such as GLIF, the Guideline Interchange Format being developed as a standard for exchanging guidelines between sites. 4. The project will link IMM/Serve to a database designed to hold IMM/Serve´s analysis of a set of cases, so that the resulting package can be used as a tool to perform compliance assessment. 5. A set of evaluation studies will be carried out to help assess the efficacy of the tools and to help improve their functionality

Keywords: artificial intelligence, computer assisted medical decision making, computer assisted patient care, computer system design /evaluation, immunization, information system, pediatrics Internet, computer human interaction, computer program /software, medical record human data

Project start date: 1998-09-30

Project end date: 2003-08-31

5R01LM006682-03 (2000): $317318


1R01LM006682-01 (1998): $272102

Informatics Research In Support Of SenseLab

Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5P01DC004732-090002 from National Institute On Deafness And Other Communication Disorders IRG: ZRG1

Keywords: computational neuroscience, data management, olfaction data collection methodology /evaluation, informatics Internet


Core--Informatics Support

Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047

Grant 5P01DC004732-049001 from National Institute On Deafness And Other Communication Disorders IRG: ZMH1


MEDICAL INFORMATICS RESEARCH TRAINING AT YALE

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 3T15LM007056-15S1 from National Library Of Medicine IRG: ZLM1

Project start date: 1987-07-01

Project end date: 2002-06-30

3T15LM007056-15S1 (2001): $200000


BIOMEDICAL APPLICATIONS OF THE NEXT GENERATION INTERNET

Perry L Miller, Professor
Yale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 5N01LM093540-001 from National Library Of Medicine

Project start date: 1999-09-30

Project end date: 2002-09-29

5N01LM093540-001 (2000): $445071


MEDICAL INFORMATICS RESEARCH TRAINING AT YALE

Perry L Miller, Professor
Anesthesiologyyale University
47 College Street, Ste 203
new Haven, Ct 065208047

Grant 3T15LM007056-14S1 from National Library Of Medicine IRG: ZLM1

Project start date: 1987-07-01

Project end date: 2002-06-30

3T15LM007056-14S1 (2000): $50000


2T15LM007056-11 (1997): $331436

MEDICAL INFORMATICS RESEARCH TRAINING

Perry L Miller, Professor
Yale University 47 College Street, Ste 203 New Haven, Ct 065208047

Grant 2T15LM007056-06 from National Library Of Medicine IRG: BLR

Project start date: 1987-07-01

Project end date: 1997-06-30

2T15LM007056-06 (1992): $240008