ENHANCED BEHAVIORAL INTERVENTION TO IMPROVE LONG-TERM WEIGHT LOSS IN YOUNG ADULTS
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Grant 5U01HL096770-02 from National Heart, Lung, And Blood Institute
Abstract: This application is in response to RFA-HL-08-007 "Targeted Approaches to Weight Control for Young Adults". As outlined in the RFA, this application will focus on development, refinement, and evaluation of a behavioral approach to weight control in young adults, with the focus of this application being on enhancing long-term weight loss. Consistent with the RFA, young adults for this application are defined as individuals 18-35 years of age. The prevalence of obesity in young adults has been increasing, and excessive body weight have been linked to numerous chronic conditions including cardiovascular disease, diabetes, many forms of cancer, and numerous musculoskeletal problems. The focus of this application is to develop and evaluate interventions that may be appropriate for young adults to improve weight loss outcomes following a 24 month intervention. Therefore, the primary aim of this study is to examine whether an enhanced weight loss intervention (EWLI) that includes technology components results in improved weight loss in young adults (18-35 years of age) compared to a standard behavioral weight loss intervention (SBWP) over a period of 24 months. Additional aims include examination of these interventions on changes in body composition, body fat distribution, fitness, physical activity, dietary intake, and behavioral/psychosocial measures that may be predictive of behavior change. Assessments will occur at 0, 6, 12,18, and 24 months. This study involves the recruitment of 480 overweight and obese young adults (18-35 years of age). Subjects will participate in a 24 month behavioral weight loss program that includes a reduction in energy ntake and moderate-to-vigorous intensity exercise (progressively increasing from 100 to 300 minutes per week). Subjects will be randomized to receive this intervention (SBWP) or this intervention in combination with technology enhancements (EWLI). EWLI will receive daily text messaging prompts to reinforce adherence to the behavioral intervention from months 7-24, and will wear a monitor from months 13-24 that provides real-time feedback on energy expenditure and achievement of daily physical activity goals. It is hypothesized that these technology enhancements to EWLI will significantly improve weight loss, body composition, body fat distribution, fitness, physical activity, and dietary intake compared to SBWP. RELEVANCE (See instructions) Obesity rates of young adults have significantly increased and the ability to sustain weight loss long-term in this age group has been less than desirable. Therefore, there is a need to develop and implement effective intervention initiatives to address this public health concern, which is the focus of this proposed intervention study. (End of )
Keywords: Achievement; Achievement Attainment; Address; Adherence; Adherence (attribute); Age Group Unspecified; Age-Years; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Body Composition; Body Weight; Body Weight decreased; Body fat; Caloric Intake; Cancers; Cardiovascular Diseases; Chronic; Conditioning Therapy; Development; Diabetes Mellitus; Dietary intake; Energy Expenditure; Energy Intake; Energy Metabolism; Enhancement Technology; Evaluation; Exercise; Exercise, Physical; Feedback; Goals; Individual; Instruction; Intervention; Intervention Strategies; Intervention Studies; Life Style Modification; Link; Malignant Neoplasms; Malignant Tumor; Measures; Methods; Monitor; Motivation; Musculoskeletal; Obesity; Outcome; Over weight; Overweight; Physical activity; Physiologic; Physiological; Prevalence; Programs (PT); Programs [Publication Type]; Public Health; Randomized; Self Efficacy; TXT; Technology; Text; Time; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; ing; adiposity; adult youth; age group; behavior change; behavior intervention; behavioral intervention; body weight loss; caloric dietary content; cardiovascular disorder; corpulence; corpulency; corpulentia; diabetes; effective intervention; expectation; fitness; improved; interventional strategy; malignancy; neoplasm/cancer; obese; obese people; obese person; obese population; programs; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; response; weight control; weight loss intervention; wt-loss; young adult
Project start date: 2009-08-20
Project end date: 2014-05-31
Budget start date: 1-JUN-2010
Budget end date: 31-MAY-2011
PFA/PA: RFA-HL-08-007
5U01HL096770-02 (2010): $1143514
Sponsored Links Excellgen http://Excellgen.com
Grants awarded to John M Jakicic
ENHANCED BEHAVIORAL INTERVENTION TO IMPROVE LONG-TERM WEIGHT LOSS IN YOUNG ADULTS
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Grant 3U01HL096770-02S1 from National Heart, Lung, And Blood Institute
Abstract: This application is in response to RFA-HL-08-007 "Targeted Approaches to Weight Control for Young Adults". As outlined in the RFA, this application will focus on development, refinement, and evaluation of a behavioral approach to weight control in young adults, with the focus of this application being on enhancing long-term weight loss. Consistent with the RFA, young adults for this application are defined as individuals 18-35 years of age. The prevalence of obesity in young adults has been increasing, and excessive body weight have been linked to numerous chronic conditions including cardiovascular disease, diabetes, many forms of cancer, and numerous musculoskeletal problems. The focus of this application is to develop and evaluate interventions that may be appropriate for young adults to improve weight loss outcomes following a 24 month intervention. Therefore, the primary aim of this study is to examine whether an enhanced weight loss intervention (EWLI) that includes technology components results in improved weight loss in young adults (18-35 years of age) compared to a standard behavioral weight loss intervention (SBWP) over a period of 24 months. Additional aims include examination of these interventions on changes in body composition, body fat distribution, fitness, physical activity, dietary intake, and behavioral/psychosocial measures that may be predictive of behavior change. Assessments will occur at 0, 6, 12,18, and 24 months. This study involves the recruitment of 480 overweight and obese young adults (18-35 years of age). Subjects will participate in a 24 month behavioral weight loss program that includes a reduction in energy ntake and moderate-to-vigorous intensity exercise (progressively increasing from 100 to 300 minutes per week). Subjects will be randomized to receive this intervention (SBWP) or this intervention in combination with technology enhancements (EWLI). EWLI will receive daily text messaging prompts to reinforce adherence to the behavioral intervention from months 7-24, and will wear a monitor from months 13-24 that provides real-time feedback on energy expenditure and achievement of daily physical activity goals. It is hypothesized that these technology enhancements to EWLI will significantly improve weight loss, body composition, body fat distribution, fitness, physical activity, and dietary intake compared to SBWP. RELEVANCE (See instructions) Obesity rates of young adults have significantly increased and the ability to sustain weight loss long-term in this age group has been less than desirable. Therefore, there is a need to develop and implement effective intervention initiatives to address this public health concern, which is the focus of this proposed intervention study. (End of )
Keywords: Achievement; Achievement Attainment; Address; Adherence; Adherence (attribute); Age Group Unspecified; Age-Years; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Body Composition; Body Weight; Body Weight decreased; Body fat; Caloric Intake; Cancers; Cardiovascular Diseases; Chronic; Conditioning Therapy; Development; Diabetes Mellitus; Dietary intake; Energy Expenditure; Energy Intake; Energy Metabolism; Enhancement Technology; Evaluation; Exercise; Exercise, Physical; Feedback; Goals; Individual; Instruction; Intervention; Intervention Strategies; Intervention Studies; Life Style Modification; Link; Malignant Neoplasms; Malignant Tumor; Measures; Methods; Monitor; Motivation; Musculoskeletal; Obesity; Outcome; Over weight; Overweight; Physical activity; Physiologic; Physiological; Prevalence; Programs (PT); Programs [Publication Type]; Public Health; Randomized; Self Efficacy; TXT; Technology; Text; Time; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; ing; adiposity; adult youth; age group; behavior change; behavior intervention; behavioral intervention; body weight loss; caloric dietary content; cardiovascular disorder; corpulence; corpulency; corpulentia; diabetes; effective intervention; expectation; fitness; improved; interventional strategy; malignancy; neoplasm/cancer; obese; obese people; obese person; obese population; programs; psychosocial; public health medicine (field); randomisation; randomization; randomly assigned; response; weight control; weight loss intervention; wt-loss; young adult
Project start date: 2009-08-20
Project end date: 2014-05-31
Budget start date: 9-SEP-2010
Budget end date: 31-MAY-2011
PFA/PA: RFA-HL-08-007
3U01HL096770-02S1 (2010): $46450
1U01HL096770-01 (2009): $749948
OBESITY/NUTRITION RESEARCH CENTER
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Grant 3P30DK046204-15S2 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: The University of Pittsburgh is seeking to renew funding of the Obesity and Nutrition Research Center for its third five-year period. Established in 1992, the initial focus of the Pittsburgh Center was on behavioral interventions. During the current funding cycle, under its new leadership, the Center has retained its focus on clinical investigation, but has substantially expanded its scope to include involvement with metabolic, epidemiological, body composition, genetic and laboratory investigations of obesity and nutrition. At the same time the Center has built upon the prior strength in behavioral interventions for obesity by expanding these endeavors into eating disorders and additional aspects of physical activity and nutrition. Collectively, the goal of the Pittsburgh ONRC is to facilitate and promote research, especially collaborative and multi-disciplinary efforts, to develop more effective interventions for the prevention and treatment of obesity and to gain a more complete understanding of the causes and complications of obesity and other nutritional disorders. This goal is of major public health significance because a majority of adults in this country are overweight or obese, this prevalence is increasing, and the prevalence of obesity in children has increased dramatically during the past two decades. Two of the major complications of obesity are cardiovascular disease and diabetes mellitus, and the research base in these areas is very strong at the University of Pittsburgh. During the past funding cycle, several of the cores have grown significantly. There is now a robust program of body composition, bio-imaging and metabolic research in children and adults, and numerous large epidemiological trials entailing nutritional and activity interventions with vascular disease outcomes. The program and core support for behavioral interventions has also grown substantially, from a few senior investigators into a group of interactive, strongly funded investigators with complementary expertise for whom the presence of the ONRC core facilities has been pivotal. There are several key new initiatives underway including multi-disciplinary programs in childhood obesity and bariatric surgery. Bolstered by strong institutional support, a more diverse scientific base, new facilities, and new partnerships with the adult and pediatric GCRCs, the Pittsburgh ONRC is prepared to continue its important leadership role in clinical research for obesity and nutritional disorders
Project start date: 1992-09-30
Project end date: 2010-05-31
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2 (2009): $257357
3P30DK046204-15S1 (2008): $0
5P30DK046204-15 (2007): $0
Enhancing Exercise Participation In Overweight Women
John M Jakicic, Chair
University Of Pittsburgh At Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260
Grant 5R01HL067826-04 from National Heart, Lung, And Blood Institute IRG: ZRG1
Abstract: The primary goal of this study is to examine whether enhancing the exercise intervention either during the initiation phase of treatment (EX-ADOPT) or during the maintenance phase of treatment (EX-MAINTAIN) improves long-term weight loss in a behavioral weight loss program compared to a standard behavioral intervention (SBWP). Secondary aims of this study include examining changes in cardio-respiratory fitness, percent body fat and body fat distribution, physical activity, and dietary intake in SBWP compared to both EX-ADOPT and EX-MAINTAIN. We will also examine potential mediators of physical activity behaviors. The prevalence of obesity has been increasing over the past few decades, and it is now estimated that in excess of 50 percent of adults are overweight. Exercise has been shown to be an important component of behavioral weight loss programs, and exercise appears to be associated with improvements in long-term weight loss. However, based on data from our studies, it appears that there may be key periods where the intervention should focus on the exercise component. One period appears to be during the adoption phase of treatment, as exercise participation early in treatment is predictive of long-term weight loss. Alternatively, it does appear that there are critical periods when exercise begins to decrease and weight begins to increase. Using a combination of proven strategies for improving exercise, we will target these two approaches in our proposed enhanced interventions (EX-ADOPT and EX-MAINTAIN), and examine if either of these approaches is more effective than SBWP for long-term weight loss. It is hypothesized that both EX-ADOPT and EX-MAINTAIN will improve weight loss, physical activity, fitness, and body composition compared to the SBWP across an 18-month intervention. Assessment of weight, fitness, and body composition will occur at 0,6,12,and 18 months. To better understand the impact of potential mediators on exercise adoption and participation in this study, we propose to assess these factors and physical activity at 0,3,6,9,12,15, and 18 months. It is believed that this proposed study will lead to improvements in exercise participation in overweight women, which will result in improvements in the long-term treatment of obesity.
Keywords: behavior therapy, exercise, motivation, obesity, weight loss, body composition, longitudinal human study, physical fitness, behavior test, behavioral /social science research tag, clinical research, female, human subject
Project start date: 2003-09-01
Project end date: 2008-08-31
5R01HL067826-04 (2006): $318481
5R01HL067826-03 (2005): $424125
5R01HL067826-02 (2004): $447775
1R01HL067826-01A2 (2003): $386840
A MENTOR-BASED APPROACH TO LONG-TERM WEIGHT LOSS
John M Jakicic, Chair
Miriam Hospital
providence, Ri 029062853
Grant 5R01DK058002-03 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZRG1
Abstract: The primary goal of this study is to examine the effect of a mentor-based intervention on long-term weight loss in overweight adult women. The primary analysis will focus on the effect of this intervention on long-term weight loss in women receiving a mentor-based intervention, with additional analysis focusing on the effect of this intervention on long-term weight loss in women functioning as mentors in this study. Despite short-term (greater than or equal to 6 months) success in weight loss programs, significant weight regain can occur in adults within the 12 months following the initial intervention period. It has been shown that maintaining long-term contact with an intervention program, maintaining exercise, and maintaining healthful eating behaviors are associated with improvements in long-term weight loss outcomes. Therefore, the challenge is to develop interventions that facilitate the adoption and maintenance of these behaviors. We hypothesize that a mentor-based intervention will improve long-term weight loss in both mentors and mentor-recipients compared to individuals receiving a standard non-mentored-based weight loss intervention. We hypothesize that this improvement will be a result of increased contact with a structured program which result in the enhanced adoption and maintenance of healthful eating and exercise behaviors. Overweight Subjects will be recruited in two phases 1) 58 subjects in Phase 1, and 2) 116 subjects in Phase 2. Subjects in Phase 1 that lose greater than or equal to 10 pounds within the initial 6 months of treatment will be randomized as a mentor or non-mentor for subjects in Phase 2. Subjects in Phase 2 will be randomize to receive or not receive a mentor (mentor-recipient versus non-mentor-recipient). Subject in Phase 1 will be followed for 24 months and subjects in Phase 2 followed for 18 months. Assessments will occur at 6 month intervals and will include body weight, body composition, fitness, eating and exercise behaviors, and mediators of behavior change. It is believed that a mentor- based intervention will lead to improvements in the long-term treatment of obesity
Keywords: behavior modification, diet, exercise, female, longitudinal human study, obesity, outcomes research, role model, weight loss behavior therapy, clinical trial, dietary control, health behavior, human middle age (35-64), nutrient intake activity, social support network, therapy compliance, women`s health, young adult human (19-34) behavioral /social science research tag, clinical research, human subject, nutrition related tag, statistics /biometry
Project start date: 1999-09-30
Project end date: 2002-04-30
5R01DK058002-03 (2001): $187549
Sponsored Links Excellgen http://Excellgen.com
5R01DK058002-02 (2000): $216734
A MENTOR BASED APPROACH TO LONG TERM WEIGHT LOSS
John M Jakicic, Chair
Miriam Hospital
providence, Ri 029062853
Grant 1R01DK058002-01 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZRG1
Abstract: The primary goal of this study is to examine the effect of a mentor-based intervention on long-term weight loss in overweight adult women. The primary analysis will focus on the effect of this intervention on long-term weight loss in women receiving a mentor-based intervention, with additional analysis focusing on the effect of this intervention on long-term weight loss in women functioning as mentors in this study. Despite short-term (greater than or equal to 6 months) success in weight loss programs, significant weight regain can occur in adults within the 12 months following the initial intervention period. It has been shown that maintaining long-term contact with an intervention program, maintaining exercise, and maintaining healthful eating behaviors are associated with improvements in long-term weight loss outcomes. Therefore, the challenge is to develop interventions that facilitate the adoption and maintenance of these behaviors. We hypothesize that a mentor-based intervention will improve long-term weight loss in both mentors and mentor-recipients compared to individuals receiving a standard non-mentored-based weight loss intervention. We hypothesize that this improvement will be a result of increased contact with a structured program which result in the enhanced adoption and maintenance of healthful eating and exercise behaviors. Overweight Subjects will be recruited in two phases 1) 58 subjects in Phase 1, and 2) 116 subjects in Phase 2. Subjects in Phase 1 that lose greater than or equal to 10 pounds within the initial 6 months of treatment will be randomized as a mentor or non-mentor for subjects in Phase 2. Subjects in Phase 2 will be randomize to receive or not receive a mentor (mentor-recipient versus non-mentor-recipient). Subject in Phase 1 will be followed for 24 months and subjects in Phase 2 followed for 18 months. Assessments will occur at 6 month intervals and will include body weight, body composition, fitness, eating and exercise behaviors, and mediators of behavior change. It is believed that a mentor- based intervention will lead to improvements in the long-term treatment of obesity
Keywords: behavior modification, diet, exercise, female, longitudinal human study, obesity, outcomes research, role model, weight loss behavior therapy, clinical trial, dietary control, health behavior, human middle age (35-64), nutrient intake activity, social support network, therapy compliance, women`s health, young adult human (19-34) behavioral /social science research tag, clinical research, human subject, nutrition related tag, statistics /biometry
Project start date: 1999-09-30
Project end date: 2002-08-31
1R01DK058002-01 (1999): $184422
DOSE-RESPONSE OF EXERCISE ON LONG-TERM WEIGHT LOSS
John M Jakicic, Chair
Miriam Hospital
providence, Ri 029062853
Grant 5R01HL064991-03 from National Heart, Lung, And Blood Institute IRG: BEM
Abstract: The primary goal of this study is to examine the dose-response of exercise on long-term weight loss in overweight adult women. Exercise is a key component of behavioral weight loss programs because of its effect on weight loss, body composition, cardiovascular disease risk factors, and other obesity related diseases such as type 2 diabetes mellitus. Despite these benefits, it is unclear whether there is an optimal exercise duration and/or intensity that will enhance long-term weight loss. The current public health recommendation for physical activity is for individuals to participate in at least 30 minutes of moderate intensity physical activity on most days of the week (approximately 150 minutes per week total). However, it is unclear whether this amount of exercise is adequate for long-term weight loss. Moreover, cross-sectional studies have shown that individuals that have been successful at long-term weight loss participate in levels of physical activity that are greater than the current public health recommendations. The researchers hypothesize that adopting higher levels of exercise duration and/or intensity, coupled with a strong behavioral intervention will enhance long-term weight loss. To test this hypothesis, they propose to recruit 200 overweight women and randomly assign them to one of four treatment groups (1) moderate intensity, moderate 1000cal/wk duration exercise, (2) vigorous intensity moderate duration exercise, (3) moderate 2000cal/wk intensity, high duration exercise, and (4) vigorous intensity, high duration exercise. All subjects will participate in a 24-month behavioral weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the interventionists. In addition, to facilitate the adoption of the exercise protocols, all subjects will be provided with a home treadmill. Assessment of body weight will occur at 0, 6, 12, and 24 months and exercise participation will be measured throughout the program. In addition, body composition, cardiorespiratory fitness, cardiovascular disease risk factors, and mediators of behavior change will occur at 0, 6, 12, and 24 months. The investigators believe that the proposed study will lead to improvements in the long-term treatment of obesity
Keywords: behavior therapy, exercise, human therapy evaluation, longitudinal human study, obesity, weight loss body composition, body weight, cardiovascular function, female, therapy compliance behavioral /social science research tag, clinical research, human subject, telecommunication, women`s health
Project start date: 1999-09-01
Project end date: 2003-08-31
5R01HL064991-03 (2001): $342249
5R01HL064991-02 (2000): $439977
DOSE/RESPONSE OF EXERCISE ON LONG TERM WEIGHT LOSS
John M Jakicic, Chair
Miriam Hospital
providence, Ri 029062853
Grant 1R01HL064991-01 from National Heart, Lung, And Blood Institute IRG: BEM
Abstract: The primary goal of this study is to examine the dose-response of exercise on long-term weight loss in overweight adult women. Exercise is a key component of behavioral weight loss programs because of its effect on weight loss, body composition, cardiovascular disease risk factors, and other obesity related diseases such as type 2 diabetes mellitus. Despite these benefits, it is unclear whether there is an optimal exercise duration and/or intensity that will enhance long-term weight loss. The current public health recommendation for physical activity is for individuals to participate in at least 30 minutes of moderate intensity physical activity on most days of the week (approximately 150 minutes per week total). However, it is unclear whether this amount of exercise is adequate for long-term weight loss. Moreover, cross-sectional studies have shown that individuals that have been successful at long-term weight loss participate in levels of physical activity that are greater than the current public health recommendations. The researchers hypothesize that adopting higher levels of exercise duration and/or intensity, coupled with a strong behavioral intervention will enhance long-term weight loss. To test this hypothesis, they propose to recruit 200 overweight women and randomly assign them to one of four treatment groups (1) moderate intensity, moderate 1000cal/wk duration exercise, (2) vigorous intensity moderate duration exercise, (3) moderate 2000cal/wk intensity, high duration exercise, and (4) vigorous intensity, high duration exercise. All subjects will participate in a 24-month behavioral weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the weight loss program, with subjects attending group meetings and receiving periodic telephone contacts from the interventionists. In addition, to facilitate the adoption of the exercise protocols, all subjects will be provided with a home treadmill. Assessment of body weight will occur at 0, 6, 12, and 24 months and exercise participation will be measured throughout the program. In addition, body composition, cardiorespiratory fitness, cardiovascular disease risk factors, and mediators of behavior change will occur at 0, 6, 12, and 24 months. The investigators believe that the proposed study will lead to improvements in the long-term treatment of obesity
Keywords: behavior therapy, exercise, human therapy evaluation, longitudinal human study, obesity, weight loss body composition, body weight, cardiovascular function, female, therapy compliance behavioral /social science research tag, clinical research, human subject, telecommunication, women`s health
Project start date: 1999-09-01
Project end date: 2003-08-31
1R01HL064991-01 (1999): $422404
THE EFFECT OF A STEPPED-CARE APPROACH TO LONG-TERM WEIGHT LOSS
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Grant 5R01HL084400-04 from National Heart, Lung, And Blood Institute
Abstract: The primary aim of this study will be to examine whether a chronic-care obesity intervention delivered in a "stepped-care" manner, results in improved weight loss compared to a standard behavioral weight loss intervention (SBWP group). It is hypothesized that there will be a significant increase in weight loss following an 18-month intervention in Stepped-Care versus SBWP. Secondary outcomes include body fat distribution, process measures of energy intake and physical activity, and behavioral/psychosocial measures that may be influence by the proposed interventions. In additional, a cost analysis will be performed to evaluate these interventions. The prevalence of overweight and obesity have been increasing over the past few decades, and it is now estimated that in excess of 65 percent of adults have a BMI >30 kg/m2. It has been suggested that a chronic care intervention in which there is continued contact between the interventionist and the weight loss participate be implemented to improve long-term weight loss outcomes. In addition, it has been suggested that a model to consider for modifying health-related behaviors is a "stepped-care" intervention, which increases the intensity and frequency of contact between the participant and the interventionist. However, the stepped-care approach has not been systematically and extensively applied to behavioral weight control interventions. This study will randomly assign 356 participants to either 1) standard behavioral weight loss program, 2) stepped-care weight loss program. The length of the intervention will be 18 months with assessments occurring at 0, 3, 6, 9,12,15, and 18 months. The stepped-care intervention will be evaluated based on the ability of the participant to achieve a predetermined weight loss goal at each assessment period. If the goal is achieved, the participant will continue with that intervention step for an additional 3 months. If the weight loss goal is not achieved, the participant is progressed to the next step which increases the intensity and frequency of the contact between the interventionist and participant. If successful, a stepped-care intervention model may have application in various health-care settings and may be appealing to health-care providers and managed care organizations by providing a criterion-based intervention to improve long-term weight loss
Keywords: 21+ years old; Accounting; Address; Adult; Analysis, Cost; BMI percentile; BMI z-score; Behavior; Behavior Conditioning Therapy; Behavior Modification; Behavior Therapy; Behavior Treatment; Behavior or Life Style Modifications; Behavioral; Behavioral Conditioning Therapy; Behavioral Modification; Behavioral Therapy; Behavioral Treatment; Blood Pressure, High; Body Weight decreased; Body fat; Body mass index; Caloric Intake; Cancers; Cardiovascular Diseases; Care, Health; Caring; Chronic Care; Chronic Disease; Chronic Illness; Conditioning Therapy; Cost Analyses; Cost Analysis; Data Banks; Data Bases; Databank, Electronic; Databanks; Database, Electronic; Databases; Depression; Diabetes Mellitus; Disease; Disorder; Documentation; Electronics; Energy Intake; Epidemic; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Frequencies (time pattern); Frequency; Goals; Health Care Costs; Health Care Providers; Health Costs; Health Personnel; Healthcare; Healthcare Costs; Healthcare Providers; Healthcare worker; Human, Adult; Hypertension; Indirect Costs; Individual; Intervention; Intervention Strategies; Investigators; Length; Life Style Modification; Link; Maintenance; Maintenances; Malignant Neoplasms; Malignant Tumor; Managed Care; Measures; Mental Depression; Methods; Modeling; Motivation; Musculoskeletal; Obesity; Outcome; Over weight; Overweight; Participant; Patients; Physical activity; Prevalence; Prevention of relapse; Process Measure; Programs (PT); Programs [Publication Type]; Quetelet index; Randomized; Relative; Relative (related person); Reporting; Research; Research Personnel; Researchers; SCHED; Schedule; Self Efficacy; Smoking; Staging; Structure; Substance abuse problem; Time; United States; Vascular Hypertensive Disease; Vascular Hypertensive Disorder; Weight; Weight Loss; Weight Reduction; Weight maintenance regimen; abuse of substances; adiposity; adult human (21+); base; behavior change; behavior intervention; behavioral intervention; body weight loss; caloric dietary content; cardiovascular disorder; chronic care model; chronic disease/disorder; chronic disorder; clinical data repository; clinical data warehouse; clinical relevance; clinically relevant; corpulence; corpulency; corpulentia; cost; cost effectiveness; data repository; diabetes; disease/disorder; disorder later incidence prevention; effective intervention; expectation; health care organization; health care personnel; health care service organization; health care worker; health provider; healthcare personnel; hyperpiesia; hyperpiesis; hypertensive disease; improved; innovate; innovation; innovative; interventional strategy; malignancy; medical personnel; neoplasm/cancer; obese; obese people; obese person; obese population; obesity treatment; prevention of disease recurrence; prevention of disorder recurrence; prevention of later incidences of a disorder; prevention of recurrence; programs; psychosocial; randomisation; randomization; randomly assigned; relational database; response; secondary outcome; social cognitive theory; substance abuse; success; theories; treatment provider; weight control; weight loss intervention; wt-loss
Project start date: 2007-09-01
Project end date: 2012-06-30
Budget start date: 1-JUL-2010
Budget end date: 30-JUN-2011
5R01HL084400-04 (2010): $704180
5R01HL084400-03 (2009): $717356
5R01HL084400-02 (2008): $716088
1R01HL084400-01A2 (2007): $770990
Technology To Improve Assessment Of Physical Activity
John M Jakicic, Chair
University Of Pittsburgh At Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260
Grant 5R21DK066150-02 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZRG1
Abstract: The goal of this study is to examine the validity and reliability of the LifeChek KAL-X Sensor to assess energy expenditure during varying modes and intensities of physical activity. We will also examine whether environmental conditions or variations in clothing impact the accuracy or performance of the KAL-X Sensor. In addition, we will examine the correlation between the KAL-X Sensor and self-reported physical activity across a period of free-living. This will also permit us to examine if participants are willing to wear this device for an extended period of time and the integrity of the sensor under free-living conditions. This application is in response to a recent program announcement by the NIH (PAR-03-009). The proposed study will involve three phases; in Phase 1 we will compare energy expenditure from the KAL-X Sensor to a criterion measure of energy expenditure (indirect calorimetry). This will involve the subjects performing a variety of activities including the following treadmill walking, cycle ergometry, armcrank ergometry, resistance exercise, and a simulation of lifestyle activity. Each activity session will be performed on a separate day with energy expenditure estimated using the LifeChek KAL-X Sensor and the criterion measure of energy expenditure will be indirect calorimetry. To assess whether variations in bodyweight and body size impact the accuracy of the KAL-X Sensor, we will recruit equal numbers of men and women from three body mass index categories (20-24.9 kg/m 2, 25-29.9 kg/m 2, 30-35 kg/m2). Based on a power analysis, 48 subjects (16 in each body mass index category) will be recruited to participate in this study. In Phase 2 subjects will perform an outdoor activity for a period of approximately 60 minutes. Again, energy expenditure will be estimated using the LifeChek KAL-X Sensor and the criterion measure of energy expenditure will be indirect calorimetry. We will also monitor environmental conditions (temperature, humidity, and cloud cover) to assess whether these factors impact the accuracy of the KAL-X Sensor. In Phase 3 subjects will wear the KAL-X Sensor for a one-week period under free-living conditions. This will allow us to compare energy expenditure from the KAL-X Sensor with energy expenditure estimated from self-report using a questionnaire. Moreover, we will be able to examine if participants are willing to wear this device and the integrity of the KAL-X Sensor under free-living conditions. We hypothesize that there will be no significant difference between the measurements of energy expenditure in the validation study between the KAL-X Sensor and indirect calorimetry. In addition, we hypothesize that clothing and environmental conditions will not affect the accuracy or reliability of the KAL-X Sensor. Moreover, we hypothesize that subjects will be willing to wear the KAL-X Sensor and that the sensor will be reliable under free-living conditions. The KAL-X Sensor is an innovative technology that may revolutionize the assessment of energy expenditure and may have implications for improving outcomes in clinical programs.
Keywords: bioenergetics, biomedical equipment development, body physical activity, monitoring device, body composition, body weight, chordate locomotion, consumer product, environment, exercise, portable biomedical equipment, temperature, adult human (21+), calorimetry, clinical research, data collection methodology /evaluation, human subject, questionnaire
Project start date: 2004-07-01
Project end date: 2007-06-30
5R21DK066150-02 (2005): $106137
Sponsored Links Excellgen http://Excellgen.com
1R21DK066150-01A1 (2004): $131283
EXERCISE ADHERENCE IN A BEHAVIORAL WEIGHT LOSS PROGRAM
John M Jakicic, Chair
University Of Kansas Lawrence 2385 Irving Hill Road Lawrence, Ks 660457563
Grant 5R29HL056127-05 from National Heart, Lung, And Blood Institute IRG: BEM
Abstract: The goal of this study is to develop intervention strategies that improve long-term exercise adherence in obese adults in order to improve long-term weight loss. Even though exercise improves long-term weight loss maintenance and reduces the risks of cardiovascular disease and Type II diabetes mellitus, obese adults are prone to drop out of exercise programs. The investigator s prior findings suggest that exercise adherence can be enhanced and short-term weight loss can be improved by making exercise more convenient via prescribing exercise in multiple short bouts, rather than one bout per day. Effects on long-term exercise adherence and weight loss have not been examined, however. His findings also suggest that providing more exercise options by placing exercise equipment in the home may also increase adherence, as evidenced by a significant correlation between the presence of home exercise equipment and physical activity. However, no experimental studies have tested whether placing exercise equipment in the home actually increases exercise adherence and weight loss. The investigator hypothesizes that prescribing exercise in multiple short bouts will improve long-term exercise adherence and long-term weight loss, and that the addition of home exercise equipment will further improve these outcomes. The research plan is to recruit 150 overweight women and randomize them to one of three treatments 1) long-bout exercise; 2) short-bout exercise; 3) short- bout exercise + home exercise equipment. All subjects will participate in an 18-month behavioral weight loss program, in which body weight is assessed at 0, 6, 12, and 18 months and exercise adherence is assessed throughout the 18 months. Cardiorespiratory fitness and cardiovascular disease risk factors will be measured at 0, 6, and 18 months.
Keywords: behavior therapy, exercise, obesity, therapy compliance, weight loss, health behavior, home health care, longitudinal human study, behavioral /social science research tag, clinical research, female, human subject, young adult human (19-34)
Project start date: 1996-05-15
Project end date: 1999-07-31
5R29HL056127-05 (1999): $13413
7R29HL056127-06 (1999): $79486
7R29HL056127-04 (1998): $74063
5R29HL056127-02 (1997): $89939
LOOK AHEAD: ACTION FOR HEALTH IN DIABETES
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Grant 5U01DK057002-12 from National Institute Of Diabetes And Digestive And Kidney Diseases
Abstract: Look AHEAD is randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145overweight volunteers with type 2 diabetes. Participants are randomized to an intensivelifestyle intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity, or to a control program of diabetes support and education. The primary outcome of Look AHEAD is the aggregate occurrence of severe cardiovascular events (fatal and non-fatal MI and stroke and cardiovascular deaths) over a planed follow-up of 11.5 years. The original grant applicationprovided funding for the first 7 years of the study (1 year for study design and 6 for execution of the trial). The present grant application is for an additional 7 years of funding to complete the Look AHEAD trial. All aspects of the study have proceeded extremely well - the sample of 5,145 participants was recruited on time; retention has been excellent and the intervention has been effective in producing initial weight loss and maintaining it over time. All 16 clinical sites have been successful in recruitment, retention, and delivery of the intervention and the DSMB has been very positive about the execution of the trial. The present application reviews the overall design of Look AHEAD, progress to date, and plans for the future. Specific Aims are to retain the cohort over time, continue to complete annual in-person visits and semi-annual telephone interviews for outcome assessments and continue to administer the lifestyle intervention. These procedures will enable us to analyze the effects of the intervention on serious cardiovascular events, on CVD risk factors, diabetes related factors and complications, and cost-effectiveness of the intervention
Keywords: 21+ years old; Active Follow-up; Adherence; Adherence (attribute); Adult; Affect; Angioplasty; Aortocoronary Bypass; Apoplexy; Applications Grants; Arm; BMI percentile; BMI z-score; Body Weight decreased; Body mass index; Bypass; Caloric Intake; Cardiac Failure Congestive; Cardiac infarction; Cardiovascular; Cardiovascular Body System; Cardiovascular Diseases; Cardiovascular system; Cardiovascular system (all sites); Carotid Endarterectomy; Cerebral Stroke; Cerebrovascular Apoplexy; Cerebrovascular Stroke; Cerebrovascular accident; Cessation of life; Clinical; Community Health Centers; Congestive Heart Failure; Control Groups; Coronary Artery Bypass; Coronary Artery Bypass Grafting; Coronary Artery Bypass Surgery; Country; Data; Death; Diabetes Mellitus; Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Ketosis-Resistant; Diabetes Mellitus, Non-Insulin-Dependent; Diabetes Mellitus, Noninsulin Dependent; Diabetes Mellitus, Slow-Onset; Diabetes Mellitus, Stable; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type II; Diet; Disease; Disorder; Education; Educational aspects; Effectiveness of Interventions; Effects, Longterm; Energy Intake; Epidemic; Event; F and A; Facilities and Administrative Costs; Facilities and Administrative Costs (F and A); Funding; Future; Goals; Grant; Grant Proposals; Grants, Applications; HOSP; Health; Heart Decompensation; Heart Failure, Congestive; Hospitalization; Human, Adult; Incidence; Indirect Costs; Intervention; Intervention Strategies; Investigators; Long-Term Effects; Longitudinal Studies; MODY; Maturity-Onset Diabetes Mellitus; Measures; Mediating; Metabolic; Minority; Morbidity; Morbidity - disease rate; Mortality; Mortality Vital Statistics; Multi-Institutional Clinical Trial; Multi-center clinical study; Multi-center clinical trial; Multi-site clinical study; Multi-site clinical trial; Myocardial Infarct; Myocardial Infarction; NIDDM; NIH; National Institutes of Health; National Institutes of Health (U.S.); Non-Insulin Dependent Diabetes; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ System, Cardiovascular; Outcome; Outcome Assessment (Health Care); Outcomes Assessment; Over weight; Overweight; Participant; Peripheral Angiopathies; Peripheral Vascular Diseases; Peripheral Vascular Disorder; Persons; Physical activity; Population; Procedures; Process; Programs (PT); Programs [Publication Type]; Protocol; Protocols documentation; Public Health; Quetelet index; Randomized; Randomized Clinical Trials; Recruitment Activity; Research Design; Research Personnel; Researchers; Risk Factors; Sampling; Satellite Centers; Stroke; Study Type; T2D; T2DM; Telephone Interviews; Testing; Time; Type 2 diabetes; Type II diabetes; United States; United States National Institutes of Health; Upper arm; Vascular Accident, Brain; Vascular, Heart; Visit; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; adiposity; adult human (21+); adult onset diabetes; base; body weight gain; body weight increase; body weight loss; brain attack; caloric dietary content; cardiac infarct; cardiovascular disease risk; cardiovascular disorder; cardiovascular disorder risk; cerebral vascular accident; circulatory system; clinical research site; clinical site; cohort; coronary angioplasty; coronary attack; coronary bypass; coronary infarct; coronary infarction; corpulence; corpulency; corpulentia; cost effectiveness; design; designing; diabetes; disease/disorder; effect of intervention; follow-up; hazard; heart attack; heart infarct; heart infarction; intervention design; intervention effect; intervention program; interventional strategy; intraluminal angioplasty; ketosis resistant diabetes; life style intervention; lifestyle intervention; long-term study; maturity onset diabetes; multi center clinical study; multi center clinical trial; multi site clinical study; multi site clinical trial; obese; obese people; obese person; obese population; obesity risk; peripheral blood vessel disorder; primary outcome; programs; public health medicine (field); randomisation; randomization; randomly assigned; recruit; secondary outcome; stroke; study design; therapy design; treatment design; volunteer; weight loss intervention; wt gain; wt-loss
Project start date: 1999-09-30
Project end date: 2013-07-31
Budget start date: 1-AUG-2010
Budget end date: 31-JUL-2011
PFA/PA: RFA-DK-05-504
5U01DK057002-12 (2010): $999397
5U01DK057002-11 (2009): $788259
5U01DK057002-10 (2008): $841575
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Keywords: Accounting; Administrator; Annual Reports; Applications Grants; Area; Awareness; Awarenesses; Back; Budgets; Caprine Species; Charge; Collaborations; Communicating Junction; Communication; Core Facility; Discipline; Dorsum; Ensure; Equipment; Gap Junctions; Goat; Grant; Grant Proposals; Grants, Applications; Guidelines; Individual; Investigators; Journals; Low-resistance Junction; Magazine; Maintenance; Maintenances; Mammals, Goats; Mission; Monitor; NIH; National Institutes of Health; National Institutes of Health (U.S.); Newsletter; Nexus; Nexus Junction; Nutrition; Nutrition Research; Nutritional Science; Nutritional Study; Obesity; Pattern; Policies; Process; Productivity; Programs (PT); Programs [Publication Type]; Publications; Reporting; Research; Research Personnel; Research Resources; Researchers; Resources; Role; Schools; Science of nutrition; Scientific Publication; Series; Services; United States National Institutes of Health; Universities; adiposity; base; corpulence; corpulency; corpulentia; meetings; nutrition; obese; obese people; obese person; obese population; programs; social role; web site
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2_6615 (2009): $103689
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Keywords: 0-11 years old; 21+ years old; Abnormal Assessment of Metabolism; Address; Adult; Advisory Committees; Aged 65 and Over; Animals; Appointment; Area; Award; Basic Research; Basic Science; Biological Models; Biopsy; Body Composition; Body Tissues; Cell model; Cellular model; Center for Translational Science Activities; Child; Child Youth; Childhood; Children (0-21); Clinical; Clinical Research; Clinical Study; Clinical Trials; Clinical Trials, Unspecified; Clinical and Translational Science Awards; Clinical assessments; Communities; Complex; Consultations; Country; DXA; Development; Discipline; Dual-Energy X-Ray Absorptiometry; Elderly; Elderly, over 65; Electronics; Energy Expenditure; Energy Metabolism; Equipment; Exercise Physiology; Expertise, Technical; Facility Accesses; Faculty; Fostering; Funding; Goals; HOSP; Hospitals; Hospitals, University; Housing; Human; Human, Adult; Human, Child; Human, General; Image; In Vitro; Institutes; Institution; Insulin Resistance; Intermediary Metabolism; Investigation; Investigators; Laboratories; Leadership; Left; Letters; Life; Location; METBL; Mammals, Rodents; Man (Taxonomy); Man, Modern; Mass Spectrum; Mass Spectrum Analysis; Measurement; Mediation; Medical; Medical Imaging, Positron Emission Tomography; Medical center; Mental disorders; Mental health disorders; Metabolic; Metabolic Processes; Metabolic Studies; Metabolism; Metabolism Studies; Method LOINC Axis 6; Methodology; Methods; Mission; Model System; Models, Biologic; Morbid Obesity; NIH; National Institutes of Health; National Institutes of Health (U.S.); Negotiating; Negotiation; Nuclear Magnetic Resonance; Nutrition; Nutrition Research; Nutritional Science; Nutritional Study; Obesity; Obesity, Morbid; Operation; Operative Procedures; Operative Surgical Procedures; Organ; Organization Charts; PET; PET Scan; PET imaging; PETSCAN; PETT; Photometry/Spectrum Analysis, Mass; Physical activity; Population; Positron Emission Tomography Scan; Positron-Emission Tomography; Prodigy; Programs (PT); Programs [Publication Type]; Proton Magnetic Resonance Spectroscopic Imaging; Psychiatric Disease; Psychiatric Disorder; Rad.-PET; Research; Research Personnel; Research Resources; Researchers; Resources; Rodent; Rodentia; Rodentias; Role; Scanning; Schools, Medical; Science of nutrition; Services; Severe obesity; Sight; Site; Spectrometry, Mass; Spectroscopy, Mass; Spectrum Analyses, Mass; Spectrum Analysis, Mass; Structure; Surgical; Surgical Interventions; Surgical Procedure; Task Forces; Technical Expertise; Time; Tissues; Translational Research; Translational Research Enterprise; Translational Science; United States National Institutes of Health; Universities; University Hospitals; Unspecified Mental Disorder; Vision; Wing; X-Ray Absorptiometry, Dual-Energy; adiposity; adult human (21+); advanced age; career development; cell imaging; cellular imaging; children; clinical investigation; corpulence; corpulency; corpulentia; design; designing; elders; energy balance; experience; fitness; geriatric; imaging; in vivo; innovate; innovation; innovative; insulin resistant; interest; late life; later life; medical schools; meetings; mental illness; metabolic abnormality assessment; method development; nutrition; obese; obese people; obese person; obese population; obesity, extreme; older adult; older person; organizational structure; pediatric; programs; psychological disorder; response; senior citizen; social role; surgery; tool; translation research enterprise; youngster
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2_9007 (2009): $29849
Sponsored Links Excellgen http://Excellgen.com
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Keywords: Animals; Assay; Basic Research; Basic Science; Bioassay; Biochemistry; Biologic Assays; Biological Assay; Body Tissues; Chemistry, Biological; Chemotherapy-Hormones/Steroids; Clinical Trials; Clinical Trials, Unspecified; D-Glucose; DNA Molecular Biology; Dextrose; Endocrine Gland Secretion; Fatty Acids; Generalized Growth; Genetic Markers; Glucose; Growth; Health; Hormones; Hydrogen Oxide; Laboratories; Lipoproteins; Microscopy; Mission; Molecular Biology; Nutrition; Nutrition Research; Nutritional Science; Nutritional Study; Obesity; Oxidative Stress; Phosphatides; Phospholipids; Research; Science; Science of nutrition; Services; Therapeutic Hormone; Tissue Growth; Tissues; Water; adiposity; base; biomarker; clinical investigation; corpulence; corpulency; corpulentia; cytokine; design; designing; nutrition; obese; obese people; obese person; obese population; ontogeny; response; stable isotope
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2_9002 (2009): $52390
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Keywords: Address; Aging; Area; Blood Vessels; Body Composition; Body Weight; Body Weight decreased; Clinical; Clinical Trials; Clinical Trials, Unspecified; Consultations; Disease; Disorder; Energy Expenditure; Energy Metabolism; Environment; Epidemiology; Equipment; Ethnic Origin; Ethnicity; Ethnicity aspects; Female Health; Funding; Genetic; Goals; Health; Image; International; Intervention; Intervention Strategies; Investigators; Japan; Laboratories; Maintenance; Maintenances; Measurement; Metabolic; Mission; Morbid Obesity; Morbidity; Morbidity - disease rate; Nutrition; Nutrition Research; Nutritional; Nutritional Science; Nutritional Study; Obesity; Obesity, Morbid; Observational Study; Pennsylvania; Physical activity; Population; Prevention; Primary Prevention; Race; Racial Group; Regulation; Research; Research Design; Research Personnel; Researchers; Role; Science of nutrition; Senescence; Services; Severe obesity; Special Population; Stocks, Racial; Study Type; Study of epidemiology; Tobago; Translating; Translatings; Vascular Diseases; Vascular Disorder; Weight; Weight Gain; Weight Increase; Weight Loss; Weight Reduction; Woman; Women`s Health; Work; adiposity; base; blood vessel disorder; body weight gain; body weight increase; body weight loss; clinical investigation; community planning; corpulence; corpulency; corpulentia; design; designing; disease/disorder; epidemiology study; human population study; imaging; interventional strategy; language translation; named group; nutrition; obese; obese people; obese person; obese population; obesity prevention; obesity treatment; obesity, extreme; patient oriented research; patient oriented study; population based; senescent; social role; study design; vascular; volunteer; weight gain prevention; wt gain; wt-loss
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2_9001 (2009): $36343
John M Jakicic
University Of Pittsburgh At Pittsburgh, Office Of Research, Pittsburgh, Pa 15213
Keywords: 0-11 years old; Behavior; Behavior assessment; Behavioral Research; Child; Child Youth; Children (0-21); Development; Eating Disorders; Human, Child; Investigation; Investigators; Leadership; Medical Imaging, Positron Emission Tomography; Mission; Nutrition; Nutrition Research; Nutritional Science; Nutritional Study; Obesity; PET; PET Scan; PET imaging; PETSCAN; PETT; Patients; Positron Emission Tomography Scan; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopic Imaging; Rad.-PET; Research; Research Personnel; Research Resources; Researchers; Resources; Science of nutrition; Services; Special Population; Technology; Wing; Work; adiposity; bariatric surgery; behavioral assessment; children; corpulence; corpulency; corpulentia; gastric banding; gastric bypass surgery; implantable gastric stimulation banding; innovate; innovation; innovative; motivational intervention; named group; nutrition; obese; obese people; obese person; obese population; obesity management; obesity surgery; stomach stapling; weight gain prevention; weight loss surgery; youngster
Budget start date: 25-JUL-2009
Budget end date: 31-MAY-2010
PFA/PA: RFA-DK-02-007
3P30DK046204-15S2_7102 (2009): $35084
Look AHEAD: Action For Health In Diabetes
John M Jakicic, Chair
Medicineuniversity Of Pittsburgh At Pittsburgh
350 Thackeray Hall
pittsburgh, Pa 15260
Grant 5U01DK057002-09 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZDK1
Keywords: human therapy evaluation, noninsulin dependent diabetes mellitus, obesity, weight loss atherosclerosis, body composition, carotid artery, clinical trial, cooperative study, cytokine, diet, disease /disorder proneness /risk, exercise, longitudinal human study, outcomes research clinical research, human subject, nutrition related tag
Project start date: 1999-09-30
Project end date: 2013-07-31
5U01DK057002-09 (2007): $1166171
Study Of Health Outcomes Of Weight-Loss (SHOW)
John M Jakicic, Chair
University Of Pittsburgh At Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260
Grant 2U01DK057002-08 from National Institute Of Diabetes And Digestive And Kidney Diseases IRG: ZDK1
Keywords: human therapy evaluation, noninsulin dependent diabetes mellitus, obesity, weight loss, atherosclerosis, body composition, carotid artery, clinical trial, cooperative study, cytokine, diet, disease /disorder proneness /risk, exercise, longitudinal human study, outcomes research, clinical research, human subject, nutrition related tag
Project start date: 1999-09-30
Project end date: 2013-07-31
2U01DK057002-08 (2006): $1054596
Effect Of Exercise On Prevention Of Weight Gain
John M Jakicic, Chair
University Of Pittsburgh At Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260
Grant 5R01HL070257-04 from National Heart, Lung, And Blood Institute IRG: ZRG1
Keywords: disease /disorder prevention /control, exercise, obesity, weight control, weight gain, body composition, cardiovascular function, diet, health behavior, longitudinal human study, outcomes research, physical fitness, respiratory function, behavioral /social science research tag, clinical research, human subject, photon absorptiometry
Project start date: 2003-01-27
Project end date: 2007-12-31
5R01HL070257-04 (2006): $388996
5R01HL070257-03 (2005): $487517
5R01HL070257-02 (2004): $525625
EXERCISE ADHERENCE IN A BEHAVIORAL WEIGHT LOSS PROGRAM
John M Jakicic, Chair
University Of Pittsburgh At Pittsburgh 350 Thackeray Hall Pittsburgh, Pa 15260
Grant 5R29HL056127-03 from National Heart, Lung, And Blood Institute IRG: BEM
Project start date: 1996-05-15
Project end date: 1998-07-31
5R29HL056127-03 (1998): $33525
1R29HL056127-01 (1996): $116947
Sponsored Links Excellgen http://Excellgen.com